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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Maxillofacial Plastic and Reconstructive Surgery
Journal Basic Information
Journal DOI :
Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Editor in Chief :
Volume & Issues
Volume 33, Issue 6 - Nov 2011
Volume 33, Issue 5 - Sep 2011
Volume 33, Issue 4 - Jul 2011
Volume 33, Issue 3 - May 2011
Volume 33, Issue 2 - Mar 2011
Volume 33, Issue 1 - Jan 2011
Selecting the target year
Inhibition of Lymphatic Endothelial Growth Factor Receptor in a Murine Model of Oral Squamous Cell Carcinoma
Kye, Jun-Young ; Park, Young-Wook ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 1~9
Purpose: Tumor associated angiogenesis and/or lymphangiogenesis are known to be linked by VEGFR signaling pathways. These processes are regulated by several growth factors including VEGFR-2, VEGFR-3. E7080 is an orally active inhibitor of multiple tyrosine kinases including VEGFR-2, 3. Therefore, it was proposed that E7080 may inhibit angiogenesis and lymphangiogenesis. The aim of this study was to determine the effect of E7080 in a nude mouse model of OSCC. Methods: KB cells were xenografted into the submucosal tissue of the mouth floor of athymic mice. Seven days after the xenograft, the mice were randomized into 2 groups. E7080 were administered orally to the experimental group once per day. The mice were sacrificed 3 weeks after the treatment. The tumors were examined histopathologically. Immunohistochemical assays with anti- VEGF-C, VEGFR-2, VEGFR-3, phosphorylated VEGFR-2/3 (pVEGFR-2/3), and D2-40 antibodies were then performed. Results: The transplantation of human OSCC tumor cells into the mouth floor resulted in the formation of orthotopic tumors. The experimental (E7080 treatment) group showed a slowly increased tumor volume. Moreover, immunohistochemical staining demonstrated higher levels of VEGF-C, VEGFR-2, VEGFR-3, pVEGFR-2/3 and D2-40 expression in the control group than in the experimental group. Conclusion: These results suggest that E7080 may provide therapeutic benefits in OSCC.
Effects of Bisphosphonates on the Proliferation and the AlkalinePhosphatase Activity of Human Bone Marrow Derived Mesenchymal Stem Cells
Jung, Jun-Ho ; Lee, Baek-Soo ; Kwon, Yong-Dae ; Ohe, Joo-Young ; Kim, Young-Ran ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 10~18
Purpose: The purpose of this study is to find out the effects of bisphosphonates (BPs) on the proliferation and the alkaline phosphatase (ALP) activity of human bone marrow derived mesenchymal stem cells (hMSCs), and thus state its correlation with bisphosphonate related osteonecrosis of the jaw (BRONJ). Methods: hMSCs was obtained by collecting and culturing cancellous bone fragments from a patient undergoing iliac bone graft. Alendronate (Aln) and Pamidronate (Pam), Ibandronate (Ibn) were added to the culture media in the concentration from
M and cell toxicity, viability were measured. For ALP activity evaluation, Aln and Pam were added to the culture media in the concentration from
M and were cultured for 1 week, 2 weeks and 3 weeks. ALP activity data were standardized using protein assay. Control groups were prepared for each examination. Results: Aln, Pam and Ibn all failed to increase the proliferation of hMSCs. With 1 week, 2 weeks of
M of Aln treatment, the ALP activity increased. Pam treatment increased the ALP activity with 2 weeks of
M. Also Ibn treatment increased the ALP activity with 2 weeks of
M. Conclusion: It is considered that BPs are not capable of improving the proliferation of hMSCs. Also, after a transient increase in the ALP activity with the lower concentration of BPs, the activity decreased again. Therefore, in patients on long-term medication of BPs, the proliferation and osteoblast differentiation of hMSCs are restrained, and thus delayed wound healing and increase in BRONJ complications may occur.
