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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
Journal Basic Information
Journal DOI :
The Korean Oriental Medical Ophthalmology and Otolaryngology and Dermatology Society
Editor in Chief :
Volume & Issues
Volume 29, Issue 3 - Aug 2016
Volume 29, Issue 2 - May 2016
Volume 29, Issue 1 - Feb 2016
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The Effect of Bangpungtongsungsan on Allergic Rhinitis Of Obese Mouse Fed High Fat Diet.
Kim, Dong-Hyun ; Hong, Seung-Ug ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 1~15
DOI : 10.6114/jkood.2016.29.1.001
Objective : For various reasons, Obesity & Rhinitis are constantly rising. So Interest of treatment has been expanding. We want to verify The Chungyeol (fire extinguishing) Lisup (Draining) effect of Bangpungtongsungsan on obese model of allergy rhinitis.Material and Methods : BALB/c mouse were divided four groups: control(CON), allergic induction(ARE), Bangpungtongsungsan extract administration(BTT), Bangpungtongsungsan double concentration extract administration (BT2T). Every group except control group were caused allergic rhinitis by Ovalbumin. BTT & BT2T were orally administered the Bangpungtongsungsan for 21days. Since then we observed the liver tissue cell and the nasal mucous membrane.Results : In comparison with ARE, experimental groups show relief of the nasal mucous membrane damage(secretion of mucus decrease, Itching decrease), Th2 eruption control(IL-4 decline), effect of anti-inflamatory(reducing TNF-α creation, decreasing of iNOS through NF-κB activation-inhibition). In addition, experimental groups show a loss in weight, diminished accumulation of fat. (decreasing within liver tissue, reducing TNF-α creation) BT2T is more effective to BTT.Conclusion : Bangpungtongsungsan treat obese model on allergy rhinitis thereby control fat augmentation, relieving inflammation.
Effects of Bojungikgi-tang on Trimellitic Anhydride-induced Contact Hypersensitivity in BALB/c Mice
Park, Yang-Gu ; Jung, Myung ; Bok, Young-Ok ; Lee, Jin-Ho ; Kang, Suk-Hoon ; Lim, Kyu-Sang ; Yun, Young-Gab ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 16~32
DOI : 10.6114/jkood.2016.29.1.016
Objective : The water extract of Bojungikgi-tang (BTE) composed with Ginseng Radix, Astragali Radix, Angelicae gigantis Radix, Atractylodes Rhizoma alba, Aurantii nobilis Pericarpium, Glycyrrhizae Radix, Cimicifuga Rhizoma, and Bupleuri Radix and it has been traditionally used for chronic diseases or weakness after illness in oriental countries. However, little is known about the effects of aqueous extract of BTE on trimellitic anhydride (TMA)-induced contact hypersensitivity (CHS). Therefore, the aim of this study was to investigate the effects of BTE on TMA-induced CHS in BALB/c mice.Methods : In this study, the extract of BTE was prepared by extracting with distilled water at 100℃ for 2.5 h. The extract was freeze-dried following filtration through 0.45 μm filter. Mice were orally administrated with or without BTE extract of different doses (25-200 ㎎/㎏/day) for 28 days. During the challenge period, mice were externally applied with different doses of BTE extract one time per day 30 min before TMA treatment. I examined the effects of BTE on the serum levels of IgE, IgG1, IgG2a, and IgG2b, nitric oxide (NO) and prostaglandin E
) production in isolated peritoneal macrophages, Th2 cytokine production in isolated spleen cells, ear swelling responses, and the leukocyte infiltration induced by TMA.Results : The orally and externally administration of BTE dose-dependently reduced the serum levels of hapten-specific immunoglobulin E (IgE), IgG1 titer, and PGE
production as well as ear swelling responses and leukocyte infiltration in TMA-induced BALB/c mice. The levels of NO and PGE
production from peritoneal macrophages stimulated with TMA-BSA were markedly suppressed by pretreatment with BTE in a concentration dependent manner. Furthermore, the levels of Th2 cytokines (IL-4, IL-5, IL-13) production from spleen cells stimulated with ConA were markedly suppressed by BTE treatment in a concentration dependent manner.Conclusions : These results suggest that BTE treatment suppresses chronic contact hypersensitivity, and it can be assumed that the suppression of ear swelling, serum IgE, NO and PGE
levels, leukocyte infiltration, and Th2 cytokines in an animal model. Therefore, these properties may contribute to the strong anti-CHS response effect of BTE.
