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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
Journal Basic Information
Journal DOI :
The Korean Oriental Medical Ophthalmology and Otolaryngology and Dermatology Society
Editor in Chief :
Volume & Issues
Volume 24, Issue 3 - Dec 2011
Volume 24, Issue 2 - Aug 2011
Volume 24, Issue 1 - Apr 2011
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Effects of Scrophulariae Radix (SR) on Allergic Contact Dermatitis (ACD) induced by DNCB in mice
Song, Jin-Soo ; Lee, Jong-Cheol ; Choi, Jung-Hwa ; Kim, Jong-Han ; Park, Soo-Yeon ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 1~16
Objective : In the theory of Korean medicine, Scrophulariae Radix (SR) can clear away heat and cool the blood, nourish yin and promote the production of the body fluids, relieve toxin and benefit the throat. The present study was carried out to investigate effects of SR on allergic contact dermatitis (ACD) induced by 2,4-dinitrochlorobenzene (DNCB) in mice. Methods : In this experiment, effects of SR on clinical aspects on the skin, histopathological changes such as spongiosis, mast cell distribution, immune cell infiltration in tissue, spleen / body ratio and production levels of serum cytokines were investigated in vivo. In addition, effects on cell viability and release of b-hexosaminidase and histamine were also investigated in vitro. Results : SR treatment diminished erythema, desquamation and keratosis which were induced by repeated painting of DNCB. Spongiosis and edema were diminished by painting of SR in histopathological observation, infiltrations of mast cell and monocytes were also decreased in SR group. In addition, spleen / body ratio was lowered compared to ADC control group. Production level of IFN-
in serum was decreased, but level of IL-4 did not affected by SR. Finally, more than 400
of SR treatment groups showed decreased cell viabilities in RBL-2H3 cells. Treatment with over 200
of SR decreased b-hexosaminidase release, and treatment with over 400
decreased histamine release in vitro. Conclusion : these data suggest that SR can decrease symptoms of ACD, then SR is useful to treat patient with ACD.
Comparison of Antimicrobial effects of Corydalis tuber and processed Corydalis tuber against Propionibacterium acnes
Lee, Jong-Rok ; Park, Sook-Jahr ; Kim, Young-Woo ; Cho, Il-Je ; Byun, Sung-Hui ; Kim, Sang-Chan ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 17~26
Objectives : Corydalis tuber has been used for promoting blood circulation and for relieving pain in Oriental medicine. In the present study, we focused on the antimicrobial activity of Corydalis tuber and compared its antimicrobial activity with the processed Corydalis tuber. Methods : Processing of Corydalis tuber was accomplished by immersing in 5% of acetic acid for 12 h and then by roasting at
for indicated time periods(0-30 min). Minimum inhibitory concentration(MIC) and the zone of growth inhibition were determined against Propionibacterium acnes(P. acnes). Results : The methanolic extracts of Corydalis tuber showed potent antimicrobial effect(MIC 62.5
). Its alkaloidal component, dehydrocorydaline, also exhibited antibacterial activity(MIC 25.0
). After processing of Corydalis tuber, its inhibitory effect on the growth of P. acnes was significantly enhanced compared with that of unprocessed Corydalis tuber. Furthermore, elevated content of dehydrocorydaline was found in the processed than the unprocessed Corydalis tuber. However, the different roasting minutes effected on antimicrobial activity. The best roasting time of Corydalis tuber was 10 min, while roasting for the time above 15 min resulted in diminishing antimicrobial activity. Thus, it was concluded that the standardized processing condition of Corydalis tuber should be established to obtain enhanced antimicrobial(P. acnes) activity. Conclusion : For antimicrobial effect against P. acnes, the best processing condition of Corydalis tuber is immersing in 5% of acetic acid for 12 h and by roasting at
for 10 min.