The Effect of PRF and PRP for New Bone Formation of
-TCP in Skull of White Rabbit
Park, Jeong-Kyun ; Joo, Hyun-Jung ; Lee, Ei-Seok ; Jang, Hyon-Seok ; Lim, Jae-Seok ; Kwon, Jong-Jin ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 19~25
Purpose: Addition of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) to grafting material has become widely accepted additively for bone regeneration because it can raise high expectations on it's clinical potential. The aim of this study was to evaluate the efficacy of PRP and PRF on early bone regeneration of rabbits when used in combination with beta tricalcium phosphate. Methods: In eight rabbits, the calvarium was exposed and the two marrows were penetrated. After then these artificial bone defects were augmented with
-TCP with PRP or
-TCP with PRF and covered. The animals were sacrificed after four and eight weeks. Histologic findings were observed under the light-microscope and histomorphometric analysis was performed by measuring calcified area of new bone formation within the CSD. Results: They demonstrated that new bone formation tended to be produced along the outline of graft materials. More amounts of newly bone was regenerated in
-TCP only and in combination of
-TCP with PRF and it was statistically significant. In contrast, there was no significant difference between nothing apply and
-TCP with PRP groups in the relative amounts of newly mineralized bone. Conclusion: Within the limitation of this study, it can be concluded that PRF in combination with
-TCP showed a positive effect on bone regeneration and statistically it was significant.
Immunohistochemical Observation of Plasma Cell Granuloma in Intraoral Chronic Inflammatory Lesions
Kim, Yeon-Sook ; Lee, Suk-Keun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 26~31
Purpose: Chronic inflammatory gingival lesions occur as pyogenic granulomas or non-specific chronic suppurative lesions. Methods: Of the 59 chronic inflammatory gingival lesions examined, plasma cell granuloma (n=14), which showed an intense antibody-mediated immune reaction with the increased infiltration of plasma cells, was observed as a pseudotumor-like gingival overgrowth and myofibroblastic or fibrohistiocytitc proliferation of stromal cells with a heavy collection of plasma cells. The levels of CD3, CD20, CD31, CD68, RANKL, cathepsin G, cathepsin K, lysozyme, TNF
, MMP-2, and MMP-9 in the 14 cases of gingival plasma cell granuloma with immunohistochemical detection were measured to determine the pathogenetic progresses of the plasma cell granuloma compared to the common pyogenic granuloma (n=45) in the gingiva. Results: The gingival lesions of the plasma cell granuloma could be divided into three histological types, plasma cell predominant type (PPT, n=8), mixed inflammatory cell type (MICT, n=2), and sclerosed fibrosis type (SFT, n=4). The PPT showed a condensed infiltration of plasma cells into the perivascular spaces of the granulomatous lesion with frequent formation of Russel's body in their cytoplasm. The MICT showed the concomitant infiltration of many macrophages together with plasma cells, resulting in the diffuse destruction of stromal fibrous tissue. The SFT showed granulomatous lesions replaced gradually by thick collagenous fibrous tissue, resembling an inflammatory pseudotumor. The SFT expressed strongly the lymphocytic markers, CD3 and CD20, and the macrophage/monocyte markers, CD31 and CD68, but showed reduced expression of common inflammatory markers, TNF
, cathepsin G, lysozyme, MMP-2, and MMP-9, as well as the reduced expression of osteoclastogenic markers, RANKL and cathepsin K. Conclusion: These results suggest that a gingival plasma cell granuloma shows variable gene expression for cell-mediated immunity and stromal tissue degeneration, undergoing sclerotic fibrosis with a persistent inflammatory reaction.
