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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Maxillofacial Plastic and Reconstructive Surgery
Journal Basic Information
Journal DOI :
Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
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Volume & Issues
Volume 32, Issue 6 - Nov 2010
Volume 32, Issue 5 - Sep 2010
Volume 32, Issue 4 - Jul 2010
Volume 32, Issue 3 - May 2010
Volume 32, Issue 2 - Mar 2010
Volume 32, Issue 1 - Jan 2010
Selecting the target year
BONE REGENERATION WITH ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM CELL AND HA/TCP
Rim, Jae-Suk ; Gwon, Jong-Jin ; Jang, Hyon-Seok ; Lee, Eui-Seok ; Jeong, You-Min ; Lee, Tai-Hyung ; Park, Jeong-Kyun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 97~106
Aim of the study: An alternative source of adult stem cells that could be obtained in large quantities, under local anesthesia, with minimal discomfort would be advantageous. Adipose tissue could be processed to obtain a fibroblast-like population of cells or adipose tissue-derived stromal cells (ATSCs). This study was performed to confirm the availability of ATSCs in bone tissue engineering. Materials amp; Methods: In this study, adipose tissue-derived mesenchymal stem cell was extracted from the liposuctioned abdominal fat of 24-old human and cultivated, and the stem cell surface markers of CD 105 and SCF-R were confirmed by immunofluorescent staining. The proliferation of bone marrow mesenchymal stem cell and ATSCs were compared, and evaluated the osteogenic differentiation of ATSCs in a specific osteogenic induction medium. Osteogenic differentiation was assessed by von Kossa and alkaline phosphatase staining. Expression of osteocyte specific BMP-2, ALP, Cbfa-1, Osteopontin and osteocalcin were confirmed by RT-PCR. With differentiation of ATSCs, calcium concentration was assayed, and osteocalcin was evaluated by ELISA (Enzyme-linked immunosorbant assay). The bone formation by 5-week implantation of HA/TCP block loaded with bone marrow mesenchymal stem cells and ATSCs in the subcutaneous pocket of nude mouse was evaluated by histologic analysis. Results: ATSCs incubated in the osteogenic medium were stained positively for von Kossa and alkaline phosphatase staining. Expression of osteocyte specific genes was also detected. ATSCs could be easily identified through fluorescence microscopy, and bone formation in vivo was confirmed by using ATSC-loaded HA/TCP scaffold. Conclusions: The present results show that ATSCs have an ability to differentiate into osteoblasts and formed bone in vitro and in vivo. So ATSCs may be an ideal source for further experiments on stem cell biology and bone tissue engineering.
COMPARISON OF RESONANCE FREQUENCY ANALYSIS BETWEEN VARIOUS SURFACE PROPERTIES
Bae, Sang-Bum ; Lee, Seong-Hyun ; Song, Seung-Il ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 107~111
Purpose: The aim of this study is to compare the stability between Mg-incorporated implant, TiUnite and Machined implant. Materials and Methods: Premolars of 3 Mini pigs (24 months) were extracted. After 2 months later, total 27 fixtures of implants (9 of each design : Machined/ TiUnite/ Mg-incorporated) were inserted into the mandible of 3 mini-pig. Implant stability was estimated by RFA in installation to 2, 4 & 6 weeks. Statistical analysis of RFA values was performed with time and between groups using repeated measure ANOVA and turkey's multiple comparison test. Results: In analyzing the mean value for the observation periods, three types of implants yielded a slight decrease in RFA mean value after 2 week, followed by increase at 4-6 weeks. Mg incorporated oxidized implants demonstrated significantly higher RFA mean values at 6 weeks comparing other groups. The difference of RFA value with time and between groups was statistically significant. Conclusion: We concluded that Mg implants may reduce failure rates of clinical implants In the early period of bone healing and Mg implants may shorten the bone healing time from surgery to functional loading.
