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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 2, Issue 2 - Dec 1972
Volume 2, Issue 1 - Mar 1972
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Studies on the Grain Size and Acid-consuming Capacity of Aiuminium-Hydroxide Gel
Roe, Tae-Sun ;
Journal of Pharmaceutical Investigation, volume 2, issue 1, 1972, Pages 5~13
There are some repels in which they studied on the change of acid-consuming capacity of aluminium hydroxide resulted from the passing of time. However, the relationship between grain sizes(particle sizes) and the acid-consuming capacity of dried aluminium hydroxide gel was not been studied. And studies on the grain sizes of aluminium hydroxide gel qualified by pharmacopoeia of Korea has not been reported. For the purpose of studying these two problems, the author prepared two-kinds of aluminium hydroxide gel as follows :
sample 2 Both of sample 1 and 2 are found to be amorphous by X-ray diffraction methods, and their acid-consuming capacities were determined by the method of pharmacopeia of Korea. The grain size was measured by X-ray diffraction method, the particle sizes observed by electron microscopy, and the change of acid-consuming capacity with passing of time was determined by the method of pharmacopoeia of Korea. The results of these studies are summerized as follows: 1. The grain size was linearly enlarged as the time goes by. The aluminium hydroxide gel gradually crystallized in a certain period of time. 2. The acid-consuming capacity was in exponential function, decreased as the grain size of them enlarged. 3. One particle consists of tens of grains.4. Grinding the Sample obtained in any period of testing time in mortar did not change both their grain size and their acid-consuming capacity. 5. The grain size of dried aluminium hydroxide gel ought to be micronized less than
for maintaining the ability such as consumes 250m1 of 0. 1N-HC1 solution per Is of
described in pharmacopoeia of Korea.
Spectrophotometric Determination of Isonicotinic Acid Hydrazide Sodium Methane Sulfonate
Park, Yonng-Ju ; Lee, Bung-Chan ; Suh, Jnng-Jin ; Kim, Sun-Nyu ;
Journal of Pharmaceutical Investigation, volume 2, issue 1, 1972, Pages 14~17
Spectrophotometric determination of isonicotinic acid hydrazide sodium methane sulfonate was examined and a new method has been established. Isonicotinic acid hydrazide sodium methane sulfonate reacts with acetylacetone solution (NASH Reagent) to produce a yellow dye, which exhibits absorption maximum at about
. Limits of masurement of isonicotinic acid hydrazide sodium methane sulfonate was
. By this method isonicotinic acid hydrazide methane sulfonate can be determined in the presence of isonicotinic acid hydrazide.
Mechanism of Urinary Excretion of Sulfadiazine in the Rabbit
Ko, Suk-Tai ; Chung, Chong-Nam ; Ko, Ok-Hyun ;
Journal of Pharmaceutical Investigation, volume 2, issue 1, 1972, Pages 18~30
Renal pathways for excretion of sulfadiazine has been studied by standard clearance technique in the rabbit. 1. Large part of sulfadiazine filtered in the glomeruli is reabsorbed in the tubules, as visualized from the fact that Csd (clearance of sulfadiazine) amounts only a fraction of simultaneously measured Ccr (GFR). 2. Csd changed linearly with the rate of urine flow, whether it is increased by the duir etics or decreased by clamping u reter. 3. Csd remained unchanged until the plasma level of the Csdremained unchanged drug reached 10.0 mg%, and the amount transported in the tubules increased linearly with the increase in the load, exhibiting No maximum capacity for transport. 4. Csd was increased by 2,4-dinitrophenol which is an uncoupling agent of oxidative phosphorylation and decreased by probenecid which is on uricosuric agent. 5. During sodium bicarbonate infusion net secretion of sulfadiazine by tubules observed. All the evidences obtained in the rabbit indicated that sulfadiazine was reabsorbed by active, energy-requiring, or passive, simple diffusion, process, and secreted simultaneously by a probenecid-sensitive, active procss.
Study on Korean Acid Clay as the Tablet Disintegrator
Roe, Tae-Sun ; Yim, Chang-Kyun ;
Journal of Pharmaceutical Investigation, volume 2, issue 1, 1972, Pages 31~39
Studies on Water Vapor Sorption through Hard Gelatin Capsules
Park, Joung-Hoon ;
Journal of Pharmaceutical Investigation, volume 2, issue 1, 1972, Pages 40~51
Water vapor sorption of corn starch in various protective film coated capsules in 100% RH chamber for 14 days were as follows: The percent of water vapor sorption were 28.63% in uncoated capsule, 25.16% in hydroxy propylcellulose(HPC) coated capsule, 15.59% in 2-methyl-5-vinyl pyridine-methyl acrylated-methacrylic acid (MPM) coated capsule and 15.50% in polyvinyl acetal diethyl amino acetate(AEA) coated capsule. 2. Water vapor sorotion of magnesium trisilicate in various protective film coated capsules in 100% RH chamber for 14 days were as follows. The percent of water vapor sorption were 13.91% in uncoated capsule, 13.30% in HPC-coated capsule, 10.87% in MPM-caated capsule and 9.9% in AEA-coated capsule. 3. Water vapor sorption of magnesium carbonate in various protective film coated capsules in 100% RH chamber for 14 days were as follows: The percent of water vapor sorption were 12.48% in uncoated capsule, 10.72% in HPC-coated capsule, 8.10% in MPM coated capsule and 7.8% in AEA-coated capsule. 4. MPM-coated capsules and AEA-canted capsules were mere effective to protect water vapor sorption than HPC-coated capsules.
Study on the Effect of Talc on the Degredation of Ascorbic Acid in its Diluted Preparation
Chung, Kee-Hwa ; Lee, Min-Hwa ; Woo, Chong-Hak ; Kim, Shin-Kenn ;
Journal of Pharmaceutical Investigation, volume 2, issue 1, 1972, Pages 52~57
There are many reports on the stability of drugs in powders and various dosage forms. The author studied on the stability of ascorbic acid mixed with talcs. From the result of this experiment, it was considered that talcs markedly accelerated oxidative degredation of ascorbic acid in powders and the acceleration rate depends on the varieties of crude talcs. Iron salts seem to be the principal factor influencing the degradation of ascorbic acid Degradation rate of ascorbic acid mixed with purified talc is significantly slower than that with the crnde talcs. The more the concetration of ascorbic acid is diluted, the faster the degradation rate and degredation rate of Ascorbic acid is the function of tme.
Studies on Application of Sterilization Method Using Ultra Violet Radiation for Liquid Preparations
Kim, Yong-Bae ; Lee, Sang-Hee ; Kim, Geon-Chee ; Kang, Gun-Il ;
Journal of Pharmaceutical Investigation, volume 2, issue 1, 1972, Pages 58~62
The stabillities of taurine, niacinamide, and pyridoxine hydrochloride under exposure to ultra violet radiation in liquid preparations were studied. And sterilization effects for E. coli in both water and liquid preparations were also comparatively evaluated. The above mentioned organic compounds were stable under this experimental conditions and viable count of E. coli reveals that organic compounds dissolved in solution display protective action for microorganisms under UV-irradiation.