Anti-atopic Effect of Chamaecyparis Obtusa oil (CHO_O) in DNCB-induced atopic dermatitis-like skin lesions NC/Nga mice
Son, Ki-Jeong ; Park, Jung-Hwan ; Kim, Youn-Ha ; Go, Ga-Yeon ; Kim, Yun-Joo ; Han, Ji-Yeon ; Ko, Ki-Tae ; Ahn, Taek-Won ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 33~46
DOI : 10.6114/jkood.2016.29.1.033
Objective : The aim of this study is to investigate the effect of Chamaecyparis Obtusa Oil to NC/Nga mice induced in Atopic dermatitis-like skin lesions by DNCB Mthods.Methods : NC/Nga mice which have been induced to Atopic dermatitis-like skin lesions by DNCB are divided into 3 groups, the one is the mice which have been spread with Chamaecyparis Obtusa Oil 2% cream, the other is which have been spread with dexamethasone (Dexa.) 0.5% on their Atopic lesion, another is the control group. then we take the blood sample of each group to measure state of the dorsal skin, the number of immunocytes. and resect the skin lesion to analyze the state of cells.Result & Conclusion : There are meaningful results of measuring the number of IgE, IL-4, IFN-γ and the state of the skin lesion and cells in the group with hamaecyparis Obtusa Oil 2% cream in comparison with the other groups.
Effects of Microneedle Therapy System(MTS) and Hwangryeonhaedoktang Pharmacopuncture Solution on Hair Growth in an Alopecia Model of C57BL/6N Mouse
Kang, Na-Ru ; Yoon, Hwa-Jung ; Ko, Wo-Shin ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 47~64
DOI : 10.6114/jkood.2016.29.1.047
Objective : This study was carried out to investigate the effect of Hwangryeonhaedoktang pharmacopuncture solution (HRHDT) and microneedle therapy system (MTS) on hair growth in an alopecia model of C57BL/6N mice.Methods : Six-week old mice were depilated and separated in 4 groups ; CON (saline), MXD (3% Minoxidil), MTS and HRHDT+MTS. The treatments were applied twice a week for 17 days. The hair growth was determined photographically. The hair density, thickness and length were identified by Folliscope and the weights of body and organs were measured. In dorsal skin tissue, the expression of hair growth-related gene and protein was analyzed by RT-PCR. In addition, the hair follicles in the dermis were observed by H&E staining.Results : The promotion of hair growth was observed in HRHDT+MTS and MTS compared to CON. The hair density, thickness and length were also improved in HRHDT+MTS and MTS compared to CON. The mRNA expression of IGF-1, PRL and PL and the protein expression of VEGF and IGF-1 were increased in HRHDT+MTS and MTS compared to CON. The hair follicles and hair root growth were improved in HRHDT+MTS and MTS compared to CON. In the above results, HRHDT+MTS were more effective than MTS.Conclusions : These results suggest that HRHDT and MTS have a hair growth activity and can be useful for the treatment of alopecia.
