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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 16, Issue 4 - Dec 1986
Volume 16, Issue 3 - Sep 1986
Volume 16, Issue 2 - Jun 1986
Volume 16, Issue 1 - Mar 1986
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Studies on Dosage Form Design of Anticancer Drug: Release of 5-Fluorouracil from Silicone Devices Containing Water Soluble Additives
Kim, Sung-Ho ; Choi, Jun-Shik ; Back, Chae-Sun ; Yu, Young-Jong ; Lee, Chi-Young ;
Journal of Pharmaceutical Investigation, volume 16, issue 1, 1986, Pages 1~7
The influences of sodium chloride, polyethylene glycol 4000 and 20000 on 5-fluorouracil release from disk type silicone polymer devices were examined in isotonic phosphate buffer. These water soluble cosolvent and sodium chloride caused devices to swell in aqueous media. Sodium chloride exerted the greatest influence on drug release. The addition of water soluble cosolvent or sodium chloride to silicone polymeric devices permitted controlled release of 5-fluorouracil, presumably due to the change of the physical microstructure of silicone network, and the solubility and diffusivity of 5-fluorouracil. It seemed that the water soluble drug was released through the hydrophilic pores or pathways formed in the device by the incorporation of a water soluble cosolvent or sodium chloride.
The Stability of Chlorobutanol Solution in Polyethylene and Glycol-modified Polyethylene Terephthalate Containers
Min, Shin-Hong ; Kwon, Jong-Won ; Jheong, Gu-Choong ;
Journal of Pharmaceutical Investigation, volume 16, issue 1, 1986, Pages 8~11
There have been many difficulties in utilization of polyethylene (PE) container for volatile ingredients because of its high permeability. We selected glycol-modified polyethylene terephthalate (PETG) lately being used and evaluated the stability of 0.5% chlorobutanol solution for PETG. We used PE bottle, glass flask and rubber stoppered vial for comparison and assayed chlorobutanol contents of the samples stored at various temperatures for nine weeks by HPLC method. The results indicated that the stability of chlorobutanol in PETG container was almost similar to that in glass flask, and was superior to that in PE bottle and rubber stoppered vial.
Pharmaceutical Studies on Microencapsulated Etilefrine Hydrochloride
Kim, Johng-Kap ; Choi, Soo-Il ;
Journal of Pharmaceutical Investigation, volume 16, issue 1, 1986, Pages 12~17
Etilefrine hydrochloride was microencapsulated with ethylcellulose by phase separation method to develop a sustained release dosage form. The results of dissolution test carried out with various microcapsules showed that the drug release was decreased with increasing the particle size of microcapsules at a constant core to wall ratio, and with decreasing the core to wall ratio. Also ethylcellulose 50 cps and fast stirring rate (900 rpm) was better in decreasing the drug release than ethylcellulose 22 cps and slow stirring rate (300 rpm), respectively.
Studies on Efficacy of Crude Drug by Processing (II): Sedative Action, Prolonged Effect of Sleeping Time and Effects on Ileum-Smooth Muscle of Anemarrhenae Rhizoma
Sul, Soo-Young ; Cho, Young-Whan ; Rho, Young-Soo ; Hong, Nam-Doo ; Kim, Sin-Kyu ;
Journal of Pharmaceutical Investigation, volume 16, issue 1, 1986, Pages 18~23
Anemarrhenae Rhizoma has been clinically used as a sedative drug in oriental medicine. We observed the sedative action and effect on the movement of isolated-ileum with each water extract of Anemarrhenae Rhizoma (F-I), saline solution treated preparation (F-II) and 25% ethanol treated preparation (F-III). The results obtained were summerized as follows; 1) Sedative actions were recognized with F-I, F-II and F-III. 2) Prolonged effect of sleeping time was recognized significantly with F-I, F-II and F-III. 3) Each fraction of Anemarrhenae Rhizoma showed the released action on the isolated-ileum of the mouse, rat, rabbit and guinea pig, and antagonic action against contraction induced by acetylcholine, barium chloride and histamine. Thus the mechanism in the released action of the smooth muscle was partly considered as the direct dependence of the smooth muscle.
