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The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
Journal Basic Information
Journal DOI :
The Korean Oriental Medical Ophthalmology and Otolaryngology and Dermatology Society
Editor in Chief :
Volume & Issues
Volume 23, Issue 3 - Dec 2010
Volume 23, Issue 2 - Aug 2010
Volume 23, Issue 1 - Apr 2010
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Effects of Kami-bangpungtongseong-san Extracts on the Mouse Skin Toxicated by Mercury
Yang, Joon-Hyoung ; Hong, Seong-Ug ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 1~7
Objective : Mercuric chloride is excreted in the urine and stool. Bangpungtongseong-san(BT) has been used commonly skin disease and has diuresis and excretion effect. This study is aimed to find out effects of Kami- bangpungtongseong-san(KBT) on the skin disease toxicated by mercury. Method : Experiment was conducted with No treated group(Normal group), Mercuric chloride subcutaneous injection group(Control group) and Kami-bangpungtongseong-san-treated group (Sample group). KBT Extracts were delivered orally in 7 days in sample group. We observed epithelial cell hyperplastic, angiogenesis, inflammatory cell infiltration of skin. For the charting the results, image analysis was taken. The result of image analysis was verified significance by Sigmaplot 2000(P<0.05). Result : This study shows an relieving epithelial cell hyperplastic, angiogenesis, inflammatory cell infiltration of exposure skin on mercuric chloride. Conclusion : According to the result of study, we can expect to the effect of KBT extracts' therapeutic action to tissue injuries of the mice' skin on acute mercurial toxication.
The Effects of Gyejijakyakjimo-Tang on the Allergic Contact Dermatitis induced by DNCB
Kim, Sung-Ho ; Kim, Hee-Taek ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 8~22
Objectives : The purpose of this study is to investigate the effects of Gyejijakyakjimo-Tang on the Allergic Contact Dermatitis caused by 2,4-dinitro-chlorobezene(DNCB). Methods : Twenty eight mice were divided into four groups ; normal, control, experimental group A and B. Control and experimental groups were induced allergic contact dermatitis by DNCB. Experimental group A was orally administered the Gyejijakyakjimo-Tang and experimental group B was orally administered the prednisolone. In this study, ear thickness measurement, auricle microphotograph observation, MPO(Myeloperoxidase) activity measurement, Reverse transcription-polymerase chain reaction(RT-PCR) analysis of the mRNA level of TNF-
were performed on these four groups. In addition, the effect of Gyejijakyakjimo-Tang on cell viability and the effect of Gyejijakyakjimo-Tang on the compound 48/80-induced histamine release from HMC and RPMC were measured. Results: 1. Both experimental group A and B had decreased ear thickness compared with control group In contact hypersensitivity assay. 2. In experimental group A, inflammatory edema was similarly observed comparing to control group. Nevertheless, inflammatory edema was obviously reduced in experimental group B. In both experimental group A and B, pathological lesion of dermatitis were alleviated. In addition, the numbers of infiltrated inflammatory cells were decreased compared with control group. 3. Compared to the normal group, there was a noticeable increase in MPO activity in control group. However, in experimental group A and B, it showed remarkable inhibition of the increase in MPO activity comparing with control group. 4. The level of expression of TNF-
in experimental group A and B were meaningfully lower than those in control group. 5. In MTT assay, the concentrations of Gyejijakyakjimo-Tang that were used on the test had no cytotoxicity. 6. Gyejijakyakjimo-Tang dose-dependently inhibited the compound 48/80-induced histamine release from both HMC and RPMC. Conclusions : According to above experiments, Gyejijakyakjimo-Tang was effective on allergic contact dermatitis.
