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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Biomedical Engineering Research
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Journal DOI :
The Korea Society of Medical and Biological Engineering
Editor in Chief :
Volume & Issues
Volume 22, Issue 6 - Dec 2001
Volume 22, Issue 5 - Oct 2001
Volume 22, Issue 4 - Aug 2001
Volume 22, Issue 3 - Jun 2001
Volume 22, Issue 2 - Apr 2001
Volume 22, Issue 1 - Feb 2001
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Successive Fuzzy Classification and Improved Parcellation Method for Brain Anlaysis
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 377~384
Generally. there have been limitations to investigate structural brain abnormalities with MR images for psychiatric patients. such as schizophrenia. depression and autism, since the brain abnormalities of psychiatric Patients are too small to be detected easily. It has been suggested to exploit the result of size-comparison or analysis of specified Part in various brain tissues. Results of brain analysis highly depend on accuracy of the brain segmentation because it is hard to segment image that the boundary between tissues in the brain MRI is inherently value. In this Paper. we improve the quality of brain segmentation so that we increase the credit of brain analysis. In addition, we Provide the improved images for studying brain abnormalities through left-right insular volume measure using handy software tool .
Magnetic Resonance Imaging of Lumen Wall using Quadrature-typed Inside-out Receiver Coil
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 385~392
This study Proposes a quadrature-typed inside-out receiver coil to obtain magnetic resonance(MR) images of lumen wall. This means that the coil should receive the signals from out-side of receiver coil. This coil has wide and uniform sensitive region to compare with previous coils such as anti-solenoid coil, octal-pole coil and so on. These coils have the disadvantages that sensitive region is narrow and inhomogenous. The proposed coil is consist of two saddle coils of which directions are orthogonal to one another. The sensitivity maps of octal-Pole coil single-saddle coil and quadrature-typed inside-out coil were obtained by computer simulation. And phantom images for each coil were obtained to evaluate the performances of the coil using both 1.5T superconducting and 0.3 Permanent magnet MRI system. The uniformity of quadrature coil's sensitivity map was superior to that of octal-polel coil. Experimentally measured SNR of quadrature coil is also 36% higher than that of single-saddle coil This study shows the possibility of quadrature-typed inside-out receiver coil for the MR lumen wall images.
Computational Study on the Hemodynamics of Cardiovascular System Including Short-term Auto-regulation Functions
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 393~402
A computational model representative of cardiovascular circulation was built using 12 standard lumped compartments. Especially, both the baroreceptor reflex and the cardiopulmonary reflex control model were implemented to explain the auto-regulation of cardiovascular system. Another important aspect of this model is to utilize the impulse-response curve of the nerve system in transferring the impulse error signals to autonomous nerve system. For the verification of this model, we have computed the normal hemodynamic conditions and compared those with the clinical data. Then. hemodynamic shock of 20% hemorrhage to cardiovascular system was simulated to test the effects of the control system model. The results of these two simulations were well matched with the experimental ones. The steady state LBNP simulation was also performed. The transient changes of hemodynamic variables due to ramp increase of bias pressure of LBNP showed good agreement with the physiological experiments. Numerical solution using only the baroreflex model showed relatively a larger deviation from the experimental data. compared with the one using the control model haying both the baroreflex and the cardiopulmonary reflex systems, which shows an important role of the cardiopulmonary reflex system for the simulation of the hemodynamic behavior of the cardiovascular system .
Numerical Simulation of The Pressure-Flow Control Characteristics of Shunt Valves Used to Treat Patients with Hydrocephalus
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 403~412
The Present study analyzed the pressure-flow characteristics of a Korean shunt valve. Changes in the characteristic currie depending on the design parameters were also investigated. The Korean shunt valve used in the present study was constant pressure type and our analyses were validated through experiments. We applied fluid-structure interaction to solve the flow dynamic Problem because the small diaphragm in the valve was made from flexible silicone elastomers. Considering the material nonlinearity of the hyper-elastic material. the Mooney-Rivlin approximation was employed. The results of the numerical analyses were close to the experimental results The major Pressure drop was observed to happen in the small diaphragm. The slope of the pressure-flow characteristic curve was computed to be 0.37mm
.hr/cc, which was similar to the average value of commercial shunt valves. 0.40mm
.hr/cc. Therefore. our valves analyzed in the Present study showed a Proper Pressure control characteristics of the constant pressure type shunt valves. The opening pressure could be controlled by adjusting the amount of predeflection of the valve diaphragm. In order to obtain opening pressures of 25mm
, respectively, and the required predeflection was found to be 10.2
m and 35.3
m. The flow orifice size was found to be within 10
m during valve operation Therefore, Precision design and manufacturing techniques are necessary for successful operations of the shunt valve. The study indicated the amount of predeflection as well as the magnitude of corner rounding of the diaphragm edge are important design parameters to influence the slope of the pressure-flow characteristic curve.
