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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Maxillofacial Plastic and Reconstructive Surgery
Journal Basic Information
Journal DOI :
Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Editor in Chief :
Volume & Issues
Volume 35, Issue 6 - Nov 2013
Volume 35, Issue 5 - Sep 2013
Volume 35, Issue 4 - Jul 2013
Volume 35, Issue 3 - May 2013
Volume 35, Issue 2 - Mar 2013
Volume 35, Issue 1 - Jan 2013
Selecting the target year
Induction of Selective Cell Death of Oral Squamous Carcinoma Cells by Integrin α
Antibody and EGFR Antibody
Choi, Yeon-Sik ; Kim, Gyoo-Cheon ; Yoon, Sik ; Hwang, Dae-Seok ; Kim, Cheol-Hun ; Jeon, Young-Chan ; Byun, June-Ho ; Shin, Sang-Hun ; Kim, Uk-Kyu ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 143~154
DOI : 10.14402/jkamprs.2013.35.3.143
Purpose: This study was to find efficacy of integrin alpha2 (
) and epidermal growth factor receptor (EGFR) as tumor marker of oral squamous cell carcinoma (SCC) and clarify the selective cell death effect of anti-integrin
and anti-EGFR on SCC cells, additionally testify conjugated gold nanoparticles (GNP) with air plasma for selective cell death of oral SCC. Methods: Expression of integrin
, EGFR on human SCC cells (SCC25) were examined by western blot. SCC25 cells were treated with anti-integrin
, anti-EGFR and analysed by Hemacolor staining, immunoflorescence staining, FACS flow cytometry. Conjugated GNP with integrin
, EGFR antibody were treated by air plasma on SCC cells. Results: Integrin
and EGFR were over-expressed on SCC25 cells than normal lung WI-38 cells. The cell viability rate of SCC25 cells treated with anti-integrin
, anti-EGFR was lower than WI-38 cells. The concentration changes of nucleus, releasing cytochrome c and apoptosis inducing factor (AIF) from mitochondria to cytosol were observed. The changes of proteins related with apoptosis were observed. Increase of bax, bcl-xL, activation of caspase-3, -7, -9, and fragmentation of PARP, DFF45 and decrease of lamin A/C in SCC25 cells were observed. In FACS, increase of sub-
and S phase was observed. Cell cycle related proteins, Such as cyclin D1, cyclin dependent kinase (CDK) 4, cyclin A, cyclin E, CDK 2, p27 were decreased. After SCC25 cells treated with conjugatged GNP-Integrin
, GNP-EGFR, additionally air plasma, the cell death rate was significantly increased. Conclusion: Integrin
, EGFR were over-expressed in oral SCC cells. Anti-integrin
, anti-EGFR in SCC25 cells induced apoptosis selectively. When GNP-anti integrin
, GNP-anti EGFR were treated with air plasma on SCC25 cells, cancer cells were died more selectively. GNP-anti integrin
, GNP-anti EGFR with air plasma could be treatment choice of oral SCC.
Salivary Bacterial Counts on Application Time of Oral Antiseptic Agents and Mechanical Irrigation
Lim, Hyoung-Sup ; Kim, Jae-Jin ; Kim, Mija ; Kim, Hak Kyun ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 155~160
DOI : 10.14402/jkamprs.2013.35.3.155
Purpose: The purpose of this study is to establish the acceptable intraoral application time of antiseptic agents and evaluate the effect of mechanical irrigation. Methods: A total of 80 subjects were selected for this study. Saliva secreted at the resting state was taken. The subjects were divided into 8 experimental groups, and kept 10% povidone-iodine (PVI) or 0.2% chlorhexidine gluconate (CHX) for 20 or 40 seconds in their oral cavity with/without irrigation of the oral cavity with sterilized normal saline, respectively. Then, the saliva was taken and diluted with phosphate buffered saline and then plated onto 5% sheep blood agar plates, which were incubated. Colony forming unit (CFU) was measured for the salivary bacterial counts. Results: After application of PVI and CHX, all the experimental groups showed statistically significant decrease in CFU (P<0.01). Group 2 (PVI, 40 s) showed more significant reduction rate in CFU than group 4 (CHX, 40 s; P<0.01). Group 6 (PVI, 40 s, irrigated) showed more significant reduction rate than group 2 (PVI, 40 s; P<0.01). Group 2 (PVI, 40 s) showed more significant reduction rate than group 1 (PVI, 20 s; P<0.01). Conclusion: Application of PVI for 40 seconds and mechanical irrigation with sterilized normal saline showed the best result among the 8 groups in terms of the reduction rate of salivary bacterial counts.
