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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Maxillofacial Plastic and Reconstructive Surgery
Journal Basic Information
Journal DOI :
Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Editor in Chief :
Volume & Issues
Volume 30, Issue 6 - Nov 2008
Volume 30, Issue 5 - Sep 2008
Volume 30, Issue 4 - Jul 2008
Volume 30, Issue 3 - May 2008
Volume 30, Issue 2 - Mar 2008
Volume 30, Issue 1 - Jan 2008
Selecting the target year
BONE TISSUE ENGINEERING USING PLLA/HA COMPOSITE SCAFFOLD AND BONE MARROW MESENCHYMAL STEM CELL
Kim, Byeong-Yol ; Jang, Hyon-Seok ; Rim, Jae-Suk ; Lee, Eui-Seok ; Kim, Dong-Hyun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 323~332
Aim of the study: Scaffolds are crucial to tissue engineering/regeneration. Biodegradable polymer/ceramic composite scaffolds can overcome the limitations of conventional ceramic bone substitutes such as brittleness and difficulty in shaping. In this study, poly(L-lactide)/hydroxyapatite(PLLA/HA) composite scaffolds were fabricated for in vivo bone tissue engineering. Material & methods: In this study, PLLA/HA composite microspheres were prepared by double emulsion-solvent evaporation method, and were evaluated in vivo bone tissue engineering. Bone marrow mesenchymal stem cell from rat iliac crest was differentiated to osteoblast by adding osteogenic medium, and was mixed with PLLA/HA composite scaffold in fibrin gel and was injected immediately into rat cranial bone critical size defect(CSD:8mm in diameter). At 1. 2, 4, 8 weeks after implantation, histological analysis by H-E staining, histomorphometric analysis and radiolographic analysis were done. Results: BMP-2 loaded PLLA/HA composite scaffolds in fibrin gel delivered with osteoblasts differentiated from bone marrow mesenchymal stem cells showed rapid and much more bone regeneration in rat cranial bone defects than control group. Conclusion: This results suggest the feasibility and usefulness of this type of scaffold in bone tissue engineering.
GROWTH INHIBITION OF ORAL SQUAMOUS CELL CARCINORMA CELL LINE INDUCED BY COX INHIBITOR
Park, Gwang-Jin ; Han, Se-Jin ; Lee, Jae-Hoon ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 333~344
The objectives of this study was to explore the growth pattern of the oral squamous cell carcinoma when overexpressed COX was inhibited, explore the pathway that COX inhibitors suppressed the proliferation of cancer cells, and then hereafter investigate the potential of COX as chemopreventive target for oral squamous cell carcinoma. For confirming the COX-dependent effect and mechanisms on growth of the oral cancer cells, we treated the nonselective NSAID, Mefenamic acid and COX-2 selective inhibitor, Celecoxib in HN4 cell line. And then the cell line was evaluated with MTT assay and growth curve, the production of PGE2, total RNA extraction and RT-PCR analysis, and TEM The results were obtained as follows: 1. After administration of medication, in the result of MTT assay, Celecoxib inoculated group inhibit the cell growth rather than Mefenamic acid inoculated group. 2. The growth curve of cell line showed as time passes by there was a dramatic cell growth in the control group, and gradual growth inhibition was found in medication inoculated group and, in Celecoxib inoculated group there was more inhibition of cell growth. 3. After the administration of medication, Celecoxib tend to inhibit the synthesis of PGE2 more than Mefenamic acid. Mefenamic acid inhibit the synthesis of PGE2 more as the concentration gets high, but Celecoxib inhibited the synthesis of PGE2 even in low concentration. 4. After the administration of medication, the revelation of COX mRNA in cell line, there was a 50% decrease in COX-1, 60% decrease in COX-2 as in
Mefenamic acid, and in Celecoxib
there was not much difference in COX-1 and 90% decrease in COX-2 was found. 5. HN4 cell line showed broken nucleus and tangled cytoskeleton bundles in cytoplasm which meant apoptotic features after the treatment of Celecoxib in TEM view. Depending on the above results, we estimate that the inhibition of the expression of COX-2 cause the growth suppression of the oral squamous cell carcinoma, and it get achieved through pathway of reduced PGE2 production and increased apoptosis. In addition to, because COX-2 selective inhibitor specifically act to COX-2, it is considered that COX-2 selective inhibitor has the adequate potential as chemopreventive agent for oral squamous cell carcinoma.
