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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Biomedical Engineering Research
Journal Basic Information
Journal DOI :
The Korea Society of Medical and Biological Engineering
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Volume & Issues
Volume 19, Issue 6 - Dec 1998
Volume 19, Issue 5 - Oct 1998
Volume 19, Issue 4 - Aug 1998
Volume 19, Issue 3 - Jun 1998
Volume 19, Issue 2 - Apr 1998
Volume 19, Issue 1 - Feb 1998
Selecting the target year
Formation of Spheroids of Adult Rat Primary Hepatocytes in Polyurethane Foam
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 215~224
This paper is fundamental study to develope the extracorporeal liver support system for patient with fulminant hepatic failure(FHF) or being expected for orthotopic liver transplantation. The polyurethane foam, which is composed of the density of 33kg/m3, the average pore diameter of 500
, the closed window of 60-70%, was manufactured with the prepolymer of 15% NCO-, Hepatocytes were inoculated to form spheroids in polyurethane foam. The time of spheroid formation in BSA(Bovine Serum Albumin) coated polyurethane foam was shorter than that in raw polyurethane foam. To verify the function of hepatocyte spheroids, we measured ammonia removal rate, urea and albumin secretion rate. Polyurethane foam was suitable for culture of hepatocyte spheroids. And culture of hepatocyte spheroids in polyurethane foam has high possibility in using as an extracorporeal liver support system.
Monte Carlo Studies on an Amorphous Silicon (a-Si:H) Digital X-Ray Imaging Device
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 225~232
Results of Monte Carlo simulations on amorphous silicon based x-ray imaging arrays are described. In order to investigate the characteristics of amorphous silicon x-ray imaging devices and to provide the optimum design parameter, Monte Carlo simulations were performed. Monte Carlo simulation codes for our purpose were developed and various combinations of x-ray peak voltages, aluminum filter thicknesses, CsI(TI) thicknesses, and amorphous silicon photodiode pixel sizes were tested in connection with detection efficiency and spatial resolution of the amorphous silicon based x-ray imager. With usual Csl(TI) thickness of 300
, detection efficiency was in the range of 70%-95% and energy absorption efficiency was in the range of 40%-70% for 60kVp-120kVp x-ray. From the simulations it was found that amorphous silicon pixel size and Csl(TI) thickness were the most important parameters which determine the resolution of the imager. By use of our simulation results we could provide proper combinations of Csl(TI) thicknesses and pixels sizes for optimum sensitivity and resolution.
Automatic Disk Disease Recognition based on Feature Vector in T-L Spine Magnetic Resonance Image
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 233~242
In anatomical aspects, magnetic resonance image offers more accurate information than other medical images such as X ray ultrasonic and CT images. This paper introduces a method that recognizes disk diseases from spine MR images. In this method, image enhancement, image segmentation and feature extraction for sagittal plane and axial plane images are performed to separate the disk region. And then template matching method is used to extract disease region for axial plane imges. Finally, disease feature vectors are integrated and disease discrimination processes are performed. Experimental results show that the proposed method discriminates between normal and diseased disk with a considerable recognition ratio.
Improved Reconstruction Algorithm for Spiral Scan Fast MR Imaging with DC offset Correction
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 243~250
Reconstruction aspects of spiral scan imaging for ultra fast magnetic resonance imagine(MRI) have been investigated with polar and rectangular coordinates-based reconstruction. For the reconstruction of the spiral scan imaging, acquired data in spiral trjectory should be converted to polar or rectangular grids, where interpolation techniques are used. Various reconstruction algorithms for spiral scan imaging are tested, and reconstructed image qualities are compared with computed phantom. An improved reconstruction algorithm with dc-offset correction in projection domain is proposed, which provides the best reconstructed image quality from the simulation. Image artifact with existing algorithms is completely removed with the proposed method.
Design of a Holter Monitoring System with Flash Memory Card
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 251~260
The Holter monitoring system is a widely used noninvasive diagnostic tool for ambulatory patient who may be at risk from latent life-threatening cardiac abnormalities. In this paper, we design a high performance intelligent holter monitoring system which is characterized by the small-sized and the low-power consumption. The system hardware consists of one-chip microcontroller(68HC11E9), ECG preprocessing circuit, and flash memory card. ECG preprocessing circuit is made of ECG preamplifier with gain of 250, 500 and 1000, the bandpass filter with bandwidth of 0.05-100Hz, the auto-balancing circuit and the saturation-calibrating circuit to eliminate baseline wandering, ECG signal sampled at 240 samples/sec is converted to the digital signal. We use a linear recursive filter and preprocessing algorithm to detect the ECG parameters which are QRS complex, and Q-R-T points, ST-level, HR, QT interval. The long-term acquired ECG signals and diagnostic parameters are compressed by the MFan(Modified Fan) and the delta modulation method. To easily interface with the PC based analyzer program which is operated in DOS and Windows, the compressed data, that are compatible to FFS(flash file system) format, are stored at the flash memory card with SBF(symmetric block format).
