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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Biomedical Engineering Research
Journal Basic Information
Journal DOI :
The Korea Society of Medical and Biological Engineering
Editor in Chief :
Volume & Issues
Volume 25, Issue 6 - Dec 2004
Volume 25, Issue 5 - Oct 2004
Volume 25, Issue 4 - Aug 2004
Volume 25, Issue 3 - Jun 2004
Volume 25, Issue 2 - Apr 2004
Volume 25, Issue 1 - Feb 2004
Selecting the target year
Effect of Gelatin Particles on Cell Proliferation in Polymer Scaffolds Made Using Particulate Leaching Technique.
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 1~4
On the background of general idea and technique of bioscience, medicine and engineering, tissue engineering aim at maintenance, improvement and repair of human body function through manufacturing and transplantation of artificial tissue and organ exchangeable human body. Basic material used in the area is scaffold that aid tissue and organ formation. Making scaffold, solvent-casting and particulate leaching technique is widely used in manufacturing of porous polymer scaffold. There are many types of particle including salt and gelatin. Salt is a most commonly used particulate because it is easily available and very easy to handle and gelatin particle is another candidate for this method because it is known as a material, which enhances cell attachment and proliferation. But there is no comparative study of two kinds of materials. In this study we compared the biocompatibility of the two scaffolds made from salt(salt scaffold) and gelatin particle (gelatin scaffold). These results demonstrated that gelatin scaffold showed better attachment of cells at the initial stage and better proliferation of cells. The better performance of gelatin scaffold is contributed to the better connection of pores in the same porosity.
Evaluation of Body Movement during Sleep with a Thermopile, Wavelets and Neuro-fuzzy Reasoning
Yoon, Young-Ro ; Shin, Jae-Woo ; Lee, Hyun-Sook ; Jose C.Principe ;
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 5~10
Body movement is one of the important factors in sleep analysis. In this study, a thermopile detector with four channels was implemented as a non-contacting detector of body movement in sleep. Using a thermopile mathematical model and several frames of thermal images, the possibility of detecting body movement was evaluated. Instant body movement signals were evaluated for the upper, lower, and entire body using the Haar wavelet. This decomposition shows the points in time when the upper-body or lower-body movement occurred and the level of body movement. Additionally, partial body movement was decomposed in head-only, whole body, and leg-only movement using the ANFIS algorithm. Finally, three subject's data were evaluated for 60 minutes, and the detection rates of instant and partial body movement, on average, were 96.3％ and 89.2％, respectively.
Automatic Detection of Stage 1 Sleep
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 11~19
Stage 1 sleep provides important information regarding interpretation of nocturnal polysomnography, particularly sleep onset. It is a short transition period from wakeful consciousness to sleep. Lack of prominent sleep events characterizing stage 1 sleep is a major obstacle in automatic sleep stage scoring. In this study, we attempted to utilize simultaneous EEC and EOG processing and analyses to detect stage 1 sleep automatically. Relative powers of the alpha waves and the theta waves were calculated from spectral estimation. Either the relative power of alpha waves less than 50％ or the relative power of theta waves more than 23％ was regarded as stage 1 sleep. SEM (slow eye movement) was defined as the duration of both eye movement ranging from 1.5 to 4 seconds and regarded also as stage 1 sleep. If one of these three criteria was met, the epoch was regarded as stage 1 sleep. Results f ere compared to the manual rating results done by two polysomnography experts. Total of 169 epochs was analyzed. Agreement rate for stage 1 sleep between automatic detection and manual scoring was 79.3％ and Cohen's Kappa was 0.586 (p＜0.01). A significant portion (32％) of automatically detected stage 1 sleep included SEM. Generally, digitally-scored sleep s1aging shows the accuracy up to 70％. Considering potential difficulties in stage 1 sleep scoring, the accuracy of 79.3％ in this study seems to be robust enough. Simultaneous analysis of EOG provides differential value to the present study from previous oneswhich mainly depended on EEG analysis. The issue of close relationship between SEM and stage 1 sleep raised by Kinnariet at. remains to be a valid one in this study.
