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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Biomedical Engineering Research
Journal Basic Information
Journal DOI :
The Korea Society of Medical and Biological Engineering
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Volume & Issues
Volume 15, Issue 4 - Dec 1994
Volume 15, Issue 3 - Sep 1994
Volume 15, Issue 2 - Jun 1994
Volume 15, Issue 1 - Mar 1994
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A Basic Study for the Development of Electrio-Cell Fusion Device and Performance-Improvement
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 1~8
Electrofusion of cabbage protoplasts was performed with a developed equipment which consists of a parallel wire electrode, a AC field generator, and a pulse generator. Exposure of protoplasts to an alternating current field of 450 KHz causes attraction to each other which leads to chains of protoplasts extending from the electrode. Intra-specific protoplast fusion was effectively induced within the pearl chains by the additional application of a single high-intensity DC square wave pulse of 1 KV/cm for 1-3 msec. To improve the performance, micro fusion electrode fabricated from the semiconductor technology and microcontroller based field an, d pulse generator was proposed. The viability of protoplasts after an application of electric field at optimum condition was reduced by only 5 % compared with that of pre-application. A prototype of fusion electrode, which consists of insulator-structure, was successfully fabricated by using photosensitive polyimide.
Targets of Antithrombotic and Fibrinolytic Therapy
Sun-Ok Kim ;
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 9~18
In Vivo Blood Compatibility of PU-PEO-SO3 as Coating Material for Blood Sac of Left Ventricular Assist Device ( LVAD)
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 19~26
Sulfonated poly (ethyleneoxide)-grafted polyurethane (PU-PEO-
) prepared by bulk modification was coated on a blood sac for electrohydraulic left ventricular assist device (ELVAD) implanted in dogs and its in vivo blood compatibility on shear stress was studied as compared with untreated Po. The effect of the wall shear stress on the protein adsorption unlike platelet adhesion is dependent on the surface characteristics of the material, although less proteins seem to be adsorbed in the region of the high shear stress. The thickness of total proteins adsorbed on PU-PEO-SOJ (400
) by trans¬mission electron microscopy(TEM) was considerably lower than that of untreated PU(l,000~1,600
), but PU-PEO-
showed high albumin adsorption, low fibrinogen and IgG adsorption, and low platelet adhesion as compared with untreated PU, suggesting that PU-PEO-
is more in vivo blood compatible. Therefore, it appears that such a blood compatible PU-PEO-
is useful for blood contacting biomaterials including artificial organs.
The Corridor Scene Analysis for a Motorized Wheelchair's Automatic Locomotion
Moon, Cheol-Hong ; Han, Yeong-Hwan ; Hong, Seung-Hong ;
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 27~34
In this paper. a way to analysis a corridor scene for a vehicle's automatic locomotion is presented In general, it's necessary for a vision system of vehicles to identify its positions in given environments. The suggested algorithm is to decide base lines of a corridor image using the vanishing point finding. Feature points are extracted on the base line using a base line extraction tree. This algorithm is suitable for a motorized wheelchair's self locomotion in a building.
An Experimental Study for the Relationship of Photon Flux Path ann Layered Properties of Biological Tissue with S- D Separation
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 35~40
A probe was designed to study the relationship of photon flux path and layered properties of bilogical tissue. The result shows that different wavelengths have different flux path and maximum reflectance position with separation. The source-detector separations on maximum reflectance of IR and GR were 7.5 mm and 2.5 mmm each other and layered properties of tissue can be discriminated bye the change of S-D separation using designed probe.
The Characterization of Mass Transfer Factors in Neuroblastoma Implanted in Immunosuppressed Nude Rats
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 41~50
The chemotherapy using macromolecules, i.e., monoclonal antibodies loaded with anticancer agents hasn't been successful in delivering therapeutic amount of the conjugates. The comprehensive evaluation of mass transfer factors in tumor is prerequisite for the development of the effective chemotherapy. Characterization of neuroblastoma implanted in immunosuppressed athymic nude rats was performed. Its growth kinetics, glucose metabolic rate (GMR) were measured along with the interstitial fluid pressure (IFP), blood perfusion rate (BPR) and pH distribution throughtout the tumor radius. Volume doubling time and GMR were 8.1 days(SD 0.44 day), 23.53 mg/min/100 g(SD 3.54 mg/min/100 g), respectively. The IFP in tumor center was increased with tumor volume, and approached to 3 mmHg (SD 2.6 mmHg) when the tumor was 3 cm high. The radial distribution of IFP, BPR and pH in 2 cm high tumors showed that BPR and pH were decreased, while IFP was increased as the ~ensors moved toward the tumor center. The elevated IFP, decreased BPR and pH in tumor center suggested that the delivery of conjugates might be increased by properly manipulating mass transfer factors.
Computer Model for Fibrinogen Adsorption on Polyurethane Surface
Kim, Jong-Won ; Shin, In-Sun ; Ryu, Gyu-Ha ; Lee, Kyu-Back ; Han, Dong-Keun ; Kim, Young-Ha ; Min, Byoung-Goo ;
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 51~56
Protein adsorption on the polyurethane surface was modelled by a modified random sequential adsorption(RSA) process. In this model, polyurethane surface was modelled as a mixed domain of hydrophobic and hydrophilic parts which was implemented by a 2 dimensional
lattice in the computer. Protein adsorption was simulated using a small box which represents a particle of the protein, and polyurethane lattice by considering their hydrophobic interaction. In order to validate the model, we perfonned fibrinogen adsorption on polyurethane surface. Isotherms of the adsorbed protein were calculated and compared to the experimental data. The protein adsorption on the polyurethane surface could be well described using this computer model.