INFLUENCE OF MINIPLATE SHAPES AS SKELETAL ANCHORAGE FOR APPLICATION OF ORTHOPEDIC FORCE: A THREE-DIMENSIONAL FINITE ELEMENT ANALYSIS
Lee, Nam-Ki ; Baek, Seung-Hak ; Choi, Dong-Soon ; Park, Young-Wook ; Kim, Ji-Hyuck ; Cha, Bong-Kuen ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 345~352
Purpose: This study was performed to evaluate the stress distribution in the bone and the displacement distribution of the miniscrew under orthopedic force with two different types of miniplate design as skeletal anchorage for orthopedic treatment. Materials and methods: Finite element models were made for 6-hole miniplate (0.8mm in thickness), which were designed in two different shapes-one is curvilinear shaped (C plate, Jeil Medical Co., Korea) and another, Y shaped (Y plate), fixed with 3 pieces of miniscrew 2mm-diameter and 6mm-long respectively. A traction force of 4 N was applied in
to imaginary axis connecting two unfixed distalmost holes of the miniplate. Results: The maximum von Mises stress in the bone was much greater in the cortical portion rather than in the cancellous portion. C plate showed greater maximum von Mises stress in the cortical bone than Y plate. The maximum displacement of the miniscrew was greater in C plate than Y plate. The more increased the angle of the applied orthopedic force, the greater maximum von Mises stress in the bone and maximum displacement of the miniscrew. It was observed that in C plate, the von Mises stress in the bone and displacement of the miniscrew were distributed around the distalmost screw-fixed area. Conclusions: The results suggest that Y plate should have the advantage over C plate and in the placement of the miniplate, its imaginary axis should be placed as parallel as possible to the direction of orthopedic force to obtain its primary stability.
AVAILABILITY OF RADIAL FOREARM FREE FLAP IN RECONSTRUCTION OF INTRAORAL SOFT TISSUE DEFECTS : REVIEW OF 50 CASES
Kim, Nam-Kyun ; Seo, Dong-Jun ; Park, Se-Hyun ; Kim, Hyung-Jun ; Cha, In-Ho ; Nam, Woong ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 353~358
Purpose: The purpose of this clinical retrospective study was to evaluate our experience of radial forearm free flap for reconstruction of the oral cavity. Material and methods: From 1997 to 2006, 50 radial forearm free flaps were employed for head and neck reconstruction in 50 patients at department of oral and maxillofacial surgery, Yonsei University, Korea. Data were obtained from chart review, and clinical follow-up. Results: Patients' age ranged from 26 to 82 years (mean 53.2). There were 39 men and 11 women. 43 of the 50(86%) patients had squamous cell carcinoma. The total flap survival were 47(94%), complication rate were revealed for 15(30%). Conclusion: In the reconstruction of soft tissue within the oral cavity, several free flaps have been used. Because of its constant anatomy, long pedicle allows a hypothetic vascular anastomosis in the contralateral neck, contourability for various type of oral defects, pliability and can be used simultaneous reconstruction in intraoral and extra oral defects, the radial forearm free flap constitutes one of the best choice of intraoral soft tissue reconstruction.
A CLINICAL STUDY ON FRACTURES OF THE MANDIBULAR CONDYLES: EFFECTIVE EXTRACORPOREAL FIXATION TECHNIQUE
Kwon, Kwang-Jun ; Chung, Ji-Hun ; Kim, Ji-Hyuck ; Park, Young-Wook ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 359~369
Purpose: Fractures of the mandibular condyle accounts for 15% to 30% of all the mandibular fractures and lots of complications are reported. Among these complications, condylar resorption is the most important one to be taken into account. The purpose of this study is evaluating condylar resorption pattern in relation to extracorporeal fixation technique. Patients & methods: Thirty four patients with 42 mandibular condylar fractures were retrospectively examined with an average follow-up of 18.5 months (6-66 months). Male/female ratio is 27 males (7 bilateral cases) and 7 females (1 bilateral case). Applicated surgical techniques were extracorporeal fixation via submandibular approach and extracorporeal fixation via intraoral approach. We compared radiographic views of post-operative periods with that of most long term follow up in 34 operated sites respectively. Result: There were 2 generalized condylar resorption sites and 3 partial resorption sites with clinical implications. Others (29 joints) showed good healing or satisfactory adaptive state of temporomandibular joints clinically. Radiologically, signs of partial condylar resorption and/or osteoarthrosis were diagnosed in 11 patients. But, 8 out of the 11 patients didn't show significant clinical symptoms, which means successful adaptive remodeling of the surgically located condylar head. Conclusion: From the above results, intentional ramal osteotomy, temporary detachment of the fractured condyle and extracorporeal fixation technique seems to be effective and useful in those cases of condylar fractures in which reduction of the dislocated condyle is very difficult or virtually impossible.
CHANGES OF SELF-CONCEPT BY ORTHOGNATHIC SURGERY IN THE PATIENTS OF SKELETAL CLASS III MALOCCLUSION
Seol, You-Seok ; Son, Woo-Sung ; Park, Soo-Byung ; Kim, Seong-Sik ; Kim, Jong-Ryul ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 370~379
Objective: This study was carried out to evaluated the psychologic changes of skeletal Class III malocclusion individuals by orthognathic surgery. Methods: One hundred and thirty seven adults skeletal Class III malocclusion individuals were selected for this study. Fifty two for pre-surgery group, forty two for 2-months after orthognathic surgery group and forty three for 6-months after orthognathic surgery group. Each group was investigated by questionnaires related to self-concept standard developed by Dr. Lee. The questionnaires included physical self-concept, ethic self-concept, characteristic self-concept, domestic self-concept, the social self-concept and capable self-concept. Each group was compared by one-way ANOVA. Results: Only the physical self-concept showed significant changes after orthognathic surgery, however it did not showed differences between after 2-months and after 6-months. But other self-concept did not show significant changes by orthognathic surgery. Conclusion: At first, it is expected that many variables related to self-concept were influenced by orthognathic surgery. But only physical self-concept showed significant change by orthognathic surgery.