Comparative Evaluation of Infection Rate according to Extraction of Teeth in the Line of Mandibular Angle Fractures Treated with Stable Internal Fixation
Kim, Jin-Ha ; Kim, Su-Gwan ; Moon, Seong-Yong ; Oh, Ji-Su ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 32~35
Purpose: Mandibular angle fractures constitute approximately 30% of mandibular fractures, and the mandibular third molar is usually in line with the fracture. This study evaluated the relationship between the extraction of a tooth in line with a mandibular angle fracture and the infection rate. Methods: One hundred and forty seven patients with mandibular angle fractures containing a tooth in line with the fracture from 2005 to 2008 were enrolled in this study. The patients were divided into two groups based on an extraction, and the infection rates were evaluated in both groups. Results: An extraction was performed in 70 patients (47.6%) and postoperative infections occurred in 14 patients (9.5%). Six (8.6%) of the 70 patients in the extraction group and 8 (10.4%) of the 77 patients in the non-extraction group had an infection. There was no significant difference between the two groups (P=0.708). Conclusion: These results show that there is no increased risk of postoperative complications when a tooth is present
Changes of Pharyngeal Airway Space after Mandibular Setback Surgery in Computed Tomography Images
Kim, Bang-Sin ; Jung, Seung-Gon ; Han, Man-Seung ; Jeoung, Youn-Wook ; Kook, Min-Suk ; Park, Hong-Ju ; Oh, Hee-Kyun ; Ryu, Sun-Youl ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 36~43
Purpose: This study evaluated the pharyngeal airway space changes in CT images in patients receiving bilateral sagittal split osteotomy (BSSRO) for the surgical correction of mandibular prognathism. Methods: A total of 22 patients with mandibular prognathism were treated using BSSRO. Computed tomography was performed 1 month (T0) before surgery and, 1 month after surgery (T1). The anteroposterior length (AP), lateral width (LAT) and cross-sectional area (AREA) at the level of soft palate (C2) and base of the tongue (C3) were measured using CT images. Results: The mean amount of mandibular setback was 7.41 mm (
3.46 mm). All the AP, LAT and AREA at the C2 and C3 level were decreased significantly 1 month after surgery (P<0.001). As the amount of mandibular setback was increased, the AP, LAT and AREA levels at the level of C2 and C3 had decreased. In addition, the reduction of the AREA at the C3 level was associated with the amount of mandibular setback (P<0.05). Conclusion: A significant decrease in pharyngeal airway space was observed 1 month after the operation. The cross-sectional area at the level of base of tongue was decreased with increasing amount of mandibular setback.
Reconstruction of Complex Zygomatico-Maxillary Defect Using the Free Vascularized Cutaneous Flap and Autogeneous Bone Graft: Case Report
Park, Ji-Hoon ; Jang, Jung-Woo ; Choi, So-Young ; Kim, Chin-Soo ; Kwon, Tae-Geon ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 44~48
Maxillary defects are inherently complex because they generally involve more than one midfacial component. In addition, most maxillary defects are composite in nature, and often require bony support, as well as a mucosal lining for reconstruction. Therefore, midfacial bone and soft tissue defects present a unique challenge because they require a complex arrangement of tissues in a relatively limited space. This might be difficult to achieve only with free osteocutaneous flaps. The use of bone grafts allows greater flexibility in a reconstruction but is limited by graft resorption. We report a case of a patient reconstructed with a lateral arm free flap, iliac bone graft, sagital split ramus osteotomy for the reconstruction of a right maxillary defect zygomatico-maxillary defect caused by a zygomatico-maxillary malignant tumor resection.
