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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Maxillofacial Plastic and Reconstructive Surgery
Journal Basic Information
Journal DOI :
Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Editor in Chief :
Volume & Issues
Volume 32, Issue 6 - Nov 2010
Volume 32, Issue 5 - Sep 2010
Volume 32, Issue 4 - Jul 2010
Volume 32, Issue 3 - May 2010
Volume 32, Issue 2 - Mar 2010
Volume 32, Issue 1 - Jan 2010
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Electrospun Silk Nano-Fiber Combined with Nano-Hydoxyapatite Graft for the Rabbit Calvarial Model
Kye, Jun-Young ; Kim, Seong-Gon ; Kim, Min-Keun ; Kwon, Kwang-Jun ; Park, Young-Wook ; Kim, Jwa-Young ; Lee, Min-Jung ; Park, Young-Hwan ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 293~298
Purpose: The objective of the present study was to determine the capability of electrospun silk fibroin as a biomaterial template for bone formation when mixed with nano-hydoxyapatite in vivo. Materials and Methods: Ten New Zealand white rabbits were used for this study and bilateral round shaped defects were formed in the parietal bone (diameter: 8.0 mm). The electrospun silk fibroin was coated by nano-hydroxyapatite and grafted into the right parietal bone (experimental group). The left side (control group) did not receive a graft. The animals were sacrificed at 6 weeks and 12 weeks, humanly. The microcomputerized tomogram (
) was taken for each specimen. Subsequently, they were undergone decalcification and stained for the histological analysis. Results: The average value of all measured variables was higher in the experimental group than in the control at 6 weeks after the operation. BMC in the experimental group at 6 weeks after operation was
and that in the control was
(P = 0.027). BMD in the experimental group at 6 weeks after operation was
and that in the control was
(P = 0.044). TMC in the experimental group at 6 weeks after operation was
and that in the control was
(P = 0.011). TMD in the experimental group at 6 weeks after operation was
and that in the control was
(P = 0.06). Gross image of both groups showed higher calcification area at 12 weeks than them in 6 weeks. The average value of
analysis was higher at 12 weeks than that in 6 weeks in both groups. BMC in the experimental group at 12 weeks after operation was
and that in the control was
(P = 0.010). BMD in the experimental group at 12 weeks after operation was
and that in the control was
(P = 0.012). TMC in the experimental group at 12 weeks after operation was
and that in the control was
(P = 0.008). TMD in the experimental group at 12 weeks after operation was
and that in the control was
(P = 0.016). Conclusion: The rabbit calvarial defect could be successfully repaired by electrospun silk nano-fiber combined with nano-hydroxyapatite.
Use of Human Adipose Tissue as a Source of Endothelial Cells
Park, Bong-Wook ; Hah, Young-Sool ; Kim, Jin-Hyun ; Cho, Hee-Young ; Jung, Myeong-Hee ; Kim, Deok-Ryong ; Kim, Uk-Kyu ; Kim, Jong-Ryoul ; Jang, Jung-Hui ; Byun, June-Ho ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 299~305
Purpose: Adipose tissue is located beneath the skin, around internal organs, and in the bone marrow in humans. Its main role is to store energy in the form of fat, although it also cushions and insulates the body. Adipose tissue also has the ability to dynamically expand and shrink throughout the life of an adult. Recently, it has been shown that adipose tissue contains a population of adult multipotent mesenchymal stem cells and endothelial progenitor cells that, in cell culture conditions, have extensive proliferative capacity and are able to differentiate into several lineages, including, osteogenic, chondrogenic, endothelial cells, and myogenic lineages. Materials and Methods: This study focused on endothelial cell culture from the adipose tissue. Adipose tissues were harvested from buccal fat pad during bilateral sagittal split ramus osteotomy for surgical correction of mandibular prognathism. The tissues were treated with 0.075% type I collagenase. The samples were neutralized with DMEM/and centrifuged for 10 min at 2,400 rpm. The pellet was treated with 3 volume of RBC lysis buffer and filtered through a 100