Hybrid Block Coding of Medical Images Using the Characteristics of Human Visual System
Park, Kwang-Suk ; Chee, Young-Joon ;
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 57~62
The demand of image compression is increasing now for the integration of medical images into the hospital information system. Even though the quantitative distortion can be measured from the difference between original and reconstructed images, it doesn't include the nonlinear characteristics of human visual system. In this study, we have evaluated the nonlinear characteristics of human visual system and applied them to the compression of medical images. The distortion measures which reflect the characteristics of human visual system has been considered. This image compression procedure consists of coding scheme using JND (Just Noticeable Difference) curve, polynomial approximation and BTC (Block Truncation Coding). Results show that this method can be applied to CT images, scanned film images and other kinds of medical images with the compression ratio of 5-10:1 without any noticeable distortion.
Medical Image Workstation Using Multimedia Technique
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 63~70
A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors'reporting results. Input int'ormation was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and Analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed id'ormation can be transferred for patient diagnosis through LAN (local area network).
The Influence of the Number of Electrodes, the Position and Direction of a Single Dipole on the Relation Between S/N ratio and EEG Dipole Source Estimation Errors
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 71~76
In the source localization using single dipole model, the influence of the number of electrodes, the position and direction of a single dipole on the relation between S/W ratio and dipole parameter estimation errors is important. Monte Carlo simulation was used to investigate this influence. The forward problem was calculated using three spherical shell model, and dipole parameters were optimized by means of simplex method. As the number of electrodes became large, as the dipole went from midbrain to cortex, and as the direction of dipole changed from radial to tangential, the average and standard deviation of estimation errors became small.
A Study on the Sensory Motor Coordination to Visual and Sound Stimulation
Kim, Nam-Gyun ; Ko, Yong-Ho ; Ifukube, T. ;
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 77~82
We investigated the characteristic of the sensory motor coordination by measuring the hand point ins and the gaze movement to the visual and sound stimulation. Our results showed that the gaze vol ocity to sound stimulation did not depend on stimulation direction, but lagged behind 0.2 sec toward the pheriperal direction to the visual stimulation. Our data showed that to both visual and sound stimulation, the error of hand pointing value increased with an increasement of eccentricity.
Transform Trellis Image Coding Using a Training Algorithm
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 83~88
The transform trellis code is an optimal source code as a block size and the constraint length of a shift register go to infinite for stationary Gaussian sources with the squared-error distortion measure. However to implement this code, we have to choose the finite block size and constraint length. Moreover real-world sources are inherently non stationary. To overcome these difficulties, we developed a training algorithm for the transform trellis code. The trained transform trellis code which uses the same rates to each block led to a variation in the resulting distortion from one block to another. To alleviate this non-uniformity in the encoded image, we constructed clusters from the variance of the training data and assigned different rates for each cluster.
Synthesis and Physical Properties of Bioc'ompatible and Biodegradable Chitin Derivatives V. -Biodegradation of liquid Crystalline Chitin Derivatives by Lysozyme-
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 89~96
The ether-type chitin derivatives were synthesized by reacting chitin with chloropropane, propylene oxide and chloropropane diol to form propyl chitin(PPC), hydroxypropyl chitin(HPC) and dihydroxypropyl chitin(DHPC). These derivatives formed a lyotropic cholesteric liquid crystallinity in concentrations over 30 wt% solution in formic acid (99%). Cast films from liquid crystalline solutions were degraded by lysozyme in pseudo-extra cellular tluid(PECF)solutions, at pH 1.2, pH 6.7 and pH 8.2. Three ether-type chitin derivatives rapidly degraded within the first week, and showed a decreased mechanical strength in neutral pH range. Dihydroxypropyl chitin showed the best biodegradation among these derivatives.
Realization of Optic Systems for the Infrared Thermography
Lee, Soo-Yeol ; Woo, Eung-Je ; Cho, Min-Hyoung ;
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 97~104
In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensionaloptic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the infrared thermography system composed ofthe proposed optic system has the temperature resolution of
under the spatial resolution of 1mrad, the image matrix size of
, and the imaging time of 4 seconds.
The Estimation of Source Locations Based on Potential Gradients of In terpolation Polynomials of EEG Records
Journal of Biomedical Engineering Research, volume 15, issue 1, 1994, Pages 105~110
In this paper, we present a method to evaluate source locations and distributed region which is specified brain activity, as indicated by locations and strengths of intracranial sources, using potential gradients of interpolation polynomials and topographic mapping of the EEG records. This method can analyze the variance of source temporally or spatially and leads to enable a quantitative evaluation of potential gradients drawing methods which is now being used in the clinic. In the result, we obtained the overall potentials distribution on the entire scalp and the information of potential source locations from the EEG records of a patient which was known to epilepsy.