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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
Journal Basic Information
Journal DOI :
The Korean Oriental Medical Ophthalmology and Otolaryngology and Dermatology Society
Editor in Chief :
Volume & Issues
Volume 28, Issue 4 - Nov 2015
Volume 28, Issue 3 - Aug 2015
Volume 28, Issue 2 - May 2015
Volume 28, Issue 1 - Feb 2015
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The Effects of Anti-Oxidant and Phototoxic Inhibitory Activity of Rubus coreanus Fruits
Lee, In-Su ; Kim, Yong-Min ; Kim, Hee-Taek ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 1~10
DOI : 10.6114/jkood.2015.28.1.001
Objectives : Oxidation by active oxygen in the body, phototoxicity and photoallergic interest has grown, antioxidant and phototoxicity inhibiting substances for research progress. The purpose of this study was to examine the effects on antioxidant and phototoxicity of Rubus coreanus Fruits. Meterial and Methods : Hs68 cell lines using the DPPH radical scavenging activity, cytotoxic, phototoxic inhibitory activity and apoptosis were measured. Results : 1. In MTT assay, the concentrations of Rubus coreanus Fruits that were used on the test had no cytotoxicity. 2. In DPPH radical scavenging activity, the concentration of
anti-oxidant effect of Rubus coreanus Fruits was statistically significant increased than control group in dose-dependantly. 3. In phototoxic inhibitory activity, Rubus coreanus Fruits dose-dependently increased the cell viability of Hs68 cell lines. 4. The concentration of
Rubus coreanus Fruits inhibited the enrichment of nucleus in the Hs68 cell stimulated with UVB. Conclusions : These results indicate that Rubus coreanus Fruits has anti-oxidant effects and Phototoxic Inhibitory Activity. If further study is performed, the use of Rubus coreanus Fruits will be valuable and beneficial in the therapy of skin aging and damage.
Inhibitory Effects of Siegesbeckia Herba Extracts on the Melanin Production and Tyrosinase Activity in B16F10 cells
Kim, Ji-Soo ; Jeong, Min-Young ; Kim, Jong-Han ; Choi, Jeong-Hwa ; Park, Soo-Yeon ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 11~22
DOI : 10.6114/jkood.2015.28.1.011
Objective : Siegesbeckia Herba can treat various skin disease by expelling wind and removing dampness and clearing away heat and toxic material effects. This study was designed to investigate effects of Siegesbeckia Herba Extracts(SHE) on skin elasticity and whitening using B16F10 cell lines. Method : In this experiment, We observed effect of SHE on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase. Results : 1. SHE treated group showed decreased cell viability rates significantly compared with non-treated group. More than SHE
of treated groups were lower levels of melanin synthesis respectively. 2. SHE significantly showed tyrosinase inhibitory activity in vitro, SHE increased tyrosinase inhibitory activity and elastase inhibitory activity in B16F10 cells, and tyrosinase inhibitory activity in vitro. 3. Tyrosinase inhibitory activity and elastase inhibitory activity in B16F10 cells, tyrosinase inhibitory activity in vitro were not accepted statistical significance compared with non-treated group. 4. SHE treated group showed increased SOD-like activity rates significantly compared with non-treated group. More than SHE
of treated groups were lower levels of melanin synthesis respectively. Conclusion : These results suggest that SHE can inhibit melanin synthesis and tyrosinase inhibtory activity. So, We suggest that SHE can be maintained skin whitening.
