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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Biomedical Engineering Research
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Journal DOI :
The Korea Society of Medical and Biological Engineering
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Volume & Issues
Volume 31, Issue 6 - Dec 2010
Volume 31, Issue 5 - Oct 2010
Volume 31, Issue 4 - Sep 2010
Volume 31, Issue 3 - Jun 2010
Volume 31, Issue 2 - Apr 2010
Volume 31, Issue 1 - Feb 2010
Selecting the target year
Breast-dedicated Positron Emission Tomography Systems
Yoon, Hyun-Suk ; Lee, Chan-Mi ; Ito, Mikiko ; Kwon, Sun-Il ; Kim, Soo-Mee ; Ko, Guen-Bae ; Lee, Dong-Soo ; Hong, Seong-Jong ; Lee, Jae-Sung ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 259~268
Breast cancer is the most prevalent woman cancer, and its prevalence rate is increasing rapidly. It is necessary to develop the breast-dedicated positron emission tomography (PET) or positron emission mammography (PEM) systems with high resolution and sensitivity to improve the accuracy of diagnosis of breast cancer. Therefore, it is necessary to develop the high-end PET system technologies, such as the measurement of depth-of-interaction (DOI) and fully digitalized data acquisition, to establish high performance breast imaging systems. In this paper, recent technical advances in breast-dedicated PET imaging systems will be reviewed.
Development of FSR Sensor Suits Controlling Walking Assist System for Paraplegic Patients
Jang, E.H. ; Chi, S.Y. ; Lee, J.Y. ; Cho, Y.J. ; Chun, B.T. ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 269~274
The purpose of this study was to develop the FSR sensor suit that controls walking assist device for paraplegic patients. The FSR sensor suit was to detect user's intent and patterns for walking by measuring pressure on the palm and the sole of user's foot. It consisted of four modules: sensing pressure from palm, changing modes and detecting pressure on the palm/at the wrist, sensing pressure from the soles of user's foot, and host module that transmit FSR data obtained from sensing modules to PC. Sensing modules were connected to sensing pads which detect analog signals obtained from the palm or the sole of foot. These collect signals from the target regions, convert analog signals into digital signals, and transmit the final signals to host module via zigbee modules. Finally, host modules transmit the signals to host PC via zigbee modules. The study findings showed that forces measured at the palm when using a stick reflected user's intent to walk and forces at the sole of the user's foot revealed signals detecting walking state.
Quantification of Clinical assessment of Rigidity in patients with Parkinson's Disease
Lee, Jae-Ho ; Kim, Ji-Won ; Kwon, Yu-Ri ; Eom, Gwang-Moon ; Koh, Seong-Beom ; Kim, Hyung-Sik ; Yi, Jeong-Han ; Lee, Jeong-Whan ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 275~279
The purpose of this study was to quantify the clinical assessment of rigidity at wrist in patients with Parkinson's disease. The experimental system was designed that the effect of gravity was negated by restricting motion at the horizontal plane and inertia was predetermined from a biomechanical measurement. Forty five patients with Parkinson's disease participated in this study. Viscoelastic properties were calculated from the experimental data acquired during intermittent passive movement of wrist. Viscoelastic constants correlated well with the rigidity scores of UPDRS, i.e., Spearman's r=0.733 and 0.905 for spring and damping constants, respectively. The results suggest that viscoelastic properties can be used as quantitative measures of rigidity.
Preparation of guidance documents item by item for one-step evaluation and approval for Medical Devices
Kim, Yong-Woo ; Shin, Chae-Min ; Bang, Ji-Young ; Yi, Jung-Yeon ; Oh, Hyeon-Joo ; Bae, Woo-Jin ; Choi, Jin-Man ; Lim, Kyung-Mi ; Oh, Heon-Jin ; Kim, Mi-Young ; Hur, Chan-Hoi ; Kim, Hyung-Bum ; Choi, Min-Yong ; Kwak, Ji-Young ; Kim, Su-Yeon ; Hwang, Sang-Yeon ; Youn, Hae-Suk ; Hong, Hye-Kyeong ; Ahn, So-Young ; Lee, Chang-Hyung ; Jeong, Jin-Baek ; Koo, Ja-Jung ; Kang, Se-Gu ; Jung, Jae-Hoon ; Lim, Kyoung-Taek ; Lim, Chang-Keun ; Kim, Min-Su ; Lee, Seong-Hyi ; Lee, Jae-Keun ; Park, Ki-Jung ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 280~284
Approvals of medical device increase every year as industry of medical device grows. Therefore KFDA keeps trying to improve approval systems. However, the firms of medical device are in trouble due to regulation amendment, a firm of small size, exchange of the person in charge. The staffs of KFDA increase their work load because applicants of approval of medical device aren't used to writing of document. Therefore the firm of medical device in business have a long term. KFDA develops eight guidance document item by item for one-step evaluation and approval for Medical Devices because applicants of approval of medical device write documents easily. KFDA reviewer can carry on quick reviewing in use of this eight guidances. This guidance are improved on satisfaction of applicants of approval of medical device.