A study on the correlation between quality of life and disease severity in adult patients with atopic dermatitis
Kim, Nam-Kwen ; Lee, Dong-Hyo ; Jo, Ga-Won ; Moon, Hyo ; Seo, Eun-Sung ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 27~36
Objective : The purpose of this clinical research was to analyze the correlation between disease severity and disease specific quality of life adjusted by general quality of life measure in adult patients with atopic dermatitis attending Wonkwang Univ. Sanbon Oriental Medical Center. Methods : A total of 35 patients participated in atopic dermatitis clinical trial from June 1st, 2010 to June 30th, 2011 were included in this study. SCORing Atopic Dermatitis(SCORAD) index, Dermatologic Life Quality Index(DLQI), Health Utility Index III(HUI-III) and EuroQoL 5-Dimension(EQ-5D) have been estimatied. Baseline statistical analysis and normality test were done by using Student t-test, Shapiro-Wilk test and ladder test. Pearson analysis and Spearman analysis were conducted to examined the correlation of each variables. Hierachial regression analysis was performed using related variables. Statistical significance was achieved if the probability was less than 5%. Results : There were statistically significance between DLQI and SCORAD index, and also between DLQI and EQ-5D. However there was no significant between DLQI and HUI-III. In the hierachial regression analysis, after adjusting for demographic variables (gender, age) and general quality of life (EQ-5D), SCORAD index significantly predict the intensity of disease specific quality of life (DLQI). Conclusions : We confirmed the correlation between SCORAD index and DLQI, and developed the inference for regression equation of DLQI using SCORAD index, EQ-5D and demographic variables.
The Effects of Herbal Medicine on The Liver Function of Inpatient with Facial Palsy
Baek, Sang-Chul ; Jo, Eun-Hee ; Park, Min-Cheol ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 37~54
Background and Objective : Recently it is true that increasing interest in Oriental medicine and usage of herbal medicine. On the other hand, there are many concerns about the stability of herbal medicine. So, this study is carried out to see whether or not the treatment with Sanghan-Bang(傷寒方) is effective on the liver function besides its effectiveness in treating facial palsy. Methods : We examined serum TP, Albumin, TB, AST, ALT, ALP, LDH,
-GGT levels, and facial palsy states in 37 patients with facial palsy who had admission treatment in an oriental medical hospital. Results and Conclusion : 1. We found the levels of TP, albumin, TB, and
-GGT had decreased statistically significant. Also, AST, ALT, LDH and ALP levels had decreased however it was not statistically significant. 2. We analyzed the herbal group that may be efficient to the liver function; Daehwang-Jae(16 case), Injin-Jae(12 case), and Chija-Jae(6 case) in this order. 3. From the eight cases using oriental medicinal concoctions using one of Daehwang, Injin-Jae or Chija as their main component, the liver function test results displayed decreasing values, re-entering into normal LFT ranges. 4. As we compared the admission House-Brackmann Scale with discharge, the treatment was efficient and statistically significant.
A Study on the Validation of Electroneuronography as Predicting Factors for Peripheral Facial Palsy Prognosis
Seo, Eun-Bi ; Joo, Hyun-A ; Lim, Jin-Young ; Hwang, Chung-Yeon ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 55~64
Objectives : This study was performed in order to investigate the effectiveness of electroneuronography as predicting factors for peripheral facial palsy prognosis. Methods : Data were gathered with 32 Bell's palsy patients. The grade of Bell's palsy were measured 2 times; first medical exam and 4 weeks after treatment, with Lucille Daniels's Muscle test. We converted the grade system use on five rating scale. The significance of treatment verified with paired t-test used on first medical exam and 4 weeks after treatment score and predicting factors of electroneuronography verified with simple regression test. Results : The improvement score were statistically significant different before and after treatment(p<.001). Mean axonal loss according to electroneuronography showed a statistically significant correlation in predicting peripheral facial palsy (P<0.01). Conclusion : Axonal loss as determined by electroneuronography has statistical significance as predicting factors for peripheral facial palsy prognosis.
The Correlation between Atopic Dermatitis Severity and Heart Rate Variability
Yu, Seung-Min ; Yoo, Seung-Yeon ; Kim, Min-Hee ; Yun, Young-Hee ; Choi, In-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 65~73
Background : There are findings indicating that the autonomic nervous system (ANS) is affected negatively in atopic dermatitis (AD). Heart rate variability (HRV) is a tool to examine ANS. But, studies investigation the relationship between AD and HRV is rare. Objective : The aim of this study was to investigate the correlation between atopic dermatitis severity and HRV and to find out the role of ANS in AD. Methods : Retrospective chart review was performed. The Severity Scoring Atopic Dermatitis (SCORAD) index and HRV parameter was investigated and analyzed. Results : There were 55 patients (25males and 30 females) who met the criteria. Objective SCORAD had significant positive correlation with HRT and Subjective SCORAD had significant negative correlation with SDNN, TP and VLF. Intensity item of SCORAD index had negative correlation with most HRV parameters, but TP, LF and LF/HF ratio had significant positive correlation with dryness. Conclusion : This study supports the concept that atopic dermatitis is a stress-responsive disorder and involves autonomic nervous system dysfunction.