Submucosal Fibrosis with Severe IgK Deposition in Behcet's Syndrome
Park, Young-Wook ; Kim, Yeon-Sook ; Lee, Suk-Keun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 49~54
A case of Behcet's syndrome found in a 22 years old male was is reported along with the histological and immunohistochemical studiesfindings. He The patient had had received prolonged medical therapy of anti-inflammatory agents for the conjunctival ulcer, genital ulcer, oral ulcer, and intestinal ulcers since the first onset of the Behcet's syndrome about approximately 7 years agoearlier. Recently, he felt the athickening of both corners of his lip causing that caused mouth opening difficultydifficulties. A plastic rReconstructive surgery was performed to enlarge the size of the oral orifice by multiple Z-plasty incisions, and finallywhich resulted in proper enlargement of the circumferential length of the lip. During the operation, a scar-like thick fibrous tissue was obtained and examined pathologically. In theThe microscopic observation the revealed the submucosal lesion was to be diffusely fibrosed with the a distribution of sclerotic collagen bundles. Particularly, sSeveral foci of collagen degeneration were found observed in the deep connective tissue, and the degenerating collagen bundles were gradually lost their fibrillar appearance. In the immunohistochemical observations, the foci of collagen degeneration was were strongly positive for IgK, but almost negative for TNF
lysozyme, and MMP-3. Taken together, it was presumed that tThe submucosal fibrosis was presumed to have firstly presented in this study was probablybeeninduced by the prolonged anti-inflammatory therapy, which may inhibit the removal of sclerosed collagen bundles by the cell-mediated immunity and proteolytic digestion of macrophages, and that it was secondarily aggravated by the deposition of immunoglobulins derived from an autoimmune origin. Therefore, even after the successful plastic surgery of the lip to ameliorate the mouth opening difficulty, the recurrent submucosal fibrosis of lip should be carefully managed in the follow-up treatment.
Switching Genioplasty- a New Genioplasty Technique in Order to Resolve Asymmetry of Chin Area: Case Report
Seo, Hyun-Soo ; Lee, Young-Joo ; Byeon, Kwang-Seob ; Hong, Soon-Min ; Park, Jun-Woo ; Hong, Ji-Sook ; Park, Yang-Ho ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 55~61
Conventional slinding genioplsty has the risk of mental nerve injury after operation and difficult to correct vertical asymmetry of chin. So, authors propose a new genioplasty to correct asymmetry of chin. Switching genioplasty is a modification method of conventional genioplasty. Between mandibular right and left canine, osteotomy line of triangular shape make until mandibular lower border. In large side, osteotome line of wedge shape is added to reduction. After osteotomy, segment of wedge shape was separated from chin. Distal segment was rotated to reduction side. Because of rotation of distal segment, space is made in opposite side. Seperated segement of wedge shape from large side is switched this space to fill. So, stability of distal segment is achieved. Authors applied to swiching genioplasty the patients who was remained the chin asymmetry after both sagittal split ramus osteotome was done because mandible asymmetry. After operation, patient and operator were satisfied with excellent esthetic results without any other complication. The switching genioplasty is effective surgical technique for chin asymmetry because it has more advantages than conventional sliding genioplasty. First, other donor side does not need for bone graft. Second, the switching genioplasty can reduce infection, bone resroption, dehiscence, capsular contraction after allograft. Third, have little mental nerve damage. Forth, anteroposterior correction is possible. Fifth, operation time is less than other genioplasty for chin asymmetry.
A Case Report of Eagle's Syndrome
Jeon, In-Chul ; Kwon, Dae-Gun ; Yoo, Dae-Hyun ; Lee, Jun ; O, Se-Ri ; Kim, Hyong-Woo ; Min, Seung-Ki ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 62~65
Eagle's syndrome occurs when an elongated styloid process or calcified stylohyoid ligament causes recurrent throat pain or foreign body sensation, dysphagia. It is supposed that this symptoms and signs are due to the compression of the styloid process on some neural and vascular structures. More uncommonly, symptoms such as dysphagia, tinnitus, and otalgia may occur in patients with this syndrome. It may also cause stroke due to the compression of carotid arteries. The compression depends on the size, shape, and orientation of the ossified styloid process Besides, degenerative or inflammatory changes in the tendinous portion of the styloid ligament insertion or rheumatic styloiditis may also cause this syndrome. Diagnosis can usually be made on physical examination by digital palpation of the styloid process in the tonsiller fossa. Three-dimensional computed tomography can utilized for supporting diagnosis. The treatment of Eagle's syndrome is primarily surgical. The styloid process can be shortened through an intraoral and extraoral approach. We report a 62-years-old man with the symptomatology of Eagle's syndrome and literature reviews.