Measurement of Prostate Phantom Volume Using Three-Dimensional Medical Imaging Modalities
Seoung, Youl-Hun ; Joo, Yong-Hyun ; Choe, Bo-Young ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 285~291
Recently, advance on various modalities of diagnosing, prostate volume estimation became possible not only by the existing two-dimension medical images data but also by the three-dimensional medical images data. In this study, magnetic resonance image (MRI), computer tomography (CT) and ultrasound (US) were employed to evaluate prostate phantom volume measurements for estimation, comparison and analysis. For the prostate phantoms aimed at estimating the volume, total of 17 models were developed by using devils-tongue jelly and changing each of the 5ml of capacity from 20ml to 100ml. For the volume estimation through 2D US, the calculation of the diameter with C9-5Mhz transducer was conducted by ellipsoid formula. For the volume estimation through 3D US, the Qlab software (Philips Medical) was used to calculate the volume data estimated by 3D9-3Mhz transducer. Moreover, the images by 16 channels CT and 1.5 Tesla MRI were added by the method of continuous cross-section addition and each of imaginary prostate model's volume was yielded. In the statistical analysis for comparing the availability of volume estimation, the correlation coefficient (r) was more than 0.9 for all indicating that there were highly correlated, and there were not statistically significant difference between each of the correlation coefficient (p=0.001). Therefore, the estimation of prostate phantom volume using three-dimensional modalities of diagnosing was quite closed to the actual estimation.
Development of Retinal Prosthesis Module for Fully Implantable Retinal Prosthesis
Lee, Kang-Wook ; Kaiho, Yoshiyuki ; Fukushima, Takafumi ; Tanaka, Tetsu ; Koyanagi, Mitsumasa ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 292~301
To restore visual sensation of blind patients, we have proposed a fully implantable retinal prosthesis comprising an three dimensionally (3D) stacked retinal chip for transforming optical signal to electrical signal, a flexible cable with stimulus electrode array for stimulating retina cells, and coupling coils for power transmission. The 3D stacked retinal chip is consisted of several LSI chips such as photodetector, signal processing circuit, and stimulus current generator. They are vertically stacked and electrically connected using 3D integration technology. Our retinal prosthesis has a small size and lightweight with high resolution, therefore it could increase the patients` quality of life (QOL). For realizing the fully implantable retinal prosthesis, we developed a retinal prosthesis module comprising a retinal prosthesis chip and a flexible cable with stimulus electrode array for generating optimal stimulus current. In this study, we used a 2D retinal chip as a prototype retinal prosthesis chip. We fabricated the polymide-based flexible cable of
thickness where 16 channels Pt stimulus electrode array was formed in the cable. Pt electrode has an impedance of
at 400Hz frequency. The retinal prosthesis chip was mounted on the flexible cable by an epoxy and electrically connected by Au wire. The retinal prosthesis chip was cappted by a silicone to pretect from corrosive environments in an eyeball. Then, the fabricated retinal prosthesis module was implanted into an eyeball of a rabbit. We successfully recorded electrically evoked potential (EEP) elicited from the rabbit brain by the current stimulation supplied from the implanted retinal prosthesis module. EEP amplitude was increased linearly with illumination intensity and irradiation time of incident light. The retinal prosthesis chip was well functioned after implanting into the eyeball of the rabbit.
Implementation of Uroflow and Urophonography Analysis System for LUTS Diagnosis
Jeon, Gye-Rok ; Jeong, Do-Un ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 302~309
The present study proposed a method of measuring uroflow and urophonography at the same time for more accurate diagnosis in case uroflow looks normal due to compensatory function hypertrophy in the expression of early obstruction. In case of early obstruction, there happens turbulent uroflow by the obstruction even if the uroflow looks normal and thus obstruction can be detected by measuring and analyzing signal caused by turbulent flow. We implemented a system that can measure both uroflow and urophonography, and evaluated its performance. In the experiment, we observed changes in uroflow and urophonography according to artificial pressure and the degree of obstruction, and confirmed that it is possible to determine the effect of compensatory function hypertrophy by analyzing urophonographyic parameter under the same uroflow. The results of our experiment show that the effect of compensatory function hypertrophy in the early-stage obstruction of lower urinary tract, which is not detectible with uroflowmetry alone, can be assessed through urophonographic analysis.