nylon cell strainer. The filtered cells were centrifuged for 10 min at 2,400 rpm. The cells were further cultured in the endothelial cell culture medium (EGM-2, Cambrex, Walkersville, Md., USA) supplemented with 10% fetal bovine serum, human EGF, human VEGF, human insulin-like growth factor-1, human FGF-
, heparin, ascorbic acid and hydrocortisone at a density of
cells/well in a 24-well plate. Low positivity of endothelial cell markers, such as CD31 and CD146, was observed during early passage of cells. Results: Increase of CD146 positivity was observed in passage 5 to 7 adipose tissue-derived cells. However, CD44, representative mesenchymal stem cell marker, was also strongly expressed. CD146 sorted adipose tissue-derived cells was cultured using immuno-magnetic beads. Magnetic labeling with 100
microbeads per 108 cells was performed for 30 minutes at
a using CD146 direct cell isolation kit. Magnetic separation was carried out and a separator under a biological hood. Aliquous of CD146+ sorted cells were evaluated for purity by flow cytometry. Sorted cells were 96.04% positivity for CD146. And then tube formation was examined. These CD146 sorted adipose tissue-derived cells formed tube-like structures on Matrigel. Conclusion: These results suggest that adipose tissue-derived cells are endothelial cells. With the fabrication of the vascularized scaffold construct, novel approaches could be developed to enhance the engineered scaffold by the addition of adipose tissue-derived endothelial cells and periosteal-derived osteoblastic cells to promote bone growth.
The Effect of Bone Marrow-Derived Osteoblasts on Mandibular Deffect in Rabbit
Park, Young-Ju ; Nam, Jeong-Hun ; Kim, Bo-Gyun ; Jeon, Min-Su ; Chung, Jae-An ; Lee, Jung-Won ; Ahn, Jang-Hoon ; Gang, Tae-In ; Park, Mi-Hee ; Lim, Sung-Chul ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 306~312
Purpose: The purpose of this experiment was to evaluate the clinical effect of cultured autoglogous osteoblasts as a way to treat the defect of mandible in rabbits. Materials and Methods: Twelve rabbits were used to determine the rate of osteogenesis. The osteoblasts were obtained from the iliac crest of rabbits using aspiration. They were then cultured in Dulbecco's Modified Eagles's Medium (DMEM) with beta-glycerophosophatate, L-ascorbicacid, and dexamethasone to proliferate and differentiate osteoprogenitor cells. The expression of osteogenic markers were detected by reverse transcription-polymerase chain reaction (RT-PCR) and silver nitrate staining techniques. Five, 10-mm holes were placed in each rabbit mandible to simulate defective regions with the use of a low speed trephine bur. In the experimental group, the previously cited defects were grafted with both activated osteoblastic and autogenous bone. The control group, however, was only grafted with autogenous bone. Both groups were then analyzed at 2, 4, and 8-week intervals using bone histomorphometric analysis. Results: According to histomorphologic analysis, the rates of new bone formation at the 2, 4, and 8-week intervals were 36%, 51%, and 23% for the control group, respectively; 52%, 39%, and 28%, for the experimental group, respectively. The experimental group showed higher rates of new bone formation compared to the control group at both the 2-week and 8-week interval. Conclusion: Bone marrow-derived osteoblasts seems to be a promising bone graft material.
