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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 21, Issue 4 - Dec 1991
Volume 21, Issue 3 - Sep 1991
Volume 21, Issue 2 - Jun 1991
Volume 21, Issue 1 - Mar 1991
Selecting the target year
Study on the Orientation of Particles in Tablets
Sohn, Young-Taek ;
Journal of Pharmaceutical Investigation, volume 21, issue 3, 1991, Pages 125~132
Using X-ray crystallography powder diffraction, the quantitative representation method of preferred orientation of particles ill tablets was developed. Selected faces of a tablet. the upper surface and faces cut parallel and normal to the upper surface, were presented to an X-ray beam and X-ray diffraction patterns for these faces were measured. The effects of particle size. tableting pressure, and particle form on the preferred orientation were also investigated. It was also recognized that the degree of anisotropy in terms of capping tendency was influenced by the preferred orientation of particles in tablets.
Quantitative Estimation of Binding Site Polarities of Water-Soluble Polyparacyclophanes in Aqueous Solution by Spectrofluorometry
Chun, In-Koo ;
Journal of Pharmaceutical Investigation, volume 21, issue 3, 1991, Pages 133~141
The fluorescence characteristics of l-anilinonaphthalene-8-sulfonate (ANS) and 2-p-toluidinylnaphthalene-6-sulfonate (TNS) made the dyes useful probes for the determination of the polarity at the binding sites of several water-soluble polyparacyclophanes. Polyparacyclophanes used were 1,6,20,25-tetraaza[ 184.108.40.206]paracyclophane (CPM 44), 1,7,21,27 -tetraaza[220.127.116.11]paracyclophane (CPM 55). 1,7,21,27 -tetraaza-14,34-dioxa[18.104.22.168]paracyclophane (CPE 55) and 1,8,22,29-tetraaza-15,36-dioxa[22.214.171.124] paracyclophane (CPE 66). The fluorescence quantum yield, emission maximum, and half bandwidth of ANS or TNS obtained in a variety of solvent systems were plotted as a function of four kinds of empirical solvent polarity scales such as dielectric constant (D), (D-l)/(2D+1). Y and Z values. It was found that the Z-value-emission maximum
profile showed the most reliable linearity. ANS and TNS interacted with CPM 44, CPM 55, CPE 55. CPE 66.
in the aqueous solution, and from the emission maxima the polarities (Z-value) of their binding sites were calculated to be 92.65, 87.50, 93.35, 84.52, 94.36, and 90.48 for ANS, respectively. and 91.07, 89.68, 85.44, 86.74 and 87.6 for TNS except for
on Polyethylene Glycol Grafted Polyurethane Film
Kim, Sung-Ho ; Ha, Chung-Hun ;
Journal of Pharmaceutical Investigation, volume 21, issue 3, 1991, Pages 143~147
was immobilized on the surface of polyethylene glycol(M.W. 2000) grafted polyurethane film using diisocyanate in an attemp to develop enzyme immobilized polymeric materials. The surface morphology of the modified polyurethane film was examined by SEM. Effects of pH and temperature on the activity of the immobilized
were investigated. The optimal pH range of the activity was
demonstrated high thermal stability and maintained consistent activity during long-term storage.
Swelling and Drug Release Characteristics of Poly (ethylene oxide)-Poly (methacrylic acid) Interpenetrating Networks
Lee, Seung-Jin ;
Journal of Pharmaceutical Investigation, volume 21, issue 3, 1991, Pages 149~153
Polyethylene oxide (PEO)-polymethacrylic acid (PMAA) interpenetrating polymer networks (IPN) were synthesized via radical polymerization of PMAA and simultaneous crosslinking of PEO using triisocyanate. The equilibrium swelling of PEO-PMAA IPN was determined at different pHs. The swelling of PEO-PMAA IPN, ranged from 20% to 90%, was more sensitive than that of homo polymer PMAA gel This is probably due to protonation and deprotonation of the PMAA network and interpolymer complex formation between PEO and PMAA. Several model drugs were loaded into the IPN matrices and the release mechanisms were investigated. The release of nonionizable drugs such as ftorafur and prednisolone was controlled by swelling of the matrices. However, he release of propranolol, positively charged drug, was more affected by the ionic interaction between the drug and PMAA newtork, and the interpolymer complexation.