Effects of Aloe and Violae herba Extract on the Anti-oxidant, Anti-inflammatory, Anti-wrinkle and Whitening
Kim, Chang-Hun ; Jung, Hyeon-A ; Roh, Seok-Sun ; Hong, Seok-Hoon ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 23~43
Objective : This study was performed to assess the effects of Aloe and Violae herba extracts on skin disease and skin beauty. Methods : Anti-oxidant effects were measured by the scavenging for DPPH radical, xanthine oxidase activity. Anti-inflammatory effects were examined by relations in NO synthesis, IL-
, IL-6, TNF-
, NF-kB, COX-2, MAP kinase. The skin wrinkle formation effects were measured by collagenase and elastase activities. The whitening effects were examined by tyrosinase activities, melanin synthesis in MNT-1 cell. Results : 1. In an anti-oxidant test, Aloe and Violae herba extracts showed high radical scavenging activity. 2. In an anti-inflammatory test, Aloe and Violae herba extracts strongly inhibited the lipopolysaccharide(LPS)-induced nitric oxide(NO) release from the RAW 246.7 macrophage cells. Aloe and Violae herba extracts also inhibited the LPS-induced IL-
and COX-2 expressions. The inhibitory effects of Aloe and Violae herba extracts on macrophage activation were via the inhibition of NF-kB, evidenced by transient transfection assay. Furthermore, Aloe and Violae herba extracts weakly inhibited the activation of Jun-N-terminal kinase(JNK) but they did not have any effects on p38 MAP kinase in RAW 264.7 cells. 3. In the skin wrinkle formation assay, Aloe extract strongly inhibited collagenase and elastase, whose activity are tightly related with the wrinkle formation. 4. In the skin whitening assay, Aloe and Viloae herba extracts weakly inhibited tyrosinase activity, however, it was not statistically significant. Besides they did not have any effects on melanin synthesis, indicating that they could not be applicable for skin whitening. Conclusion : This study show that Aloe and Violae herba extracts may play a significant role in skin disease and skin beauty.
The Effect of Silibinin Extracted from Cirsium Japonicum on Allergic Inflammation
Kim, Beom-Rak ; Kim, Koung-Jun ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 44~58
Silibinin is the major active molecule of silymarin, the mixture of flavonolignans extracted from Cirsium japonicum (CJ). It has been used for treatment of hepatitis and inflammation related diseases. The aim of this study was to prove whether Silibinin has effectiveness for allergic inflammation. Silibinin processes the inflammatory reaction in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (PMA plus A23187) stimulated human mast cell line (HMC-1). Its effect was examined by ELISA, RT-PCR, Western blot, and Luciferase assay. The results were Silibinin inhibited the expression of histamine, TNF-
(tumor necrosis factor-
), IL-6 (interleukin-6), and IL-8 (interleukin-8). Silibinin suppressed NF-
(nuclear factor kappa B) activation in stimulated HMC-1 (human mast cell-1). This effect was mediated through inhibition of phosphorylation and degradation of
, an inhibitor of NF-kB. Silibinin significantly inhibited induction of NF-kB promoter mediated Luciferase assay. These results suggest that Silibinin has a potential molecule for therapy of mast cell-derived allergic inflammatory diseases.
The Effects of Samulsopungeum and Prednisolone on NC/Nga Atopic Mice
Yun, Chae-Sung ; Joo, Hyun-A ; Hwang, Chung-Yeon ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 59~74
Objectives : Atopic dermatitis(AD) is a chronic recurrent skin disease which usually developed in infancy or childhood. AD often repeat improvement and relapse. The cause of AD is so indefinite that many methods of therapies(moisturizer, steroid ointment, antihistamine, immunomodulator, immunosuppressant, herbal medicine, alternative medicine, etc.) are tried. Recently, a lot of studies were made. But there is no report about the effect of Samulsopungeum(SM) and Prednisolone(PN) on AD. So, author aimed to investigate the effects of SM and PN on AD of NC/Nga mice. Methods : Thirty two mice(8 Balb/c mice and 24 NC.Nga mice) were divided into four groups; Balb/c mice was normal group. NC/Nga mice were divide into three group : control, PN, SM group. AD was induced in the control, PN, SM group by spreading DNCB. Then normal saline, PN and SM were orally administered three times in a week for 8 weeks to the control, PN, SM group, respectively. We observed changes of clinical skin severity score, serum IgE, IgG1, IFN-
, IL-2, IL-4, IL-5, IL-10, IL-13, and so on. We used one-way ANOVA test statistically(p<0.01). Results : The clinical skin severity scores of PN group and SM group in 8th week were decreased compared to the control group. Serum IgE, IgGl levels of PN group and SM group were significantly decreased compared to the control group. Serum IFN-
in SM group was significantly increased compared to the control group. But, Serum IFN-
in PN group was significantly decreased compared to the control group. Serum IL-10 levels of PN group and SM group were significantly decreased compared to the control group. Serum IL-2, IL-4, IL-5, IL-13 levels of PN group and SM group were significantly decreased compared to the control group. mRNA expression levels of IL-2, IL-4, IL-5, IL-13 in the dorsal skin tissues of PN group and SM group were significantly decreased compared to the control group. According to biopsy reports of the ear and skin tissues showed that the tissue damage of PN group and SM group were highly reduced compared to the control group. Creatinine, BUN, ALT, AST levels of PN group and SM group were normal. Conclusion : According to the above results, it is considered that SM is effective treatment for the AD.
