Go to the main menu
Skip to content
Go to bottom
REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 21, Issue 4 - Dec 1991
Volume 21, Issue 3 - Sep 1991
Volume 21, Issue 2 - Jun 1991
Volume 21, Issue 1 - Mar 1991
Selecting the target year
Quantitative Determination of Total Bile Acids from Bezoar and Bezoar-containing Liquid Preparation by Enzymatic Technique
Ha, In-Sik ; Kim, Seung-Hwan ; Cha, Bong-Jin ; Kwon, Jong-Won ; Yang, Joong-Ik ; Min, Shin-Hong ;
Journal of Pharmaceutical Investigation, volume 21, issue 2, 1991, Pages 67~71
A simple and sensitive method was developed for the quantification of free and conjugated bile acids in bezoar without prior hydrolysis.
bile acids are first oxidized to 3-keto bile acids in the reaction catalyzed by
. During this oxidative reaction, an equimolar quantity of nicotinamide adenine dinucleotide(NAD) is reduced to NADH and subsequently oxidized to NAD with concomitant reduction of nitrotetrazolium blue(NTB) to diformazan by the catalytic action of diaphorase. The diformazan has an absorbance maximum at 540 nm. The intensity of the color produced is directly proportional to bile acids concentration in the bezoar extracts. The optimum conditions for the enzymatic reaction such as effects of reaction time, reaction temperature and pH, and stability were investigated. Calibration plots for the sodium chelate observed to be linear and intra-, inter-assay analytical recovery of bile acids averaged
. Therefore, it is considered that the quality control of total bile acids from bezoar or bezoar-containing liquid preparation using this simple and sensitive assay system will be acceptable. Also current bezoars and bezoar-containing liauid preparations were examined their total bile acids from this method.
Study on the Design of Propranolol Rectal Suppository
Kim, Ga-Na ; Choi, Jun-Shik ; Lee, Jin-Hwan ;
Journal of Pharmaceutical Investigation, volume 21, issue 2, 1991, Pages 73~78
The influence of different suppository bases on the rectal absorption and the dissolution rate of propranolol was investigated. The bioavailability of propranolol in rectal suppository was determined by comparing the area under the concentration-time curves(AUC) for oral administration with rectal suppositories in rabbits. The dissolution
were higher in such order as tween (TWE), witepsol H-15(WIT), polyethylene glycol(PEG) suppository. The maximum blood concentrations
were 803.9 ng/ml for TWE suppository, 770.2 ng/ml for WIT suppository, 281.2 ng/ml for PEG suppository and 177.1 ng/ml for oral administration. The relative bioavailabilities were 233.5% for TWE suppository, 218.1% for TWE suppository, 191.3% for PEG suppository. The correlation between
and AUC, the time for dissolution in 75% and
, the mean dissolution time and the mean residence time showed significant linear relationship respectively.
Determination of Vitamin
by Agar Diffusion Method
Lee, Sung-Ho ; Cho, Chin-Sung ; Song, Young-Joon ;
Journal of Pharmaceutical Investigation, volume 21, issue 2, 1991, Pages 79~84
The agar diffustion method using Escherichia coli was investigated for determination of Vitamin
instead of turbidimetric method using Lactobacillus leichannii (USP XXII method). The turbidimetric method is difficult to control the test organism and it has complicated procedure. From this study, it was found that the agar diffusion method on the determination of Vitamin
in pharamaceutical preparation is simple and convenient as compared with turbidimetric method. Also we found that the coefficient of variation in reproducibility and the standard error in recovery were 2.18% and 1.83%, respectively.
Biopharmaceutical Studies of 1,2-Ethanediolester and 1,4- Butanediolester of Flurbiprofen
Rho, Jae-Il ; Lee, Wan-Ha ;
Journal of Pharmaceutical Investigation, volume 21, issue 2, 1991, Pages 85~90
Prodrugs of flurbiprofen, 1,2-ethanediolester(FE) and 1,4-butanediolester(FB) were prepared and their biopharmaceutical studies were performed. The prodrugs showed high stability in simulated gastric fluid, simulated intestinal fluid and pancreatin-saturated solution. Pharmacokinetic parameters of the prodrugs were similar to those of their parent drug. However they showed less acute toxicity and gastric irritation and higher anti-inflammatory and analgesic effects.