The Effect of
-Tricalcium Phosphate and Deproteinized Bovine Bone on Bone Formation in the Defects of Rat Calvaria
Jung, Seung-Gon ; Park, Hong-Ju ; Ryu, Sun-Youl ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 313~323
Purpose: This study was conducted to evaluate the effect of beta-tricalcium phosphate (Cerasorb
, Germany) and deproteinized bovine bone (Bio-Oss
, Switzerland) grafted to the defect of rat calvaria artificially created and the effect of use of absorbable membrane (BioMesh
, Korea) on new bone formation. Materials and Methods: Transosseous circular calvarial defects with diameters of 5 mm were prepared in the both parietal bone of 30 rats. In the control group I, no specific treatment was done on the defects. In the control group II, the defects were covered with absorbable membrane. In the experimental group I, deproteinized bovine bone was grafted without absorbable membrane; in the experimental group II, deproteinized bovine bone was grafted with absorbable membrane; in the experimental group III, beta-tricalcium phosphate was grafted without absorbable membrane; in the experimental group IV, beta-tricalcium phosphate was grafted with absorbable membrane. The animals were sacrificed after 3 weeks and 6 weeks respectively, and histologic and histomorphometric evaluations were performed. Results: Compare to the control groups, the experimental groups showed more newly formed bone. Between the experimental groups, beta-tricalcium phosphate showed more resorption than deproteinized bovine bone. Stabilization of grafted material and interception of the soft tissue invasion was observed in the specimen treated with membrane. There was no statistical difference between the experimental group I, III and experimental group II, IV classified by graft material, but statistically significant increase in the amount of newly formed bone was observed in the experimental group I, II and II, IV classified by the use of membrane (P<0.05). Conclusion: Both beta-tricalcium phosphate and deproteinized bovine bone showed similar osteoconductibility, but beta-tricalcium phosphate is thought to be closer to ideal synthetic graft material because it showed higher resorption rate in vivo. Increased new bone formation can be expected in bone graft with use of membrane.
Clinical Cases Analysis of Forearm Free Fasciocutaneous Flaps on Oral Cavity Defect Area
Kim, Uk-Kyu ; Lee, Kwang-Ho ; Song, Won-Wook ; Hwang, Dae-Seok ; Kim, Yong-Deok ; Shin, Sang-Hun ; Kim, Jong-Ryoul ; Chung, In-Kyo ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 324~331
The radial forearm free flap (RFFF) has become a workhorse flap as a means of reconstructing surgical defects in the head and neck region. We have transferred 12 RFFFs with fasciocutaneous type on oral cavity defects in 12 patients after cancer resection and submucous fibrotic lesion ablation from 2005 to 2007 at Department of oral and maxillofacial surgery, Pusan National University Hospital. We reviewed retrospectively patients' charts and followed up the patients. Clinical analysis on the cases with RFFFs focusing on flap morbidity, indications and available vessels was done. The results of study are follows: 1. RFFF could be applied for all kind of defects after resection of tongue, floor of mouth, buccal mucosa, denuded bone of palate, maxilla, and mandible. 2. All free flaps could be used for primary reconstruction. The survival rate of 12 RFFFs was 92%. Partial marginal loss of the flaps was shown as 3 cases among 12 cases. Large size-vessels like superior thyroid artery, facial artery, internal jugular vein were favorable for microvascular anastomosis. 3. Parenteral nutrition instead of nasal L-tube also can be favorable for postoperative a week for better healing of the flap if the patients couldn't be tolerable with nasal tubing. 4. Donor sites with thigh skin graft were repaired with wrist band for 2 weeks. The complications included scarring, abnormal sensation on hand, and reduced grip strength in few patients, but those didn't induce major side effects. 5. Most RFFFs were well healed even if mortality rate of cancer patients was shown as 50% (5/10 persons). The mortality of patients was not correlated with morbidity of the flaps. We could identify the usefulness of RFFF for restoration of oral function, esthetics if the flap design, tissue transfer indications, and well controlled operation are proceeded.
Analysis of Keratocystic Odontogenic Tumor
Lim, Hyoung-Sup ; Kim, Su-Gwan ; Moon, Seong-Yong ; Oh, Ji-Su ; Moon, Kyung-Nam ; Yoon, Jeong-Hoon ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 332~336
We reviewed 30 cases of keratocystic odontogenic tumor (KCOT) managed during the 8-year period between 2001 and 2008. This case report described the clinical, radiographic and histopathologic features of these KCOT. Of the 30 patients in whom KCOTs were diagnosed, 18 (60%) of the patients were male and 12 (40%) were female. The mean age of these patients was 34.2 years, with peak incidence occurring in the third decade of life. The lesions were mostly located in the mandible (74.2%) and in the maxilla (25.8%). There was a marked predilection to occur in the posterior mandible. Radiographically, 19 (63%) out of the 30 cases were unilocular type with a well demarcated border, while 11 cases (37%) were multilocularin appearance. Histopathologically, 73% of the cysts were lined with parakeratinized stratified squamous epithelium, while only 3% of the cysts were lined with mixed parakeratinized of orthokeratinized epithelium. 22 cases (73%) contained keratin in the lumen. A satellite cyst was observed in 14 cases (47%). All cysts were treated by enucleation. The recurrence rate was shown as 10% for 3 patients with a follow up period and recurred lesions were treated by re-enucleation.