Gagamyeonryunggobon-dan(Jiājiǎnyánlínggùběn-dān) induces hair regrowth effect from activating hair follicle
Cho, Ah-Ra ; Hong, Seung-Ug ; Yoon, Young-Joon ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 65~80
DOI : 10.6114/jkood.2016.29.1.065
Objective : The purpose of this study is to report the hair regrowth effect of Gagamyeonryunggobon-dan on ICR mice from measuring the change of diverse factors.Methods : Gagamyeonryunggobon-dan was treated by oral administration with 2.5㎎/㎏/day amount for 3 weeks per mouse everyday. Hair regrowth was estimated by change of morphology, angiogenesis, hair follicle activation. The change of morphology was observed with external, internal change and sebaceous gland. Angiogenesis was estimated by image analysis, capillary distribution and angiogenic chemokine(MIP-2). Hair follicle activation was estimated by PCNA, IGF-2 and serotonin.Results : 1. Gagamyeonryunggobon-dan treated group had more and thicker hairs than the group not treated. Especially well developed sebaceous glands were seen in dermis of treated group. 2. Gagamyeonryunggobon-dan treated group had more capillaries near hair follicles of subcutaneous layer and more 2019% MIP-2 positive activity than the group not treated. 3. Gagamyeonryunggobon-dan treated group increased positive activity up to 596% in PCNA, 187% in IGF-2 and 547% in serotonin more than the group not treated.Conclusion : These results shows that Gagamyeonryunggobon-dan have the hair regrowth effect through verifying change of morphology, angiogenesis, chemokines. Consequently Gagamyeonryunggobon-dan is expected to apply to take care of extensive hair loss symptoms.
A Clinical Study for Moisturizing Effects of Herbal Cosmetics Containing Sinhyotakrisan Extracts
Kang, Min-Seo ; Kim, Yong-Min ; Kim, Hee-Taek ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 81~92
DOI : 10.6114/jkood.2016.29.1.081
Objectives : The purpose of this study is to confirm the moisturizing effects of Herbal cosmetics containing Sinhyotakrisan(SHTL) extracts on facial skin.Methods : A total of 23 women who visited Semyung Oriental Medical Center from January 10th, 2014 to Feburary 12th, 2014 were included in the study. Provided both cosmetics containing Sinhyotakrisan extract and control products, all the subjects applied one of them to half face and another to remaining half for 4 weeks. We observed change of skin hydration, skin elasticity, skin scale in 0 week, 2 weeks, and 4weeks. Statistical anyalysis was performed by using SPSS, and statistical significance was achieved if the proability was less than 5%(p<0.05).Results : 1. After 4 weeks of using SHTL, skin hydration showed a statistically significant increase compared with using control product(p=0.011). And improvement rate also did(p=0.031). 2. After 4 weeks of using SHTL, skin elasticity showed statistically significant increase compared with using control product(p=0.025). But improvement rate didn't showed statistically significant increase(p=0.068). 3. After 4 weeks of using SHTL, skin scale showed a statistically significant decrease compared with using control product(p=0.029). And improvement rate also did(p=0.047).Conclusions : Considering the above results, herbal cosmetics containing Sinhyotakrisan extracts were effective for skin moisturizing.
Comparative Study on Treatment of Acne Scar
Lee, Hyung-Kee ; Cho, Soo-Young ; Kim, Kyu-Nam ; Choi, Yong-Hun ; Lee, Jung-Hwan ; Kim, Jung-Ho ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 93~102
DOI : 10.6114/jkood.2016.29.1.093
Objective : This study performed to evaluate that duration of acne scars effects on Qualitative Global Acne Scarring Grading System(QGASC) grade changing and treatment duration. Also this study performed to evaluate the relationship between dysmenorrhea and acne scars, and the effects of each treatment on treatment duration and Korean Acne Grading System(KAGS) and QGASC grade.Methods : 95 patients with acne scars were understood by medical records and case photos, and we evaluated pre and post acne scar grade based on KAGS and QGASC. We analyzed data by SPSS 22 for windows program, and figured out the relation between duration of acne and QGASC grade and treatment duration by Spearman correlation analysis, and performed Mann-Whitney U-test to figure out the relation between dysmenorrhea and QGASC grade. We performed Wilcoxon test to evaluate that treatment of acne scars effects on KAGS grade and QGASC grade, and performed Kruskal-Wallis test to figure out the difference of each treatment which effects on KAGS grade and QGASC grade, and performed Post-hoc analysis to figure out the group comparison.Results & Conclusions : QGASC grade depending on duration of acne was statistically significance. Subcision and Microneedle Therapy System(MTS) and pharmacopuncture were significantly improved acne scars. Other treatments were significantly more effective than subcision and pharmacopuncture combined treatment. Treatment duration of Subcision and MTS combined treatment was significantly most shortest than other treatment.