IMMUNOHISTOCHEMICAL STUDY OF AURORA-2 KINASE IN THE ORAL SQUAMOUS CELL CARCINOMA
Han, Se-Jin ; Kim, Se-Woong ; Kim, Kyung-Wook ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 112~117
Aurora kinases represent a novel family of serine/threonine kinases crucial for cell cycle control. Aurora-2 kinase is mainly involved in centrosome function, mitotic entry, and spindle assembly. Aurora-2 kinase overexpression causes centrosome amplification and the formation of multipolar mitotic spindles, which leads to tumor aneuploidy and so it has been found to play an important role in tumorigenicity in many cancers such as colorectal cancer, breast cancer and cervical cancer. Hence, the goal of this study is to identify the correlation of clinicopathlogical factors and overexpression of Aurora-2 kinase in oral squamous cell carcinoma. We studied the immunohistochemical staining of Aurora-2 kinase in 20 specimens of 20 patients with oral squamous cell carcinoma and the relationships between Aurora-2 kinase over expression and each of the clinico-pathological parameters were analyzed by Pearson correlation analysis. Statistical significance was set at P < 0.05. The results were as follows. 1. In the immunohistochemical study of poorly differentiated and invasive oral squamous cell carcinoma, the high level staining of Aurora-2 kinase was observed. 2. The correlation between immunohistochemical Aurora-2 kinase expression and histopathological differentiation of specimens was significant. These findings suggest that overexpression of Aurora-2 kinase may play a important role in carcinogenesis of oral squamous cell carcinoma.
BONE METASTASIS MODEL OF ORAL SQUAMOUS CELL CARCINOMA
Park, Young-Wook ; Oh, Yu-Jin ; Lee, Hee-Su ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 118~125
Background and Purpose: Bone metastases rarely occur in patients with oral squamous cell carcinoma (OSCC), so the molecular mechanisms of bone metastasis of OSCC remains unclear. Studies with animal models allow progresses in understanding the molecular events for bone metastasis and provide new targets for therapy. So we tried to establish a murine model for bone metastasis of oral squamous cell carcinoma. Materials and Methods: Human OSCC cells (KB cell line) were xenografted to nude mice via direct inoculation into the tibial marrow. Mice with tibial tumors were sacrificed once a week, until seven weeks after the injection of human tumor cells. Growth of tibial tumors were observed by histology. Expression of TGF-
and CXCR-4 in bone OSCC (experimental) and subcutaneous tumor (control) was also evaluated by immunohistochemical staining. Results: Bone OSCC was successfully induced by intra-tibial injection of KB cells. Tumor mass was developed in the marrow tissues of tibia and finally invade the endosteum of tibia. Immunohistochemical staining showed higher expression of TGF-
in bone tumors than in subcutaneous tumors. Conclusion: A murine model of bone metastasis of OSCC was suggested that imitated the clinical findings of distant vascular metastasis. This bone tumor model should facilitate understanding of the molecular pathogenesis of OSCC bone metastasis, and aid in the developement of treatment strategies against OSCC bone metastasis.
POSTOPERATIVE STABILITY OF FIXATION WITH ABSORBABLES IN SIMULTANEOUS MAXILLOMANDIBULAR ORTHOGNATHIC SURGERY
Park, Jung-Min ; Park, Young-Wook ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 126~131
Objectives: This study is aimed to determine any differences in the postoperative stability between absorbable and titanium plate systems for fixation in orthognathic surgery with simultaneous maxillomandibular procedures especially including maxillary posterior impaction and advancement. Study Design: Forty patients with dentofacial deformities were randomly assigned into titanium (4 males and 6 females) and absorbable (17 males and 13 females) fixation group. All patients had undergone surgical alterations of maxilla with posterior impaction and advancement. A comparison study of the change in the maxillary position after the simultaneous surgery was performed with 1-day, 6-months postoperative lateral cephalograms compared to preoperative lateral cephalogram by tracing. Wilcoxon rank sum test was used for statistical analysis. Result: The position of the maxilla was stable after surgery and was not changed significantly from 1 day to 6 month after the simultaneous maxillomandibular surgery both in the experimental (absorbable plates) and control (titanium plates). Conclusion: This study suggests that application of absorable plating system in the fixation of maxillary segment in the simultaneous maxillomandibular procedures, leads to a predictable short-term postoperative skeletal stability comparable to the titanium plating system. Long term follow-up and further studies will be needed.