Anti-inflammatory Effects of Gamiyunjo-tang on Lipopolysaccharide Induced Inflammatory Responses in RAW 264.7 Cells
Choi, Jong-Min ; Kim, Yong-Min ; Kim, Hee-Taek ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 23~31
DOI : 10.6114/jkood.2015.28.1.023
Objectives : Allergic disease has been well known as an IgE-dependent immunologic response. Recently, interest about the late inflammatory reaction has grown up as well as early allergic reaction characterized by IgE and mast cell. The purpose of this study was to find the anti-inflammatory effect of Gamiyunjo-tang(GMYJT) in allergic reaction. Methods : The experiment was performed using Raw 264.7 cells pretreated with GMYJT extracts. In this study, we observed the toxicity of cells by MTT analysis and measured the production of LPS-induced NO,
, IL-6 and TNF-
at a concentration of 50, 100, 200 and
. Results : No toxicity of GMYJT (50, 100, 200,
) on RAW 264.7 cells was found after 24 hours incubation. LPS-induced NO production was reduced after treatment with GMYJT (100, 200,
was reduced after treatment with GMYJT (100, 200,
did not decrease at any dose. IL-6 decreased at 200,
production decreased only at
(P<0.05). Conclusions : These data suggest that GMYJT has anti-inflammatory effects in late allergic reaction.
An Experimental Study on the Effect of Angelica acutiloba Ethanol Extract on Hyaluronic Acid Synthesis
Kang, Min-Seo ; Ha, Hun-Yong ; Kim, Hee-Taek ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 32~40
DOI : 10.6114/jkood.2015.28.1.032
Objectives : Hyaluronic acid(HA) is a mucopolysaccharide, occuring naturally in living organisms. It is one of the most hydrophilic molecules, so it has been known as being related to skin hydration and anti-aging. The purpose of this study is to examine the effects of Angelica acutiloba ethanol extract on hyaluronic acid synthesis. Methods : To determine cytotoxicity and hyaluronic acid synthase 2 gene expression, hyaluronic acid production in HaCaT cells, MTT assay and RT-PCR ELISA was used. Results : There was no cytotoxicity in
concentration Angelica acutiloba extract in MTT assay. Hyaluronic acid synthase 2(HAS2) gene expression was increased by all treated concentration Angelica acutiloba extract. Hyaluronic acid production was higher in
concentration Angelica acutiloba extract than control group. Conclusions : Hyaluronic acid production was increased by Angelica Acutiloba extracts. Therefore, We suggest that Angelica acutiloba can make a contribution to the moisturing effect on human skin. Conclusions : Hyaluronic acid production was increased by Angelica Acutiloba extracts. Therefore, We suggest that Angelica acutiloba can make a contribution to the moisturing effect on human skin.
Inhibitory Effect of the Ethanol Extract of Rosae rugosae Flos on the Hyperpigmentation and its Action Mechanism Induced by α-MSH
Lee, Jin-Ho ; In, Myung-Hee ; Kang, Suk-Hoon ; Mun, Yeun-Ja ; Woo, Won-Hong ; Lim, Kyu-Sang ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 41~52
DOI : 10.6114/jkood.2015.28.1.041
Objective : This study investigated the inhibitory mechanism of the hypopigmentating effects on ethanol extract of Rosae rugosae Flos (ERR) that has not yet been examined. Methods : We analyzed the anti-melanogenic effects of ethanol extracts from Rosae rugosae Flos by tyrosinase activity, melanin contents. We also examined protein expression levels of tyrosinase, TRP-1, TRP-2, MITF and ERK by western blot analysis in melanoma cells. Results : In this investigation, ERR effectively reduced
-MSH-stimulated melanin synthesis by suppressing expression of tyrosinase and tyrosinase-related protein-1 (TRP-1). On the other hand, the expression of tyrosinase-related protein-2 (TRP-2) were not affected by treatment with ERR. ERR inhibited the expression of microphthalmia-associated transcription factor (MITF) as a key transcription factor for tyrosinase expression regulating melanogenesis. The upstream signaling pathway including cAMP response element-binding protein (CREB) and MAPKs were also inhibited by ERR. Pretreatment with PD98059, ERK inhibitor, attenuated the inhibitory effect of ERR on
-MSH-induced tyrosinase activity. Conclusions : Our study suggested that the anti-melanogenic activity of ERR is correlated with the suppression of tyrosinase gene through CREB/MITF/ERK pathway.
