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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Biomedical Engineering Research
Journal Basic Information
Journal DOI :
The Korea Society of Medical and Biological Engineering
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Volume & Issues
Volume 36, Issue 6 - Dec 2015
Volume 36, Issue 5 - Oct 2015
Volume 36, Issue 4 - Aug 2015
Volume 36, Issue 3 - Jun 2015
Volume 36, Issue 2 - Apr 2015
Volume 36, Issue 1 - Feb 2015
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Temperature-Range-Dependent Optimization of Noninvasive MR Thermometry Methods
Kim, Jong-Min ; Kumar, Suchit ; Jo, Young-Seung ; Park, Joshua Haekyun ; Kim, Jeong-Hee ; Lee, Chulhyun ; Oh, Chang-Hyun ;
Journal of Biomedical Engineering Research, volume 36, issue 6, 2015, Pages 241~250
DOI : 10.9718/JBER.2015.36.6.241
Noninvasive temperature monitoring is feasible with Magnetic Resonance Imaging (MRI) based on temperature sensitive MR parameters such as
relaxation times, Proton Resonance Frequency shift (PRFs), diffusion, exchange process, magnetization transfer contrast, chemical exchange saturation transfer, etc. While the temperature monitoring is very useful to guide the thermal treatment such as RF hyperthermia or thermal ablation, the optimization of the MR thermometry method is essential because the range of temperature measurement depends on the choice of the measurement methods. Useful temperature range depends on the purpose of treatment methods, for example,
for RF hyperthermia and over
for thermal ablation. In this paper, MR thermometry methods using
relaxation times and PRFs-based MR thermometry are tried on a 3.0 T MRI system and their results are reported and compared. In addition, the scanning protocol and temperature calculation algorithms from
relaxation times and PRFs are optimized for the different temperature ranges for the purpose of RF hyperthermia and/or thermal ablation.
Biodegradable Polymers for Tissue Engineering : Review Article
Park, Byoung Kyeu ;
Journal of Biomedical Engineering Research, volume 36, issue 6, 2015, Pages 251~263
DOI : 10.9718/JBER.2015.36.6.251
Scaffolds play a crucial role in the tissue engineering. Biodegradable polymers with great processing flexibility and biocompatability are predominant scaffolding materials. New developments in biodegradable polymers and their nanocomposites for the tissue engineering are discussed. Recent development in the scaffold designs that mimic nano and micro features of the extracellular matrix (ECM) of bones, cartilages, and vascular vessels are presented as well.
Time-Varying Hemodynamic Characteristics Simulation using Computerized Mock Circulatory Loop System with Servo Flow Regulator
Moon, Youngjin ; Son, Kuk Hui ; Choi, Jaesoon ;
Journal of Biomedical Engineering Research, volume 36, issue 6, 2015, Pages 264~270
DOI : 10.9718/JBER.2015.36.6.264
A mock circulatory loop system has been developed to construct a simulator for trainees in cardiopulmonary bypass systems or to simulate a test environment for cardiac-assist devices. This paper proposes a computerized mock circulatory loop system whose node is modularized by using a servo control flow regulator to simulate dynamic change of the hemodynamic status. To observe the effect of time-varying resistance, one with hemodynamic properties, the proposed system replicates the planned cross-sectional areas of the outlet of a ventricular assist device in terms of voltage input of a servo valve. The experiment is performed (1) for steady-input commands of selected area sizes and (2) for dynamic commands such as monotonous increase and decrease, and oscillatory functions of the voltage input, and a computer program based on LabVIEW (National Instruments, Austin, USA) processes every measured data and control command to the servo valve. The results show that the pressure and flow at the target points with respect to time-varying resistance match intuitive estimation: the pressure at the outlet and the pressure drop between both sides of the valve increased and the flow at the outlet decreased for increased resistance.
Development of a Multi-nozzle Bioprinting System for 3D Scaffold Fabrication
Park, Sanghoon ; Kim, Seongjun ; Song, Seung-Joon ; Choi, Jaesoon ;
Journal of Biomedical Engineering Research, volume 36, issue 6, 2015, Pages 271~275
DOI : 10.9718/JBER.2015.36.6.271
The aim of this study was to develop a multi-nozzle based bioprinting system for fabrication of three-dimensional (3D) biological structure. In this study, a thermoplastic biomaterial that has relatively high mechanical stability, polycaprolactone (PCL) was used to make the 3D structure. A multi-nozzle bioprinting system was designed to dispense thermoplastic biomaterial and hydrogel simultaneously. The system that consists of 3-axes of x-y-z motion control stage and a compartment for injection syringe control mounted on the stage has been developed. Also, it has 1-axis actuator for position change of nozzle. The controllability of the printed line width with PCL was tested as a representative performance index.
