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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Maxillofacial Plastic and Reconstructive Surgery
Journal Basic Information
Journal DOI :
Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Editor in Chief :
Volume & Issues
Volume 30, Issue 6 - Nov 2008
Volume 30, Issue 5 - Sep 2008
Volume 30, Issue 4 - Jul 2008
Volume 30, Issue 3 - May 2008
Volume 30, Issue 2 - Mar 2008
Volume 30, Issue 1 - Jan 2008
Selecting the target year
A STUDY ON THE OSTEOGENIC DIFFERENTIATION OF ADIPOSE-DERIVED ADULT STEM CELL
Lee, Eui-Seok ; Jang, Hyon-Seok ; Kwon, Jong-Jin ; Rim, Jae-Suk ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 133~141
Stem cells have self-renewal capacity, long-term viability, and multiline age potential. Adult bone marrow contains mesenchymal stem cells. Bone marrow-derived mesenchymal stem cells (BMSCs) are progenitors of skeletal tissue components and can differentiate into adipocytes, chondrocytes, osteoblasts, and myoblasts in vitro and undergo differentiation in vivo. However, the clinical use of BMSCs has presented problems, including pain, morbidity, and low cell number upon harvest. Recent studies have identified a putative stem cell population within the adipose tissue. Human adipose tissue contains pluripotent stem cells simillar to bone marrow-derived stem cells that can differentiate toward the osteogenic, adipogenic, myogenic, and chondrogenic lineages. Human adipose tissue-derived stem cells (ATSCs) could be proposed as an alternative source of adult bone marrow stem cells, and could be obtained in large quantities, under local anesthesia, with minimal discomfort. Human adipose tissue obtained by liposuction was processed to obtain ATSCs. In this study, we compared the osteogenic differentiation of ATSCs in a specific osteogenic induction medium with that in a non-osteogenic medium. ATSCs were incubated in an osteogenic medium for 28 days to induce osteogenesis respectively. Osteogenic differentiation was assessed by von Kossa and alkaline phosphatase staining. Expression of osteocyte specific bone sialoprotein, osteocalcin, collagen type I and alkaline phosphatase, bone morphogenic protein 2, bone morphogenic protein 6 was confirmed by RT-PCR. ATSCs incubated in the osteogenic medium were stained positively for von Kossa and alkaline phosphatase staining. Expression of osteocyte specific genes was also detected. Since this cell population can be easily identified through fluorescence microscopy, it may be an ideal source of ATSCs for further experiments on stem cell biology and tissue engineering. The present results show that ADSCs have an ability to differentiate into osteoblasts. In the present study, we extend this approach to characterize adipose tissue-derived stem cells.
A BIOLOGIC STUDY ON TOOTHASH - PLASTER OF PARIS MIXTURE WITH ABSORBABLE COLLAGEN MEMBRANE IN THE TREATMENT OF PERI-IMPLANT DEFECTS
Choi, Hee-Yeon ; Kim, Hak-Kyun ; Kim, Su-Gwan ; Moon, Seong-Yong ; Kim, Sang-Yeol ; Park, Kwang-Bum ; Kim, Young-Min ; Lim, Seong-Chul ; Kim, Eun-Seok ; Lee, Jeong-Hoon ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 142~149
The purpose of this study was to evaluate histomorphometrically a toothash - plaster of Paris mixture associated with collagen membrane (
), regarding new bone formation in the peri-implantitis defects in dogs. Three mandibular molars were removed from 1-year-old mongrel dogs. After 2 months of healing, 2 titanium implants with sandblasted with large grit and acid etched (SLA) surface were installed in each side of the mandible. Experimental peri-implantitis was induced with ligatures after successful osseointegration. Ligatures were removed after identification of bone defect beneath the level of 5th thread of fixture on radiographic image. The mucoperiosteal flaps were elevated and the contaminated fixtures were treated with chlorhexidine and saline. The bone defects were assigned to one of the following treatments: no guided bone regeneration (GBR) procedure (group 1), GBR with Bio-
(group 2), or GBR with toothash - plaster of Paris mixture (TPM) and Bio-
(group 3). The dogs were sacrificed after 8 or 16 months. The mean percentages of new bone formation within the limits of the 5 most coronal threads were
(8 weeks) and
(16 weeks) in group 1,
(8 weeks) and
(16 weeks) in group 2, and
(8 weeks) and
(16 weeks) in group 3, respectively. The present study confirmed statistically considerable new bone formation within the threads in group 3 compared with group 1 at 8 and 16 weeks (P<0.05). Although, data analysis did not reveal significant differences between group 2 and 3, the latter showed better results during the period of 8 or 16 weeks. Our findings support the effectiveness of TPM as a GBR material in the treatment of peri-implantitis bone defect.
