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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Biomedical Engineering Research
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Journal DOI :
The Korea Society of Medical and Biological Engineering
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Volume & Issues
Volume 31, Issue 6 - Dec 2010
Volume 31, Issue 5 - Oct 2010
Volume 31, Issue 4 - Sep 2010
Volume 31, Issue 3 - Jun 2010
Volume 31, Issue 2 - Apr 2010
Volume 31, Issue 1 - Feb 2010
Selecting the target year
Current Status of Stem cell Research and its Connection with Biomedical Engineering Technologies
Park, Yong-Doo ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 87~93
Researches for stem cells have been focused on scientists in biomedical sciences as well as clinical application for its great therapeutic potentials. Stem cells have two distinct characteristics: self-renewal and differentiation. In this short review, the links between stem cell research and biomedical engineering is discussed based on the basic characteristics of stem cells. This concept can be extended to the fundamental questions of biological sciences for cells such as proliferation, apoptosis, differentiation, and migration. For understanding proliferation and apoptosis of stem cells, techniques from biomedical engineering such as surface patterning, MEMS, nanotechnologies have been used. The advanced technologies such as microfluidic technologies, three dimensional scaffold fabrication, and mechanical/electrical stimulation have also been used in cell differentiation and migration. Basic and unsolved questions in the stem cell research field have limitations by studying conventional technologies. Therefore, the strategic fusion between stem cell biology and novel biomedical engineering field will break the barriers for understanding fundamental questions of stem cells, which can open the window for the clinical applications of stem cell based therapeutics as well as regeneration of damaged tissues.
MREIT Conductivity Imaging of Pneumonic Canine Lungs: Preliminary Post-mortem Study
Kim, Hyung-Joong ; Kim, Young-Tae ; Jeong, Woo-Chul ; Minhas, Atul S. ; Lee, Tae-Hwi ; Lim, Chae-Young ; Park, Hee-Myung ; Kwon, O-Jung ; Woo, Eung-Je ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 94~98
In magnetic resonance electrical impedance tomography (MREIT), a current-injection MR imaging method is adopted to produce a cross-sectional image of an electrical conductivity distribution in addition to MR images. The purpose of this study was to test the feasibility of MREIT for differentiating the canine lung parenchyma without and with pneumonia. Three normal healthy beagles and two mixed breed dogs with pneumonia were used. After attaching electrodes around the chest, we placed the dog inside our MR scanner. We injected as much as 30 mA current in a form of short pulses into the chest region. Reconstructed conductivity images of normal canine lungs exhibit a peculiar pattern of a relatively coarse salt and pepper noise. On the contrary, conductivity images of pneumonic canine lungs show significantly enhanced contrast of the lesions while the corresponding MR images show a little bit of contrast in the middle and caudal lung parenchyma due to the accumulation of pleural fluid. This preliminary study indicates that MREIT imaging of the chest may deliver unique new diagnostic information.
In-vitro Study on Hemorheological Behaviors of Blood Flow Through a Micro Tube
Kang, Myung-Jin ; Ji, Ho-Seong ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 99~105
In order to obtain velocity profile of blood flow with high spatial resolution, a micro PIV technique consisted of a fluorescent microscope, double-pulsed YAG laser, cooled CCD camera was applied to in-vitro blood flow experiment through a micro round tube of a diameter
. Velocity distributions of blood flow for rabbit were obtained. The viscosity profiles for shear rate were found at flowing condition. To provide hemorheological characteristics of blood flow, the viscosities for shear rate were evaluated. The viscosity of blood also steeply increase by decreasing shear rate resulting in Non-Newtonian flow, especially in low shear rate region caused by RBC rheological properties. The results show typical characteristics of Non-Newtonian characteristics from the results of velocity profile and viscosity for blood flow. From the inflection points, cell free layer and two-phase flow consisted with plasma and suspensions including RBCs can be separated.
