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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
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Volume & Issues
Volume 1, Issue 1 - Nov 1971
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Studies on the Drug Absorption in Rat Intestine Effect on Acrid Condiments for the Absorption of Drugs
Park, Jung-Yong ; Woo, Chong-Hak ; Kim, Shin-Keun ; Han, Se-Ho ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 3~12
Many of the studies on absorption and excretion of drugs have been reported in the field of pharmaceutics, but the effect of acrid condiments for the absorption of drugs has not been. Hereupon, the authors investigated them in small intestine canal of rat in situ. In this experiment, aminopyrine, sulfadiazine and salicylic acid appended acrid condiments such as garlic, red pepper and pepper showed more increased absorption than constituted drugs. In particular, pepper showed the most increased than pepper, red pepper and garlic take lower absorption than pepper. When two drugs and over exist at a time, the efficacy is different from each other. Therefore, it is necessary to research of each circumstances administering one drug or compound drugs. We considers that we are abet to get safe and effectivecopound preparations when we studies on the effect. of drug action.
Effect of Robinia Pseudo Acacia Linne on Serum Total Cholesterol,
Content, Serum Glutamic Transaminase Activity of Rabbits
Young, Jae-Ick ; Ben, Shin-Za ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 13~21
The effects of alcohol. extract of acacia on total cholesterol,
content and S-GOT activity in serum of rabbit were examined. Rabbits were divided into four groups. A : Control group B : Cholesterol group C : Cholesterol+aca. alc. ex. (A) group D : Cholesterol+aca. alc. ex. (B) group Each group had four rabbits. A Group was fed with the stock diet only for the experimental period of 28 days. B Group was fed with the stock diet containing 500mg of cholesterol. C Group was fed with the stock diet containing 500mg of cholesterol and 300mg of acacia alcohol extract. D Group was fed with the stock diet containing 500mg of cholesterol and 500mg of acacia aocohol extract. Total cholesterol
content and S-GOT activity in serum was determined with spectrophotometer, spectronic 20. It was confirmed that the extract of acacia alcohol inhibits the increase of total cholesterol,
content and S-GOT activity in serum but the statistical probability was not significant.
Interaction of Pharmaceuticals with Beta-cyclodextrin II -Interaction with Barbituric and thiobarbituric Acid-
Min, Shin-Hong ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 22~29
Study on the analgesic Effect of Salicylamide and Combined with some Parasymptholytics and Serveral Antihistaminics
Kim, Kyl-Hhung ; Kim, Jae-Wan ; Woo, Chong-Hak ; Kim, Shin-Keun ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 30~33
Comparative studies were made on the analgesic effect of salicylamide, used individually and combined with parasympatholytics (propantheline and atropine) and antihistaminics (tripelennamine, diphenhydramine) as regards the analgesic effect (in thermal contact method) were examined by its oral administration with each combined drug to mouse (three assumption cross-over test), and the following effects were found. 1. The increasing order of the parasympatholytics to the analgesic effect of salicylamide is as follows: propantheline>atropine. 2. The increasing order of the antihistaminics to the analgesic effect of salicylamide is as follows: chlorpheniramine>diphenhdramine>tri pelennamine. In the ratio '1 : 1' salicylamide to parasympatholytics and antihistaminics, the analgesic effect of salicylamide was more increase than the other ratio in this study.
Influence of Oxytocin on the Renal Function of the Chicken
Ko, Suk-Tai ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 34~46
The existence of oxytocin in the pituitary gland of chicken has been ascertained, but its physiological roles are still obscure. In the study the action of oxytocin on renal function of the chicken was investigated during water diuresis, utilizing clearance and the Sperber technique. The results obtained are summarized as follows: Oxytocin, like in many species of mammals, elicited a profound diuretic response in the chicken. Urine flow, excretion of electrolytes, as well as glomerular filteration rate increased, with intravenous infusion of
. Oxtocin, infused into the renal portal circulation via hindleg vein in a dose of
. elicited marked increase in urine flow, glomerular filteration rate and sodium excreted in the urine. The diuretic effect was more pronounced in the infused side. It is suggested that diuretic response to oxytocin in the chicken results from dual action of oxytocin: increase of GFR and inhibition of sodium reabsorption on the renal tubule. The possibility that oxytocin might act through some endogenous substances could be ruled out.