Comparative Study of Particulate Contamination from Ampoule and Prefilled Syringe
Shim, Chang-Koo ; Han, Yong-Hae ; Kwon, Don-Sun ;
Journal of Pharmaceutical Investigation, volume 21, issue 3, 1991, Pages 155~160
Particulate is the foreign insoluble material in injectable solution inadvertently present in a given product. Considerable efforts have been made to avoid or minimize particulate contamination by pharmaceutical manufacturers during the production of parenteral products. Particulate contamination of the parenteral products can occur mainly during the opening (cutting) the container immediately before clinical use. In this study, particulate contamination generated during the opening process of ampoules (conventional type, 1-point and color-break ampoules) was compared with that of a prefilled injectable container (prefilled syringe). The particles were examined under a microscope after filtration of the total fluids in the containers. Particles having wide range of size distribution were found from all the ampoules tested. The contamination from the I-point ampoule and colorbreak ampoule was much less than from the conventional ampoule. Glass particles generated by cutting the glass-made ampoules seemed a principal source of the particulate contamination. The glass-partiaulte contamination could be improved substantially by replacing the ampoule containers with the prefilled syringe. Prefilled syringe, which can be used without any cutting process. did not generate particulates during the use. Therefore, it was concluded that prefilled syringe is most preferable container for the small volume parenteral (SVP) fluids in terms of particulate contamination.
Preparation and Characteristics of Unsaturated PE Immunoliposome Incorporated with Ganglioside
Kim, Chang-Soo ; Lee, Eun-Ok ; Kim, Jong-Duk ;
Journal of Pharmaceutical Investigation, volume 21, issue 3, 1991, Pages 161~170
The storage stabilities of immunoliposomes incorporated with variable amounts of ganglioside
were investigated as a function of time. temperature. and composition by observing absorbance of visible light and calcein release. In the column chromatographe, the layer of unsaturated PE(dioleoylphosphatidylethanolamine : DOPE). unable to form stable liposomes at physiological temperature and pH, were formed when palmitoyl-immunoglobulin G(IgG)
added. The incorporation of ganglioside
into immunoliposome. enhanced the stabilities of bilayers during the extended period of storage. The turbidities of immunoliposomes coated with ganglioside
exhibited the maximum near 20 mol%
mol. probably because of the disturbance of the bilayer characteristics, i.e., layer transition or reorientation of interaction sites. At low temperature. the higher stability was achieved than at elevated temperatures. After one week of storage. the redispersed liposomal solutions at lower temperatures maintained the original elution patterns in chromatography but broader distribution at elevated temperatures. During the storage, it is suggested the aggregation is the more dominant phenomena for liposomes kept at
than the fusion. while he fusion is at elevated temperatures.
Quantitative Analysis of Pyridostigmine Bromide in Tablets by HPLC
Phi, Taek-San ; Cho, Young ; Sok, Dae-Eun ; Cha, Seung-Hee ; Chung, Yun-Su ;
Journal of Pharmaceutical Investigation, volume 21, issue 3, 1991, Pages 171~177
A reverse-phase, ion-pair high performance liquid chromatographic (HPLC) method for the simultaneous quantative determination of pyridostigmine and its hydrolytic product, 3-hydroxy-N-methylpyridinium (HMP), is descrihed, The assay of pyridostigmine and HMP was linear in the range of amount from 24 to 60 mg/tablet and from 2.4 to 12.0 mg/tablet, respectively, with coefficient of variation (C.V.) of 0.05-0.12% (n=7) and 0.25-0.52% (n=5), respectively, and applicable conveniently even in the case of the mixture of pyridostigmine and HMP. Meanwhile, the conventional UV method gave inaccurate results for the aged pyridostigmine tablets. In the extraction of pyridostigmine from tablets prior to be assayed by HPLC, methanol was found to be more effective than ethanol or distilled water. Multiple extraction (four times) with methanol resulted in the full recovery of pyridostigmine, whereas ethanol gave 95% recovery even after four times extraction. Based on these results. the present method would be very useful for the accurate determination of pyridostigmine in the aged pyridostigmine tablets.
Validation Process of HPLC Assay Methods of Drugs in Biological Samples
Chi, Sang-Cheol ; Jun, H.-Won ;
Journal of Pharmaceutical Investigation, volume 21, issue 3, 1991, Pages 179~188
An HPLC assay method of a drug to be applied to the pharmacokinetic studies of the drug should be completely validated. The validation process for an HPLC assay method in a biological sample was discussed using the data obtained from the development of HPLC method for the simultaneous quantitation of verapamil and norverapamil in human serum. The validation criteria included were specificity, linearity, accuracy, precision, sensitivity, recovery, drug stability, and ruggedness of an assay method.