Implant Survival Rates of Maxillary Sinus Augmentation: a Literature Review of Graft Materials
Lim, Hyoung-Sup ; Kim, Su-Gwan ; Oh, Ji-Su ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 337~343
Purpose: By reviewing literature on the subject, we compared the survival rate of implants placed in various graft materials used for maxillary sinus augmentation. Materials and Methods: The search protocol used the Pubmed electronic database, with a time limit from 1998 to 2009. Keywords such as 'sinus lift,' 'sinus augmentation,' 'sinus floor elevation,' 'sinus graft,' 'bone graft,' 'implants,' 'oral implants,' and 'dental implants' were used, alone and in combination, to search the database. We selected articles and divided them into three groups by type of graft materials: Group 1. Autogenous bone group: autogenous bone alone; Group 2. Combined bone group: autogenous bone in combination with bone substitutes; and Group 3. Substitute group: bone substitutes alone or bone substitute combinations. Results: We selected 37 articles concerning a total of 2,257 patients and 7,282 implants; 417 implants failed. The total implant survival rate (ISR, %) was 94.3%. In Group 1, 761 patients and 2,644 implants were studied; 179 implants failed and the ISR was 93.2%. In Group 2, 583 patients and 1,931 implants were studied; 126 implants failed and the ISR was 93.5%. In Group 3, 823 patients and 2,707 implants were studied; 112 implants failed and the ISR was 95.9%. Conclusion: Implants inserted in grafts composed of bone substitutes alone or in grafts composed of autogenous bone in combination with bone substitutes may achieve survival rates better than those for implants using autogenous bone alone (P<0.05).
A Case Report of Progressive Hemifacial Atrophy
Choi, Moon-Gi ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 344~350
A progressive hemifacial atrophy is characterized by progressive atrophy of subcutaneous fat and rarely muscle and bone. Its contour follows the underlying muscle. Unilateral involvement is common. The treatment goal has been focused on the augmentation of the soft tissue. Many materials such as implants, collagen, fat graft, fat injection, dermal fat graft, filler and vascualized autogenous graft have been used. Although these materials have been used, the best treatment hasn't been achived. In severe cases underlying soft tissue, muscle and bone may be atrophied and massive soft tissue graft, implant and orthognathic surgery must be used. The author used the dermal-fat tissue for the pupose of soft tissue augmentation. We can get the massive soft tissue by the dermolipectomy procedure through the mini-abdominoplsty. The facial augmentation was done by augmentation of the dermal-fat tissue. The progressive hemifacial atrophy is hard to treat by only one procedure and many modalites must be considered.
Correction of Facial Asymmetry Using Costochondral Graft and Orthognathic Surgery in Hemifacial Microsomia Patient: Case Report
Park, Sung-Soo ; Suh, Jin-Won ; Choi, Jin-Young ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 351~358
A 31-year-old woman with hemifacial microsomia presented to the Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital. The patient was previously treated with distraction osteogenesis device to elongate right maxilla and mandibular ramus. But, the result was not satisfactory, to correct residual facial asymmetry due to hemifacial microsomia we planned costochondral graft for reconstruction of ramus and condyle, Le Fort I osteotomy and sagittal split ramus osteotomy for facial asymmetry. The right mandibular condyle and ramus was reconstructed with right eleventh costochondral graft via submandibular approach. Using costochondral graft and orthognathic surgery the facial asymmetry in hemifacial microsomia patient was corrected. 1-stage treatment consists of costochondral graft and orthognathic surgery can achieve function and esthetics at the same time, is timesaving to both patient and surgeon.