Comparison of Balance Ability on the Heel Height and the Habituation to the High Heel
Lee, H.J. ; Lee, S.J. ; Tae, K.S. ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 106~113
The aim of this study was to evaluate effects of the balance ability on the heel height (flat, low heel[3cm], and high heel[7cm]) and high heeled habituation (group A is used to a low heeled shoes (<7cm) and group B is used to a high heeled shoes (
). Thirty-five subjects participated in this study. In this study, the static balance with opened eyes and closed eyes and dynamic balance were measured. Also functional reach test was tested. The results found that the static balance ability was the best in a 7cm heeled shoes with open eyes and closed eyes, but there was not significant difference between group A and Group B. Dynamic balance ability with walking velocity and cadence were significant difference between Group A and B. In the walking velocity, a flat was the fastest, followed by 7cm heel and 3cm heel with Group A while 3cm and 7cm, then a flat with Group B. Also Cadence pattern was similar. Functional balance ability was the highest with a flat, but it was not difference significantly between Group A and B. Therefore, this study demonstrated that the habituation to the high heel altered gait velocity and cadence of dynamic balance ability.
Image Fusion of Lymphoscintigraphy and Real images for Sentinel Lymph Node Biopsy in Breast Cancer Patients
Jeong, Chang-Bu ; Kim, Kwang-Gi ; Kim, Tae-Sung ; Kim, Seok-Ki ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 114~122
This paper presents a method that registers a lymphoscintigraphy to the real image captured by a CMOS camera, which helps surgeons to easily and precisely detect sentinel lymph nodes for sentinel lymph node biopsy in breast cancer patients. The proposed method consists of two steps: pre-matching and image registration. In the first step, we localize fiducial markers in a lymphoscintigraphy and a real image of a four quadrant bar phantom by using image processing techniques, and then determines perspective transformation parameters by matching with the corresponding marker points. In the second step, we register a lymphoscintigraphy to a real images of patients by using the perspective transformation of pre-matching. To examine the accuracy of the proposed method, we conducted an experiment with a chest mock-up with radioactive markers. As a result, the euclidean distance between corresponding markers was less than 3mm. In conclusion, the present method can be used to accurately align lymphoscintigraphy and real images of patients without attached markers to patients, and then provide useful anatomical information on sentinel lymph node biopsy.
Research of Developing of Standards for Electronic Thermometers
Kim, E.J. ; Lee, M.J. ; Lee, B.Y. ; Park, K.G. ; Kim, D.S. ; Lee, I.S. ; Park, H.D. ; Jeong, H.K. ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 123~128
The thermometers is widely used in diagnostic medical devices, and the safety and accurate performance of these devices are important in the diagnosis and monitoring of personal health. Especially, the accuracy of infra-red thermometer is highly emphasized. Here two typical thermometers are utilized for this purpose: the electronic thermometers measure body temperature by contacting to subject while infra-red thermometers measure by no contacting to subject. Therefore, the evaluating items of each thermometer are different, and the standard for each temperature is highly needed. But, there have been no international standards of each thermometer such as IEC. In this paper, we developed the standards of electronic and infra-red thermometer based on national standards such as KS, ASTM, EN, JIS and FDA guidance. The new standards focused on the safety and suitable performance for health care. This standards were applied to enact and revise the electronic medical device standards. So it can be applied to evaluate the safety and performance on technical file review. We predict that this standard will improve the quality of diagnostic medical devices (thermometers) and increase the international competitive power of domestic product.
Guideline Development to Evaluate the Safety and Performance of Intense Pulsed Light(IPL)
Kang, Dong-Yeon ; Son, Tae-Yoon ; Joo, Yea-Il ; Choi, Eung-Ho ; Jung, Byung-Jo ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 129~133
Intense pulsed light(IPL) is a photo-therapeutic medical device using xenon lamps with optical characteristics of incoherence, defocusing, and polychromatic. IPL has been recognized as a representative medical therapeutic device with growth of domestic skin care market. However, there is no standard regulation manual and guideline to evaluate the safety and performance of IPL. International Electrotechnical Commission(IEC) is being statued "Technical Report IEC TR 60825-16" which is a guidelines for the safe use of intense light source equipment on humans and animals. In this study, a standard Korea Food & Drug Administration (KFDA) regulation for the safety and performance of IPL was suggested by developing minimal evaluation methods for optical parameters of IPL such as output energy density, pulse mode, spot size, wavelength and uniformity of output light. We expect that this study may be a step to statue a standard regulation manual and guideline for IPLs used in domestic.
