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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Biomedical Engineering Research
Journal Basic Information
Journal DOI :
The Korea Society of Medical and Biological Engineering
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Volume & Issues
Volume 14, Issue 4 - Dec 1993
Volume 14, Issue 3 - Sep 1993
Volume 14, Issue 2 - Jun 1993
Volume 14, Issue 1 - Mar 1993
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Synthesis of Model Microspheres and Adsorption Study of Bovine Albumin
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 209~220
Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, Immunomagnetic cell separation. To synthesize micro-spheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio or synthesized microspheres was always smatter than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6-13 times higher than thats of the ml crospheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin Is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption Isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin ) . The effect of the kind and the amount of surface functional group was also examined.p was also examined.
Design and Diafiltration Performance of Modified Cellulose and Regenerated Cellulose Hollow Fiber Membrane Hemodiafilter
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 221~226
Modules of hemodiafilter were manufactured by using MC-Hp200 and RC-HP4DOA hoi low fiber membranes of Enka Co. in a unique design. The performances of she hemodiafillers were evaluated by measuring the molecular weight cut-off, ultrafiltration rate, clearance, and pressure drop across the hemodiafiter. As a whole, the performances of the RC-HP400A module were superior to those of the MC-Hp200 module. The modules prepared in thls study showed the satisfactory performances for hemodiafiltration.
Design and Filtration Performance of Polysulfone Hollow Fiber Membrane Hemofilter
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 227~234
Hemofilter was optimally designed and manufactured using polysulfone hollow fiber mem- brane with surface area of 0.6mE Molecular weight cut-off of the hemofilter was measured with polyethylene glycol and dextran aqueous solutions of various molecular weights and it was ranged from 9,500 to 38,900. Ultrafiltration rates were measured with pure water in a static system and flowing system. The clearance of urea, creatinlne, and vitamine BIB were measured using aqueous solutions.
The Application of 3-dimensional Surface Imaging to the Early Detection of Sacroiliitis
Jeon, Jae-Han ; Kim, Seon-Il ; Lee, Du-Su ;
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 235~242
In the early stage of sacroilitis, it is'difficult to detect sacroiliac(Sl) abnormalities by conventional plain X-ray even though there are characteristic symptoms of ankylosing spondylitis. 3 dimensional volume rendering from the CT image was performed to make an early de tection of the structural changes of Sl joint. 2 cases who had clinical impression of ankylosing spondylitis without sacroilitis in plane X-ray and 1 case of typical ankylosing spondylitis as well as 1 case of normal control were studied. The Sl Joints were separated and each joint surface of sacrum and ilium was independently reconstructed by a special 3D manipulation program. All 2 patiant who complained of inflammatory lower back pain with no abnormal findings in the plain X-ray showed structural changes in 3 dimensionally reconstructed surface Image of the Sl joint compared to the normal control. Authors tried several parameters, such as fourler analysis of each surface and the mean and variance of Sl joint gap. We couldn't tell the statistical significance because of the limited number of cases. However, the parameters showed difference according to the progression of disease.
On the Development of a Video Endoscope Having a Swallowable Insertion Tube
Wooshik Kim ; Woo ;
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 243~250
An endoscope is a medical device which observes the inner surface of an organ inside a body. Recently, a new type of endoscope using a CCD image sensor has been developed and turned out to have many strong points over the conventional optical fiber endoscope system. A swallowable insertion tube is an insertion tube having so small a diameter that the head of the insertion tube can reach the end of stomach only by mechanical movement of the esphagus and stomach or the patient's external movement. This paper presents some of the results that the Institute of Biomedical Engineering at Seoul National University has obtained while developing an electronic endoscope having a swallowable insertion tube. After some of the features of the developed system are presented, some of the image processing techniaues are addressed.
Stimulus Artifact Suppression on the type of Nerve Stimulator
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 251~256
The conduction velocity of the nerve is of importance to the diagnosis of various negromuscular disorders. A major technical problem encountered in nerve stimulation technique is the control of stimulus artifact and the convenience of nerve stimulator. The remained artifacts must be removed by processing the contaminated signal. This paper discusses about the artifact cancellation algorithms in constant voltage type nerve stimulator(CVS) and constant current type nerve stimulator(CCS).
Fabrication of Glass Ceramics for Dental Artificial Tooth(II) -Biocompatibility-
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 257~264
A study on the biocompatibility of two types of new glass-ceramics materials, metal disc and dental porcelain that were already made for dental artificial tooth in the previous study, have been attempted. The chemical behavior and the Victor's hardness change in she artificial saliva and Ringer's solution have been also investigated. From the experiment of Implantation of glass-ceramics Into dorsal subcutaneous tissue of Sprague-Dawley rats, glass-cerarmics did not show any particular system of rejection for histrocompatibility.
Waveform Detection Algorithm based on the Search of Distinctive Line-Segments
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 265~272
We present a new waveform detection method, based on the search of distinctive line-segments. The method is based on the basic assumption that the waveform morphology of biological signals is readily characterized by a sequence of the distinctive line-segments and their structural features. In this method, the distinctive line-segments are first searched for, and a structural feature analysis is performed an the distinctive line-segments found. Experiments of detecting epileptic spikes were carried out to evaluate the detection per formance of the method. Two subjects were used for training and tuning the algorithm and four subjects for testing the method. The results were obtained on two different performance indices, detection ratio and the number of false detections per minute.
A Basic Study on the Variation of Temperature Characteristics for Attenuation Coefficient and Sound Velocity in Biological Tissues
Park, Heung-Ho ;
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 273~282
This study is concerned with the temperature dependence characteristics of ultrasound parameters in biological tissues, which are basic on the noninvasive deep body temperature estimation. Used parameters are ultrasonic attenuation coefficient and sound velocity In order to accomplishment our purpose, several signal processing methods were used. Attenua4iorl coefficient was estimated by spectral difference method and sound velocity was estimated by P-P method. And we also examined these methods through a series of IN VITRO experi mentis that used tissue-mimicking phantom samples and biological tissue samples. In order to imitate the biological soft tissue two kinds of phantom samples are used, one is agar phantom sample which is composed of agar, graphite, N-propyl alcohol and distilled water, and the other is fat phantom sample which is composed of pure animal fat. And the ultrasound transmission mode and reflection mode experiments are performed on the pig's spleen, kidney and fat. As a result, it is found that the temperature characteristics are uniform in case of phan- tom samples but not in biological tissues because of complicate wave propagation within them. Consequently, the possibility of temperature measurement using ultrasound on biological tissue is confirmed and its results may contribute to the establishment of reference values of internal temperature measurement of biological tissues.
A Study of the Characteristics of Cast Ni-Ti Alloy for Biomaterial with Compositional Change
Journal of Biomedical Engineering Research, volume 14, issue 3, 1993, Pages 283~290
In thls study, the effects of the composltional change of cast Ni-Ti alloys on its characteristics including mechanical properties, phase transformation temperature, and ion releasing rate were investigated. brittle:behavior was shown in the stress-strain curve of the alloy containing low Ti content (Ni-44.0%Ti). By increasing the Ti content, the trend in stress-strain curves changed from that of superelasticity to that of shape memory effect(Ni-44.4%Ti, Ni-45.1%Ti, Ni-45, 5%Ti). Phase transformation temperature (
point) increased with increasing the Ti content. lon releasing rate of four types of Mi-Ti alloys was very low compared to that of the dental commerical Ni-Cr alloy.