Effects of Gamijaungo on the burn mice model and the study of hematologic, pathologic and molecular mechanism
Lee, Jong-Chul ; Kim, Gyung-Jun ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 53~67
DOI : 10.6114/jkood.2015.28.1.053
Objective: The aim of this study was to investigate the wound healing effect of herbal ointment, Gamijaungo, on the burn-induced model. Reports about Gamijaungo on the wound healing effect by local application in mice model or human study have published in the several domestic or internationally, but most are anecdotal and lack solid scientific evidence. Method: We observed the morphologic and histologic changes in the burn-induced mice model. we counted white blood cell and platelet changes. we confirmed VEGF, PI3K and pAkt protein expression by Western blot analysis. Result: In this study, we observed that Gamijaungo showed strong wound healing effects in the morphologic and histologic changes in the burn-induced mice model. Also we found that the significant changes of white blood cell and platelet changes by the treatment of Gamijaungo. In molecular mechanism, we got the strong positive effect by Gamijaungo treatment on angiogenesis, a key process in the formation of the granulation tissue during wound healing. Conclusion: These findings suggest the potential use of Gamijaungo as a therapeutic in thermal burn-induced skin injuries.
Anti-inflammatory effects of herbal medicines(Rubus coreanus, Rehmanniae Radix, Houttuynia cordata, Betulae cortex) EtOH extract on acute atopic dermatitis mice
Jung, Jae-Hoon ; Kim, Gyung-Jun ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 68~84
DOI : 10.6114/jkood.2015.28.1.068
Object : The object of this study was effected of composed of 4 herbal medicines(Rubus coreanus, Rehmanniae Radix, Houttuynia cordata, Betulae cortex) on acute atopic dermatitis mice. Methods : BALB/c mice were divided 4 groups ; normal group, negative control group of acute atopic dermatitis mice induced by DNCB, treated apply to the back skin with the herbal medicine group, and treated orally with herbal medicine group. Treated with herbal medicine and DNCB during 2 weeks. After treated, measured WBCs, RBCs, and platelet in the blood, and analysed mRNA expression of spleen. Result : Composed herbal medicines could reduce WBCs, lymphocytes, monocytes, neutrophils, and eosinophils in the mouse blood. And, could down TNF-
levels in spleen. In the skin tissue histology results, herbal medicines reduce the cells and T cells. Conclusion : Composed herbal medicines help to another inflammatory disease because they reduce the cells and T cells in the skin tissues. And they have inhibitory effects of TNF-
mRNA expression, and Th 2 immune responses. Therefore herbal medicines use for an acute atopic dermatitis treatment.
Retrospective Study about the Effectiveness of a long-term Korean Medicine Treatment on 1035 Atopic Dermatitis Patients
Cho, Ah-Ra ; Han, Su-Ryun ; Park, Gun ; Seo, San ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 85~99
DOI : 10.6114/jkood.2015.28.1.085
Objective : The purpose of this study is to report the effectiveness of a long-term Korean Medicine Treatment on 1035 atopic dermatitis patients Methods : Objective SCORAD Index(OSI) is used for measuring the degree of atopic dermatitis with photos of total 1035 atopic dermatitis patients who has visited oriental clinic from January 9, 2011 to October 31, 2013. Then, OSI was estimated according to gender, age, period of treatment and intensity. Results : 1. The ratio of male to female was 44.4 : 55.6. All patients were constituted with 26.5% of 0~11 year-old group, 15.7% of 12~18 year-old and 57.9% of 19 and more year-old. 2. The ratio of OSI improvement was significantly higher in women than in men after 3 month treatment, but there was no significant difference after 6, 9 and 12 months. 3. The OSI improvement of 0~11 year-old group was significantly higher than the other groups after 3 month treatment. But at the other periods of treatment, there was no significantly difference of the improvement among 3 different groups of age. 4. After 3, 6, 9 and 12 month treatment, the score of OSI was significantly lower than before treatment. After 12 month treatment, the score of OSI was lowest compared to the other periods of treatment. 5. The final OSI score of 87.7% patients was decreased compared to the initial. 6. All patients had been divided with 1.93% of the mild, 22.7% of the moderate and 75.4% of the severe by OSI intensity at initial visit. At final visit, the composition of patients was changed to 14.6% of the mild, 53.7% of the moderate and 31.7% of the severe. 7. The mild patients had got 42.56% of OSI improvement at the final. And the moderate had got 37.72% of OSI improvement at the final. 8. The severe patients had got 36.76% of OSI improvement at the final. And 89.2% of the severe had got decreased final OSI score compared to the initial. Conclusion : There was a definite decreasing of OSI score on the significant rate of Atopic dermatitis patients who had been treated by Korean medicine treatment at least for 3 months.