THE CORRECTION OF CLASS III MANDIBULAR ASYMMETRY USING BILATERAL SAGITTAL SPLIT RAMUS OSTEOTOMY AND LATERAL ANGLE REDUCTION
Kang, Hee-Jea ; Song, In-Woo ; Kang, Yung-Ki ; Kim, Jong-Ryoul ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 132~140
Purpose: The aim of this study is to identify the usefulness of unilateral mandibular angle ostectomy, so-called "Lateral Angle Reduction", in asymmetric prognathism patients by the assessment of postoperative stability and esthetic results Patients and methods: For the retrospective study, 10 skeletal class III mandibular asymmetry patients who were performed SSRO and unilateral mandibular angle ostectomy, Lateral Angle Reduction, was selected. Lateral and posterioanterior cephalogram was taken before surgery (T0), 1day after surgery (T1) and 6month after surgery (T2). To know the esthetic results the facial width and lateral facial contour were examined on posterioanterior cephalogram and to know the postoperative stability B point and Incisor inferius was examined on lateral cephalogram. Statistical analysis was performed. Results: From T0 to T1, Intergonial width was significantly decreased, dominantly at shortened side but no significant changes at lengthened side. Those were well-maintained during 6 months. Lateral facial angle and Ramus angle was significantly decreased on only shortened side from T0 to T1. As a result, after surgery, there were no significant differences in all measurements between shortened side and lengthened side. Ramus deviation angle in shortened side and ramus angle in lengthened side which reflect the angulation of ramus on frontal plane didn't show significant changes after surgery and during postsurgical periods. Lower dental midline showed no statistical changes during postsurgical period. The relapse rate on B-point was 11.92%. Conclusion: Unilateral "Lateral angle reduction" in the asymmetric mandible is valuable to obtain the narrow lower face and symmetric facial contour with a good stability.
CLINICAL STUDY OF SENSORY ALTERATIONS AFTER SAGITTAL SPLIT RAMUS OSTEOTOMY
Choi, Jun-Young ; Yoo, Jun-Yeol ; Yoon, Bo-Keun ; Leem, Dae-Ho ; Shin, Hyo-Keun ; Ko, Seung-O ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 141~148
The bilateral sagittal split ramus osteotomy (BSSRO) is preferred method of surgical correction for mandibular prognathism, retrognathism and asymmetry. This technique performed from primarily an intraoral incision to avoid a scar. After forward movement of the distal segment of the mandible, healing of bone by primary or secondary intention is easily accomplished through large areas of cancellous bony overlap. When rigid fixation is used for the BSSRO, it is possible to open the mouth during the immediate post-operative period because it promotes the healing process. Although this surgical procedure has been well-documented, the incidence of postoperative trigeminal neurosensory disorder in the region of the inferior alveolar nerve and the mental nerve remains one of the major complication. However, evaluation of objective methods for sensory recovery patterns is insufficient although most patients find their sensory return. Neurometer electrodiagnostic device performs automated neuroselective sensory nerve conduction threshold evaluation by determining current perception threshold (CPT) measures. The purpose of this study was to evaluate the sensory recovery patterns of inferior alveolar and mental nerve over time. Nerve examination with a neurometer was performed in 30 patients undergoing the BSSRO at pre-operative, post-operative 1-, 2-, 4- week, and 2-, 3-, 4-, 5-, 6- month follow-up visits after the osteotomy to compare the differences of nerve injury and recovery patterns after the BSSRO with or without genioplasty and sensory recovery patterns associated with the kind of nerve fiber.
THE SKELETAL STABILITY OF LE FORT I MAXILLARY ADVANCEMENT
Seo, Min-Gyo ; Koo, Sung-Young ; Kim, Eun-Ju ; Leem, Dae-Ho ; Shin, Hyo-Keun ; Ko, Seung-O ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 149~153
The purpose of this retrospective study was to evaluate relapse, comparing large and small maxillary advancements with four-plate rigid fixation and without bone grafting. All patients had skeletal class III malocclusion, and underwent bimaxillary surgery. Standardized cephalometric analysis by one examiner was performed on serial radiographs of 14 patients immediately before surgery, and within 1 week and at least 6 months postoperatively (mean 10 months). The group was divided into two subsets to determine whether the magnitude of relapse. In group 1 (
5 mm, n = 8), the average advancement was
, with a mean relapse of
. In group 2 (6-8 mm, n = 4), the average advancement was
, with a mean relapse of
. There was no statistical difference in the measured relapse among the groups. Maxillary advancement with a 1-piece Le Fort I osteotomy is a relatively stable procedure.