Effect of Phellinus igniarius Quel Extract on the Anti-inflammatory, Anti allergy, Anti-oxidant, Anti-wrinkle
Yun, Woo-Sik ; Jung, Hyun-A ; Roh, Seok-Seon ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 75~93
Objectives : This study was carried out to investigate the effects of Phellinus igniarius Quel extract on the Anti-inflammatory, Anti allergy, Anti-oxidant and Anti-wrinkle. Methods : To investigate in vitro anti-oxidant activity assay, ethanol extracts of medicinal plants tested by DPPH method. In the next experiment, to investigate anti-inflammatory test, the RAW 264.7 macrophage cells was cultured using DMEM including the 10% FBS. To study anti-allergic effect, we blended cultured Human Mast Cells(HMC-1), and then observe TNF-
, IL-8 by ELISA Results : Phellinus igniarius Quel extract has the effects of anti-inflammation and anti-allergy, which may be due to its inhibitory potential on the macrophage activation. Furthermore, Phellinus igniarius Quel extract has the anti-wrinkle effects through the inhibitory potential on the collagnease, elastase and gelatinase activities. Conclusions : The above results suggest that Phellinus igniarius Quel extract could be applicable for improvement of several skin functions.
Effects of Cryptotympana pustulata on the expression of cytokine genes in human monocytes of THP-1
An, Jong-Hyun ; Kim, Kyung-Jun ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 94~110
Objective : This study was performed to evaluate the effect of immune reaction inductive substances such as phorbol-myristate-acetate(PMA), lipopolysaccharide(LPS), dermato-phagoides pteronyssus crude extract(DPE), dinitrochloro-benzene(DNCB) and Cryptotympana pustulata(CP), the Cryptotympana pustulata extracting substance at simultaneously on the translocation of nuclear factor-kappa B(NF-
) towards to the nucleus and the mRNA expression patterns of various cytokine genes in Human acute monocytic leukemia cell line(THP-1 cells), monocytes of human. Experiment : To analyze cytokine genes expression patterns, the RT-PCR method was used, measuring tumor necrosis factor(TNF)-
that had been secreted during cell culture in the ELISA method. The morphological change in the cell observed during THP-1 cell culture was observed using a scanning electron microscope (SEM) and the quantitative distribution in the cell NF-
was analyzed through immunocytochemistry and a confocal microscopy. Result : CP showed different influences onto the mRNA expression patterns of cytokine genes with PMA, LPS. DPE and DNCB according to the types of immune inductive substances in the THP-1 cells. The expressions of inter-leukin(IL)-10, interferon(INF)-
and monocyte chemoattractantant protein(MCP)-1 induced by PMA were suppressed by CP while the expression of transforming growth factor(TGF)-
was promoted. Regarding the secretion pattern of TNF-
according to PMA processing, its secretion amount was increased by CP concurrent processing, in case of processing CP onto PMA and LPS, We discovered that the secretion amount of TNF-
was increased. Upon processing PMA and LPS on the THP-1 cell strain at the same time or either additionally processing CP thereon, the movement increase towards the nucleus from the NF-
cell cytoplasm, a transcription factor was able to be observed. Conclusion : In this study, Cryptotympana pustulata extracting substance was confirmed that it had an influence on expression patterns of cytokine genes according to the actions of a variety kinds of immune reaction inductive substances processed on the monocyte THP-1 cell of humans. Therefore, additional studies as for the immune adjusting function of Cryptotympana pustulata are considered to be able to offer important materials for curing immune abnormal diseases such as atopy dermatitis afterward.