Cephalometric Predisposing Factors of the Snoring and Obstructive Sleep Apnea
Seo, Eun-Woo ; Lee, Ho-Kyung ; Han, Min-Woo ; Seo, Mi-Hyun ; Kim, Hyun-Jun ; Song, Seung-Il ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 161~166
DOI : 10.14402/jkamprs.2013.35.3.161
Purpose: This study was intended to perform a cephalometric comparison between the patients with and without obstructive sleep apnea (OSA). The factors influencing the OSA in the lateral cephalogram were also investigated. Methods: Fifty patients who had visited the Sleep Disorder Clinic at the Ajou University Hospital and evaluated with the polysomnograph (PSG) and cephalogram, were included in the study. The patients had the apnea-hypopnea episode over 5 times per hour (apnea-hypopnea index
) were diagnosed as OSA after the overnight PSG. To evaluate the hard and soft tissue profiles, the cephalometric radiograms were taken at the maximal intercuspation. The correlation between the patient's age, height, weight, body mass index (BMI) and AHI was inspected in the OSA and control group. The difference between the OSA and control group was evaluated (Mann-Whitney U Test). The cephalometric influencing factors to OSA were analyzed (Pearson's correlation coefficient) statistically using SPSS statistics. Results: The OSA Group had a significantly higher BMI than the control group. The mean lower facial height (ANS-Me) was longer in the OSA group; however, statistically significant difference was not detected in the anteroposterior craniofacial measurements. The distance between mandibular plane and hyoid bone of the OSA group was significantly longer than that of the control group. The hyoid position (MP-Hyoid) had a positive correlation between AHI (P<0.001). However, the measurements of oropharyngeal airway were not different between the two groups. The hypothesis, that the antero-posteriorly narrow oropharyngeal airway may aggravate the airway resistance and give rise to a higher AHI, was rejected in the study. Conclusion: We suggest that the lateral cephalogram may be utilized as a useful method to evaluate OSA. The patients with a lower hyoid position can be expected to have higher risks of OSA. However, a comprehensive intraoral inspection, including the soft palate and tonsilar hypertrophy, is emphasized, as the lateral cepahlogram cannot visualize the oropharyngeal status completely.
Marginal Bone Resorption Analysis of Dental Implant Patients by Applying Pattern Recognition Algorithm
Jung, Min Gi ; Kim, Soung Min ; Kim, Myung Joo ; Lee, Jong Ho ; Myoung, Hoon ; Kim, Myung Jin ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 167~173
DOI : 10.14402/jkamprs.2013.35.3.167
Purpose: The aim of this study is to analyze the series of panoramic radiograph of implant patients using the system to measure peri-implant crestal bone loss according to the elapsed time from fixture installation time to more than three years. Methods: Choose 10 patients having 45 implant fixtures installed, which have series of panoramic radiograph in the period to be analyzed by the system. Then, calculated the crestal bone depth and statistics and selected the implant in concerned by clicking the implant of image shown on the monitor by the implemented pattern recognition system. Then, the system recognized the x, y coordination of the implant and peri-implant alveolar crest, and calculated the distance between the approximated line of implant fixture and alveolar crest. By applying pattern recognition to periodic panoramic radiographs, we attained the results and made a comparison with the results of preceded articles concerning peri-implant marginal bone loss. Analyzing peri-implant crestal bone loss in a regression analysis periodic filmed panoramic radiograph, logarithmic approximation had highest
value, and the equation is as shown below.
