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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 15, Issue 4 - Dec 1985
Volume 15, Issue 3 - Sep 1985
Volume 15, Issue 2 - Jun 1985
Volume 15, Issue 1 - Mar 1985
Selecting the target year
Immobilization of Urease on Chitosan Matrix
Lee, Chi-Young ; Kim, Sung-Ho ;
Journal of Pharmaceutical Investigation, volume 15, issue 3, 1985, Pages 93~99
For the effective immobilization of urease on chitosan matrix with glutaraldehyde, optimal activation methods were studied, and its enzymatic properties was investigated. In the stability of enzyme. the retained activity of the native urease was 55% after it was soaked af pH 7 for 10 hrs., while the retained activity of immobilized one was about 62% after soaked at pH 6.5-8.5 for the same time. After heat treatment at
for 10 hrs., the native urease lost the most of its activity, while immobilized urease retained 54% of its activity by the same treatment. The retained activity of immobilized urease did not decrease nearly when it was stored at room temperature for 25 days. From Linweaver-Burk plots, the
value of native urease was
and that of immobilized urease was
, while Km value 40mM/l for both enzymes was unaltered.
Studies on Dissolution Rate of Flurbiprofen from Solvent Deposition Systems
Choi, Bo-Kyung ; Yong, Jae-Ick ;
Journal of Pharmaceutical Investigation, volume 15, issue 3, 1985, Pages 100~112
Dissolution characteristics of flurbiprofen solvent deposited on
, lactose and corn starch were studied to evaluate the pharmaceutical aspects of solvent deposition method where drug was solvent deposited on the surface of excipients. In a solvent deposition system, the drug to excipient ratio and kind of excipient affect much on dissolution rates of flurbiprofen. The solvent deposition system formation was confirmed by scanning electron microscope. By increasing the amounts of matrix, it was possible to enhance the dissolution rate of flurbiprofen solvent deposition system. The amount of flurbiprofen dissolved from
deposition system (1:10) at 60 minutes was enhanced 6.5 times in water and 28 times in simulated gastric juice compared with flurbiprofen alone. Flurbiprofen solvent deposited system (1:10) enhanced dissolution rate greater than inclusion complex and dispersion system.
Pharmacokinetics of Lithium Carbonate in Rabbits with Experimental Renal Failure
Burm, Jin-Pil ; Kim, Yong-Hyun ;
Journal of Pharmaceutical Investigation, volume 15, issue 3, 1985, Pages 113~120
The pharmacokinetics of lithium carbonate were investigated in rabbits with folate-induced renal failure. The blood level, the area under the blood concentration curve (AUC) and the biological half·life were increased significantly, and the urinary excretion was decreased significantly compared with those of normal rabbits. Correlation of serum creatinine concentration and AUC, biological half-life, and correlation of creatinine clearance and renal clearance of lithium carbonate have linear relationship respectively. In short, dosage regimen of lithium carbonate is considered to be adjusted in the dose size and the dosing interval by degree of experimental renal failure.
Influence of Various Waxes on Consistency of W/O Type Cream
Bae, Bong-Jean ; Choi, Young-Uk ; Kim, Johng-Kap ;
Journal of Pharmaceutical Investigation, volume 15, issue 3, 1985, Pages 121~129
Influences of various waxes on the consistency of cream was investigated by inspections through microscope, rheometer and sensory test. Fatty acids, higher fatty alcohols, hydrocarbons, and some of natural waxes were used in this experiment. Most above waxes showed good state of emulsion at low concentration, but at higher concentration
, they showed not only an unstable emulsion state but also a critical point of content in consistency. At this critical point of content, the consistency of w/o type cream was increased irregularly. So, it could be identified that consistency of a w/o type cream was strongly dependent on kinds and contents of waxes in continuous phase.
Studies on Inclusion Compounds of Suprofen with Cyclodextrins
Han, Soon-Young ; Yong, Jae-Ick ;
Journal of Pharmaceutical Investigation, volume 15, issue 3, 1985, Pages 130~139
Inclusion compounds of suprofen with
were studied in comparison with suprofen alone and commercial suprofen capsules. Inclusion compound formations of suprofen with
in aqueous solution and in solid state were confirmed by UV absorption, circular dichroism spectroscopies, IR spectroscopy, differential scanning calorimetry and X-ray diffraction measurements. Solid inclusion complexes were prepared by freeze-drying method, and their molar ratios were found to be 1 : 1. The dissolution rate of inclusion complexes of suprofen with CyDs was notably higher than that of suprofen alone.
Effects of Binders on Pharmaceutical Properties of Aspirin Tablets
Kwon, Kwang-Hyen ; Shin, Young-Hee ; Lee, Chi-Ho ;
Journal of Pharmaceutical Investigation, volume 15, issue 3, 1985, Pages 140~150
The influences of three binders, hydroxypropyl cellulose(HPC), microcrystalline cellulose (MCC) and polyvinylpyrrolidone(PVP), on the transmittance of compression pressure from upper punch to lower punch and the disintegration of aspirin tablets prepared by direct compression were studied. The optimum concentration of three binders for the disintegration of aspirin tablets was about 20w/w% and several physical properties of the powder and tablets were also investigated. The tablet machine was specially made for the measurement of compression pressure of the tablets.
Studies on Determination of Aliphatic Carbamates -Quantitative Analysis of Carisoprodol-
Kim, Jeoung-Sook ; Kim, Bak-Kwang ;
Journal of Pharmaceutical Investigation, volume 15, issue 3, 1985, Pages 151~159
For the determination of aliphatic carbamates, the quantitative analysis of carisoprodol was investigated by gab chromatography (GC) and spectrophotometry. All the methods studied were found to be very quantitative. The minimum experimental amounts of GC method, spectrophotometric method I and II were approximately
mole, respectively. The obtained results showed that GC method I was much more sensitive and rapid than spectrophotometric method II.