THE COMPARATIVE EVALUATION USING HATCH REAMER TECHNIQUE AND OSTEOTOME TECHNIQUE IN SINUS FLOOR ELEVATION
Cho, Seong-Woong ; Kim, Sang-Jung ; Lee, Dong-Keun ; Kim, Chin-Soo ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 154~161
Many edentulous posterior maxilla are found to be compromised by alveolar resorption and increased pneumatization of the sinus. One of the surgical procedures to overcome this anatomical limitation is sinus floor elevation with bone graft, which is reported as more appropriate and more successful procedure. Commonly, if the residual bone height is over 5mm, sinus floor elevation is operated through transcrestal approach using osteotome technique. But, it is possible for patients to feel discomfort during operation and dizziness after operation while malleting, sinus floor elevation, using osteotome technique. Some instruments and methods has been used to overcome these problems and use more easily. The aim of this study is to compare between the surgical procedure of sinus floor elevation using Hatch reamer technique and that of sinus floor elevation using osteotome technique. From 2004 Feb to 2007 Oct, we investigate patients (osteotome group: 72, Hatch reamer group: 70) who were given implant surgery with sinus floor elevation (osteotome group: 92, Hatch reamer group: 98). We analysed gender, age, residual bone height, amount of sinus floor elevation, used graft material, total success rate, failure rate by residual bone height and implant type and discomfort during operation, etc. The results obtained were as follows. 1. In the amount of sinus elevation was osteotome group was
and Hatch reamer group was
. There was no statistically significant difference between the two groups (P > 0.05). 2. At the total success rate, osteotome group was 92.4% and Hatch reamer group was 94.9%. There was no statistically significant difference between the two groups (P > 0.05). 3. On the discomfort during the operation by using numerical rating scale, osteotome group was
and Hatch reamer group was
. There was statistically significant difference between the two groups (P < 0.05). The Hatch reamer group clinical results was similar to osteotome group and we thought that Hatch reamer technique can overcome the faults of osteotome technique.
A CLINICAL CASE OF ALLOPLASTIC CONDYLE REPLACEMENT WITH CONDYLAR PROSTHESIS IN SEVERE DEGENERATIVE JOINT DISEASE
Jeon, Yong-Min ; Kim, Chang-Hyun ; Cha, Jeong-Seop ; Min, Kyung-Gi ; Kwon, Jong-Jin ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 162~167
This is a case report about patient who had suffered from degenerative joint disease and treated by TMJ reconstruction with condylar prosthesis. The patient visited Korea University An-am hospital on 2007 complaining symptom about both TMJ pain, mouth opening limitation and open bite. From CT view there was severe resorption of both condylar head, therefore condylar prosthesis reconstruction was planned. After 3D RP model analysis for preparation, the patient was operated under general anesthesia for condylar prosthesis reconstruction and the symptom was alleviated. (increased mouth opening, reduced anterior open bite, full mouth occlusal contact achieved) Follow up was carried out monthly, but after this, patient refused follow up. After 26 months from the operation, the patient revisited for anterior open bite. In clinical evaluation, occlusal contact was remained, but anterior open bite was relapsed. From cephalometry analysis, severe resorption of glenoid fossa was found. Therefore, Autogenous disc reconstruction with alloplastic material was planned on August 2009. After another surgery, condylar prosthesis was regained its normal position in glenoid fossa, and occlusion was recovered properly.
MANDIBULAR OSTEOBLASTOMA: REPORT OF 3 CASES
Kim, Jong-Yun ; Kim, Hak-Jin ; Kil, Tae-Jun ; Kim, Jae-Young ; Kim, Hyung-Jun ; Cha, In-Ho ; Nam, Woong ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 168~172
Osteoblastoma is a rare tumor of bone representing less than 1% of all tumors of the maxillofacial region. This is a neoplasm of bone characterized by a proliferation of osteoblasts forming bone trabeculae. Because the clinical feature of benign osteoblastoma is nonspecific and osteoblastoma has a pleomorphic histologic appearance, the differential diagnosis is difficult problem. We studies the case records 3 new patients with osteoblastoma. We discussed the case from clinical, radiologic, and histologic feature for differential diagnosis. Three cases from our clinic is reported and analized with previously described cases.
A CASE REPORT: STAFNE'S CYST IN THE ANTERIOR MANDIBLE
Jang, Hak-Sun ; Kim, Eun-Ju ; Yoon, Bo-Keun ; Leem, Dae-Ho ; Ko, Seung-O ; Shin, Hyo-Keun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 173~177
In 1942, Stafne described 35 "bone cavities" at the angle of the mandible. They appeared as unilocular, well-circumscribed, round or elliptical radiolucencies located below the inferior dental canal and between the angle of the mandible and first molar tooth. Since 1942, these lesions have been frequently described under various terms: aberrant or ectopic salivary gland; static or latent or idiopathic defect, cavity or cyst; mandibular salivary gland inclusion; lingual mandibular cavity; and Stafne's cyst, defect or cavity. Usually they were asymptomatic, with a predilection for men between age 50 and 70 years, and almost unilateral. At surgical exploration, they appeared as concavities on the lingual cortex and contained salivary gland tissue, often in continuity with the submandibular gland. In 1957, Richard and Ziskind were the first to report the appearance of a Stafne's cyst in the premolar region. Contrary to posterior defects, the anterior defects are difficult to diagnose clinically because the mandibular canal is not present, and the unilocular radiolucency can be confused with other cysts (radicular, residual, odontogenic, lateral periodontal,etc). The purpose of the present report is to describe an unusual case of Stafne's cyst in the anterior region of the mandible in 58-years-old woman.