HISTOMORPHOMETRIC EVALUATION OF OSTEOGENESIS WITH BRUSHITE IMPLANT SURFACES IN DOGS
Moon, Chul-Woong ; Kim, Su-Gwan ; Kim, Hak-Kyun ; Moon, Seong-Yong ; Lim, Sung-Chul ; Oh, Ji-Su ; Baik, Sung-Mun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 150~157
This study evaluated the influence of smooth and brushite-coated implant surfaces in dogs. The first through fourth mandibular premolars were extracted from eight young adult dogs. Twelve weeks after extraction. implantation was performed at the extraction sites. In total, 40 implant fixtures were implanted in the dog mandibles. Twenty machined implants served as controls and twenty brushite-coated surfaces served as tests. Dogs were sacrificed 2 and 4 weeks after implantation. The hemi-mandibles were obtained and processed histologically to obtain non-decalcified sections. Longitudinal sections of each implant were made and analyzed using light microscopy. The overall implant success rate was 83.3%. Histomorphometrically. the experimental group had a better percentage of bone-implant contact than the control group (p<0.05) and there was a significant difference between the 2- and 4-week groups after implantation (p<0.05) Our results suggest that the implant surface morphology influences the increase in peri-implant osteogenesis in the early period of peri-implant healing.
EFFECT OF PLATELET-RICH PLASMA ON AUTOGENOUS BONE GRAFT FOR BONE FORMATION IN RABBIT
Jeon, Min-Su ; Kim, Bo-Gyun ; Song, Jun-Ho ; Yeon, Byong-Moo ; Lee, Young-Woo ; Noh, Kyung-Lok ; Kim, Da-Young ; Pang, Ean-O ; Kim, Jun-Hyun ; Nam, Jeong-Hun ; Gang, Tae-In ; Lim, Sung-Chul ; Park, Young-Ju ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 158~164
Purpose : Recently, various materials were developed for enhancing bone formation capacity. Platelet rich plasma(PRP) is an autologous source with several growth factors and obtained by sequestering and concentrating platelets by gradient density centrifugation. This study was to evaluate the effect of PRP on healing of grafted bone. Materials and methods : Two blood samples were obtained and analysed for measuring platelet counts of normal blood and PRP. In experimental group, two defects of mandibular bone, 10mm in diameter and 4.0mm deep, were created in the mandible and immediately grafted with autogenous bone chips mixed with PRP. In control group, same bone defects were prepared and grafted with autogenous bone chips. Gelform was used for carrier of PRP. 2 weeks, 4 weeks, 8 weeks later, each group was evaluated with histologi-cal and histomorphometric analyses. Results : According to histological observation, experimental group was showed more anastomosing newly-formed woven bone having osteoblastic activation than control group. According to histomorphometric analysis, there were 9.11% more newly-formed bone volume in experimental group than control group at 2 weeks, 7.91% more at 4 weeks, 20.08% more at 8 weeks. Conclusion: Our results demonstrated PRP in autogenous bone graft could enhance the bone formation.