Development and evaluation of estimation model of ankle joint moment from optimization of muscle parameters
Son, J. ; Hwang, S. ; Lee, J. ; Kim, Y.H. ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 310~315
Estimation of muscle forces is important in biomechanics, therefore many researchers have tried to build a muscle model. Recently, optimization techniques for adjusting muscle parameters, i.e. EMG-driven model, have been used to estimate muscle forces and predict joint moments. In this study, an EMG-driven model based on the previous studies has been developed and isometric and isokinetic contraction movements were evaluated to validate the developed model. One healthy male participated in this study. The dynamometer tasks were performed for maximum voluntary isometric contractions (MVIC) for ankle dorsi/plantarflexors, isokinetic contraction at both
. EMGs were recorded from the tibialis anterior, gastrocnemius medialis, gastrocnemius lateralis and soleus muscles at the sampling rate of 1000 Hz. The MVIC trial was used to customize the EMG-driven model to the specific subject. Once the subject's own model was developed, the model was used to predict the ankle joint moment for the other two dynamic movements. When no optimization was applied to characterize the muscle parameters, weak correlations were observed between the model prediction and the measured joint moment with large RMS error over 100% (r = 0.468 (123%) and r = 0.060 (159%) in
dynamic movements, respectively). However, once optimization was applied to adjust the muscle parameters, the predicted joint moment was highly similar to the measured joint moment with relatively small RMS error below 40% (r = 0.955 (21%) and r = 0.819 (36%) and in
dynamic movements, respectively). We expect that our EMG-driven model will be employed in our future efforts to estimate muscle forces of the elderly.
Interpolation Technique to Improve the Accuracy of RR-interval in Portable ECG Device
Lee, Eun-Mi ; Hong, Joo-Hyun ; Cha, Eun-Jong ; Lee, Tae-Soo ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 316~320
HRV(Heart rate variability) analysis parameter is widely used as an index to evaluate the autonomic nervous system and cardiac function. For reliable HRV analysis, we need to acquire the accurate ECG signals. Most of commercially available portable ECG devices have low sampling rate because of low power consumption and small size issues, which make it difficult to measure RR-interval accurately. This study is to improve the accuracy of RR-interval by developing R-wave interpolation technique, based on the morphological characteristics of the QRS complex. When the developed method was applied to ECG obtained at 200 Hz and the results were compared with 1000 Hz reference device, the error range decreased by 1.33 times in sitting and by 2.38 times in cycling exercise. Therefore, the proposed interpolation technique is thought to be useful to improve the accuracy of R-R interval in the portable ECG device with low sampling rate.
Parameter Extraction and Simulation in order to Manufacture Ready-made Ear Shell for CIC Type Hearing Aids
U, Erdenebayar. ; Jeon, Y.Y. ; Park, G.S. ; Song, Y.R. ; Lee, S.M. ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 321~327
Most of the ear shells of hearing aids are manufactured manually, and it is one of the reasons that the cost of the custom-made hearing aids can be increased. Thus it is required to manufacture the ready-made ear shell for the purpose of easy manufacturing and decrease in cost. In this study, we extract parameters in order to manufacture the ready-made ear shell for CIC type hearing aids and simulate to reconstruct the ear shell using the extracted parameters. To parameter extraction, we set up the eleven parameters for the ready-made ear shell based on anatomical characteristics of the ear canal, and we found values of the parameters from twenty-one impressions in their 20s and twelve impressions in their 60s using aperture detection and feature detection algorithms. Classifying the parameters by size, we also determine the parameters of ready-made ear shell into three types for people in their 20s and two types for people in their 60s. Each ready-made ear shell was simulated to reconstruct using figured parameters, and evaluated the rate of agreement with unused impressions for setting parameters. To evaluate the ready-made ear shell, we calculate the volume ratio and intersection between of the each impression and ready-made ear shell, and the intersection ratio using the intersection volume and ready-made ear shell volume. As a result, the volume ratio was about 70%, and volume match ratio was also up to 70%. It means that the ready-made ear shell we simulated is the significantly matched to impression.
A Study on the Quantitative Pulse Type Classification of the Photoplethysmography
Jang, Dae-Jeun ; Farooq, Umar ; Park, Seung-Hun ; Hahn, Min-Soo ;
Journal of Biomedical Engineering Research, volume 31, issue 4, 2010, Pages 328~334
Over the past few years, a considerable number of methods have been proposed and applied for the classification of photoplethysmography (PPG). Most of the previous studies, however, focused on the qualitative description of the pulse type according to specific disease and thus provided ambiguous criteria to interpreters. In order to screen out this problem, we present a quantitative method for the pulse type classification including the second derivative of photoplethysmography (SDPTG). In the PPG signal, we have classified the signal as 4 types using the position and the presence of the dicrotic wave. In addition, we have categorized the SDPTG signal as 7 types using the position and the presence of "c" and "d" wave and the sign of "c" wave. In order to check the efficacy of the proposed pulse type classification rule, we collected pulse signals from 155 subjects with different ages and sex. From the correlation analysis, Class 1(p<0.01) and Class 2(p<0.01) in the PPG signal are significantly correlated with ages. In a similar manner Class A(p<0.01), Class C(p<0.05), Class D(p<0.01), and Class F(p<0.01) in the SDPTG signal are considerably correlated with the ages. From these observations, and some earlier ones , , we can conclude that since the newly proposed method has objectivity and clarity in pulse type classification, this method can be used as an alternative of previous classification rules including similar age-related characteristics.