Alveolar Ridge Augmentation Using Titanium Reinforced Goretex (TRG) and Titanium Mesh in Severe Alveolar Bone Loss Area: Case Report
Kim, Won-Jik ; Yoon, Kyung-Sun ; Hong, Su-Ryun ; Choi, Jin-Kyung ; Lee, Yong-Uk ; Kim, Dong-Suk ; Hyun, Jong-Oh ; Cho, Hyo-Won ; Choi, Ji-Hye ; Jung, Tae-Woong ; Bae, Yoon-Ki ; Kwon, Sun-Kyu ; Choi, Hyun-Joon ; Lee, Hyun-Su ; Yang, Su-Nam ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 66~72
A severely vertical resorbed ridge is a significant challenge in implant dentistry. To solve this problem, several augmentation techniques, such as guided bone regeneration (GBR), onlay bone grafts, distraction osteogenesis, and ridge splitting techniques, have been proposed and used for several years. Among these methods, vertical ridge augmentation using guided bone regeneration aims to build space and guide osteoblasts to this space to promote osteogenesis. The aim of guided bone regeneration is to maintain and stabilize the space and block the proliferation of adjacent soft tissue. In our hospital, we encountered a case of a woman in her forties with an atrophied mandible, who underwent implant surgery in the right mandible. Titanium reinforced Gore-Tex (TRG) was used to augment the mandible and titanium mesh was used in the left mandible. Favorable results were obtained. This report compares the two methods and reviews the relevant literature.
Heterotopic Gastrointestinal Cyst of the Tongue: Case Report
Kim, So-Mi ; Kil, Tae-Joon ; Hahm, Tae-Hoon ; Kim, Hyun-Sil ; Yi, Choong-Kook ; Cha, In-Ho ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 73~76
Gastrointestinal cyst found within the oral cavity has been reported as a rare occurrence with less than 40 cases. The tongue is the preferred site with almost 60% of cysts occurring within oral cavity. The cyst usually shows an asymptomatic swelling in the floor of the mouth, about 30% of affected individuals have symptoms related to difficulties with feeding, swallowing and respiration. The histopathologic features of the cyst vary with respect to the type of epithelium lining; gastric, squamous, intestinal and respiratory epithelium. The pathogenesis is not known, but it may be related to entrapment of undifferentiated endoderm within oral cavity during early fetal development. In this article, we report a case of a gastrointestinal cyst of the tongue in a 16-month-old girl.
A Long-term Follow-Up Case of Enucleation of Dentigerous Cyst in the Maxilla: Case Report
Lee, Eun-Young ; Kim, Kyoung-Won ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 77~82
A long-term follow-up study of a case of impacted teeth associated with a large dentigerous cyst in the left maxilla is presented. The patient was a 30-year-old man who had a large dentigerous cyst in the premaxilla and left posterior maxilla, which impacted the canine and supernumerary tooth. This is one of the most prevalent types of odontogenic cysts associated with an erupted or developing tooth, particularly the mandibular third molars. The other teeth commonly affected in order of frequency are the maxillary canines, maxillary third molars and rarely, the central incisor. Radiographically, the cyst appears as huge ovoid well-demarcated unilocular radiolucency with a sclerotic border and causes ectopic displacement of the inferior border of the maxillary sinus without destruction. Dentigerous cysts may grow unnoticed to such extensive sizes as to occupy a considerable portion of the maxillary sinus. These cysts appear to be associated with a supernumerary tooth in the maxillary anterior incisors region called the mesiodens and impacted canine. The present case report describes the surgical enucleation of a dentigerous cyst involving the permanent maxillary left canine and mesioden. After surgery, left maxillary sinus recovered their normal size and apposition of bone was observed around the apex of the posterior teeth. During the subsequent years, there was no recurrence of the cystic lesion but the inflammation was evoked in the anterior maxilla after 42 months. This complication appeared to have correlated with bony healing in the enucleation site of the cyst. We report the healing status of a huge dentigerous cyst in the maxilla for 5 years with a review of the relevant literature.