, unit: month (x), mm (y) Results: Panoramic radiograph is a more wide-scoped view compared with the periapical radiograph in the same resolution. Therefore, there was not enough information in the radiograph in local area. Anterior portion of many radiographs was out of the focal trough and blurred precluding the accurate recognition by the system, and many implants were overlapped with the adjacent structures, in which the alveolar crest was impossible to find. Conclusion: Considering the earlier objective and error, we expect better results from an analysis of periapical radiograph than panoramic radiograph. Implementing additional function, we expect high extensibility of pattern recognition system as a diagnostic tool to evaluate implant-bone integration, calculate length from fixture to inferior alveolar nerve, and from fixture to base of the maxillary sinus.
Surgical Management of Bisphosphonate Related Osteonecrosis of the Jaw Using Pedicled Buccal Fat Pad Flap
Lee, Jang-Ha ; Kim, Min-Keun ; Kim, Seong-Gon ; Park, Young-Wook ; Park, Sang-Wook ; Park, Young-Ju ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 174~177
DOI : 10.14402/jkamprs.2013.35.3.174
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a disease characterized by jaw necrosis and delayed wound healing in patients who had received bisphosphonates. Buccal fat pad (BFP) can be used as a pedicled flap in the posterior region of the oral cavity. BFP pedicle flap needs simple surgical technique and it shows less donor site morbidity and aesthetic problem than other vascularized flap. BFP pedicled flap was fed by 3 arteries-facial, internal maxillary, and transverse facial artery. Osteomyelitis was generally related with poor blood supply. Thus, rich blood supply of BFP pedicle flap can have a potential advantage to BRONJ patients. In this case report, we presented 3 BRONJ patients treated by BFP pedicle flap after sequestrectomy.
Repair of Unilateral Incomplete Lesser Form Cleft Lip
Park, Hye Jeong ; Jung, Hwi-Dong ; Mulliken, John Butler ; Jung, Young-Soo ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 178~183
DOI : 10.14402/jkamprs.2013.35.3.178
Cleft lip arises from congenital underdevelopment with various degrees and patterns. Mulliken named a unilateral incomplete cleft lip with no severe cleft as a lesser-form cleft lip and categorized it into three subgroups. Anatomically categorized subgroups are minor-form, microform, and mini-microform cleft by the extent of vermilion-cutaneous dysjuntion. The vermillion cutaneous notch is more than 3 mm from the regular Cupid's bow peak for minor-form, less than 3 mm for microform, and almost no gap with discontinuity on the vermillion cutaneous border for mini-microform. The treatments are rotational advancement flap for minor-form, double unillimb Z-plasty for microform, and vertical lenticular excision for mini-microform, respectively. This article aims to present the literature review about the incomplete lesser form cleft lip classified by Mulliken and to report our experiences.
Correction of the Traumatic Enophthalmos Using Titanium Reinforced Porous Polyethylene
Lee, Jae-Yeol ; Kim, Yong-Deok ; Shin, Sang-Hun ; Kim, Uk-Kyu ; Chung, In-Kyo ; Hwang, Dae-Seok ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 184~188
DOI : 10.14402/jkamprs.2013.35.3.184
Post-traumatic enophthalmos is a relatively common problem following orbitozygomatic fractures. Bony-volume expansion and soft tissue atrophy are considered the main etiological causes of this condition. Enophthalmos is corrected mostly through reducing the enlarged orbit volume. Autogenous graft and various alloplastic materials are used for this purpose. Porous polyethylene is highly biocompatible, durable, and remarkably stable. Also, the titanium plate embedded in a porous polyethylene sheet provides radiographic visibility and increased sheet strength and contour retention. We present experiences of titanium reinforced porous polyethylene for correction of the traumatic enophthalmos with literature review.