Biomechanical Analysis of a Combined Interspinous Spacer with a Posterior Lumbar Fusion with Pedicle Screws
Kim, Y.H. ; Park, E.Y. ; Lee, S.J. ;
Journal of Biomedical Engineering Research, volume 36, issue 6, 2015, Pages 276~282
DOI : 10.9718/JBER.2015.36.6.276
Recently, during the multi-level fusion with pedicle screws, interspinous spacer are sometimes substituted for the most superior level of the fusion in an attempt to reduce the number of fusion level and likelihood of degeneration process at the adjacent level. In this study, a finite element (FE) study was performed to assess biomechanical efficacies of the interspinous spacer combined with posterior lumbar fusion with a previously-validated 3-dimensional FE model of the intact lumbar spine (L1-S1). The post-operative models were made by modifying the intact model to simulate the implantation of interspinous spacer and pedicle screws at the L3-4 and L4-5. Four different configurations of the post-op model were considered: (1) a normal spinal model; (2) Type 1, one-level fusion using posterior pedicle screws at the L4-5; (3) Type 2, two-level (L3-5) fusion; (4) Type 3, Type 1 plus Coflex
at the L3-4. hybrid protocol (intact: 10 Nm) with a compressive follower load of 400N were used to flex, extend, axially rotate and laterally bend the FE model. As compared to the intact model, Type 2 showed the greatest increase in Range of motion (ROM) at the adjacent level (L2-3), followed Type 3, and Type 1 depending on the loading type. At L3-4, ROM of Type 2 was reduced by 34~56% regardless of loading mode, as compared to decrease of 55% in Type 3 only in extension. In case of normal bone strength model (Type 3_Normal), PVMS at the process and the pedicle remained less than 20% of their yield strengths regardless of loading, except in extension (about 35%). However, for the osteoporotic model (Type 3_Osteoporotic), it reached up to 56% in extension indicating increased susceptibility to fracture. This study suggested that substitution of the superior level fusion with the interspinous spacer in multi-level fusion may be able to offer similar biomechanical outcome and stability while reducing likelihood of adjacent level degeneration.
Development of Online Speller using Non-contact Blink Detection Glasses
Lee, Jeong Su ; Lee, Hong Ji ; Lee, Won Kyu ; Lim, Yong Gyu ; Park, Kwang Suk ;
Journal of Biomedical Engineering Research, volume 36, issue 6, 2015, Pages 283~290
DOI : 10.9718/JBER.2015.36.6.283
We proposed blink based online speller for the locked-in syndrome (LIS) patients, paralyzed in nearly all voluntary muscles expect for the eyes, with a simple and easy-to-use eye blink detection glasses. Electrooculogram (EOG) is the golden standard method of eye movement or blink measurement with Ag/AgCl electrodes. However, this method has several drawbacks such as skin irritation and dehydration of conductive gel. To resolve the shortcomings, we used a blink detection system based on a transparent capacitively coupled electrode, which is conductive indium tin oxide (ITO) films. The films make it possible to measure eye blink without direct skin contact and obstruction of field of view. We finally developed user-friendly blink based online speller with the blink detection system. To classify voluntary and non-voluntary blink, we used the double blink for command of the speller. The online speller experiment result with six healthy subjects shows that mean accuracy is 98.96% and letter per minute (LPM) is 4.73, which are better result by comparison with conventional P300 or auditory brain-computer interface (BCI) paradigm. The result of the experiment demonstrates the possibility of applying the proposed system as a communication method for the LIS patients.
Studies on Osmotically Driven Drug Infusion Pump Under the Change in Body-Simulating Environment
Yoon, Chul Whan ; Ahn, Jae Hong ; Park, Doh ; Lee, Jae Yeon ; Park, Chun Gwon ; Park, Min ; Choy, Young Bin ;
Journal of Biomedical Engineering Research, volume 36, issue 6, 2015, Pages 291~295
DOI : 10.9718/JBER.2015.36.6.291
Various types of implantable drug delivery devices have attracted significant attention for several decades to improve drug bioavailability and reduce side effects, thus enhancing therapeutic efficacy and patients` compliance. However, when implanted into the body, the devices may be influenced by the changes in physiological condition, such as temperature, pH or ionic concentration. Thus, the drug release rates could be also altered concurrently. Therefore, in this work, we employed an implantable ALZET
Osmotic Pump, which has been widely used to locally deliver various therapeutic agents and examined the effect of pH, temperature and ionic concentration on its drug release rate. For this, we performed in vitro cell tests to simulate the condition of local tissues influenced by the altered drug release rates, where we used diclofenac sodium as a model drug.
Effect of Cytosine Arabinoside Pre-treatment in Dorsal Root Ganglion Explant Culture
Jung, H.Y. ; Han, S. ; Park, J.W. ; Youn, I. ;
Journal of Biomedical Engineering Research, volume 36, issue 6, 2015, Pages 296~301
DOI : 10.9718/JBER.2015.36.6.296
Explant culture condition of dorsal root ganglion have been used to investigate the pathophysiology of peripheral nerve injury, while applying for the various clinical symptom such as trauma, pressure, and stretch. However, explant culture is usually contaminated by mitotic cells, which may observed as a newly divided cells including fibroblast or glia. The mitotic cells could be able to interrupt and change the cell signaling that make it difficult to avoid detrimental effects during the experiments. To eliminate mitotic cells, anti-mitotic reagents like mixture of uridine and 5-fluorodeoxyuridine or cytosine arabinoside were added to the cultures on the following day, but there is no research that investigate viability of anti-mitotic reagent in dorsal root ganglion explant culture. In this study, we investigate inhibition effect of cytosine arabinoside to mitotic cells in dorsal root ganglion explant culture. Also we visualized and analyzed anti-mitotic effect and toxicity of cytosine arabinoside in various concentration condition. This dorsal root ganglion explant culture condition can be applied to research that effect and mechanism of various stimulation and chemical application which affect peripheral nerve regeneration.