Acute Toxicity Study on Bangpungtongsung-san (Fangfengtongsheng-san) in Sprague-Dawley Rats
Shin, In-Sik ; Kim, Jung-Hoon ; Ha, Hye-Kyung ; Seo, Chang-Seob ; Lee, Mee-Young ; Huh, Jung-Im ; Shin, Hyeun-Kyoo ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 111~117
Objectives : This study was conducted to evaluate the acute toxicity and safety of Bangpungtongsung-san (Fangfengtongsheng-san) in Sprague-Dawley rat though the current regulatory guideline. Methods : The preliminary study showed that the single oral administration of Bangpungtongsung-san (Fangfengtongsheng-san) did not induce any toxic effect at a dose level of 2000 mg/kg. Based on the results, 2000 mg/kg was selected as the limited dose. In this study, 10 rats of each sex were randomly assigned to two groups of 5 rats each and were administrated singly by gavage at dose levels of 0 and 2000 mg/kg. Mortalities, clinical signs, and body weight changes were monitored for the 15-day period following administration. At the end of observation period, all animals were sacrificed and complete gross postmortem examinations were performed. Results : Throughout the study period, no treatment-related deaths were observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Conclusions : These results showed that the single oral adminstration of Bangpungtongsung-san (Fangfengtongsheng-san) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. In conclusion, the
of Bangpungtongsung-san (Fangfengtongsheng-san) was considered to be over 2000 mg/kg body for both sexes.
The Inhibitory Effects of Yang Geouk San Hwa-Tang on LPS-stimulated inflammation in RAW264.7 macrophage cells
Tak, Mi-Jin ; Tark, Myoung-Rim ; Kang, Kyoung-Hwa ; Ko, Woo-Shin ; Yoon, Hwa-Jung ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 118~134
Objective: Yang Geouk San Hwa - Tang (YGSHT) has been widely used in Sasang Constitutional Medicine of Korea for treatment of acute inflammatory symptom, such as palatine tonsillitis, polydipsia, headache, papule, pimple however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the mechanism of the inhibitory effect of YGSHT on LPS-induced inflammation. Materials and methods: The effect of YGSHT was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results: We found that YGSHT suppressed not only the production of pre-inflammatory cytokines (IL-
), the generation of nitric oxide (NO) and prostaglandin E (PGE)2, but also the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2. Furthermore, YGSHT was shown to inhibit the phosphorylation of ERK1/2 and JNK1/2 and the activation and translocation of NF-kB from cytosol to nuclear in LPS-stimulated RAW264.7 cells. Conclusions: These results suggest that YGSHT exerts an anti-inflammatory effect through the regulation of the ERK1/2 and JNK1/2 pathway and NF-kB pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.
The Anti-wrinkle Effects and Whitening Effects of Galla Rhois
Park, Jin-Mee ; Park, Kyung-Jun ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 135~148
Recently, the demands for the effective and safe depigmentating and anti-aging agents of the skin have increased due to the medical, pharmaceutical and cosmetic reasons. The aim of this study is to search Galla Rhois (GR) inhibitory activity against aging process of skin in vitro. GR was screened for their inhibitory activity against elastase. GR (final concentration 1 mg/ml) appeared over 40% of inhibition of elastase activity. So we investigated anti wrinkle effects of GR look through MMP-1 inhibition activity. Also Extracts of GR showed higher anti-tyrosinase activity than arbutin (final concentration 1 mg/ml). These results suggest that GR could be potential sources of anti-aging and whitening effects for the skin. Objective : Galla Rhois extracts, Elastase (pancreatic from porcine pancreas), N-Succinyl-(Ala)3-p-nitroanilide, Ursolic acid, mushroom tyrosinase, L-tyrosine, arbutin, Amicon Ultra, Hand Hold UV lamp, MMP-1 primary antibody, MMP-1 secondary antibody Result : 1. GR appeared over 40% of elastase inhibitory activity. 2. GR had MMP-1 inhibition activity. 3. GR showed higher anti-tyrosinase activity than arbutin. Conclusion : According to above results, it is supposed that Galla Rhois could be strong potential sources of anti-aging and whitening effects for the skin.