Treatment of Osteochondroma of the Mandibular Condyle with Inferior Adhesion of Meniscus: A Case Report
Seol, Dong-Ju ; Choi, Byung-Joon ; Kim, Yeo-Gab ; Lee, Baek-Soo ; Ohe, Joo-Young ; Lim, Ji-Min ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 189~194
DOI : 10.14402/jkamprs.2013.35.3.189
Osteochondroma is a benign neoplasm, osseous projection surrounded with cartilage, 35.8% of benign osseous tumor, 8.5% of whole osseous tumor and usually arises from the skeletal bone. Osteochondroma is a cartilaginous derivation and relatively uncommon in the craniofacial bone. Osteochondroma of the mandible has slow growth rates which mainly affect women around forty years of age and it can appear through the coronoid process and mandibular condyle, especially in the medial half. Clinical finding associated with osteochondroma of condyle are primarily a palpable, painless temporomandibular area mass with facial asymmetry, malocclusion and midline deviations. Sometimes pain and dysfunction like trismus often accompany the anatomic derangement. Other features include malocclusion with open-bite on the affected side and cross-bite on the contralateral side. In this study, a 45-years old female patient exhibits pain on the left temporo-mandibular joint area and malocclusion due to loss of the molar region with osteochondroma on the top left of her mandibular condyle head. The patient is able to recover gradually from the symptom through treatments on manipulation, stabilization splint, arthroscopic lavage and surgical excision, thus, this is reported as a clinical case.
Pseudoaneurysm of the Inferior Alveolar Artery after Surgical Curettage for Keratocystic Odontogenic Tumor: A Case Report
Lee, Sang-Chang ; Kim, Jong-Bae ; Chin, Byung-Rho ; Kim, Jin-Wook ; Kim, Chin-Soo ; Kwon, Tae-Geon ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 195~199
DOI : 10.14402/jkamprs.2013.35.3.195
Pseudoaneurysms are rare complications of orgthognathic surgery, trauma or other surgical procedures in the head and neck regions. Surgical approach is a routine procedure of bleeding control. However, bleeding control using angiography and embolization can also be an excellent method. We experienced pseudoaneurysm of the inferior alveolar artery occurring after surgical curettage of cystic lesion. The 33-year-old man who underwent surgical curettage of keratocystic odontogenic tumor was presented with severe bleeding in the right mandible ramal inner surface 14 days after the surgical curettage. After hemostasis with vaseline gauze packing and pressure, bleeding temporarily stopped. However, bleeding started after 14 days and soon it has been continued. Finally, the patient was diagnosed as pseudoaneurysm of the inferior alveolar artery from the enhanced-computed tomography images, and angiographic embolization was performed successfully. We report a rare case of pseudoaneurysm of the inferior alveolar artery after benign tumor curettage and review of the previewer's literature.
Application of Perforator Flap for the Oral and Maxillofacial Reconstruction
Kim, Soung Min ; Oh, Jin Sil ; Kang, Ji Young ; Myoung, Hoon ; Lee, Jong Ho ;
Maxillofacial Plastic and Reconstructive Surgery, volume 35, issue 3, 2013, Pages 200~209
DOI : 10.14402/jkamprs.2013.35.3.200
Over the past few years, a large number of perforator flaps have been revised by several microsurgeons in the USA, France, Canada and Japan. A perforator flap is a flap of skin or subcutaneous tissue that is based on the dissection of a perforating vessel, which is a perforator. In short, a perforator is a vessel that has its origin in one of the axial vessels of the human body. By reducing any muscle harvesting and trauma to a minimum, perforator flaps aim to minimize donor site morbidity, and by avoiding the transfer of dennervated muscle, the long-term bulk of the free tissue transfer becomes more predictable. There are a finite number of potential perforator flaps in the body, which are based on the named source arteries. The most commonly used perforator flaps are deep inferior epigastric perforator, superior gluteal artery perforator, thoraco dorsal artery perforator, medial sural artery perforator, and anterolateral thigh perforator flap. For a better understanding of perforators as a routine reconstructive procedure in oral and maxillofacial surgery, the definition with nomenclature, classifications with special characteristics, and review points for their individual applications must be learned and memorized by the young doctors in the course regarding the special curriculum periods for the Korean national board of oral and maxillofacial surgery. Perforator flaps have been known to have many advantages, so this review article summarized their applications to the maxillofacial reconstruction in the Korean language.