Drug Release Characteristics of Crosslinked Poly(alkylene oxide) Hydrogels
Kim, Shin-Jeong ; Lee, Seung-Jin ;
Journal of Pharmaceutical Investigation, volume 21, issue 2, 1991, Pages 91~95
Polyethylene glycol, polypropylene glycol and block copolymer of ethylene glycol and propylene glycol were crosslinked by triisocyanate to form water swellable, rubbery polymer. The equilibrium swelling of the hydrogels ranged from 3% to 60% according to the hydrophobic-hydrophilic properties of the prepolymers. Model drugs, sodium salicylate and prednisolone were incorporated in the polymer matrices by swelling loading. Physical properties of the drugs affected the drug release mechanisms due to the change in the swelling behaviors of the polymeric devices. Zero order release was observed in the case of relatively hydrophobic polymer matrices.
Percutaneous Absorption of Ascorbic acid Dipalmitate in Various Ointment Bases
Moon, Yong-Koo ; Lee, Wan-Ha ;
Journal of Pharmaceutical Investigation, volume 21, issue 2, 1991, Pages 97~101
Six different O/W cream bases containing 4% ascorbic acid dipalmitate and two different O/W cream bases containing 1% ascorbic acid were prepared. Percutanceous absorption of ascorbic acid as well as safety were determined using rabbits. The stability of the creams was also tested at room temperature. Ascorbic acid concentrations in urines varied depending on the characteristics of cream bases used. The absorption of ascorbic acid was increased and sustained with the cream bases containing branched chain esters of fatty acid instead of natural oils used currently. The excretion level of ascorbic acid in urine was high with the cream base including nonionic surfactants and a small quantity of natural oils. The creams containing nonionic surfactants showed excellent stability, while those containing anionic surfactants were not stable in terms of pH, odor and coloring test at room temperature during six months. But, the two creams containing ascorbic acid were unstable. All the cream bases tested showed good safety.
Biopharmaceutical Studies of Lonazolac Acetic Acid Ester and Lonazolac Argininate
Ham, Kwang-Su ; Lee, Wan-Ha ; Yang, Jae-Heon ;
Journal of Pharmaceutical Investigation, volume 21, issue 2, 1991, Pages 103~110
Two new prodrugs of lonazolac, lonazolac acetic acid ester and lonazolac argininate, were prepared and examined for physicochemical properties and biopharmaceutical characteristics. The prodrugs were stable in solid state and lonazolac argininate showed higher dissolution rate than lonazolacca in both artificial gastric and intestinal juices. These prodrugs have higher analgegic effect than that of lonazolac-Ca in mice, and increased anti-inflammatory activities in rats. In addition, ulcerogenic effects and acute toxicity of these prodrugs were lower than those of lonaaolac-Ca. Lonazolac acetic acid ester showed larger area under the plasma concentration-time curves (AUC) than that of lonazolac. Therefore, it was suggested that these prodrugs of lonazolac have advantages over lonzolac-Ca for not only enhanced bioavailability but also decreased ulcerogenic and toxic effects.
Preparation and Release Characteristics of Dextromethorphan HBr Ion-exchange Albumin Microcapsule
Ahn, Eun-Sun ; Ku, Young-Soon ; Kim, Kil-Soo ;
Journal of Pharmaceutical Investigation, volume 21, issue 2, 1991, Pages 111~116
Dextromethorphan HBr (DMP HBr) ion exchange albumin microcapsules were prepared by the interfacial polymerization method. The incorporation of drugs in empty albumin microcapsules was more increased in case of glutaraldehyde (GA) and formaldehyde (FA) than terephthaloyl chloride (TC) as a cross linking agent. The amount of DMP HBr incorporated into empty albumin micorcapsules was augemented with increasing DMP HBr concentration and the amount of empty microcapsules in the incorporation medium. Increasing the salt concentration in the release medium, the release rate and the DMP HBr amount released from microcapsules were increased. The release rates of DMP HBr from microcapsules retarded considerably compared with DMP HBr powder.