WARTHIN'S TUMOUR IN LEFT PAROTID GLAND: REPORT OF TWO CASES
Suh, Joon-Ho ; Lee, Baek-Soo ; Kwon, Yong-Dae ; Kim, Yeo-Gab ; Choi, Byung-Joon ; Kim, Young-Ran ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 178~182
Warthin's tumour is also known as papillary cystadenoma lymphomatosum or adenolymphoma. This tumour represents 6% of all salivary gland tumour, and is the second most common neoplasm of the salivary gland. It occurs mostly in the parotid gland and in rare instances, it has been reported to occur within the submandibular gland or minor salivary glands. In the past, there was higher incidence in males than females, but more recent investigation shows a more balanced sex predilection. The mean age at diagnosis is 62 years and this tumour is uncommon in a patients younger than age 40. This tumour occurs most frequently in the tail of the parotid gland near the angle of the mandible. Surgical removal is the treatment of choice. But sometimes, parotidectomy is recommended because of its potential for being multifocal.
A CASE REPORT OF MAXILLARY LEIOMYOSARCOMA WITH REGIONAL LYMPH NODE METASTASIS
Park, Soong ; Lee, Baek-Soo ; Kim, Yeo-Gap ; Kwon, Yong-Dae ; Choi, Byung-Joon ; Kim, Young-Ran ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 183~188
Leiomyosarcoma is a malignant neoplasm of smooth muscle origin and mostly originate from the wall of uterus and gastrointestinal tract, but primary leiomyosarcoma of the oral cavity is extremely rare. This tumor has a very poor prognosis due to high recurrence and metastasis rate, with 5 year survival rate of 32%. And regional lymph node metastasis is uncommon event. Complete wide surgical excision is the treatment of choice. A 64-year old man who had a painful ulcerative lesion on the labial & palatal gingiva of #11, 21 visited our department, and was diagnosed as leiomyosarcoma through a biopsy. Partial maxillectomy was carried out, with no following radiotherapy or chemotherapy. After months follow-up, there has been no evidence of recurrence or metastasis. But after months, we clinically find out two enlarged immobile palpable lymph node in right submandibular area of patient. So a biopsy was performed via an extraoral incision under local anesthesia. Histopathologic diagnosis diagnosis of the biopsy was lymph node metastasis of prior existed leiomyosarcoma. We report a case of a primary leiomyosarcoma occurred in a 64 year-old male patient involving the anterior maxillary region with regional lymph node metastasis with a review of literature.
EMERGENCY BLEEDING CONTROL BY RAPID ENTIRE OROPHARYNGEAL PACKING IN A PATIENT WITH ACTIVE OROPHARYNGEAL BLEEDING FOLLOWING BASAL SKULL FRACTURE: REPORT OF A CASE
Mo, Dong-Yub ; Yoo, Jae-Ha ; Choi, Byung-Ho ; Kim, Ha-Rang ; Lee, Chun-Ui ; Ryu, Mi-Heon ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 2, 2010, Pages 189~195
Excessive oral and maxillofacial bleeding causes upper airway obstruction, bronchotracheal & gastric aspiration and hypovolemic shock. Therefore, the rapid & correct bleeding control is very important for life-saving in the medical emergency room. In spite of the bleeding control methods of the wound suture & direct pressure, the postoperative bleeding can be occurred, because of the presence of various bleeding disorders & postoperative delayed wound infections. The proper care of bleeding disorders & wound infections are very important for the control of the delayed postoperative rebleeding. In spite of these methods, active oral bleeding can be presented by the other causes of head injury. A rare but particularly dangerous sort of bleeding that may have an especial importance to the patient with severe basal skull fracture that damage large vessels and even the cavernous sinus. The occurrence of profuse nasal or oropharyngeal bleeding may arise from damage to the anterior and posterior ethmoidal vessels, but when mixed with brain tissue it is evidence of mortal damage. In this condition, rapid entire oropharyngeal packing is essential for the control of active oral bleeding. This is a case report of rapid rational bleeding control method by much amount of wet gauze packings, in a 44-years-old male patient with active oropharyngeal bleeding by basal skull fractures.