Research on Effects and Possibility of Commercialization of Coptidis Rhizoma Mask Pack
Lee, Kyou-Young ; Hong, Chul-Hee ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 100~108
DOI : 10.6114/jkood.2015.28.1.100
Objectives : This study was planned to examine the enhancing effect of Coptidis Rhizoma mask pack on water, oil contents and skin texture, and to check the possibility of commercialization. Methods : We measured the change of water, oil contents and skin texture before and after the use of Coptidis Rhizoma mask pack. Measuring was conducted twice at an interval of ten days using accurate SK-03 skin analyzer. Measuring site was right and left SI18 and CV24 acupoints. Results : We can examine the improvement of water, oil contents and skin texture on every acupoints measured, except for CV24. On CV24, no difference was observed from water contents of both 1st, 2nd visit, and skin texture of 1st visit. Conclusions : We could confirm the boosting effect of Coptidis Rhizoma mask pack on water, oil contents and skin texture, especially around the SI18 acupoints. We should take follow-up measures to improve the absorption of a liquid herbal medicine around the CV24 acupoint, and heighten the potential for commercialization.
A Study on Correlation between ARIA, TNSS and Nasal Endoscopy as Instruments of Evaluation for Allergic Rhinitis
Lee, Kyu-Jin ; Yun, Young-Hee ; Kim, Kyu-Seok ; Jang, Soo-Bin ; Choi, In-Hwa ; Ko, Seong-Gyu ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 109~118
DOI : 10.6114/jkood.2015.28.1.109
Objectives : We performed a clinical study to investigate characteristics of pattern identifications using nasal endoscopy for allergic rhinitis (AR). Methods : We assessed 32 patients with allergic rhinitis using nasal endoscopy, classifications of allergic rhinitis and it's impact on asthma (ARIA) and total nasal symptom score (TNSS). Results : The watery rhinorrhea score of nasal endoscopy was significantly high in 'persistent and moderate/severe' group (P<0.05). Patients were classified as rhinorrhea group and nasal obstruction group according to nasal endoscopy. TNSS and rhinorrhea score was significantly high in rhinorrhea group (P<0.05). Conclusions : The result may provide that the watery rhinorrhea of nasal endoscopy is useful as 'Cold' and 'Deficiency' pattern identification diagnostic tool.
Narrative Review and Propose of Thread Embedding Acupuncture Procedure for Facial Wrinkles and Facial Laxity
Yun, Young-Hee ; Kim, Tae-Yeol ; Lim, Tae-Jung ; Hwang, Yong-Ho ; Choi, In-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 119~133
DOI : 10.6114/jkood.2015.28.1.119
Objective : Thread embedding acupuncture has become popular as a minimally invasive treatment for facial wrinkles and laxity. However, there is little published clinical practice guidelines. This study is to developing a specific procedure of thread embedding acupuncture for facial wrinkles and laxity. Method : We reviewed and summarized 6 studies on thread embedding acupuncture for facial wrinkles and laxity. And, four practitioners who have more than four year of clinical experience and one hundred of cases were participated in developing a thread embedding acupuncture procedure for facial wrinkles and laxity. Result and conclusion : We developed a thread embedding acupuncture procedure for facial wrinkles and laxity which consists of correction of lower jaw, facial laxity, nasolabial fold and eye wrinkles.