Disinfection, Sterilization and Aseptic Technique for Thread Embedding Acupuncture
Yun, Young-Hee ; Son, Jae-Woong ; Ko, Seong-Gyu ; Choi, In-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 103~112
DOI : 10.6114/jkood.2016.29.1.103
Objective : Thread embedding acupuncture has become popular as a minimally invasive treatment for facial wrinkles and laxity. However, there is little published clinical practice guidelines about disinfection, sterilization and aseptic technique for thread embedding acupuncture. This study is to introducing a specific guidelines about disinfection, sterilization and aseptic technique for thread embedding acupuncture.Method : We reviewed internal regulations and guidelines about hospital infection, and Traditional Korean medicine doctors, nurses, and director of central supply room discussed in depth and established a regulation of disinfection, sterilization and aseptic technique for thread embedding acupuncture.Result : The regulation of disinfection, sterilization and aseptic technique for thread embedding acupuncture consisted of ① management of supplies, ② guidelines of disinfection, sterilization, and reuse, ③ aseptic technique for thread embedding acupuncture.Conclusion : Microbial management is an essential element of medical care and quality. Traditional Korean medicine doctors will care for disinfection, sterilization, and this should not neglect to comply with the procedures and guidelines in the medical field as well as to understand the aseptic techniques.
A Review on the Pharmacopuncture Used in Herpes Zoster Related Articles Published in the Journal of Korean Medicine
Cho, Young-Sun ; Sim, Sung-Yong ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 113~122
DOI : 10.6114/jkood.2016.29.1.113
Objective : This study was carried out to analyze the trends of pharmacopuncture used to treat Herpes Zoster related articles that have been published in the Korean medicine journal.Method : We studied 14 research papers treated with pharmacopuncture for Herpes Zoster in Korean medicine journal. We analyzed for type of pharmacopuncture used, treatment point and clinical type.Results : 1. The number of searched journal is 14 papers. 2. The most common clinical type is herpes zoster generalisatus. Others types are postherpetic neuralgia, ramsay hunt syndrome, herpes zoster ophthalmicus, postherpetic paralysis 3. Pharmacopunctures used to treat herpes zoster are BV, Hwangreonhaedok-tang pharmacopuncture, Ginseng Pharmacopuncture, CF, JsD, Immuno-yakchim, etc. The most frequently used type of harmacopuncture is BV. 4. The most used part as a treatment point is a-shi point.Conclusions : It is needed to improve the cure rate through a comprehensive analysis of the Herpes zoster treatments. It is necessary to comprehensively analyze the treatments to increase the cure rate of about Herpes zoster.
Review of the TCM Papers about Direct Moxibustion Therapy Used in the Treatment of Warts
Park, Ji-Hyun ; Son, Hyeon-Eui ; Seo, Hyung-Sik ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 123~130
DOI : 10.6114/jkood.2016.29.1.123
Objective : The aim of this article is to report the chinese published papers on the results using the direct moxibustion to treat warts.Methods : Searching chinese published papers, we classified the results involved in the direct moxibustion treatment about warts. And analysed remedy methods, periods, cure rate, etc.Results : According to chinese published papers, the direct moxibustion itself may be effective in patients with warts. In all paper, the direct moxibustion showed more than 90% cure rate. The recurrence rate was low.Conclusion : We introduce a variety of wart treatments with the direct moxibustion which is made in China and report meaningful results. We hope to this paper contributes to various studies on cauterization of direct moxibustion.