Isolative Determination of Ethinyl Estradiol and Norethindrone Acetate in the Mixed Preparations
Lee, Jung-Hyun ; Young, Jae-Ick ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 47~52
Application of the spectrophotometer to the analysis of 17
acetate mixture in oral contraceptive has been accomplished. It is used Beckman Du Spectrophotometer as a apparatus. The petroleum ether extract of ethinyl estradiol is determined at
and the chloroform extract of norethindrone acetate is determined at
respectively. This analytical method is formed Lambert Beer's law. This method can be used to the analysis of ethinyl estradiol aid norethindrone acetate mixture in commercial dosage form of routine assay.
Studies on the Comparative Assay for the Alcohol Contents by the Determination of Alcohol Number and Diffusion Method
Park, Joung-Hoon ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 53~57
A Diffusion analysis method is described for the determination of alcohol content in tinctures and spirits and then, the comparison test of the official alcohol number test with the diffusion analysis method has hen carried out. Throughout this experiments, a transformed Widmark apparatus is used. It is found that the diffusion analysis method using the transformed Widmark apparatus is very simple and occapy a small space. One of the most convenient fact is many sample can be analyzed at a time with this apparatus. Experimental data indicate that 95% of alcohol content obtained by the official alcohol number test is found in the diffusion analysis.
Studies on the Stabilities of Hormones Combined with Some Stabilizers
Kim, Jae-Wan ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 58~61
Comparatives studies were made on stabilities of some hormons, used individually and combined with some stabilizers, and the following results were found. 1. The increasing order of antiallergic hormons (prednisolone, dexamethasone) to the stabilities as follows : Chlorpheniramine>Menadione>Inositol>Ascorbic acid. 2. The increasing order of sulfonylureas in as follows : Chlorpheniramine>Thiamine>Inositol>Ascorbic acid.
Studies on the Drug Availability of Dosage Forms I. Computer Calculation for the Rats of Absorption and Availability in a Pharmacokinetic Model
Lee, Min-Hwa ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 62~69
The method of assessing drug availability has been the subject of much concern and the equation is presented to estimate the drug availability of dosage forms and to calculate the desirable rates of drug absorption in a model.
To facilitate the calculations involved in the equation, a program in Fortran with Format was used in the IBM 1130 digital computer system. Using availability,
, and the given rates of elimination from the blood, the desirable rates of drug absorption in the model were calculated and shown in detail. Applicabiliy of the equation to estimate the drug availability of dosage forms in the model was demonstrated with different sets of data from the literatures.
The Study Concerned with the Hardness of Ointment 1. The Apparent Logarithmic Hardness of Ointment Registered on the Pharmacopeia of Korea
Kim, Johng-Kap ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 70~77
The ointment, had discovered and used from the ancient, have not ever defined to qualitity as the hardness concerned with the absorned With the absorption of the effect of durg through the skin. Auther, for the first time, suggest the apparent logarithmic hardness against the penetration of ointment registered on the pharmacopeia of the Republic of Korea, the results are as the followings. 1. The speciality of this apparent logarithmic hardness ie in proportion for the solidity on the contrary to the penetration of oiniment, and the distribution range of it are between 1.68 to 3.53 for their ointments examined. 2. The specific gravity of the verious ointments according to the apparent logarithmic hardness may be ignore on the calculaiotn, the mean valve of the samples was 2.9303. 3. The determination of apparent logarithmic hardness(H) by the penetration method follows the under equation.
where, the h is the penetrate length described centimeter, and p is the weight of the cone.