The Case Report of Tinea Pedis with Id Reaction
Kwon, Kang ; Kim, Chul-Yun ; Lee, Dong-Jin ; Kim, Nam-Kwen ; Seo, Hyung-Sik ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 134~142
DOI : 10.6114/jkood.2015.28.1.134
Objective : This study was carried out to find out the effect of Korean medical treatments on tinea pedis with id reaction. Method : We treated a 33-year-old man was afflicted with tinea pedis complicating id reaction with herbal medicine, acupuncture, ointment, wet-dressing and steam treatment. After treatments, we measured the status of scales, fissures and the degree of pruritus. We followed up symptom changes by taking pictures and compared before and after. Result & Conclusion : Three days after admission, erythema occurred at upper and lower limbs and the degree of pruritus increased by id reaction. As tinea pedis improved, id reaction decreased, too. Consequently, both sites of primary lesions of tinea pedis and secondary id reactions were significantly improved, and accompanied symptoms were resolved simultaneously.
Clinical Report of 4 Vitiligo Cases Treated as Korean Medicine
Kim, Ki-Bae ; Kim, Tae-Wook ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 143~151
DOI : 10.6114/jkood.2015.28.1.143
Objectives : The purpose of this study was to investigate the clinical efficacy of treatment of vitiligo patients in Korean Medicine Treatment. Methods : This case study was done on four vitiligo patients who had visited Korean Medicine Clinic. All the patients are treated with herbal medication and acupuncture treatment. Photographs were used to evaluate the symptom change. Results : Four vitiligo patients who were treated by Korean Medicine Treatment (herbal medication and acupuncture) showed efficient clinical results. Conclusion : Most symptoms of patients were improved in this study. Herbal medication and acupuncture treatment can be effective in patients who were diagnosed as Vitiligo.
Four cases of Soyangins vitiligo patients gotten better by Oriental medical treatment who have the symptoms in the hands
Hong, Yo-Han ; Kim, Sung-Won ; Cho, Young-Chen ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 152~159
DOI : 10.6114/jkood.2015.28.1.152
Purpose : This rearch aims to prove effects of an oriental medical complex therapy on vitiligo patients who have the symptoms in the hands. Method : The rearch conducted its investigation targeting these four patients who have the symptoms in the hands. The study resolved the findings through the comparison on the pictures before and after the therapy. Result : After making a comparison on the pictures, the study confirmed positive changes in the conditions of the patients. The oriental medical complex therapy turned out to be effective enough to treat the patients who have the symptoms in the hands. Conclusion : Such result leads the study to a conclusion that the oriental medical complex therapy can be an effective method to treat these patients who have the symptoms in the hands. In addition, more case studies and research will be necessary.
3 Cases of Emotional Facial Flush Treated with Gagamhwanggeum-tang
Cho, Jae-Gon ; Seo, San ; Park, Seon-Jung ; Han, Su-Ryun ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 160~168
DOI : 10.6114/jkood.2015.28.1.160
Objective : The purpose of this study is to report the effect of Gagamhwanggeum-tang on emotional facial flush. Methods : This case study was done on 3 Facial Flush patients who have visited Korean Medicine Clinic. Gagamhwanggeum-tang was prescribed to all 3 patients and evaluated the symptom change through photographs and questionnaire. Investigator's Global Assessment(IGA) was used to evaluate the objective symptom and Visual Analogue Scale(VAS) was used to evaluate the subjective change Results & Conclusion : The IGA and VAS were decreased in 3 patients in our study. Most symptoms of 3 patients were improved. As a result of examining IGA, VAS scores and photographs, Gagamhwanggeum-tang can be effective on emotional facial flush in 3 case in our study.
An Opinion about English inscription of Thread-embedding Therapy
Yun, Young-Hee ; Choi, In-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 28, issue 1, 2015, Pages 169~171
DOI : 10.6114/jkood.2015.28.1.169