Development of the PDA Based Mobile System for Body Fat Measurement and Diagnosis Using Bioelectrical Impedance Method
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 21~26
Recently, many people want to know their state of health, such as a body fat rate, anywhere and anytime. The Personal Digital Assistance(PDA) is the portable wireless apparatus that has become widely popular. There are many application areas of the IDA to be in mobile care devices. In this study, we developed the PDA based body fat measurement system, composed of a cradle type measurement module and a WindowCE operated software module, a regression equation for predicting lean body mass (LBM). Sixty-three weight-stable subjects (53 men, 10 women) aged 20∼32yr participated in this study. A regression model, LBM ＝ (0.0005＊Height2 - 0.0160＊Impedance ＋ 0.3920＊Weight - 0.0684＊Age - 5.8141＊Sex ＋ 25.984, was found. The correlation coefficient( r) of body fat rate between developed system and HTM1000plus(BionetTM) was 0.928. HTM1000plus is a commercially available and approved by KFDA. These results indicated that developed system is reliable for estimation of body fat rate. Although developed system is the PDA based miniaturized, it shows good performance comparing with other commercial product.
Biomechanical Evaluation of PMMA Injection in Vertebroplasty
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 27~32
In this study, method of PMMA injection is suggested for vertebroplasty in patients with osteoporotic compression fracture. The finite element analysis is used to investigate the vertebroplasty quantitatively. In order to improve previous works with simplified geometry of vertebral body more exact geometry has been constructed from CT image data with 1m thickness. An ideal method of PMMA delivery, with respect to location and amount of injectate, into vertebral body has been suggested based on evaluation of the insert positions and the insert shapes of injected PMMA. It is shown that vertebral body can be compensated most efficiently when PVIMA is highly concentrated on the top-front of trabecular bone of compressed vertebra.
Accuracy Evaluation of Three-Dimensional Multimodal Image Registration Using a Brain Phantom
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 33~41
Accuracy of registration between images acquired from various medical image modalities is one of the critical issues in radiation treatment planing. In this study, a method of accuracy evaluation of image registration using a homemade brain phantom was investigated. Chamfer matching of CT-MR and CT-SPECT imaging was applied for the multimodal image registration. The accuracy of image correlation was evaluated by comparing the center points of the inserted targets of the phantom. The three dimensional root-mean-square translation deviations of the CT-MR and CT-SPECT registration were 2.1
0.8 mm and 2.8
1.4 mm, respectively. The rotational errors were ＜ 2
for the three orthogonal axes. These errors were within a reasonable margin compared with the previous phantom studies. A visual inspection of the superimposed CT-MR and CT- SPECT images also showed good matching results.
Software Development for the Visualization of the Orientation of Brain Fiber Tracts in Diffusion Tensor Imaging Using a 24 bit Color Coding
Jung-Su Oh ; In Chan Song ; Ik-Hwan Cho ; Jong-Hyo Kim ; Kee Hyun Chang ; Kwang-Suk Park ;
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 43~47
Interests in human brain functionality and its connectivity have much frown up. DTI (Diffusion tensor imaging) has been known as a non-invasive MR) technique capable of providing information on water diffusion in tissues and the organization of white matter tract. Thus. It can provide us the information on the direction of brain fiber tract and the connectivity among many important cortical regions which can not be examined by other anatomical or functional MRI techniques. In this study. was used the 24 bit color coding scheme on the IDL platform in the windows environment to visualize the orientation of major fiber tracts of brain such as main association, projection, commissural fibers and corticospinal tracts. We additionally implemented a color coding scheme for each directional component and FA (fractional anisotropy), and used various color tables for them to be visualized more definitely. Consequently we implemented a fancy and basic technique to visualize the directional information of fiber tracts efficiently and we confirmed the feasibility of the 24 bit color coding scheme in DTI by visualizing main fiber tracts.
Mouse Tumor Necrosis Using Photodynamic Therapy
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 49~55
In this paper, we investigated the effects of the photodynamic therapy(PDT) for the tumor mass in mice. In the experimental method, we divided the mice into two control and test group which HepG2 and HeLa cell line induced cancer mass in mice. Photofrin was administered to the tumor-bearing mouse, followed 30 hours later by 630nm and 650nm laser light exposure. After photodynamic therapy we analyzed the two mice group for the tumor mass size, tumor growth, tumor cell necrosis, pathological anatomy change. According to the results, tumor cell necrosis was shown in the tissues which the reduce size of tumor and tumor cell necrotic change according to the irradiation time and light dose amount. The considerable difference, however, between the 630nm and 650nm wavelength was not found for the tumor cell necrotic change and other damage of normal tissue was not found.
