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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 20, Issue 4 - Dec 1990
Volume 20, Issue 3 - Sep 1990
Volume 20, Issue 3 - Sep 1990
Volume 20, Issue 2 - Jun 1990
Volume 20, Issue 1 - Mar 1990
Selecting the target year
Studies on Application of Soybean Fatty Acid for Development of Cosmetic Formulation
Lee, Chi-Ho ; Shin, Young-Hee ; Lee, Une-Hyang ;
Journal of Pharmaceutical Investigation, volume 20, issue 2, 1990, Pages 55~64
Soybean fatty acid, the largest byproduct in the production of soybean oil, was formulated for hand cream, oil in water emulsion base, to improve the suppleness and elasticity of skin. The stability of emulsion observed by a macroscopic method was used as a characteristic index for deciding an optimum formula of hand creams. The optimum formula of the most stable hand cream was obtained from polynomial regression equation, contour graphs and partial derivative graphs. The values of soybean fatty acid and stearyl alcohol in the obtained optimum formula were 9.75 and 14.75 w/w%, respectively, and sodium lauryl sulfate was not needed. Experimental value for the stability of hand cream prepared according to the optimum formula was 76,14 days, and the prediction value by computation method was 73.25 days. From the results of accelerated tests by elevated temperature, the stability of hand cream by optimum formula was 1.7 year at room temperature
. The hand cream containing soybean fatty acid was found to be free of primary irritant substance to the skin by Draize technique.
Effect of Crystal Form(Habit) on Dissolution Rate of Aspirin and Phenacetin
Cho, Ji-Woon ; Sohn, Young-Taek ;
Journal of Pharmaceutical Investigation, volume 20, issue 2, 1990, Pages 65~71
Some studies reported physicochemical factors of drugs affecting solubility and dissolution rate. However, few have been reported about pharmaceutical application of crystal forms (habits). Therefore, using acetylsalicylic acid and phenacetin as model substances, we monitored the effects of crystal forms on the dissolution rates.
Fluorometric Determination of D-Penicillamine with 9-Fluorenylmethyl Pentafluorophenyl Carbonate
Byeon, Seung-Yeon ; Choi, Jung-Kap ; Yoo, Gyurng-Soo ;
Journal of Pharmaceutical Investigation, volume 20, issue 2, 1990, Pages 73~78
A sensitive fluorometric method using 9-fluorenylmethyl pentafluorophenyl carbonate (FMPC) as the fluorescent labeling agent was developed to determine D-penicillamine (D-PA). The fluorophore had excitation and emission wavelengths of 260 nm and 313 nm, respectively. After derivatization, the fluorescent product was separated, and quantified by spectrofluorometry. The derivative was highly fluorescent and stable. Optimum condition for the reaction was investigated. A linear response was obtained over the range of
with the correlation coefficient of 0.999 (n=6). The procedure described was successfully applied to the determination of the dosage forms of capsule with the recovery of
, (250 mg).
A Model for Diffusion and Dissolution Controlled Drug Release from Dispersed Polymeric Matrix
Byun, Young-Rho ; Choi, Young-Kweon ; Jeong, Seo-Young ; Kim, Young-Ha ;
Journal of Pharmaceutical Investigation, volume 20, issue 2, 1990, Pages 79~88
A numerical model for diffusion and dissolution controlled transport from dispersed matrix is presented. The rate controlling process for transport is considered to be diffusion of drug through a concentration gradient coupled with time-dependent surface change and/or disappearance of the dispersed drug in response to the dissolution. The transport behavior of drug was explained in terms of
value means a ratio of diffusion time constant and dissolution time constant. This general model has wide range of application from where release is controlled by the diffusion rate to where release is governed by the dissolution rate. Based on this model, theoretical drug concentration, particle size distributions in the polymer matrix system and the resulting release rate were also investigated.
Dissolution of Chlorpheniramine Mallate (CMP) from Sustained-Release Tablets Containing CPM in the Coated Film Layer
Yu, Jei-Man ; Shim, Chang-Koo ; Lee, Min-Hwa ; Kim, Shin-Keun ;
Journal of Pharmaceutical Investigation, volume 20, issue 2, 1990, Pages 89~95
Ethylcellulose-PEG 4000 film coated on core tablets was investigated as a potential drug delivery system for the controlled release of chlorpheniramine maleate (CPM). The kinetic analysis of the release data indicated that CPM release followed a diffusion-controlled model, where the quantity released per unit area is proportional to the square root of time. The effect of the film composition, CPM concentration, plasticizer concentration and CPM solubility on the release characteristics were examined. The release rate constant increased as CPM concentration increased. It also increased as the PEG 4000 content in the film increased above 10%(w/w), however, it decreased as the PEG 4000 content increased in the concentration range below 10%(w/w). The release rate constant was not affected by the coated weight on the core tablet. The film-coated tablets which contain CPM only in the coated film layer seemed to be a potential oral drug delivery system for the controlled release of CPM.
Study on the Polymorphism of Acetaminophen
Sohn, Young-Taek ;
Journal of Pharmaceutical Investigation, volume 20, issue 2, 1990, Pages 97~103
The metastable modification of acetaminophen was prepared in industry scale. It was found that the dissolution rate of the metastable modification was greater than that of the original powder. The metastable modification was transformed to the stable modification by grinding, but it was not transformed by compression. Starch and lactose inhibited this transformation of the metastable modification to the stable modification by grinding.