Development of Detection and Analysis System for Electrogastrographic Signal
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 261~268
Electrogastrography(EGG), the cutaneous recording of the myoelectrical activity of the stomach using surface electrodes, is a non-invasive technique to detect gastric motility disorder, We developed a detection and analysis system for the EGG signal, which consists of hardware(bio-amplifier, filter) and softwere(user interface, analysis algorithm, patient database). The EGG signal was amplified and filtered by 3 channel bio-amplifiers, and simultaneously digitized and stored on IBM PC with a sampling frequency of 16 Hz. The stored EGG signal was analyzed using developed algorithm to extract clinically useful information from the signal. The developed system has tested through animal experiments, and is under clinical evaluation.
Development of a Stress ECG Analysis Algorithm Using Wavelet Transform
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 269~278
This paper describes a development of efficient stress ECG signal analysis algorithm. The algorithm consists of wavelet adaptive filter(WAF), QRS detector and ST segment detector. The WAF consists of a wavelet transform and an adaptive filter. The wavelet transform decomposed the ECG signal into seven levels using wavelet function for each high frequency bank and low frequency bank. The adaptive filter used the signal of the seventh lowest frequency band among the wavelet transformed signals as primary input. For detection of QRS complex, we made summed signals that are composed of high frequency bands including frequency component of QRS complex and applied the adaptive threshold method changing the amplitude of threshold according to RR interval. For evaluation of the performance of the WAF, we used two baseline wandering elimination filters including a standard filter and a general adaptive filter. WAF showed a better performance than compared filters in the noise elimination characteristics and signal distortion. For evaluation of WAF showed a better performance than compared filters in the noise elimination characteristics and signal distortion. For evaluation of results of QRS complex detection, we compared our algorithm with existing algorithms using MIT/BIH database. Our algorithm using summed signals showed the accuracy of 99.67% and the higher performance of QRS detection than existing algorithms. Also, we used European ST-T database and patient data to evaluate measurement of the ST segment and could measure the ST segment adaptively according to change of heart rate.
Blood Gas Management of a Membrane Oxygenator During Cardiac Surgery with Deep Hypothermic Circulatory Arrest
Kim, Won-Gon ; Im, Cheong ; Baek, In-Hyeok ;
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 279~284
Deep hypothermic circulatory arrest(DHCA), in which systemic temperatures of 2
or less are used to allow temporary cessation of the circulation, is an useful adjunct in cardiac surgery. Because man in natural circumstances is never exposed to the extreme hypothermic condition, however, one of the controversial aspects is appropriate blood gas management(
STAT versus PH-STAT) during DHCA. This study aims to compare
STAT with PH-STAT management for control of blood gases in experimental cardiopulmonary bypass(CPB) circuits with a membrane oxygenator. Fourteen young pigs were assigned to one of two strategies of gas manipulation. After a median sternotomy, CPB was established. Core cooling was initiated and continued until nasopharyngeal temperature fell below 2
. The flow rate was set at 2,500 ml/min. Once their temperatures were below 2
, the animals were subjected to circulatory arrest for 40mins. During cooling, blood gas was maintained according to either
STAT or pH-STAT strategies. After DHCA, the body was rewarmed to normal body temperature. Arterial blood gases were measured before the onset of CPB, before cooling, before DHCA, at the point of 27
during re-warming, on completion of re-warming. Cooling time was significantly shorter in
-STAT than PH-STAT strategy, while there was no significant differences in rewarming time between two groups. Carbon dioxide was added between 5.5 and 3.0% in PH-STAT, while no carbon dioxide was added in
STAT management. Amounts of oxygen administration were gradually lowered as temperature decreased. In this way, criteria of PH, PaCO, and PaO adjustments were satisfied in both
STAT and PH-STAT management groups.