Development of Shunt Valves Used to Treat Patients with Hydrocephalus
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 413~418
We developed shunt valves used to treat patients with hydrocephalus. The valves under development were constant Pressure type ventriculoperitoneal (VP) calves made of silicone elastomer. In vitro experiments showed that our valves had similar Pressure-flow control characteristics to the valved currently available in the market. Our valves also showed competent performance in the 28 days of continuous pumping tests acording to the IS07197 specifications. We artificially inducted hydrocephalus to a 10kg beagle do9. The size of the ventricles of the dog was substantially increased and the dog showed abnormal behavior. After our valve being implanted, the ventricles recovered regular size with the normal behavior observed in the dog. The flow orifice of the shunt valve diaphragm was in the older of 10
m during calve operation and hence the pressure-flow control characteristics tended to change by a small chance in the valve dimension. Therefore, precision design and manufacturing techniques were necessary for successful operations of the shunt valves .
A Study of the Mechanical Properties of Human Trabecular Bone by Spherical Indentation Test
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 419~424
We intended to evaluate the Young's modulus of trabecular bone of a human distal femur by spherical Indentation test and CT images and to quantify relationships between the direction of load, density. and Young's modulus. The specimens were scanned at 1 mm intervals on CT scanner After scanning the bones were sectioned with diamond saw. producing 8mm cubes of trabecular bone. The tubes were mechanically tested in inferior-superior(IS), anterior-posterior(AP). and medial-lateral(ML) direction with custom-made device. After testing, the real apparent density of specimens were measured. The results of this study showed that the IS modulus was significant1y greater than both the AP and ML modulus and the AP modulus was also greater than ML modulus significantly(p〈0.01) A significant Power relationship between the apparent density and the modulus was also found.
Some Mental Activity Which Can be Discriminated Only on Non-linear Analysis of EEG Measure
Lee, J.M. ; Park, C.J. ; Lee, Y.R. ; Shin, I.S. ; Park, K.S. ;
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 425~430
The Purpose of this study was to find the way of discriminating EEG for some mental activity. which are not characterized within linear spectral analysis but with non-linear analysis . We lave investigated the way of characterizing EEG changes during emotional and cognitive states in healthy volunteered subjects who responded to three designed status. in which the subjects were relaxing with ease and eyes closed. listening to music and computing a simple subtraction with eyes closed. Especially, we estimated EEG dimensional complexity by Skinner s Point-wise correlation dimension(PD2) method for each mental states. As a result it has been found that the subjects, who responded that the\ulcorner had concentrated well during the arithmetic task. show higher PD2 in their non-linear EEG measures. in comparison with the subjects who responded that they had not concentrated during the task This highness of PD2 is also significant in statistical analysis. A subject who had the highest score in evaluating the intensity of induced emotion during emotional task shows significantly lower PD2 in statistical analysis than other subjects who had lower scores. Linear spectral analysis was also performed on these data. However, they did not show and significant difference. Only non-linear dynamical analysis shows the significant different result on these mental status
Filter Design to Eliminate Motion Artifact of Pulse Oximetery
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 431~438
Oxygen saturation of blood is defined as ratio of total hemoglobins density to oxyhemoglobins density And the accuracy of pulse oxymeter that measures the oxygen saturation of blood by a noninvasive method is influenced by a measuring environment, breathing and motion of patient. Especially when patient moved his arms and fingers, it is difficult to eliminate motion artifact because the motion artifact signal has features that are overlap or closed at normal signal in frequency domain. We propose the filtering method that construct the filter banks and a matched falter to improve the Problem. When experimented by the proposed method, the ratio regulation of the proposed methods has 4.1% below than an adaptive filter (39.7%) and a moving average filter (11.2%). So. the Proposed method will be able to get a stable ratio of SpO2.
Spectral Properties of the Sound From the Mechanical Valve Employed in an Implantable Biventricular Assist Device
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 439~448
This paper considers the acoustical characteristics of the closing click sounds of the mechanical valves employed in an implantable biventricular assist device (BYAD) and their re1evance to the Physical states of the valved. Bj rk Shiley Convexo Concave tilting disk valve was chosen for the study and acoustic measurement was made for the BYAD operated in a mock circulatory system as well as implanted in an animal (sheep). In the BYAD operated in the mock circulatory system. three different states of the valve were examined, ie. normal. mechanically damaged. pseudo-thrombus attached. Microphone measurement for the BVAD implanted in the animal was carried out for five days at a regular time interval from one day after implantation. Characteristic spectrum of the sound from the valve was estimated using Multiple Signal Classification (MUSIC) in which the optimal order was determined according to Bayesian Information Criterion (BIC) . It was observed that the mechanical damage of the valve resulted in changes of the structure of the acoustic spectrum. In contrast. the thrombus formed on the valve did not change much the basic structure of the spectrum but brought about altering the spectral Peak frequencies and energies. Maximum spectral Peak (MSP) with the greatest energy was seen at 2 kHz for the normal valve and it was shifted to 3 kHz for the calve attaching the Pseudo-thrombus. Unlike the normal valve, strong spectral Peak appeared around 7 kHz in the sound from the valve mechanically damaged. In the case of the BYAD implanted in the animal. as the thrombus grew, acoustic energy was reduced relatively more in the low frequency components (〈 2 kHz) and the frequencies of the 1st, 2nd and 3rd MSP were increased little. The thrombus formation would result in reduction in both the variability of the 1st, 2nd and 3rd MSP and the value of the BIC optimal order.