The Literature Study on the Relationship between Tinnitus and Temporomandibular disorder
Kim, Bong-Hyun ; Nam, Hae-Jeong ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 74~83
Objective : We investigated relationship between tinnitus and temporomandibular disorder(TMD) and tried to find approach possibility in oriental medicine. Method : We searched Pubmed, Scopus, The Cocharane library and additional sources for published and unpublished trials. Search word was "Tinnitus and TMD" Result : We investigated 18 studies. We divided these studies into three parts, epidemiological studies, mechanical studies and treatment studies. In many epidemiological studies. there was significant relationship between tinnitus and TMD. The mechanism was not clear but in recently several studies proposed neurological approach. TMD treatment showed significant improvement in tinnitus accompanied by TMD. Conclusion : In tinnitus accompanied by TMD, TMD treatment can be available to resolve or reduce tinnitus. Especially in oriental medicine acupuncture can be applied to treat this.
A clinical study for the effect of ointment contained Takrisodok-Eum on recovering the damaged skin barrier by Atopic dermatitis
O, Min-Ji ; Yoo, Young-Beup ; Lim, Sin-Heuk ; Kim, Hee-Taek ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 84~107
Purposes : The purpose of present study is to detect the effects of ointment contained Takrisodok-Eum on the skin barrier's recovery of the Atopic dermatitis. Methods : A total of 44 patients who visited Semyung Oriental Medical Center from April 27th, 2011 to September 20th, 2011 were included in the study. In this study, the patients were treated with Takrisodok-Eum (experimental group) and positive control group. For 8 weeks of gross examination, hematological examination and instrumental asessment were made before and after the study to examine how well the products for experimental group with those for control group in recovering the damaged skin barriers by Atopic dermatitis. Results : 1. In the primary endpoint, SCORAD Index showed a statistically significant decline in experimental group. 2. In the secondary endpoint index of skin hydration, both the experimental group and the control group showed statistical significance. 3. In the secondary endpoint index of TEWL, the experimental group showed greater statistical significance than the control group. 4. In the secondary endpoint index of skin pH, skin pH showed a statistically significant decline in both the control group and the experimental group within the normal range. 5. In the secondary endpoint index of Total IgE, Eosinophil count, IL-10, IL-13, both the experimental group and the control group showed no statistical significance. 6. To evaluate the safety of the products for the human body, hematological examination and hematological biochemical examination, vital sign check were conducted; both control group and experimental group showed no abnormal level. And There were no severe adverse events during this study. Therefore, it is suggested that the safety of the products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that Takrisodok-Eum should be effective for the Atopic dermatitis.
A Clinical Report on 35 Inpatients with Facial Paralysis Effects of Early Oriental Medicine Treatment on House-Brackmann Grade in Bell's Palsy
Yang, Hyun-Ju ; Joo, Hyun-A ; Baek, Sang-Chul ; Park, Jin-Soo ; Hong, Seok-Hoon ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 108~118
Objective : This study was designed to evaluate the influence of time from onset of Bell's palsy until commenced Oriental medicine therapy on Bell's palsy. Methods : We investigated 35 cases of patients with peripheral facial palsy who visited Wonkwang University Oriental Hospital from 10th, December 2010 to 31st August, 2011 and classified them as time from onset of Bell's palsy until commenced Oriental medicine therapy. Time from onset of Bell's palsy until commenced Oriental medicine therapy of Group A was within 3 days. Group B was from 4 days to 8 days. We evaluate the treatment effect of each group by House-Brackmann grade before treatment and 1,3 week treatment. Results : 1. There was a statistical difference in period from onset of Bell's palsy until commenced Oriental medicine therapy between Group A and Group B. 2. There was a statistical difference after 1 week treatment in Group B. 3. There was a statistical difference after 3 weeks treatment in both Group A and B.3. After 3 week treatment, there was statistical significant difference in decreased value of House-Brackmann grade between Group A and Group B. Group A showed more recovery compared with Group B. Conclusions : 1. These results suggest that early oriental medicine treatment could be more effective in recovery of Bell's palsy. 2. Further studies will be required to identify the beneficial effect of early oriental medicine treatment in bell's palsy.