Forced Eruption of Severe Angulated and Impacted Permanent Teeth after Marsupialization of Dentigerous Cyst: Case Report
Nam, Jeong-Hun ; Noh, Kyung-Lok ; Yoo, Woo-Geun ; Lee, Byeong-Min ; Jeon, Ji-Hyeon ; Park, Su-Hyun ; Ahn, Jang-Hoon ; Kim, Jung-Hee ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 83~88
The goal of this treatment is the surgical-orthodontic eruption of impacted permanent teeth associated with a large dentigerous cyst in a preadolescent patient. Although enucleation of the entire cyst and the extraction of impacted teeth are common treatments, missing permanent teeth cause several problems in young patients. In this report, an 11-year-old female visited with the chief complaint of a large radiolucent lesion from the mandibular anterior area to the left mandibular posterior area. The permanent left canine and premolars were displaced toward the mandibular inferior border area. The extraction of infected deciduous teeth and marsupialization were performed. After 4 months, orthodontic buttons for forced eruption were applied to the impacted permanent teeth. The teeth emerged into the oral cavity 3 months after the orthodontic treatment. Although the root form was abnormal, there were no other pathogenic signs. The alveolar bone had a normal trabecular pattern and the teeth appeared to be well maintained at postoperative 24 months.
Recurrent Herpes-Stomatitis Mimicking Acute Necrotizing Ulcerative Gingivitis
Kim, Han-Seok ; Lee, Suk-Keun ; Park, Young-Wook ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 89~92
Herpes simplex is caused by viruses of the herpesvirus hominus family. HSV have four categories: type 1, 2, 6, and 8. Generally HSV-1 affects the mouth. Once infected by HSV, the person's infection is permanent. Retrograde transport through adjacent neural tissue to sensory ganglia leads to a lifelong latent infection. Recently, we treated a patient with recurrent herpes-stomatitis mimicking acute necrotizing ulcerative gingivitis (ANUG). The results were satisfactorty so we report this case. 31 years old male patient showed sore throat, gingival ulceration, palpable both submandibular lymph node, and sulcular pus formation around posterior decayed teeth. This is the third time he has suffered from this symptom. Tentative diagnosis was acute necrotizing ulcerative gingivitis. Antibiotic therapy was started. But, intraoral symptom got worse in process of time. Especially ulcer of marginal gingiva got worse. Viral disease was suspected. We carried out viral cultivation. At the same time topical application of antiviral ointment (herpecid
) was performed on oral ulcer unilaterally for the purpose of diagnosis and reducing pain experimentally. The next day pain was decreased dramatically on application area. Basing on the viral cultivation and clinical effect of antiviral ointment (herpecid
), we have diagnosed it as a recurrent herpes-stomatitis and concluded that viral infection was major cause of disease and bacterial infection was secondary.
Anatomical Review of Radial Forearm Free Flap for the Oral Cavity Reconstruction
Kim, Soung-Min ; Seo, Mi-Hyun ; Kang, Ji-Young ; Eo, Mi-Young ; Myoung, Hoon ; Lee, Suk-Keun ; Lee, Jong-Ho ;
Maxillofacial Plastic and Reconstructive Surgery, volume 33, issue 1, 2011, Pages 93~101
Reconstruction following a resection of malignant oral cavity tumors is one of the most difficult problems in recent oral oncology. The radial forearm free flap (RFFF) is a thin, pliable soft tissue flap with large-caliber vessels for microvascular anastomosis. Its additional advantages include consistent flap vascular anatomy, acceptable donor site morbidity and the ability to perform simultaneous flap harvest with a tumor resection. For a better understanding of RFFF as a routine reconstructive procedure in oral and maxillofacial surgery, the constant anatomical findings must be learned and memorized by young doctors during the special curriculum periods for the Korean national board of oral and maxillofacial surgery. This review article discusses the anatomical basis of RFFF in the Korean language.