The Avalibility of C-Arm in Reduction of Zygomatic Arch Fracture Intraoperatively: Case Report
Seo, Mi-Hyun ; Cheon, Kang-Yong ; Yun, Jun-Yong ; Yoo, Chung-Kyu ; Lee, Eun-Kyung ; Lee, Won-Deok ; Suh, Je-Duck ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 359~362
The zygoma is second most commonly vulnerable facial bone in fracture, in number only by nasal fractures. It is difficult to evaluate reduction state intraoperatively, because almost surgeons reduce the fractured zygoma by blind method. We suggest the use of orthopedic C-arm intraoperatively. We use plain radiography, CT to evaluate preoperative state. Gilles approach or intraoral approach were used to reduce the fractured zygomatic arch. The C-arm was positioned at chin area, used to evaluate reduction intraoperatively. We got postoperative image by CT or submento-vertex view. There are variable methods to evaluate reduction intraoperatively: palpation, ultrasonography, CT, plain films. C-arm is considered superior diagnostic tool to other methods. The use of intraoperative C-arm was very efficient, it could bring better results.
A Giant Sialolith in a Wharton's Duct: Report of Two Cases
Na, Hye-Jung ; Yoon, Kyu-Ho ; Cheong, Jeong-Kwon ; Bae, Jung-Ho ; Kim, Hae-Lin ; Jo, Kyu-Hong ; Shin, Jae-Myung ; Baik, Jee-Seon ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 363~367
Sialolithiasis is the most commom disease of salivary gland. The main symptoms are pain and swelling of the involved gland during eating. It can occur at any age but patients in their third to fifth decade present most cases. Males are more frequently affected than females. Most sialoliths are located within the duct system of the submandibular gland. Submandibular sialoliths close to the hilum of the gland tend to become large and ovoid shape, whereas sialoliths in the duct tend to be elongated. Commonly, sialoliths measure from 1 mm to less than 10 mm, and larger than 15 mm are considered rare. In one case we have removed a giant sialolith which was located in a wharton's duct and in the other case we have removed multiple sialolith including a giant sialolith which were also located in a Wharton's duct. We report these 2 cases with literature reviews.
Botryoid Odontogenic Cyst on Mandibular Anterior and Both Body Area: a Case Report
Nam, Jeong-Hun ; Kim, Da-Young ; Park, Young-Ju ; Ahn, Jang-Hoon ; Gang, Tae-In ; Park, Mi-Hee ; Yu, Woo-Geun ; Kim, Bo-Gyun ; Lee, Jung-Won ; Kim, Jung-Hee ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 368~372
Botryoid odontogenic cyst (BOC) is considered a rare multilocular variant of the lateral periodontal cyst. In this report, a 67-year-old male visited with chief complaint of severe mobility on mandibular incisors. Multilocular radiolucent lesion was seen from the right premolar to the left premolar area, involving almost the whole mandible. Histologically, the botryoid odontogenic cyst showed focal nodular thickening of the lining epithelium. These thickening often showed swirling appearance of the cells. Cyst enucleation and bone graft on mandible anterior and both body area were performed under general anesthesia, and postoperative healing was favorable without recurrence.
The Treatment of Hemangioma in Lower Lip
Lee, Eun-Young ; Kim, Kyoung-Won ; Lee, Ji-Yeoun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 32, issue 4, 2010, Pages 373~377
Vascular anomalies are common birthmarks. A eight-month-old male infant had a small size, bright red swelling on the lower lip since birth. On cutaneous examination there was a small brightly erythematous, lobulated, soft plaque on the left side of the lower lip of
mm. Ultrasonogram examination revealed the lesion and confirmed the diagnosis of capillary hemangioma. The decision to initiate treatment is based on many factors, including size, location and risks and benefits of the proposal therapy. Systemic corticosteroids are decided to prevent the scarring and deforming. Prednisolone was given at a dose of 2 mg/kg/day for 2 weeks followed by tapering for 6 weeks for treatment. After eight weeks there was 80% reduction in the size of the lesion and the left lower lip almost completely cleared without intraoral bleeding. Furthermore, intervention by way of systemic steroids, laser therapy or surgical debulking is appropriate and safe in a select group of patients presenting with a proliferating hemangioma. This report describes a case that was sucessfully treated by systemic steroid therapy for hemangima in intraoral region.