Case Study of Facial Palsy Sequela include spasm treated with Miso Facial Rejuvenation Acupuncture
Lee, Yu-Jin ; Choi, Joo-Ho ; Lee, Jong-Cheol ; Park, Su-Yeon ; Kim, Jong-Han ; Choi, Jeong-Hwa ; Chun, Hea-Sun ; Yoon, In-Ae ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 119~128
Object : The purpose of this study is to evaluate the effect of Miso Facial Rejuvenation Acupuncture on Facial Palsy Sequela. Miso Facial Rejuvenation Acupuncture is an Korean medical treatment technique used for face lifting and facial disease. Method : We tereated a male patients who has Facial palsy sequela include contraction, spasm, synkinesis with Miso Facial Rejuvenation Acupuncture. The treatment was performed one times a week for thirteen times. The effects of the treatment were evaluated VAS(visual analogue scale). Result : After the treatment the grade of VAS was decreased and clinical symptoms were gradually disappaered. Conclusion : Miso Facial Rejuvenation Acupuncture showed improvement in sequela of facial palsy.
Two Clinical Case Reports of Ipsilateral Facial Palsy and Conjugate Gaze Palsy caused by Foville Syndrome ＆ Foville-Millard-Gubler Syndrome
Kim, Ji-Eun ; Hong, Chul-Hee ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 129~137
Objective : Foville syndrome & Foville-Millard-Gubler syndrome is a disease characterized by facial palsy, ipsilateral conjugate gaze palsy and ipsilateral internal strabismus. There has never been a clinical report of this disease in oriental medicine. Since gradual improvement has been experienced with oriental medical treatments based on facial palsy and paralytic strabismus in this case, it is worthwhile to introduce this disorder and report the case referring to clinical record. Methods : 75-year-old female patient and 45-year-old male patient suffering right facial palsy, right conjugate gaze palsy and right internal strabismus were treated with acupuncture, herbal medicine, pharmacopuncture and electroacupuncture. Result : Concurrence of right facial palsy, right conjugate gaze palsy and right internal strabismus was diagnosed with Foville syndrome or Foville-Millard-Gubler syndrome which is generally caused by the impairment of PPRF, abducens and facial nerves on the affected side and showed improvement with oriental medical treatments. Conclusion : More accurate diagnosis, more aggressive treatments and further researches are all required on this disease afterwards.
A Case of Urticaria and Angioedema Caused from Serum Sickness Reaction by Bee Venom
Kim, Jung-Hyun ; Kang, Da-Hae ; Kim, Jee-Young ; Lim, Hae-Won ; Kim, Ja-Heon ; Kwon, Kang ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 138~146
Objective : This study was performed to prove the effect of the oriental medical treatments on urticaria and angioedema caused from serum sickness reaction by bee venom. Method : We treated one case of urticaria and angioedema with oriental medical treatments such as 8 constitution acupuncture, herbal medicine, venesection therapy and facial pack therapy. We took pictures through the treatment to evaluate the improvement. Six items, itching, burning sensation, pain, wheal, redness, edema were used to diagnose urticaria and angioedema. Result & Conclusion : After treatments the urticaria and angioedema were improved. The symptom of itching, heating, pain, wheal, redness of whole body and facial edema disappeared.
A Clinical Study about the Effect of Gyejigajakyak-Tang on a Peritonsillar Abscess Patient
Baek, Sang-Chul ; Joo, Hyun-A ; Yang, Hyun-Ju ; Jo, Eun-Hee ; Park, Min-Cheol ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 147~153
Background and Objective : Peritonsillar abscess occurs when the bacterial infection of the palatine tonsil spreads to the potential peritonsillar space deep behind the tonsil. We observed and treated a case of peritonsillar abscess patient from a child acute tonsillitis. We present this case because there were no former reports of peritonsillar abscess treated by herbal medicine. Methods : We used herbal medication for 24 days. We diagnosed the patient through abdominal examination and have decided the treatment principle accordingly. We used the visual analogue scale(VAS). Results : After the treatment the grade of VAS was decreased and clinical symptoms were improved. Conclusions : Gejigajagyak-Tang in considerably effective on the treatment of pus of peritonsillar abscess.
Case report: Correction of nasolabial fold with needle embedding therapy
Yun, Young-Hee ; Cho, Seung-Pil ; Choi, In-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 24, issue 3, 2011, Pages 154~161
Objective : Needle embedding therapy is a newly induced therapy which uses specialized tools. The purpose of this study is to report the nasolabial folds correction effect of needle embedding therapy on 5 cases. Method : Five women with no disease were received needle embedding therapy four to six times over one to two months. The photos of each patient were taken before and after the treatment. Also, Glogau photoaging classification were assessed before and after the treatment. Result and conclusion : Needle embedding therapy may be an effective and safe treatment for the correction of nasolabial folds.