Inhibitory Effects of Herb and Seeds of Oenothera odorata on the Melanogenesis
Choi, Mi-Eun ; Woo, Won-Hong ; Mun, Yeun-Ja ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 149~157
Effects of Jeungson-Ojeok-Hwan-Bijukbang on Solid Tumor in Mice
Lee, Yu-Jin ; Kim, Jong-Han ; Park, Su-Yeon ; Choi, Jeong-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 158~168
Objective : Jeungson-Ojeok-Hwan Bijukbang(JOH) has been used to treat patients with tumor etc. In the theory of Korean medicine, JOH can treat Juk-Chui. JOH is known to have treat Juk-Chui. Juk-Chui is analogous to tumor. Methods : For these reasons, the present study was designed to investigate the effects of JOH on solid tumor in mice in terms of immune-potentiating and direct cytotoxic action of JOH in vitro and vivo study. The present author investigated thymocyte and splenocyte proliferation to confirm immune-potentiating activity of JOH and also investigated tumor/body weight ratio and survival rates in tumor bearing mice. Results : In this study, administration of JOH decreased tumor/body weight ratio significantly, and prolonged survival duration compared to non-treated control. In addition, treatment with JOH suppressed proliferation rate of Sarcoma 180 (S-180) cells significantly, and elevated proliferation rates of thymocytes isolated from normal mice. These results were co-related with in vivo study. Conclusion : these results suggest that JOH is useful to treat patient with solid tumor, because JOH has direct toxic action for tumor cell and immune-potentiating action for T cells. Further study will need to elucidate exact mechanisms related in anti-cancer action of JOH.
Combination Therapy with Gwakhyangjeonggisangamibang and Sojangjeonggyeok for the Treatment of Verruca Plana
Yun, Jeong-Min ; Shin, Sang-Ho ; Yoon, Hwa-Jung ; Ko, Woo-Shin ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 169~181
Objective : The purpose of this study was to investigate the effects of Combination therapy with Gwakhyangjeonggisangamibang and Sojangjeonggyeok on patients with verucca plana. Methods : Sixty-five patients(male 19, female 46) with verruca plana were treated with Gwakhyangjeonggisangamibang and Sojangjeonggyeok for at least 3 months. After treatment, a clearance rate was divided into 4 scales such as; complete clearance / partial clearance-good / partial clearance-poor / no change. Statistical analysis was performed by using Independent-sample t-test. Results : Mean age of patients was 30.3 and mean period of disease duration was 64.6 months. Fifty-eight patients(73.8%) showed complete clearance, nine(13.8%) partial clearance-good, and eight(12.3%) partial clearance-poor. Complete clearance group(CC group) was statistically younger than failure group and disease duration of CC group was shorter than failure group. Although treatment period of failure group was statistically longer than CC group and dosage(貼) of herbal medicine of failure group was more than CC group, failure group showed partial clearance. Conclusion : This data demonstrates that combination therapy with Gwakhyangjeonggisangamibang and Sojangjeonggyeok could be an effective and safe treatment for the verucca plana.
A Literature Study on the Korean Acupuncture for Oral, Glottal, Labial and Dental diseases
Han, Chang-Hyun ; Ahn, Sang-Young ; Kwon, Oh-Min ; Park, Sang-Young ; Lee, Jeong-Hyeon ; Ahn, Sang-Woo ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 182~198
Background : The varieties of manifestations referred to oral, glottal, labial and dental diseases has been long complicated physicians in the efficient diagnosis and treatment of these diseases. Acupuncture has been widely used in Korea throughout the history and provides an efficient method in the treatment of them Objectives : Establish a distinctive and efficient acupuncture method for the treatment of oral, glottal, labial and dental diseases based in literature research Method : We reviewed four Korean medical literature, "Guide to Swollen Sore Treatment", "Treasured Mirror of Eastern Medicine", "Experiential Prescriptions of Acupuncture and Moxibustion", and "Essential Rhymes on Acupuncture and Moxibustion by Master Sa-am", and analyzed the therapeutic characteristics in the treatment of oral, glottal, labial and dental diseases Result : 1. According to "Guide to Swollen Sore Treatment", we could noted frequent application of blood letting methods in the affected area, then rinse ones mouth with salty water and further application of taro plaster. Also found acupuncture methods utilizing heated mole cricket or silkworm in the sublingual region. Regarding herbal method, Realgar was rubbed in the affected area. Mainly used acupuncture points in the treatment of oral, glottal, labial and dental diseases were GV20, GB20, LU5, and auricular anterior hairline 2. In "Treasured Mirror of Eastern Medicine", blood letting method in the sublingual region and burning needle searing method were the most frequently applied in the treatment of oral, glottal, labial and dental diseases. Moxibustion was also applied in the treatment of labial and dental diseases. Particularly, said to apply 3 moxa cones in ear zones of both sides, when no medicine is effective. This demonstrates how emphasized the importance of moxibustion in this kind of disease. Mainly used acupuncture points were GV16, CV24, LI4, EX-HN12, and EX-HN13 3. In "Experiential Prescriptions of Acupuncture and Moxibustion", no other methods beside wrist. Superstitious methods like applying moxibustion on the tooth picture drawn on the roofing tile need further confirmation. Mainly used acupuncture points were LI4, ST36, and HT7. 4. "Essential Rhymes on Acupuncture and Moxibustion by Master Sa-am", identified the cause of diseases according to visceral pattern identification. Stomach and Spleen in charge of vocal, lingual, and labial disease, Kidney for dental disease, and further scrutinizing identification according to Liver, Heart, Stomach, Lung, and Kidney manifestations. Used supplementation and draining needling methods of self meridians and other correlating meridians. Conclusions : After previous study on stroke and eye diseases, we could also find various efficient methods according to oral, glottal, labial and dental diseases, through literature research of korean medical classics. This study will concurrently result in establishing distinctive therapeutic method characteristic of Korea.