Analysis and Improvement of System Efficiency for the Moving-actuator type Bi-Ventricular Assist Device (
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 449~458
This is a test report of system efficiency for the moving-actuator type Bi-ventricular assist device (AnyHear
) Seoul National University).
), as an energy converter. utilities a brushless DC motor(S/M 566-26A. Sierracin/ Magnedyne, Carlsbad, CA. U.S.A.) generating their pendulous motion in the epicyclic gear train. It is necessary to know about the overall efficiency of the system. The system is subdivided into three parts: motor part, actuator part and blood sac part (including valves, etc.) according to system mechanism. The motor was operated with a variable range of torque. angular speed and width of voltage Pulse In this report.
is focused on the efficiency of the motor and actuator parts. 4
pump output. which is normal condition of
system, the total system efficiency is 8%, which is composed of 50%, 85% and 17% efficiency (motor Part, actuator Part and blood sac Part) respectively. In the analyzed result. applied input voltage on normal condition of
is determined. Also speed Profile with considering filling state of blood sac is Provided. In the test of the in vitro mock circulation. some experimental results are Provided to demonstrate the effectiveness of the Presented approach
A New Experimental Error Reduction Method for Three-Dimensional Human Motion Analysis
Mun, Joung-Hwan ;
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 459~468
The Average Coordinate Referenee System (ACRS) method is developed to reduce experimental errors in human locomotion analysis. Experimentally measured kinematic data is used to conduct analysis in human modeling, and the model accuracy is directly related to the accuracy of the data. However. the accuracy is questionable due to skin movement. deformation of skeletal structure while in motion and limitations of commercial motion analysis system . In this study. the ACRS method is applied to an optically-tracked segment marker system. although it can be applied to many of the others as well. In the ACRS method, each marker can be treated independently. as the origin of a local coordinate system for its body segment. Errors, inherent in the experimental process. result in different values for the recovered Euler angles at each origin. By employing knowledge of an initial, calibrated segment reference frame, the Euler angles at each marker location can be averaged. minimizing the effect of the skin extension and rotation. Using the developed ACRS methodology the error is reduced when compared to the general Euler angle method commonly applied in motion analysis. If there is no error exist in the experimental gait data. the separation and Penetration distance of the femoraltibial joint using absolute coordinate system is supposed to be zero during one gait cycle. The separation and Penetration distance was ranged up to 18 mm using general Euler angle method and 12 mm using the developed ACRS.
Home Health Care Service Using Routine Vital Sign Checkup and Electronic Health Questionnaires
Journal of Biomedical Engineering Research, volume 22, issue 5, 2001, Pages 469~477
In this Paper. we describe a home health care service using electronic health questionnaires and routine checkup of vital signs Including ECG (Electrocardiography) , blood pressure. and SpO
(Oxygen Saturation) . This system is for patients at home with chronic diseases, discharged Patients, or any normal people for the Prevention of disease The service requires a home health care terminal and a PC with Interned connection installed at Patient home. The distance health care management center is equipped with a vital-sign and questionnaire interpreter as well as database, Web, and notification servers with UMS (Unified Messaging System). Participating Physician can access the servers at the center using a Web browser running on a PC available to them at any time. These components are linked together through various kinds of data and voice communication channels including PSTN (Public Switched Telephone Network) . CATV(Community Antenna TV) . Interned. and mobile communication network. Following the Physician's direction given to a Patient. he or she uses the home health care terminal to collect vital signs and fill out the questionnaire. When the terminal automatically transmits these data to the management center. the data interpreter and servers at the center process the information fo1lowing the Protocol implemented on the system. Physicians can retrieve and review data corresponding to their Patients and send back their diagnostic reports to the center. UMS at the center delivers the physician 's recommendation to the corresponding patient through the notification server. Patients can also reprieve and review their own records as well as diagnostic reports from physicians. The system Provides a new way of collecting diagnostic information and delivering doctor's recommendation to patients at home for their health management. Future works are needed in the development of new technology for measurements and interpretations of various vital signs .