A Study on Shape Optimization and Hemolysis Evaluation of Axial Flow Blood Pump by Using Computational Fluid Dynamics Analysis
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 57~64
The non pulsation blood pump is divided into axial flow and centrifugal style according to the direction of inlet and outlet flow. An axial flow blood pump can be made smaller than a centrifugal blood pump because centrifugal pump's rpm is fewer than axial flow pump. Hemolysis is an important factor for the development of an axial flow blood pump. It is difficult to identify the areas where hemolysis occurs. Evaluation of hemolysis both in in-vitro and in-vivo test requires a long-time and more expensive. Computational fluid dynamics(CFD) analysis enables the engineer to predict hemolysis on a computer which just can get not only amount of htmolysis but also location of hemolysis. It takes shorter time and less expensive than in-vitro test. The purpose of this study is to git Computational fluid dynamics in axial flow pump and to verify the accuracy of prediction by the possibility of design comparing CFD results with in-vitro experimental results. Also, wish to figure out the correction method that can bring improvement in shape of axial flow blood pump using CFD analysis.
In-vivo Evaluation of Pneumatic Ventricular Assist Device and Durability Improvement
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 65~70
In this paper, we described 23 cases of animal experiment with our pneumatic ventricular assist device and new durability-improvement method. The blood pump consists of blood housing, and back plate made by the injection molding of isoplast, and the diaphragm fabricated by dipping of polyurethane solution onto the aluminum mold. Its volume was 75
and in-vitro test showed that maximum output was 4.5
/min at the 100 mmHg. The adult female sheep with weight of 50 ＋ 10 kg were employed for tile in-vivo experiments and the mean blood flow was sustained at 3.0 1/min. 4 animals survived more than 15 days and the longest survival time was 28 days. In the prior 10 cases, the major causes of death were the tearing of diaphragm at the diaphragm to blood housing junction. By the new mesh and alumina ball milling methods, the durability was enhanced, and its qualitative and quantitative improvement was proved via the in-vivo and in-vitro methods. Animal experiments demonstrated that all the physiologic parameters a ere maintained within the permissible ranges and no thrombus formation was observed through the visual and blood test. The in-vivo experiments demonstrated our pneumatic ventricular assist device to he one month's bridge to transplantation device.
Effects of Fusion Level for Scioliotic Spine Correction Simulation with Pedicle Screw and Rod Derotation Method
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 71~76
In order to investigate the Post-operative changes in scoliotic spine according to selection of fusion level a mathematical finite element model of King-Moe type II scoliotics spine system was developed. By utilizing this finite element scoliosis model surgical correction simulation procedures of pedicle fixation and derotation were simulated. In consequence of the calculation by changing the fusion Levels, postoperative changes like Cobb angle, apical vertebrae axial rotation (AVAR), thoracic kyphosis, and rib hump were Qualitatively analyzed. In the analysis of operative kinematics, the decrease or Cobb angle was most prominent in distraction than in deroation. Applying the rod derotation only was not effective in decrease of Cobb angle but just caused increase of At AR and rib hump. From the operative simulation, co-action or distraction and translation during rod insertion has major impact on Cobb angle decrease and maintenance of kyphosis. With rod rotation, Cobb angle decrease was obtained, but combined increase of AVAR and rib hump was simulation observed as well. The case of most extended instrumentation range with 60o rod rotation produced double decrease of Cobb angle, but the increase of rib hump and AYAR occurred corresponding1y. The optimum selection of fusion level was proved as one level less than inflection position of the thoracic spine curvature.
Development of a Management System for Image and Personal Information for the Development of a Standard Brain for Diverse Koreans
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 77~82
The purpose of this study is to establish a reference for image acquisition for completion of a standard brain for diverse Korean population, and to develop a management system that saves and manage database of the acquired brain image and personal information of those who were tested. 3D MP-RAGE technique, which has excellent SNR and CNR and reduces the times for image acquisition, was selected for anatomical Image acquisition, and parameter values were obtained for the optimal image acquisition. The database management system was devised to obtain not only anatomical image data but also subjects' basic demographic factors, medical history, handedness inventory state-trait anxiety inventory, A-type personality inventory, self-assessment depression inventory questionnaires of Sasang Constitution Mini-Mental State Examination, intelligence test, and personality test via a survey questionnaire and to save and manage the results of the tests. In addition, this system was designed to have functions of saving, inserting, deleting, searching, and Printing of image da a and personal information of subjects, and to have accessibility to them as well as automatic connection setup with ODBC. This newly developed system may have major contribution to the completion of a standard brain of diverse Korean population in that it can save and manage their image date and personal information.
Iris Code Construction for Human Identification
Kim, Dong-Min ;
Journal of Biomedical Engineering Research, volume 25, issue 1, 2004, Pages 83~86
The variation of the directional properties of an image is used to extract the iris code for human identification. In order to conserve the original information while minimizing the effect of noise, scale-space filtering is applied. Resulting binary codes have been tested on a set of 272 iris images obtained from 18 persons.