Quality of Life and Economic Impact of Adult Atopic Dermatitis Patients in Seoul
Yun, Young-Hee ; Choi, In-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 199~214
Objective : Atopic dermatitis (AD) may profoundly affect patient's quality of life (QOL), and also cause economic impact. The aim of our study was to evaluate the quality of life and the economic impact of adult atopic dermatitis patient in Seoul. We also evaluate the relationship of QOL and economic impact with severity of AD. Methods : 30 adult atopic dermatitis patient were included and evaluated by using the SCORAD Index and EASI. Patients were asked to fill in the questionnaires about their quality of life and financial costs during the past year by AD. Data about sleep disturbance and pruritus were also obtained. Pearson's correlation were used for statistical analysis. Results : 1. Among 30 patients, women were 19(63.3%), men were 11(36.7%). The mean age of the patients were 27.3 years old, patients between the ages of 17 and 30 years were 23, over 30 were seven. 2. The mean score of Objective SCORAD was
, Subjective SCORAD was
and EASI was
이었다. 3. The mean score of Skindex-29 was
, DLQI was
. 4. By analyzing the questionnaire, a monthly average cost of 583,200 won for each patient was determined. Direct cost was 236,800 won and indirect cost was 346,300 won. 5. By analyzing the correlation between the severity of AD and QOL, Objective SCORAD and EASI were positively correlated with QOL(Skindex-29, DLQI) but not significant, meanwhile subjective SCORAD were significantly and positively correlated with QOL(Skindex-29, DLQI). 6. By analyzing the correlation between the severity of AD and economic impact, Objective SCORAD were significantly and positively correlated with direct cost and indirect cost. Also, EASI were significantly and positively correlated with direct cost and oriental medical hospital visits. Conclusions : The above results show that the QOL of the patients with atopic dermatitis is significantly related to their disease severity. Atopic dermatitis patients pay 583,200 won a month, and the economic impact of the patients is significantly related to their disease severity.
A Research on Quality of Life and Cost of Oriental Medical Care in Adult Patients with Chronic Atopic Dermatitis in Korea
Kim, Nam-Kwen ; Oh, Yong-Leol ; Seo, Eun-Sung ; Lee, Dong-Hyo ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 215~223
Objective : The aim of this study is to assess the impact of chronic atopic dermatitis (AD) on quality of life (QoL) as well as the economic burden associated with oriental medical treatment on adult patients with chronic AD in Korea. Methods : The EQ-5D health states, existence and duration of AD in the 2007 National Health and Nutrition Examination Survey (NHANES) were used to obtain the study subjects. A questionnaire including the questions on direct medical and direct non-medical costs associated with oriental medical treatment for adult patients with AD was specifically designed. Twenty-nine, members of the Korean Oriental Medical Ophthalmology, Otolaryngology and Dermatology Society (KOMOODS), completed the questionnaires. Results : The incidence of AD was around 3.09% in 2007 NHANES (sample survey, n=2981). Three months and above in duration of disease was 1.35%. The QoL data revealed as follows: 0.932 in non-chronic AD, 0.916 in chronic AD, and 0.908 in non-AD. We also stratified our analysis by age. The QoL data in 40's was statistically significant (P<0.023). But, no significant differences were reported in 20's, 30's, and 50's. The total direct medical costs of oriental medical treatment for AD was about 2,560,717 Won, and total direct non-medical costs was about 605,125 Won in a year. Conclusions : This study might be applied to find the evidence of economic evaluation in oriental medicine for AD. More rigorous studies are warranted.