Studies on CNS-Depression and Antiinflammatory Action of Ssangwhatang
Jung, Jee-Chang ; Park, Dai-Kyu ;
Journal of Pharmaceutical Investigation, volume 16, issue 1, 1986, Pages 24~30
Ssangwhatang which has been known to have antipyretic, analgesic and antifatigue effects are composed of Paeoniae Radix, Angelicae gigantis Radix, Astragali Radix, Rehmaniae Radix, Cnidii Rhizoma, Cassiae Cortex, Glycyrrhizae Radix and Puerariae Radix. Effects of some formulations of Ssangwhatang were studied with respect to the analgesic, antipyretic, hypothermic, anticonvulsive and antiinflammatory actions in experimental animals. The results obtained were as follows: 1) Prescription A, B, C and D of Ssangwhatang were showed significant analgesic effect by the acetic acid stimulating method in mice. 2) All Ssangwhatang-prescriptions used in this studies had hypothermic effect in normal mice. 3) Significant antipyretic effect in febrile rabbits were recognized in prescription A and C of Ssangwhatang, while not in prescription B and D of Ssangwhatang. 4) Prescription A, B, C and D of Ssangwhatang showed marked antiinflammatory effect against the edema induced by carrageenin in rats. 5) Prescriptions of Ssangwhatang did not show significant anticonvulsive effect against the convulsion induced by picrotoxin and strychnine in mice. From the above results, analgesic, hypothermic, antipyretic and antiinflammatory effects were recognized in Ssangwhatang. Ssangwhatang A- and C- prescriptions added with Pueraiae Radix showed better effects than prescription B and C of Ssangwhatang.
Drug Interaction of Sulfamethazine and Ethanol
Choi, Jun-Shik ; Chun, Jong-Churl ; Lee, Jin-Hwan ; Yu, Young-Jong ;
Journal of Pharmaceutical Investigation, volume 16, issue 1, 1986, Pages 31~35
Effect of ethanol on the absorption rate, blood level and bioavailability of sulfamethazine (SM) in rats was determined. Absorption rate of SM was determined both by the in vitro and in situ experiment. In vitro, absorption rate of SM in rat small intestine was increased by 0.3, 1.0 and 3.0% ethanol. In situ, absorption rate of SM was increased by 0.3 and 1.0% ethanol but not by 3.0% ethanol. After oral administration, blood level of SM was elevated and relative bioavailability was significantly increased to 114.8% at the dose of 0.6g/kg ethanol but not significantly at the dose of 3.0g/kg ethanol. The time for attainment of peak blood level was changed from 2.5 to 1.5hr. Ethanol enhanced absorption rate constant of SM significantly and reduced elimination rate constant of SM administered orally at the dose of 0.6g/kg ethanol.
Enhancement of Dissolution Properties of Ketoprofen from Ground Mixtures with Chitin or Chitosan
Koh, Ik-Bae ; Shin, Sang-Chul ; Lee, Yong-Bok ;
Journal of Pharmaceutical Investigation, volume 16, issue 1, 1986, Pages 36~41
The ground mixtures of ketoprofen with chitin or chitosan were prepared by grinding in a ball mill to increase the dissolution rate. The ground mixture showed a faster and more enhanced dissolution rate than the physical mixture or intact ketoprofen. The X-ray diffraction peaks indicated the production of the amorphous form of ketoprofen in the ground mixture. An interaction, in the ground mixture, such as association between the functional groups of ketoprofen and chitin or chitosan might occur in the molecular level. The endothermic peak due to the fusion of ketoprofen disappeared in the ground mixture indicating the different thermal property. The co-grinding technique with chitin or chitosan provided a promising way enhancing the dissolution rate of practically insoluble drug.