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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Biomedical Engineering Research
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Journal DOI :
The Korea Society of Medical and Biological Engineering
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Volume & Issues
Volume 18, Issue 4 - Dec 1997
Volume 18, Issue 3 - Sep 1997
Volume 18, Issue 2 - Jun 1997
Volume 18, Issue 1 - Mar 1997
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Gamma-Irradiated Ultra-high Molecular Weight Polyethylene : Anisotropic Changes in Crystallinity and Crosslinking
Lee, Kwon-Yong ;
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 107~112
The effect of gamma-irradiation sterilization on molecular structural changes in orthopaedic surgical-grade polyethylene was studied. The relative crystallinity ud. percent crosslinking of the substance increased as a result of the gamma irradiation and varied anisotropically as a function of depth. Samples from the articulating surfaces showed 5% Venter relative crystallinity than those from the mid-sections, whereas samples from the mid-sections exhibited 15% greater crosslinking than those from the surfaces. These anisotropic variations are discussed in assDciation with oxidation.
A Study on the Optimal Design for the reconstruction Filter in Single Photon Emission Computed Tomography (SPECT)
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 113~120
This paper presents an optimal design for the SPECT reconstruction filter, based on a physical limit of SPECT lesion detection capability. To increase the performance of the filter on lesion detectability, the filter design was focused on increasing the local SyW ratio of a threshold lesion, that was determined by minimum detectable lesion size (MDU) from SPECT lesion detectabllity contrast-detail curve. The proposed filter showed flexible window characteristics of resolution recovery and noise smoothing for MDLSs in the resolution-limited and photon-limited regions, respectively, compennting for the relative impact of the main limitation factors on threshold detectability. The simulated results showed good adaptability of the proposed filter to the changes in physical parameters of photon counts, object contrast, and detector system resolution.
Development of Digital Endoscopic Image Processing System
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 121~126
Endoscopy has become a crucial diagnostic and therapeutic procedure in clinical areas. Over the past three years, we have developed a computerized system to record and store clinical data pertaining to endoscopic surgery of laparascopic cholecystectomy, pelviscopic endometriosis, and surgical arthroscopy. In this study, we developed a computer system, which is composed of a frame yabber, a sound board, a VCR control board, a LAN card and EDMS(endoscopic data management software. Also, computer system has controled peripheral instruments such as a color video printer, a video cassette recorder, and endoscopic input/output signals(image and doctor's comment). Digital endoscopic data management system is based on open architecture and a set of widely available industry standards, namely: windows 3.1 as a operating system, TCP/IP as a network protocol and a time sequence based database that handles both images and doctor's cotnments. For the purpose of data storage, we used MOD and CD-R. Digital endoscopic system was designed to be able to store, recreate, change, and compress signals and medical images.
Development of lontophoresis System for Transdermal Drug Delivery
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 127~132
Recently there has been increased interest in the use of iontophoresis for the transdermal delivery of drugs, both ionic and nonionic. The use of iontophoresis has been rare over the years due to the lack of domestic supplies of the instrument and the expensive iontophoresis instrument made by foreign country. The purpose of this study was to design a commercially available iontophoresis system (WIT- 1 ). The efficacy of WT- 1 system was well defined. In clinical trial, procaine iontophoresis produced local anesthesia of significantly longer duration than swabbing and placebo groups. The 4% procaine iontophoresis using WIT-1 significant difference in anesthetic duration between WIT- 1 system and IontopherTM PM system. The result of this study suggest that WIT-1 system can be used for the transdermal delivery of drugs in various clinical conditions.
Development of a Module-Based Bedside Monitor for Patient Monitoring
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 133~146
In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases, each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO with plethysmograph.raph.
A Study on the Evaluation of Hydrodynamic Performance of Trileaflet Prosthetic Heart Valves
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 147~156
Various prosthetic heart valves have been developed and used clinically, but they have problems, such as thrombogenecity, hemoltsis, high cost and low durability. New types of trileaflet polymer heart valves have been developed in order to use them as inlet and outlet valves in a ventricular assist device. The aim of this study is to determine the hydrodynamic effectiveness of the newly designed trileaflet polymer valves and their feasibility for temporary use in the blood pumps. Trileaflet polymer valves are made of polyurethane, because of its good blood compatibility, high tonsil strength and good resistance to fatigue. An in vitro experimental investigation was perf'ormed in order to ev91ua1e hydrodynamic performance of the trileaflet polymer valves having different design and fabrication tech- niques. The St. Jude Medical valve (SJMV) and floating-type monoleaflet polymer valve (MLPV) were also tested The pressure drop across the valve, leakage volume, and the flow patterns mere investigated for valves. The result of comparative tests showed that the trileaflet polymer valves had a better hydrodynamic performance than the others. TPV which has two stable membrane shape showed the lowest back flow. The pressure hops of TPVs were lower than that of MLPV, but slightly higher than SJMV. The hydrodynamic performance of valves under the pulastile flow showed the similar results as steady flow. The velocity profiles and turbulent intensities were measured at the distal sites of valves using a hot-film anemometer. Central flow was maintained in trileaflet polymer valves, and the maximum turbulent intensities were lower in TPVs comparing to MLPV.