A Biopharmaceutical Study on the Absorption of Some Compounding Drugs
Kim, Jae-Wan ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 78~84
The comparative studies were made on Salicylamide, used individually and compounded with antihistaminics as regards. (1) the absorption rate through isolated rat small intestine (in vitro) (2) the absorption rate through rat small intestine (in vivo), and the following effects were found. 1. The Absorption velosity of 2 m Mole gm. of salicylamide in the small intestine were decreased, when the agents compounded with tripelennamine indicating the greatest absorption inhibition in the case of m Mole gm. of tripelennamine. 2. The Absorption velosity of 2m Mole gm. of salicylamide in the small intestine were decreased, when the agents compounded with diphenhydramine indicating the greatest absorption inhibition in the case of 2m Mole gm. of diphenhydramine. 3. The Absorption velosity of 2m Mole gm. of salicylamide in the small intestine were increased, when the agents compounded with chlorpheniramine indicating the greatest absorption augmentation in the case of 0.2m Mole gm. of chlorpheniramine.
Renal Action of Furosemide in the Chiken
Ko, Suk-Tai ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 85~89
The renal action of furosemide was investigated in the chicken, a species which has poorly developed loops of Henle and only rudimentary counter-current system in the kidney. Furosemide was infused into a hindleg vein, which is known to lead to the peritubular capillaries, forming renal portal system. A dose of 0.03 mg/kg/20 min. furosemide elicited a profound diuresis with saluresis, limited only to the infused side. This action rests on the inhibition of sodium reabsorption in the tubules, as the GFR remained unchanged or even decreased. It is thus inferred that the action of furosemide on Henle's loop contributes to the overall diuretic action only a negligible degree.
Studies on the Problems about Preparation and Packagin of Granular Enzymic Digestives
Lee, Seung-Koo ; Yi, Pyung-Kuk ; Kim, Cheong-Soo ; Bae, Young-Hwan ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 90~100
It is well known that the commonly used granular enzymic digestives are easy to diminish it's potency through preparation and custody. We made an experinent to know the proper way of manufacturing and keeping the granules without a loss of potency by
orthogonal Tables. The factors, we considered, decomposition of enzyme activity through manufacturing are (1) sufficiency of granules drying (2) with or without sodium bicarbonate
in gramules (3) separate wet granulation of enzyme and the rest of the component or mix together (4) kind of packing materials (Polycello or quartet silner paper) Besides we counted (5) humidity (6) temperature as block factors. Then we tested the potency of each sample by intervals of. a week, 2 weeks and we foretelled the potency of after one year by the life test. From the experimental results, main factor of activity loss is preserving humidity. Therefor the sufficiency of packing is became a main problem and the granules have to be made by separate wet granulation to inhibit it's decomposition. Temperature is the factor that accelerates loss of activity by humidity but does not so much by itself mixing enzyme toge therwith
is not became a matter so far as it is dried.
Studies on the Stabilities of Insectcides Combined with some Stabilizers
Woo, Chong-Hak ; Kim, Jae-Wan ;
Journal of Pharmaceutical Investigation, volume 1, issue 1, 1971, Pages 101~108
The stability and toxicity test for p.p'-DDT, DDVP and dipterex that put to used sample in this study effects is follows A. about p.p'-DDT (1) In elevating the stability of p.p'-DDT, best stabilizing solvent was benzene. (2) The stability-agent has no difficulty as long as it not contain metal ion for instance
but in case of contain
, the combination of salicylaminoguanidine is best effective. (3) Using this product for water-suspension, We must use span 40 for stability agent and adding it at the same time. (4) We must use container which does not week alkali and metal ion but it is to preserved in tight light-resistant container. (5) The stopper of container is adapted with above-mentioned condition of container, but it is better not to use metal material. (6) This product needs opening ventilation more than 30 minutes after diffusion or spray and in the room we remove cause of remained poison by cleaning the bottom. B. about DDVP and Dipterex (1) Benzene or toluene in best solvent to preserve stability of DDVP and Dipterex. (2) Span 40 is superior for stability agent of this product and second is span 80. (3) The pH of solution is very stable in pH 5-6 and comparative stable in alkali more than p,p'-DDT. (4) Container is to preserved in tight, lightresistant container and especially be careful of outflow and inflow of water. (5) Because this product is centeral stimulant poison, we must pay attention to prevent cause of contact diadermic toxicity after use.