Oral administration of the Herbal Medicines in animal models for treatment of Allergic Rhinitis: a Review of Animal Study Reports Published in Korea
Jo, Hyung-Rae ; Hwangbo, Min ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 131~144
DOI : 10.6114/jkood.2016.29.1.131
Objective : This study is to review the effect of herbal medicines on treatment of Allergic Rhinitis in animal models reported in Korean domestic journals.Methods : The Databases(NDSL, Koreantk, OASIS, KISS) are searched with terms as Allergic Rhinitis. among them, only animal study reports were reviewed. Animal model, intervention, and observation methods of measuring indicators were extracted.Results : 27 articles were reviewed. All studies used OVA to induce Allergic Rhinitis. 7 studies used simple herbal medicines, 20 studies used complex herbal medicines, To evaluate the effect of the Herbal medicines, 23 studies used immunological examination, 18 studies used histological examination, 16 studies used hematologic examination, 3 studies used macroscopy The evidences of 5 studies is insufficient to show that Herbal medicines are effective for treatment of Allergic Rhinitis.
A Literature Review for Developing the Clinical Phenotype Evaluation System of Atopic Dermatitis
Ahn, Jin-Hyang ; Yun, Young-Hee ; Kim, Kyu-Seok ; Jang, Bo-Hyeong ; Ko, Seong-Gyu ; Choi, In-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 145~156
DOI : 10.6114/jkood.2016.29.1.145
Objective : We performed a literature review for developing the clinical phenotype evaluation system of atopic dermatitis.Methods : We searched the papers that describe symptoms for atopic dermatitis through Oriental Medicine Advanced Searching Integrated System(OASIS) and Korean Studies Incategoryation Service System(KISS). We looked through all the papers and finally chose 47 papers that are suitable for inclusion. Then, we extracted symptoms from these papers and arranged them in order of frequency and validity through experts' conference.Results : We found 360 papers and chose 47 papers. We decided to include general information of patients, systemic and dermatologic symptoms in evaluation category of atopic dermatitis. Through experts' conference, it was decided that general information has age, sex and body type; Systemic symptoms have 9 items; Dermatologic symptoms have 15 items.Conclusion : To evaluate atopic dermatitis objectively, the standardization of diagnostic tool is needed. Therefore we developed a clinical phenotype evaluation system of atopic dermatitis.
Two Cases of Korean Medical Treatments of Sudden Sensorineural Hearing Loss without Corticosteroid Treatments
Son, Jae-Woong ; Kim, Min-Hee ; Ko, Seong-Gyu ; Choi, In-Hwa ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 157~167
DOI : 10.6114/jkood.2016.29.1.157
Objective : The purpose of this study is to know the effect of Korean medical treatments on sudden sensorineural hearing loss(SSNHL) without systemic or intratympanic steroid treatments.Method : We conducted retrospective review who was diagnosed as SSNHL and treated with Korean medicine in Dept. of Otolaryngology Kyung Hee University Hospital at Gangdong. There were two patients with SSNHL who refused to be treated with western medicine and were treated with Korean medicine including acupuncture, moxibustion, and herbal medicine.Result : One patient recovered completely after eight days of admission, and another patient partial recovered during 30 days through Korean medical treatments.Conclusion : Through these studies, SSNHL is expected to treated more effectively by conventional Korean medical treatments than corticosteroid treatments alone. But the additional study is needed to reveal the exact effects of Korean medical treatments.
Follow-up Study on Chronic Idiopathic Urticaria Patients Treated with Pyungweesangamibang
Lee, Jin-Huk ; Kim, Se-Yon ; Kim, Jeong-Hun ;
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, volume 29, issue 1, 2016, Pages 168~173
DOI : 10.6114/jkood.2016.29.1.168
Objective : The purpose of this study is to investigate the recurrence rate of Chronic Idiopathic Urticaria patients treated with Pyungweesangamibang through long-term follow-up survey.Methods : This tracing study was conducted for sixty-seven Chronic Idiopathic Urticaria patients who received and have finished treatment with Pyungweesangamibang at Woobo Korean Medicine Clinic in 2013 and 2014.Result : 81.4% of the patients, who had spent over 1 year since the finish of treatment with Pyungweesangamibang, did not relapse. In case of more than 2 years elapse, 66.7% of the patients did not suffer relapse.Conclusion : The result of tracing recurrence of the Chronic Idiopathic Urticaria patients treated with Pyungweesangamibang describes that the Korean medical treatment (Pyungweesangamibang prescription) shows lower recurrence rate than other general treatment shows.