A Quantitative Assissment of Static ann Dynamic Postural Sway in Normal Adults
Shin, Y.I. ; Kim, Y.H. ; Kim, N.G. ;
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 157~166
Postural balancing in human is known to be maintained by the complex mechanism coupled with cerebellum, equilibrium organ of ear, proprioception and other various organs. We developed a Computerized Balance Evaluation and Training system(COBET system) to evaluate postural control and to rehabilitate geriatrics and disabled patient. In addition, 55 normal adult were tested to investigate the influencing factors on balancing posture. For the analysis of static postural sway, areas of the moving center of pressure were calculated under 8 different positions of subjects. And subjects were also asked to follow the visual targets on monitor for the evaluation of the dynamic postural sway. In comparison of the first and the second sets of tests, there was test-retest reliability(
< 0.05). The controllability of the static pmtwn sway was decreased as the ages of subjects increase. When the ages of subject are over 60, the controllability was significantly decrease4 The dynamic postural sway was significantly greater in the age groups of 7th and 8th decade than the younger groups. It is concluded that COBET system is a reliable system in the evaluation of postural sway. The COBET system is considered to be a valuable training modality for the disabled patients as well as the elderly.
Application of NMR Microscopy for the Study of the Swelling Effect in Biopolymers
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 167~172
Novel measurement method has been performed for the noninvasive study of the swelling effect detected in hydrophilic polymers using Magnetic Resonance Microscopy. iN NMR images were acquired to measure geometric changes due to the swelling effect occurred in the polymer specimens. In addition to the geometric changes, the water ingress process was visualized noninvgsively. The measurement method performed .in the present study utilized some of NMR's valuable properties, both noninvasiveness and parameter selectivity. It is believed that the method used in the present study may be applicable to the study of biopolymers in which noninvasiveness is particularly important.
Noninvasive study of Drug Delivery Systems using Nuclear Magnetic Resonance Microimaging
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 173~178
pH sensitive polymers have long been utilized as one important type among many interesting drug delivery systems. This is due to the reason of different pH environments in human organs, which requires different pH control mechanism depending upon the organs. In the present study the pH sensitivity was investigated for both pH sensitive and pH insensitive biopolymers using the diffusion effect along with the swelling effect. NMR microscopy was performed along with optical microscopy. For the analysis of diffusion effect, UMR Microscopy was perFormed to measure diffusion coefficients for various liquids such as distilled water, acetone and DMSO(dimethyl sulfoxide). Also, this technique is expected to contribute to the studies for many pH drug delivery systems.
Velocity and Shear Stress Distributions for Steady and Physiological Flows in the Abdominal Aorta/lLIAC Artery Bifurcation
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 179~186
Steady and physiological flows of a Newtonian fluid and blood in the abdominal gorta/iliac artery bifurcation are numerically simulated to understand the etiology and pathogenesis of atherosclerosis. Distributions of velocity, pressure, and wall shear stress in the bifurcated arterial vessel model are calculated to investigate the differences of flow characteristics between steady and physiological flows and to compare flow characteristics of blood with that of a Newtonian fluid For the given Reynolds number the flow characteristics of physiological flows for a Newtonian fluid and blood in the bifurcated arterial vessel are quite different from thcse of steady flows. No flow separation or flow reversal in the bifurcated region appears downstream of a stenosis during the acceleration phase. However, during the deceleration phase the flow exhibits flow separation in the outer walls of daugtlter branches, which extends to the entire wall region.
3-D Flow Analysis of Blood and Blood Substitutes in a Double Branching Model
Suh, Sang-Ho ; Yoo, Sang-Sin ; Roh, Hyung-Woon ;
Journal of Biomedical Engineering Research, volume 18, issue 2, 1997, Pages 187~196
The three-dimensional flow analysis using the finite volume method is presented to compare the steady flow characteristics of blood with those of blood substitutes such as water and aqueous polymer solution in an idealized double branching model. The model is used to simlllate the region of the abdominal aorta near the celiac and superior mesenteric branches. Apparent viscosities of blood and the aqueous Separan solution are represented as a function of shear rate by the Carreau model, Water and aqueoiu Separan AP-273 500wppm solution are frequently used as blood substitutes in vitro experiments. Water is a typical Newtonian fluid and blood and Separan solution are non-Newtonian fluids. Flow phenomena such as velocity distribution, pressure variation and wall shear stress distribution of water, blood and polymer solution are quite different due to differences of the rheological characteristics of fluids. Flow phenomena of polymer solution are qualitatively similar to those of blood but the phenomena of water are quite different from those of blood and polymer solution. It is recommended that a lion-Newtonian fluid which exhibits very similar rheological behavior to blood be used in vitro experiments. A non-Newtonian fluid whose rheological characteristics are very similar to those of blood should be used to obtain the meaninylll hemodynamic data for blood flow in vitro experiment and by numerical analysis