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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
Editor in Chief :
Volume & Issues
Volume 6, Issue 3 - Sep 1976
Volume 6, Issue 2 - Jun 1976
Volume 6, Issue 1 - Mar 1976
Selecting the target year
Practice of Drug Interaction and Side Action
Kim, Jae-Wan ;
Journal of Pharmaceutical Investigation, volume 6, issue 2, 1976, Pages 33~57
Studies on the Content Uniformity of Pharmaceuticals -On the Content Uniformity of Phenformin Hydrochloride and Chlorpheniramine Maleate Tablets-
Baek, Kyung-Ja ; Yong, Jae-Ick ;
Journal of Pharmaceutical Investigation, volume 6, issue 2, 1976, Pages 58~68
120 tablets of 25mg phenformin hydrochloride tablet and 4mg chlorpheniramine maleate tablet, respectively, were assayed and analyzed to obtain basic data on the content uniformity of domestic pharmaceuticals. All of the tablets of phenformin hydrochloride and that of chlorpheniramine maleate were met the requirements of the test for weight variation and content but no regularity was found in the content unformity specifications. In case of chlorpheniramine maleate tablets, standard deviation of active ingredient content of B maker was 4.1% and that of C maker 7.1%.
Studies on the Preparation of Digestive Enzyme Tablets(III)
Kim, Yong-Bae ; Yi, Pyong-Kuk ; Min, Shin-Hong ; Shin, Hyun-Jong ;
Journal of Pharmaceutical Investigation, volume 6, issue 2, 1976, Pages 69~82
Tablet product design problem was structured as constrained optimization problem and subsequently solved by multiple regression analysis and Lagrangian method of optimization. We used Lagrangian method for the purpose of finding the reason of the previous results. Biodiastase and cellulase were the enzymes, chosen,
and corn starch or calcium carboxy methyl cellulose were the binder and disintegrant, respectively. The effect of the dry binder and disintegrant concentration on tablet hardness, friability, volume, disintegration time was recorded. Optimization of this parameter was studied by using the constrained optimization method. In addition to finding a optimal condition of the enzyme tablets, the application of sensitivity analysis studies to such problems was also illustrated. In order to get a stable preparations of the enzyme tablets, accelerated test of coating tablets was carried out in this study. the results are as follows. 1) The minimum disintegration time, such that the average tablet volume did not exceed 0.0154 cubic inch and the average friability value did not exceed 0.62%, was 6.6 minutes and then
and corn starch were 15.4% and 17.2%, respectively. 2) The multiple-correlation coefficients for the regression models of tablet hardness, friability, disintegration time and volume were with in the 95% confidence range. 3) According to the test results, calcium carboxymethyl cellulose can be used as a disintegrant instead of corn starch.
Spectrophotometric Determination of N-3-Pyridylmethyl-N'-p-nitrophenyl Urea in Rodenticide
Kim, Bak-Kwang ;
Journal of Pharmaceutical Investigation, volume 6, issue 2, 1976, Pages 83~87
Microanalysis of rodenticide by visible absorption method was attempted. The following procedure was found to be very simple and to give accurate results. RH-28787 was added to dimethylformamide (DMF), and extracted after stirring for about 20 minutes in extractor
. After extraction, the absorbance of DMF solution, was measured at 346 nm by using spectrophotometer. The result agrees closely with the experimentally determined value by means of the gas chromatograph.
The Effects of Pretreatment with Carbon Tetrachloride on the Absorption and Excretion of Sulfisoxazole
Choi, Jun-Shik ;
Journal of Pharmaceutical Investigation, volume 6, issue 2, 1976, Pages 88~94
This paper attempted to investigate the effect of pretreatment with carbon tetrachloride on absorption, excretion, protein binding, and biological half-life of sulfisoxazol from rats and rabbits. Absorption of sulfisoxazol was found to decrease in severe damage rats, compared with that of normal rats, but in mild rats, absorption of sulfisoxazol was similar to that of nomal rats. Absorption of sulfisoxazol was decreased significantly in severe damage rabbit pretreated with carbon tetrachloride but in mild damage rabbit, absorption of sulfisoxazol was not influenced significantly. Pretreatment with carbon tetrachloride gave the effect on clearance of sulfisoxazol in part but protein binding percent of sulfisoxazol was not influenced by concentration of carbon tetrachloride.
Effect of pH of Precipitation on Physical and Chemical Properties of Hydrous Aluninum Oxide
Rhee, Gye-Ju ;
Journal of Pharmaceutical Investigation, volume 6, issue 2, 1976, Pages 95~100
A study on the effect of the pH of precipitation on the acid consuming capacity, aging stability, physical and chemical properties of hydrous aluminum oxide prepared by the reaction of aluminum chloride and ammonium hydroxide solution was carried out by means of X-ray diffraction, IR spectra and differential thermal analysis. The results from these experiments are as follows: 1. Hydrous aluminum oxide precipitated at lower pH showed better acid consuming capacity, higher stability and more anion contained in the structure than that prepared at higher pH. 2. The hydrous aluminum oxide prepared at lower pH is amorphous and that prepared at higher pH is crystalline hydrated hydrous aluminum oxide, i.e., Bayerite and these results are conformed to Rhee's hypothesis. 3. The rate of loss of reactivity and the end-point reactivity are related to the pH of precipitation.
Hypotensive Action of Atractylodes rhizoma alba Extract
Ko, Suk-Tai ; Su, Se-Min ;
Journal of Pharmaceutical Investigation, volume 6, issue 2, 1976, Pages 101~110
1. In the rabbit and the dog, the blood pressure response to water extract and methanol extract obtained from Atractylodes rhizoma alb'a was investigated. 2. Water extract and methanol extract, when administered into the rabbit and the dog by the route of vein, produced fall of the blood pressure. 3. The depressor response of the rabbit to water extract and methanol extract was not affected by
, propranolol and atropine. 4. The depressor response by water extract and methanol extract in the rabbit was not affected by guanethidine, but water extract and methanol extract produced elevation of blood pressure in this rabbit. 5. Pretreatment of rabbit with chlorisendamine or phenoxybenzamine weakened the depressor response to water extract and methanol extract, and the both extracts produced secondary elevation of blood pressure in this rabbit. 6. The pressor response of the chlorisondamine-treated rabbit to water extract and methanol extract was not affected by atropine. 7. Water extract decreased the pressor action of tyramine and depressor action of pilocarpine and isoproterenol, but did not affect the blood pressure response of nor einephrine, angiotensin and dimethylpehnyl piperazinium iodide(DMPP).
Studies on the Components of Sambucus speices ( I ) -Isolation and Identification of Rutin from the Leaves of Sambucus latipinna var. coreana-
Lee, Soon-Chul ; Kim, Hack-Seang ; Kim, Jae-Wan ;
Journal of Pharmaceutical Investigation, volume 6, issue 2, 1976, Pages 111~113
Rutin was isolated from the leaves of Sambucus latipinna var. coreana and identified by comparison of its mixed melting point and IR spectrum against the authentic sample.