A Novel Method of Shape Quantification using Multidimensional Scaling
Park, Hyun-Jin ; Yoon, Uei-Joong ; Seo, Jong-Bum ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 134~140
Readily available high resolution brain MRI scans allow detailed visualization of the brain structures. Researchers have focused on developing methods to quantify shape differences specific to diseased scans. We have developed a novel method to quantify shape information for a specific population based on Multidimensional scaling(MDS). MDS is a well known tool in statistics and here we apply this classical tool to quantify shape change. Distance measures are required in MDS which are computed from pair-wise image registrations of the training set. Registration step establishes spatial correspondence among scans so that they can be compared in the same spatial framework. One benefit of our method is that it is quite robust to errors in registrations. Applying our method to 13 brain MRI showed clear separation between normal and diseased (Cushing's syndrome). Intentionally perturbing the image registration results did not significantly affect the separability of two clusters. We have developed a novel method to quantify shape based on MDS, which is robust to image mis-registration.
Kinetic Analysis of Human Simulation for the Soft Golf Swing
Kwak, K.Y. ; Yu, M. ; So, H.J. ; Kim, S.H. ; Kim, N.G. ; Kim, D.W. ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 141~150
The purpose of this study was to analyze the golf swing motion for a soft golf clubs and regular golf club. Soft golf is a newly developed recreational sports for all ages, including the elderly and the beginners of golf. To quantify the effect of using soft golf club, which much lighter club than regular clubs, a motion analysis has been performed using a 3D optoelectric motion tracking system that utilizes active infrared LEDs and near-infrared sensors. The subject performed swing motion using a regular golf club and a soft golf club in turn. The obtained motion capture data was used to build a 3D computer simulation model to obtain left wrist, elbow shoulder and lumbar joint force and torque using inverse and forward dynamics calculations. The joint force and torque during soft golf swing were lower than regular golf swing. The analysis gave better understanding of the effectiveness of the soft golf club.
The Analysis of Swing Pattern during the Soft Golf Swing
So, H.J. ; Yu, M. ; Kwak, K.Y. ; Kim, S.H. ; Kim, N.G. ; Kim, D.W. ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 151~161
Soft Golf is a newly developed recreational sport in our research team aimed to become a safe and easy-to-learn sport for all ages. The advantage of Soft Golf stems from lighter weight of the club and much larger area of the sweet spot. The purpose of this study is to analyze ground reaction force(GRF) and joint angle during soft Golf club and regular golf club swing. The GRF of golf swing was recorded by 3-D motion analysis system and forceplate. The joint angle of golf swing was obtained from computer simulation model. The GRF and joint angle of golf swing are used to analysis of golf swing pattern. The pattern of GRF and joint angle during soft golf club swing was similar to that during regular golf club swing. This result means that soft golf club reduces the risk of injury and has an effect on similar entertainment of regular golf.
Walking Will Recognition Algorithm for Walking Aids Based on Torque Estimation
Kong, Jung-Shik ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 162~169
This paper deals with the recognition algorithm of walking will based on torque estimation. Recently, concern about walking assistant aids is increasing according to the increase in population of elder and handicapped person. However, most of walking aids don't have any actuators for its movement. So, general walking aids have weakness for its movement to upward/download direction of slope. To overcome the weakness of the general walking aids, many researches for active type walking aids are being progressed. Unfortunately it is difficult to control aids during its movement, because it is not easy to recognize user's walking will. Many kinds of methods are proposed to recognize of user's walking will. In this paper, we propose walking will recognition algorithm by using torque estimation from wheels. First, we measure wheel velocity and voltage at the walking aids. From these data, external forces are extracted. And then walking will that is included by walking velocity and direction is estimated. Here, all the processes are verified by simulation and experiment in the real world.
Heart-rate Measurement During Exercise Using PPG Signal
Lee, Keun-Sang ; Baek, Young-Hyun ; Park, Young-Chool ;
Journal of Biomedical Engineering Research, volume 31, issue 2, 2010, Pages 170~175
A method of measuring heart rate using photoplethysmograph(PPG) signal during exercise is proposed. PPG's are composed of strong base tones and their harmonics, and the strong base tones are trackable by the adaptive notch filter (ANF) which adjusts its coefficients to minimize the output power. The proposed heart rate measurement algorithm continuously notches the frequency component with the maximum power in the measured PPG, so that the fundamental frequency corresponding to heart rate is traced. We also presents methods of detecting degeneration and impulsive noise blocks to minimize the coefficient fluctuation. Experiments were conducted using real PPG signals captured during exercise. Results showed that the proposed algorithm is capable of consistently tracking the heart rate embedded in the noisy PPG's.