CORRECTION OF MICROSTOMIA BY BILATERAL COMMISSUROPLASTY USING "OVER AND OUT" BUCCAL MUCOSA FLAPS: REPORT OF A CASE
Ryu, Sun-Youl ; Kim, Hyun-Syeob ; Park, Hong-Ju ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 380~385
Microstomia can be occurred as a result of direct injury to tissues such as chemical, thermal and electrical burns, and animal bites. It also may be secondary to contracture of burned perioral skin, or may result from scarring after reconstructive lip surgery. Narrowing of the oral aperture is not only disfiguring, but also limiting the oral access needed for introduction of food, insertion of dentures, oral hygiene, and dental treatment. Limited mouth opening may also interfere with mastication and speech. Few reports exist regarding correction of microstomia and reconstruction of the corners of the mouth. A 16-year-old girl with a bilateral cleft lip and palate presented with the limited mouth opening (approximately 20 mm), the esthetic problem due to the small lip, and the cleft lip-nasal deformity. The microstomia was corrected by bilateral commissuroplasty using "over and out" buccal mucosa flaps proposed by Converse. The intercommissure distance was increased from the preoperative 40 mm to the postoperative 60 mm. The one-year postoperative intercommissure distance was 54 mm, because the 6 mm relapse was occurred. The bilateral commissuroplasty using "over and out" buccal mucosa flap could increase the width and general size of the oral aperture and improve the lip appearance.
RECONSTRUCTION WITH A VASCULARIZED FREE ILIAC OSTEOMUSCULAR FLAP AFTER HEMIMANDIBULECTOMY FOR OSTEOSARCOMA OF THE MANDIBULAR CONDYLE REGION : A CASE REPORT
Park, Hong-Ju ; Yu, Min-Gi ; Kook, Min-Suk ; Oh, Hee-Kyun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 386~394
Osteosarcoma of the jaw is a rare malignant bone tumor which usually leads to a poor prognosis. It commonly occurs in young patients, especially in male. The tumor can involve mandible or maxilla with same frequency. The swelling in the involved area and facial deformity are common clinical findings. The pain and sensory changes are also complained by the patients. Although radical surgery plays an important role in the management of this tumor, the adjuvant chemotherapy or radiotherapy is used to enhance local control and to prevent distant metastases. We treated a 22-year-old male patient who had osteosarcoma in the left condylar region. The radical surgery which consisted of hemimandibulectomy and total parotidectomy, was done and an immediate mandibular reconstruction was performed with a vascularized free iliac osteomuscular flap. The obtained results, both esthetic and functional, were satisfactory. The patient was received postoperative chemotherapy. This is a case with reviews of the literatures.
BISPHOSPHONATE(ZOLEDRONIC ACID) RELATED OSTEOMYELITIS ON MANDIBLE-A CASE REPORT
Lee, Su-Youn ; Choi, So-Young ; Kim, Jin-Wook ; Kwon, Tae-Geon ; Jang, Hyung-Jung ; Kim, Chin-Soo ; Lee, Sang-Han ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 395~398
Bisphosphonate are a class of drugs with a chemical structure which inhibit bone resorption, actually used for metastatic bone disease, osteoporosis, Paget's disease and multiple myeloma. Significant complication associated with their use is reported recently : mandibular and maxillary osteomyelitis or osteonecrosis. So we here report our case about the patient who was diagnosed of prostate cancer in 2004 April and treated with bisphosphonate(Zoledronic acid-
, Novartis Co.) intravenously every 3 to 4weeks at a dose of 4mg to prevent bone metastasis, and also, the patient who came to the hospital due to the bony exposure of mandible and pain in 2006 November and was diagnosed osteomyelitis of mandible as a result of biopsy, bone scan, PET CT examination.
BENIGN FIBROUS HISTIOCYTOMA OF MANDIBLE - A CASE REPORT-
Choi, So-Young ; Kim, Jin-Wook ; Kwon, Tae-Geon ; Shin, Hong-In ; Byeon, Ki-Jeong ; Kim, Chin-Soo ;
Maxillofacial Plastic and Reconstructive Surgery, volume 30, issue 4, 2008, Pages 399~403
Benign fibrous histiocytoma(BFH) is a mesenchymal cell-originated tumor composed of cells with fibroblastic and histiocytic differentiation. BFH occurs predominantly on sun-exposed skin of extremities. Oral BFH lesions are uncommon. The majority of oral lesions includes the soft tissue but not the jaw bones. The lesion appears as well-defined multilocular radiolucencies associated with bony swelling when it occurs on the jaw. The lesion induces the thinning and expansion of the cortex and shows many thin, indistinct septa in the lesion. Surgical excision is the choice of treatment. The recurrence rate is low and metastasis has not been reported. We report the clinical, radiographic and microscopic findings of a BFH case occurred in the mandible with literature reviews.