Effect of Compliant Structure in the Accelerated Heart Valve Fatigue Tester on the Surface Pitting of the Disk
Kim, Dong-Uk ; Lee, Hwan-Seong ; Kim, Nam-Gyun ;
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 285~290
There are various reports on the fracture of mechanical heart valves implanted in human or animal, and they are pointed out that problems are induced by an erosion of disk surface, due to a cavitation effect. We have been investigating this mechanism using accelerated fatigue tester, and it was found that erosion was enhanced by a compliance effect in the test circuit. In this study, effects of compliance value and location on erosion were discussed, while disk closing velocity was measured by a high speed video camera. It was clarified that faster closing velocity was resulting in a enhancement of erosion on the disk surface.
Design of a Mechanical Artificial Heart Valve Prosthesis Appliing Design Methodology
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 291~296
A new mechanical heart valve prosthesis has been designed appling systematic design methodology. The function of the heart valve was defined, and search for design variation has been carried out according to the functional structure, Optimal model among the various variations was determined in view of the design specificationn. Proto type valve was fabricated and test has been carried out using a mock circulation system. It has been observed that the pressure profile, cardiac output and behavior characteristics are generally satisfactory.
The Effects of Distal Sinus on the Hydrodynamic Performance of the Prosthetic Heart Valves
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 297~303
The sinus distal to the prosthetic heart valve influences the valve closure behavior and velocity field near the valve, therefore affects the hydrodynamic performance of the prosthetic heart valve. In order to study the effects of valve distal geometry on the hydrodynamic performance of the prosthetic valves, mechanical bileaflet valve(SJMV), monoleaflet polymer valve(MLPV) and trileaflet polymer valve(FTPV) are inserted in the test sections which have the straight and the sinus shape distal to the valve. Leakage volumes and systolic mean pressure drops are measured in the pulsatile mock circulation flow loop. Leakage volumes are slightly less and systolic mean pressure drops are higher in the sinus test section comparing to those in the straight test section, but the differences are statistically insignificant. Flow waveforms are analyzed in order to predict the valve closure behavior. The distal sinus does not affect the closure of the MLPV, but early valve closure of SJMV is observed in the sinus test section. This effect is more significant in FTPV, and the reverse flow peak of FTPV is reduced in the sinus test section. Therefore the sinus distal to the valve can reduce the reverse flow jet caused by sudden valve closure.
Design of PC-based CR-PACS using Multiresolution Wavelet Transform
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 305~312
A small PACS based on PC is designed for CR. To receive the digital image from CR, a DICOM Interface Unit (DIU) is designed that complied with the medical image standard, DICOM V3.0. The CR images acquired through the DIU are stored in a file-server; the patient information of the images is stored in a database. To improve the performance of PC and to use it easily, multiresolution images are constructed by wavelet transform and displayed progressively. Wavelet compression method is newly adopted to store the images hierarchically to storage units. In this compression method, the image is decomposed into subclasses of image by wavelet transform, and then the subclasses of the image are vector quantized using a multiresolution codebook. The storage units for CR images were divided into the short-term storage in file-server and the harddisk in viewing station. Image processing tools supported by general PACS is implemented based on PC.
Emulation of Tri-Phasic Pulsatile Flow Using LVAD
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 313~320
Tri-phasic pulsatile flow is the general flow pattern of human circulary system. In emulating the various situation of cardiovascular system, it is essential to make tri-phasic source flow. To emulate tri-phasic pulsatile flow, we used electro-hydronic style LVAD(Left Ventricular Assist Device) with glass phantom and rubber tube. We have selected control parameters and examined the changing effect of each parameter by using Doppler ultrasound. In this experiment, it was shown that the distal compliance and the break time were the major factors to form tri-phasic flow. The results make it possible to emulate and explain the various situation of human vascular system. In this point, this results will be an useful method in the clinic application.
An Efficient Method for Estimating Average Speed of Sound in Ultrasound Medical Imaging
Journal of Biomedical Engineering Research, volume 19, issue 3, 1998, Pages 321~325
This paper presents a simple, practical, and efficient method for estimating the speed of sound in reflection mode in ultrasound medical imaging. Its accurate determination is indispensable in order to obtain both good resolution and correct geometrical and volumetric information about human organs such as heart and kidney. Up to now, there have been several methods available, but they all suffer from either poor performance or high complexity. The proposed method finds out an optimum focusing delay profile in such a way that the brightness in a region of interest is maximized using continuous dynamic focusing in receive under fixed transmit focusing. Experiments carried out on a real ultrasound medical phantom reveals that the method a quite simple and effective in providing good speed of sound estimation, hence improved resolution and images, adding to dignostic utility.