INFERIOR ALVEOLAR NERVE INJURY FOLLOWING REMOVAL OF MANDIBULAR THIRD MOLAR AND PANORAMIC RADIOLOGICAL RISK SIGN
Lee, Yong-In ; Kim, Chang-Soo ; Hong, Jong-Rak ; Lee, Jun-Hee ; Shin, Chang-Hun ; Pyo, Sung-Woon ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 165~171
The aim of this study was to evaluate the incidence of panoramic radiological risk signs related with mandibular third molar extraction, and the relationship between these risk signs and inferior alveolar nerve (IAN) injury after tooth extraction. Cases were defined as 1000 mandibular third molars extracted by surgical approach at Samsung Medical Center during the period from March 2001 to December 2006. Seven radiological risk signs were assessed on the panoramic radiogram by three expert oral surgeons. Clinical demographic data and severity of IAN injury were examined on medical records. Bivariate analyses were completed to assess the relationship between radiological risk signs and IAN injury. The radiological risk signs showed in 381 cases(38.1%). The incidence of each radiological risk signs were; interruption of IAN white line, 152 cases(15.2%); deflected roots, 141 cases(14.1%); darkening root, 119 cases(11.9%); diversion of IAN, 57 cases(5.7%) ; IAN narrowing, 37 cases(3.7%); root narrowing, 17 cases(1.7%); dark and bifid apex, 10 cases(1.0%). The incidence of IAN injury in cases with risk signs were: in the case of any sign, 3.6%; interruption of IAN white line, 2.6%; deflected roots 5.7%; darkening root. 3.4%; diversion of IAN, 5.7%; IAN narrowing, 3.7%; root narrowing, 5.9%; dark and bifid apex, 0%. No IAN injury was showed in 619 cases without risk sign (p<0.05). In conclusion, the presence of panoramic risk signs was associated with an increased risk for IAN injury during mandibular third molar extraction, whereas the absence of risk signs was associated with a minimal risk of nerve injury.
CASE REPORT OF MULTIPLE ODONTOGENIC KERATOCYSTS WITH BASAL CELL NEVUS SYNDROME
Park, Ji-Hyun ; Yoon, Kyu-Ho ; Park, Kwan-Soo ; Cheong, Jeong-Kwon ; Shin, Jae-Myung ; Choi, Mun-Kyung ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 172~177
Basal cell nevus syndrome, also known as Gorlin-Goltz syndrome, is a hereditary condition transmitted as an autosomal dominant trait that exhibits high penetrance and variable expressivity. It is an ecto-mesodermal polydysplasia with numerous manifestations that affect multiple organs. Odontogenic keratocysts, palmar and plantar pits, and hypertelorism are the most frequently observed anomalies. Currently there are new lines of investigation based on biomolecular studies, which aim at identifying the molecules responsible for these cysts and thus early allowing an early diagnosis of these patients. We report two cases of multiple odontogenic keratocysts associated with basal cell nevus syndrome.
AMELOBLASTOMA ORIGINATED FROM A DENTIGEROUS CYST: A CASE REPORT
Shin, Jae-Myung ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 178~181
Much has been written about the possibility that the lining of a dentigerous cyst might undergo neoplastic transformation to an ameloblastoma which is defined as mural ameloblastoma. Mural ameloblastomas are estimated to constitute 5% of all ameloblastomas. 85% of the mural ameloblastomas were associated with dentigerous cyst, all of which were observed before the age of 30. The frequency of recurrence after simple enucleation of the cyst containing this lesion is considerably lower than that for ameloblastomas in general that are treated in a similar manner. Therefore, further and more extensive surgery is not required for mural ameloblastoma. We diagnosed a cystic appearance of a 17 year-old female as dentigerous cyst and undergone marsupialization. For 2 years of period, no significant change was observed and therefore enucleation was undergone and diagnosed as ameloblastoma. We report this case with a review of related literatures.
RESORBABLE PLATES FOR THE FIXATION OF MANDIBULAR FRACTURES: CASE REPORTS AND REVIEW OF THE LITERATURE
You, Jae-Seek ; Kim, Su-Gwan ; Kim, Hak-Kyun ; Moon, Seong-Yong ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 182~190
Fracture of mandible is the most frequent fracture among many types of maxillofacial fracture, and reduction of mandible fracture is performed using various methods of treatment to maintain bonding strength of fractured bone. Among these treatment of bone fracture, a semirigid fixation method which can reduce the period of intermaxillary fixation using metal mini plate under general or local anesthesia is spotlighted these days. The metal mini plate used during this semirigid fixation procedure is Titanium which is bio-inactive one and was used widely, but because the side effect of fracture reduction using titanium have been demonstrated recently, fracture reduction using biodegradable plate become to attract people's attention. The purpose of this study was to report the clinical case and review of the literature with the reduction of mandible fracture using biodegradable plate.