A Study on the Tinnitus of Huangdi's Internal Classic
Byun, Seok-Mi ; Tark, Myoung-Rim ; Kang, Na-Ru ; Ko, Woo-Shin ; Yoon, Hwa-Jung ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 224~252
Objective : The purpose of this study is to investigate tinnitus of Plain Questions
and Miraculous Pivot
. Methods : We conducted a study on the original text paragraphs of Internal Classic
containing the tinnitus and analysis of Yang, Ma, Zhang, Wang etc. We drew a parallel between tinnitus from Internal Classic
and matching diagnoses from western medicine. Results : The results were as follows. 1. Tinnitus in Plain Questions
Tong Pyeong Heo Sil Ron <通評虛實論> was similar to the symptoms of diabetes mellitus complication and schizophreniform disorder in western medicine. 2. Liver fire tinnitus in Plain Questions
Yuk Won Jeong Gi Dae Ron <六元正紀大論> was similar to the symptoms of psychological distress in western medicine. 3. Phlegm fire tinnitus in Plain Questions
Ji Jin Yo Dae Ron <至眞要大論> was similar to the symptoms of meniere's disease and malfunction of autonomic nervous system in western medicine. 4. Blood deficiency tinnitus in Miraculous Pivot
Sa Gi Jang Bu Byeong Hyeong <邪氣藏府病形> was similar to the symptoms of anemia in western medicine. 5. Tinnitus in Miraculous Pivot
Gyeong Geun <經筋> was similar to the myofacial pain syndrome of the sternocleidomastoid muscle and the masseter muscle in western medicine. 6. Gallbladder deficiency tinnitus in Miraculous Pivot
Gwol Hyeong <厥病> was similar to the symptoms of otitis media and labyrinthitis in western medicine. 7. Kidney deficiency tinnitus in Miraculous Pivot
Gyeol Gi <決氣> and Hai Ron <海論> was similar to the symptoms of degenerative auditory organ in western medicine. 8. Tinnitus in Internal Classic
showed close relations with the symptoms of the wind character. Conclusion : We analyzed the original text paragraphs of Internal Classic
and explanations about tinnitus. Further studies are needed to compare oriental medicine and western medicine diagnoses to develop better treatments for tinnitus.
The complexion of Korean female changed by 7 years.
Kim, Eun-Joo ; Roh, Ho-Sik ; Kim, Duck-Hee ; Kim, Hank-On ; Cho, Ga-Young ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 253~259
Objectives: We investigated
value on the face to correlate the complexion of Korean female with aging theory of Neijing(內經) in Suwen-Shanggutianzhenlun(素問,上古天眞論). Methods: Three hundreds and thirty one Korean females, aged 22-64 years(
years) were participated in this study. We measured the skin properties of the face with Spectrophotometer CM2600d(Minolta, Japan). Trisimulus
value divided on 7 years were and analyzed by regression analysis method. Results:
, ITA value decreased and
increased as the age increases. Among these, we found out that ITA value is most related to aging.
value decreased among the group of 28 to 35 years old. ITA value decreased among the group of 35 to 42 years old.
value decreased among the group of 42 to 49 years old. Conclusions: Unique aging pattern by 7 years of female in Oriental medicine is reflected to complexion.
