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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 17, Issue 4 - Dec 1987
Volume 17, Issue 3 - Sep 1987
Volume 17, Issue 2 - Jun 1987
Volume 17, Issue 1 - Mar 1987
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Preparation of Furosemide Retard Tablets Using Hydroxyethylcellulose as Matrix Forming Material
Kim, Choong-Ho ; Shim, Chang-Koo ; Lee, Min-Hwa ; Kim, Shin-Keun ;
Journal of Pharmaceutical Investigation, volume 17, issue 2, 1987, Pages 47~53
Furosemide retard tablets were prepared using hydroxyethylcellulose(HEC) as a matrix material. Dissolution of furosemide from this tablet was retarded significantly comparing with conventional tablets and greatly dependent on HEC concentration and pH of the dissolution medium. The mechanism of retarded release was supposed to be due to HEC gel formation and drug diffusion through the gel matrix.
An Improved HPLC Assay Using Hg/Au Electrochemical Detector for S-2-(3-aminopropylamino) ethylphosphorothioate and S-2-(3-methylaminopropylamino) ethylphosphorothioate in Human Plasma
Han, Kun ; Lin, Emil T. ;
Journal of Pharmaceutical Investigation, volume 17, issue 2, 1987, Pages 55~60
WR 2721 (S-2-(3-aminopropylaminoethylphosphorothioate) is a radioprotective drug that is now undergoing clinical trials in the United States and Japan. a liquid chromatographic electrochemical method for the determination of WR 2721 an WR 3689 [S-2-(3-methylaminopropylamino)ethylphorothioate] in human plasma was developed in this study. This method includes the use of a Hg/Au electrochemical detector and a cyano column for the direct measurement of WR 2721 and WR 3689 in plasma. An analog of WR 2721, WR 149846 was used as an internal standard. WR 2721 and WR 3689 could be well separated from the solvent front, with a mobile phase of acetonitrile-water (20:80), 0.1M acetic acid and 1.2 mM sodium octane sulfonate. This method was shown to be precise. Both intra-day and inter-day results were within 10% CV. Also, sample preparation was fairly simple. Since WR 2721 and WR 3689 were unstable at room temperature, it was essential to use an automatic sample processor with a refrigerator, especially for carrying out routine analyses.
Synthesis and Antiinflammatory Activity of 4-Substituted-1,2-benzothiazine-3-carboxamide-1,1-dioxides
Suh, Jung-Jin ; Hong, You-Hwa ; Kim, Byung-Chae ;
Journal of Pharmaceutical Investigation, volume 17, issue 2, 1987, Pages 61~65
4-Pivaloyloxy, 4-benzenesulfonyloxy and 4-p-toluenesulfonyloxy compounds of piroxicam (2a, 2b and 2c) and isoxicam(4a, 4b and 4c) were synthesized in fairly good yield. Antiinflammatory and ulcerogenic effects of the 6 compounds were determined. Antiinflammatory effect of 2a was comparable to that of piroxicam and ulcerogenic effect of 2a was less than that of piroxicam.
Pharmaceutical Studies on Microencapsulated Propranolol Hydrochloride
Yoon, Mi-Ae ; Yong, Jae-Ick ;
Journal of Pharmaceutical Investigation, volume 17, issue 2, 1987, Pages 67~73
Propranolol hydrochloride was microencapsulated with ethylcellulose by means of phase separation from cyclohexane. The surface of the microcapsules examined using scanning electron microscope was porous. The dissolution rate of drug from microcapsules decreased as the weight ratio of propranolol hydrochloride to ethylcellulose decreased and as the size of microcapsules increased. The dissolution rate of drug from microcapsules decreased as the viscosity of ethylcellulose and pH of dissolution medium decreased.
Heparin Release from Polyurethane Devices
Kim, Sung-Ho ;
Journal of Pharmaceutical Investigation, volume 17, issue 2, 1987, Pages 75~78
The release rate of heparin from monolithic devices composed of raffinose,
, polyethylene oxide (Mw 20,000, PEO), and hydrophobic polyether urethane (biomer) was investigated. Water soluble raffinose,
, and PEO blended into the biomer provided a controlled release of heparin. The release rate of heparin could be controlled by the content of raffinose,
, and PEO in the devices. The mechanism of release rate increased by the raffinose,
, and PEO may result from the formation of channels and pores in the biomer matrices following the swelling and the change in the physical structure of polymer net work. Hydrophobic polyurethane containing raffinose,
, and PEO can provide a hydrophilic antithrombogenic material for prolonged release of heparin.
Pharmaceutical Studies on Ferroglycine Fumarate (I) -Studies on Glycine Complex of Ferrous Fumarate-
Shin, Hyun-Jong ; Lee, Wan-Ha ;
Journal of Pharmaceutical Investigation, volume 17, issue 2, 1987, Pages 79~88
In order to reduce gastric irritation of iron preparations, one prodrug, glycine complex of ferrous fumarate, was synthesized, identified, examined for physico-chemical properties and compared with ferrous fumarate, ferrous sulfate and ferroglycine sulfate. That novel ferroglycine fumarate (FGF) resulted in higher dissolution rate in water, artificial gastric and intestinal juice. The absorption rate constants
in rat of FGF was greater and ulcerogenic dose on stomach was increased remarkably than those of iron parent materials and ferroglycine sulfate.
Effects of Blended Chinese Traditional Medicine, Ssang Wha Tang, on Hepatic Clearance of Sulfobromophthalein in Rats
Cho, Tae-Yung ; Shim, Chang-Koo ; Lee, Min-Hwa ; Kim, Shin-Keun ;
Journal of Pharmaceutical Investigation, volume 17, issue 2, 1987, Pages 89~93
Effects of Ssang Wha Tang (SWT), a blended Chinese traditional medicine, on the pharmacokinetics of sulfobromophthalein (BSP) were studied in the rats. BSP was administered via portal vein to the control and the SWT-treated rats. The in vitro distribution of BSP to blood cells and the hemato-physiological conditions, liver weight, GOT. GPT activity were also examined. The systemic clearance
of BSP was increased with the administration of SWT, but no significant differences were observed in the liver weight and in vitro distribution of BSP to blood cells. These results suggest that the intrinsic clearance of free BSP of the liver is increased with the administration of SWT in the rats.
Drug Interaction of Probenecid and Lithium Carbonate
Lee, Jin-Hwan ; Lee, Chong-Ki ;
Journal of Pharmaceutical Investigation, volume 17, issue 2, 1987, Pages 95~98
The drug interaction between probenecid and lithium carbonate was studied pharmacokinetically in rabbits. The blood level and the area under the concentration curve (AUC) of lithium carbonate administered orally were elevated by coadministration of probenecid. Probenecid inhibited the urinary excretion of lithium carbonate in rabbits. Biological half-life and
of lithium carbonate were prolonged by coadministration of probenecid. From these results, dosage regimen of lithium carbonate is considered to be adjusted for effective and safe therapy in the coadministration of probenecid.