MIGRATION OF MANDIBULAR THIRD MOLAR TO THE CONDYLE WITHOUT CYSTIC CHANGE: A CASE REPORT
Kim, Jin-Tae ; Cho, Myung-Chul ; Jeon, Kug-Jin ; Park, Kwang-Ho ; Huh, Jong-Ki ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 191~193
Impacted third molars of the mandible are generally found at or close to the second molar. If the third molar is impacted far distant from its original site, it may be affected by cysts or tumors. Ectopic impaction of third molar in the condyle area is very rare. Furthermore, impaction without cystic lesion is even less common. The etiology of migration of the mandibular third molar without cystic lesion is unknown. So periodical X-ray taking is essential.
NASOLABIAL CYAT; A CASE REPORT
Kim, Il-Kyu ; Cho, Hyun-Young ; Baek, Min-Kyu ; Chang, Keum-Soo ; Park, Seung-Hoon ; Park, Jon-Won ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 194~197
Nasolabial cyst is a rare non-odonotogenic, soft-tissue, developmental cyst arising inferior to the nasoalar region of the face. The most common clinical finding of the nasolabial cyst is that of a slowly enlarging asymptomatic swelling typically without radiographic abnormalities. This case report describes a 25-year-old man in which the clinicopathologic findings and an erosive finding on the computed tomographic scan on maxilla were consistent with nasolabial cyst. The histopathologic features, differential diagnosis, treatment and prognosis are discussed.
BEHCET DISEASE WITH SUPERIOR VENA CAVA THROMBUS IN A PATIENT PRESENTING DELAYED FACIAL WOUND HEALING : A CASE REPORT
Choi, Sun-Mi ; Ha, Joo-Hyo ; Kim, Sun-Ae ; Choi, Mi-Ra ; Jung, Su-Jin ; Lee, Hyen-Soo ; Yang, Soo-Nam ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 198~204
Behcet Disease is a multisystem inflammatory disorder of unknown orign. It is characterized by recurrent oral ulcer, genital ulcer, skin lesions and ocular inflammation, and which may involve the joints, skin, central nervous system and gastrointestinal tract. Because Behcet Disease dose not have any specific symptoms and laboratory findings, the diagnosis is made on the basis of the criteria proposed by the the International Study Group for Behcet Disease. Behcet Disease is affecting both arteries and veins, and clinically manifest large vessel involvement occurs in between 7 and 49% of patients. Superior vena cava thrombosis is a rare but well-recognized manifestation of Behcet disease. We report a case of a Behcet Disease with superior vena cava thrombosis in a patient presenting delayed facial wound healing.
UNDERSTANDING OF EPIGENETICS AND DNA METHYLATION
Oh, Jung-Hwan ; Nishimura, Ichiro ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 2, 2008, Pages 205~212
Genetic variation in the human genome occurs on various levels; from the single nucleotide polymorphism to large, microscopically visible chromosome anomalies. It can be present in many forms, including variable number of tandem repeat (VNTRs; e.g., mini- and microsatellites), presence/absence of transposable elements (e.g., Alu elements), single nucleotide polymorphisms, and structural alterations (e.g., copy number variation, segmental duplication, inversion, translocation). Until recently SNPs were thought to be the main source of genetic and phenotypic human variation. However, the use of methods such as array comparative genomic hybridization (array CGH) and fluorescence in situ hybridization (FISH) have revealed the presence of copy number variations(CNVs) ranging from kilobases (kb) to megabases (Mb) in the human genome. There is great interest in the possibility that CNVs playa role in the etiology of common disease such as HIV-1/AIDS, diabetes, autoimmune disease, heart disease and cancer. The discovery of widespread copy number variation in human provides insights into genetic variability among populations and provides a foundation for studies of the contribution of CNVs to evolution and disease.