Cost-effectiveness Analysis of Bojungikgitang and Banhabaekchulchonmatang in Chronic Tinnitus Patients
Kim, Nam-Kwen ; Oh, Yong-Leol ; Seo, Eun-Sung ; Lee, Dong-Hyo ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 260~269
Background : Bojungikgitang(BJT) and Banhabaekchulchonmatang(BBT) are known to treat the tinnitus patients, which were registered Korean National Health Insurance coverage lists. Objective : Few studies have evaluated economic benefits of both herbal medicines. This research is to investigate the cost-effectiveness of Bojungikgitang(BJT) and Banhabaekchulchonmatang(BBT) in chronic tinnitus patients over nineteen years old. Method : We built the decision tree model of chronic tinnitus and executed the deterministic analysis and threshold sensitivity analysis based on randomized clinical trial. Effectiveness was measured in quality-adjusted life-years(QALYs), and costs were in 2009 KRW(South Korean Currency). The perspective is societal, time horizon is 10 weeks, and Korean willingness to pay threshold is assumed to 20,000,000KRW. Results : In the base case analysis, BJT treatment resulted is better outcomes as low cost, so BJT is dominant medicine and BBT is dominated. But both cost per QALYs (BJT is 3,120,339KWN per QALY, BBT is 3,505,780KWN per QALY) are lower than the threshold, that could be covered by Korean National Health Insurance(KNHI). Conclusion : This study results showed that BJT was more cost-effective than BBT treating tinnitus patients for 10 weeks, and the cost per QALYs of both alternatives were lower than Korean national threshold.
New Paradigm Teaching Method on the Oriental Medical Ophthalmology & Otolaryngology Class
Lim, Kyu-Sang ; Lee, Jang-Cheon ; Park, Young-Gue ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 270~281
Objectives : The purpose of this study is to survey the needs of Oriental Medical students about the existing teaching methods and to investigate satisfaction of new teaching & learning method on the Oriental medical Ophthalmology & Otolaryngology Class. Methods : 1. The needs of Oriental medicine whole students(475 persons) were surveyed with questioning paper. 2. Oriental medical Ophthalmology & Otolaryngology were studied by new paradigm teaching method with 116 students(3rd grade, school of Oriental medicine). 3. The satisfaction of school lesson of Oriental medicine 3rd grade students(106 persons) were surveyed with questioning paper before & after applying new paradigm teaching method. Results : 1. 43% students did not know well the purpose of lessons. 2. 46.7% students answered the curriculum has a large quantity. Conclusions : 1. Students want to study with various teaching & learning methods on school lessons. 2. 72.6% students were replied the problem based learning is effective to make a diagnosis and treatment of patients in the future. 3. 58.5% students take a part positively in the conduct of Team based learning study. 4. Team based learning was effective to the interaction with professor and students.
A Review on Perspiration in the aspect of BiaoLi-YinYang(表裏陰陽) in Hwangjenaegyung(黃帝內經)
Kim, Kyu-Seok ; Kim, Yoon-Bum ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 282~288
In our review, the conclusions on the concept and principle of perspiration are as follows. 1. It is the physiological perspiration that Qingyang(淸陽) from Jing(精), Qi(氣), Xie(血) synthesized by digestion of food and drink(水穀), is increased and secreted from pores on the skin(腠理). 2. The main center to control perspiration is heart(心), but lver(肝), stomach(胃), spleen(脾), lung(肺), bladder(膀胱), kidney(腎) and triple energizer(三焦) can be also related to perspiration indirectly. 3. As Weiqi(衛氣) make the body warm and keep the body temperature constant by controlling perspiration, it is very important to make a diagnosis of Weiqi(衛氣) Xushi(虛實) by skin temperature. 4. We guess that perspiration can be secreted by the control of BiaoLi-YinYang(表裏陰陽) such as centrifugal(氣) and centrifetal force(形) of Qi(氣). 5. Sweating therapy can make the level of Biaoyang(表陽) correct and control the balance between centrifugal(氣) and centrifetal force(形) of Qi(氣).
A Case of Bilateral Sudden Sensorineural Hearing Loss with Incomplete Recovery by Oriental and Western Medical therapy
Song, Min-Kyung ; Hong, Seung-Ug ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 23, issue 1, 2010, Pages 289~299
Back ground & Objectives : Bilateral sudden sensorineural hearing loss(SSNHL) is very rare disease. This is the first case report in the oriental medical literature. This study describes a case of bilateral SSNHL with incomplete recovery. Methods : We treated 1 patient who had SSNHL sequentially in both ears. He received oriental and western medical treatments for more than 2 weeks and measured the hearing recovery. For diagnosis on this case, pure tone audiometry was used. The degree of improvement was evaluated by Siegel's Criteria. Results & Conclusions : This patient discharged without hearing improvement. For bilateral SSNHL patients, the result of treatment is important for their qualities of life. But the recovery rate of hearing in bilateral SSNHL is lower than unilateral SSNHL. The oriental medical therapy had some theraputic effects on SSNHL and the theraputic effects on bilateral SSNHL requires further study.