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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 14, Issue 4 - Dec 1984
Volume 14, Issue 3 - Sep 1984
Volume 14, Issue 2 - Jun 1984
Volume 14, Issue 1 - Mar 1984
Selecting the target year
The Use of Stable Isotope Compounds in Pharmaceutical Research
Kang, Gun-Il ;
Journal of Pharmaceutical Investigation, volume 14, issue 4, 1984, Pages 145~155
The use of stable isotope compounds in pharmaceutical research was described with recent 33 references, which include synthesis, selected ion monitoring, pharmacokinetics, drug metabolism, and mechanism of drug action.
Pharmacokinetics of Acetaminophen in Rabbits with Carbon Tetrachloride Induced Hepatic Failure
Lee, Jin-Hwan ; Choi, Jun-Shik ; Burm, Jin-Pil ;
Journal of Pharmaceutical Investigation, volume 14, issue 4, 1984, Pages 156~160
The pharmacokinetics of acetaminophen administered intravenously(20mg/kg) was investigated in the rabbits of carbon tetrachloride induced hepatic failure. The blood level, the total AUC and the biological half life of acetaminophen were increased significantly in hepatic failure rabbits compared with those of normal rabbits. The urinary excretion and the overall elimination rate of acetaminophen were decreased significantly in hepatic failure rabbits. There was significant relationship between GOT value and AUC or biological half life of acetaminophen.
Studies on Dissolution of Lorazepam Preparation
Yang, Jae-Heon ;
Journal of Pharmaceutical Investigation, volume 14, issue 4, 1984, Pages 161~169
The tests of dissolution and bioavailability of six formulas of lorazepam tablet under various binders were performed. Lorazepam can be seperated in pharmaceutical preparation and biological plasma by high performance liquid chromatograph. Dissolution process of lorazepam tablet was largely influenced by binder and the dissolution rate was increased by sodium starch glycolate and microcrystalline cellulose, the slower dissolution rate in starch. Bioavailability of lorazepam tablet got relationship with dissolution rate, because tablets containing sodium starch glycolate and microcrystalline cellulose as binder maintained higher plasma level than other binders.
Effect of Mineral Silicates on Preparation of Spray Dried Agglomerates with CMEC
Min, Shin-Hong ; Yang, Joong-Ik ; Kwon, Jong-Won ; Yu, Bong-Gyu ;
Journal of Pharmaceutical Investigation, volume 14, issue 4, 1984, Pages 170~177
For the purpose of improving the fluidity of enteric-coated powders, various mineral silicates were added during spray drying process. Aqueous slurries of cimetidine, mineral silicates containing CMEC (carboxy methyl ethyl cellulose) were spray dried using a centrifugal wheel atomizer. The finely agglomerated powders obtained by this process were flowing as opposed to the original powders. The effect of four mineral silicates (colloidal silica, talc, bentonite, and kaolin) on the micromeritic properties and dissolution profiles of spray dried agglomerates were examined.
Studies on Antifatigue Activity of Crude Drug Extracts.( I ) -Ethanol Extracts of Polygonatum Officinale-
Jung, Ki-Hwa ;
Journal of Pharmaceutical Investigation, volume 14, issue 4, 1984, Pages 178~182
Extract of drugs in commerce was administered to mice for 3 days and 7 days and its antifatigue effects were compared with those of P. ginseng extract and A. sessiliflorum extract. Mice were used for these experiments divided into ethyl alcohol and water extract of R. glutinosa(saengjihwang), R. glutinosa (sookjihwang), A. japonica(changchool), A. japonica(baekchool), P. officinale, C. japonica, C. morifolium, A. calamus were given ordinary dose rally. For antifatigue test, swimming performance were determined after the extract administration. The group of P. officinale gave high improvement of the swimming performance in ethyl alcohol extract group.
Interaction of Erythrosine with Several Pharmaceutical Gelatins
Min, Shin-Hong ; Kwon, Jong-Won ; Jheong, Yeoub ;
Journal of Pharmaceutical Investigation, volume 14, issue 4, 1984, Pages 183~188
The interactions of FD & C Red No.3 (erythrosine) in 1 or 2% concentrations with various types of pharmaceutical gelatins were studied. In visible region spectroscopy type A gelatin showed 6 nm bathochromic shift in
of erythrosine, but no shifts were observed in other gelatins. Various results were obtained in the decrease of absorbance from 0.06 to 0.25. In dissolution study, the gelatin that showed the greatest spectral change exhibited the worst profile. From above results, it is concluded that erythrosine interacted to the greatest extent with type A gelatin and in the case of type B gelatin the degree of the interaction in different according to their specifications.
Study on Relative Bioavailability of Doxycycline Hyclate and Doxycycline-L-methylenelysine
Choi, Young-Wook ; Lee, Chang-Hoon ; Kim, Jeong-Ho ; Kim, Johng-Kap ;
Journal of Pharmaceutical Investigation, volume 14, issue 4, 1984, Pages 189~194
The present study was undertaken to evaluate the relative bioavailability of doxycycline hyclate and doxycycline-L-methylenelysine, a new synthetic derivative of doxycycline. Single doses, equivalent to 100mg of doxycycline hyclate, were administered orally to 10 healthy male volunteers. Serum concentrations were determined periodically over 12 hrs. by microbiological assay. Peak serum concentrations were reached within 4 hrs. Doxycycline hyclate
gave 1.66 tines higher concentration than doxycycline-L-methylenelysine
. And the areas under the serum concentrationtime curves 0 to 12 hrs were
(doxycycline hyclate) and
Studies on Antifatigue Activity of Crude Drug Extracts( II ) -Extracts of Poria Cocos and Sophora japonica-
Jung, Ki-Hwa ;
Journal of Pharmaceutical Investigation, volume 14, issue 4, 1984, Pages 195~199
Extract of drugs in commerce was administered to mice for 3 days and its fatigue effects were compared with those of P. ginseng extract and A. sessiliflorum extract. Mice were used for these experiments divided into ethyl alcohol and water extract of P. cocos, S. japonica, P. multiflorum, L. chinense, A. cochinchinensis, S. indicum, N. nucifera were given ordinary dose orally. For antifatigue test, swimming performance were determined after administration of the extract The group of P. cocos gave high improvement of the swimming performance in ethyl alcohol extract group. And the group of S. japonica an improvement was also observed in water extract group.