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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmaceutical Investigation
Journal Basic Information
Journal DOI :
The Korean Society of Pharmaceutical Sciences and Technology
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Volume & Issues
Volume 8, Issue 4 - Dec 1978
Volume 8, Issue 3 - Sep 1978
Volume 8, Issue 2 - Jun 1978
Volume 8, Issue 1 - Mar 1978
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A Study on Influences of the Antibacterial Activity of Methampicillin Lysinate by the Several Medicinals
Kim, Seung-Up ; Kim, Young-Il ; Kim, Johng-Kap ;
Journal of Pharmaceutical Investigation, volume 8, issue 1, 1978, Pages 1~5
Drug interaction of a new antibiotic, methampicillin lysinate (MAL) with nine drugs were investigated using four species of gram positive and gram negative bacteria. The experimental results were as follows: 1. MIC of MAL were found to be decreased against E. coil when combined with mefenamic acid, probenecid, aluminium hydroxide gel or corticosteroids. The other drugs did not affect MIC of MAL against the same bacteria. 2. MIC of MAL were found to be increased against Staphylococcus aureus ATCC 6538-P, 9441 when combined with mefenamic acid, aluminum hydroxide gel or dexamethasone acetate. The other drugs did not affect MIC of MAL against the same bacteria. 3. MIC of MAL were found to be increased against Shigella dysenteriae when either of the nine drugs was combined. 4. MIC of MAL were found to be increased approximately 2.5 times when combined with Streptokinase-Streptodornase or hydrocortisone and to be decreased approximately 2 times when combined with probenecid or dexamethasone against Salmonella typhi(type 2). It seems the other drugs do not affect the MIC of MAL against the same bacteria.
A Study on the Hypotensive Action of Acanthopanax Extract in Rabbit
Ko, Suk-Tai ; Kim, Sung-Won ; Lim, Dong-Yoon ;
Journal of Pharmaceutical Investigation, volume 8, issue 1, 1978, Pages 6~16
We obtained 4 kinds of extract fraction from Acanthopanacis Radicis Cortex and studied on the influence to the blood pressure of rabbit. These 4 fractions were obtained as follows; Fraction I was insoluble fraction by 99% ethanol from 80% methanol extract of Acanthopanacis Radicis Cortex, fraction II, precipitated fraction by ether from 99% ethanol soluble fraction of 80% methanol extract of Acanthopanaacis Radicis Cortex, fraction III, no precipitated fraction by ether from 99% ethanol soluble fraction of above 80% methanol extract and fraction IV, water extract of Acanthopanacis Radicis Cortex. All of fractions, when administered into ear-vein of rabbit, produced fall of blood pressure. Among these 4 fractions, although fraction III was not only the most potent but had the greatest efficacy, we observed the mechanism of hypotensive action of Acanthopanacis Radicis Cortex, making use of fraction II which was thought as a comparatively pure fraction. Hypotensive action of fraction II (APF II) was not affected by vagotominization but markedly inhibited by atropine. Pretreatment of bethanidine showed a tendency to weaken the depressor action of APF II, although it was not a significant result, but diphenhydramine did not influence APF II action. Phentolamine, guanethidine and chlorisondamine inhibited significantly the hypotensive action of APF II. APF II elicited the potentiation of norepinphrine pressor action dependent on the time-factor whereas it did not influence angiotesin pressor action. It is seemed that APF II exhibited hypotensive action, causing peripheral muscarinic-effect and centrally induced sympatholytic action.
The Effects of Long-Term Administration of Acanthopanax EtOH Extract on the Serum Total Cholesterol Content in Normal and Cholesterol-Administered Rabbits
Ko, Suk-Tai ; Kim, Sung-Won ; Lim, Dong-Yoon ;
Journal of Pharmaceutical Investigation, volume 8, issue 1, 1978, Pages 17~26
Effects of Acanthopanax EtOH Extract (AEE) on the serum total cholesterol content of normal and cholesterol administered rabbits were investigated as a series of studies on pharmacological action, especially blood pressure to Korean Acanthopanax. AEE was administered orally(100mg/kg/day) and subcutaneously (30mg/kg/day) in both normal and cholesterol administered rabbits for 36 days. In this experiment the results obtained by comparing with values of the corresponding control group were as follows; 1) In the normal rabbits, long-term administration of AEE for 36 days did not entirely influence the serum total cholesterol content measured at 12th, 24th and 36th day and also not affect the original blood pressure and changes of blood pressure to norepinephrine, angiotensin and acetylcholine recorded at 36th day. 2) In the cholesterol administered rabbits, hypercholesteremia was induced by oral administration of cholesterol(300mg/kg/day) with feed. The rise rate of serum total cholesterol content was not modified at 12th day, whereas significantly inhibited at 24th and 36th days after begining this examination in both groups orally and subcutaneously administered AEE. Original blood pressure was declined and depressor action of acetylcholine was weakened in only group admininstered orally AEE of cholesterol-fed groups. Changes of blood pressure to norepinephrine and angiotensin in these all cholesterol-fed groups, and to acetylcholine in subcutaneous group of these cholesterol-fed groups were not affected significantly by AEE.
Pharmaceutical Studies on Anti-inflammatory Enzyme Preparations
Lee, Kang-Choon ; Yang, Joong-Ik ; Min, Shin-Hong ; Rhee, Shang-Hi ; Kim, Yong-Bae ;
Journal of Pharmaceutical Investigation, volume 8, issue 1, 1978, Pages 27~36
Spherical granules of anti-inflammatory enzyme were prepared by mixer granulation and the recovery rate of enzyme activity by processing was compared with tablet ones. In the enteric granule coating .processing, the effect of the amount of coating solution and the conentration of fatty alcohol on disintegration and stabilities on the accelerated conditions were also studied. Being prepared in non-pressure and non-aqueous condition, spherical granules of enzyme made better recovery of enzme activity than tablet ones by 10 times. Combined processing of both mixer granulation and enteric granule film coating provided the noble enteric coated granules, in the sense of disintegration and stabilities, was obtained from using 0.125% fatty alcohol in coating solution.