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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Advances in biomechanics and applications
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Volume 1, Issue 4 - Dec 2014
Volume 1, Issue 3 - Sep 2014
Volume 1, Issue 2 - Apr 2014
Volume 1, Issue 1 - Mar 2014
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Electro-osmotic pump in osteo-articular tissue engineering: A feasibility study
Lemonnier, Sarah ; Naili, Salah ; Lemaire, Thibault ;
Advances in biomechanics and applications , volume 1, issue 4, 2014, Pages 227~237
DOI : 10.12989/aba.2014.1.4.227
The in vitro construction of osteo-articular large implants combining biomaterials and cells is of great interest since these tissues have limited regeneration capability. But the development of such organoids is particularly challenging, especially in the later time of the culture, when the extracellular matrix has almost filled the initial porous network. The fluid flow needed to efficiently perfuse the sample can then not be achieved using only the hydraulic driving force. In this paper, we investigate the interest of using an electric field to promote mass transport through the scaffold at the late stage of the culture. Based on the resolution of the electrokinetics equations, this study provides an estimation of the necessary electric driving force to reach a sufficient oxygen perfusion through the sample, thus analyzing the feasibility of this concept. The possible consequences of such electric fields on cellular activities are then discussed.
Biomechanical evaluation of a bioactive artificial anterior cruciate ligament
Guerard, Sandra ; Manassero, Mathieu ; Viateau, Veronique ; Migonney, Veronique ; Skalli, Wafa ; Mitton, David ;
Advances in biomechanics and applications , volume 1, issue 4, 2014, Pages 239~252
DOI : 10.12989/aba.2014.1.4.239
This study aimed to assess the biomechanical performance of a new generation of artificial ligament, which can be considered "bioactive" and "biointegrated," implanted in sheep. Thirty sheep were implanted: 15 sheep received the artificial ligament grafted with a bioactive polymer (grafted) and 15 received the artificial ligament without a bioactive polymer (non-grafted). The animals were sacrificed 3 or 12 months after implantation. The knee kinematics, namely flexion-extension, anterior drawer, and varus-valgus tests, were evaluated using a fully characterized custom-made device. Afterward, the specimens were tested under uniaxial tension until failure. The flexion-extension showed significant differences between (grafted or non-grafted) artificial and native ligaments 3 months after implantation. This difference became non-significant 12 months postoperatively. The anterior tibial drawer was significantly increased 3 months after implantation and remained significantly different only for non-grafted ligament 12 months after implantation. Twelve months after implantation, the differences between grafted and non-grafted ligament biomechanical properties were significant in terms of stiffness. In terms of load to failure, grafted ligaments seem to have had slightly better performance than non-grafted ligaments 12 months postoperatively. Overall these results suggest that grafted artificial ligaments have slightly better biomechanical characteristics than non-grafted artificial ligaments 12 months after implantation in sheep.
On the properties of brain sub arachnoid space and biomechanics of head impacts leading to traumatic brain injury
Saboori, Parisa ; Sadegh, Ali ;
Advances in biomechanics and applications , volume 1, issue 4, 2014, Pages 253~267
DOI : 10.12989/aba.2014.1.4.253
The human head is identified as the body region most frequently involved in life-threatening injuries. Extensive research based on experimental, analytical and numerical methods has sought to quantify the response of the human head to blunt impact in an attempt to explain the likely injury process. Blunt head impact arising from vehicular collisions, sporting injuries, and falls leads to relative motion between the brain and skull and an increase in contact and shear stresses in the meningeal region, thereby leading to traumatic brain injuries. In this paper the properties and material modeling of the subarachnoid space (SAS) as it relates to Traumatic Brain Injuries (TBI) is investigated. This was accomplished using a simplified local model and a validated 3D finite element model. First the material modeling of the trabeculae in the Subarachnoid Space (SAS) was investigated and validated, then the validated material property was used in a 3D head model. In addition, the strain in the brain due to an impact was investigated. From this work it was determined that the material property of the SAS is approximately E = 1150 Pa and that the strain in the brain, and thus the severity of TBI, is proportional to the applied impact velocity and is approximately a quadratic function. This study reveals that the choice of material behavior and properties of the SAS are significant factors in determining the strain in the brain and therefore the understanding of different types of head/brain injuries.
A numerical method for improving the reliability of knee translation measurement in skin marker-based motion analysis
Wang, Hongsheng ; Zheng, Nigel ;
Advances in biomechanics and applications , volume 1, issue 4, 2014, Pages 269~277
DOI : 10.12989/aba.2014.1.4.269
In skin-marker based motion analysis, knee translation measurement is highly dependent on a pre-selected reference point (functional center) on each segment determined by the location of anatomical landmarks. However, the placement of skin markers on palpable anatomical landmarks (i.e., femoral epicondyles) has limited reproducibility. Thus, it produces large variances in knee translation measurement among different subjects, as well as across studies. In order improve the repeatability of knee translation measurement, in this study an optimization method was introduced, by which the femoral functional center was numerically determined. At that point the knee anteroposterior translation during the stance phase of walking was minimized. This new method was tested on 30 healthy subjects during walking in gait lab with motion capture system. Using this new method, the impact of skin marker position (at anatomical landmarks) on the knee translation measurement has been minimized. In addition, the ranges of anteroposterior knee translations during stance phase were significantly (p<0.001) smaller than those measured by conventional method which relies on a pre-selected functional center (
). The results of anteroposterior translation using this new method were very close to a previously reported knee translation (12.4 mm) from dual fluoroscopic imaging technique. Moreover, this new method increased the reproducibility of knee translation measurement by 50%.
Coronary three vessel disease: hydrodynamic simulations including the time-dependence of the microvascular resistances
Harmouche, Majid ; Anselmi, Amedeo ; Maasrani, Mahmoud ; Mariano, Chiara ; Corbineau, Herve ; Verhoye, Jean-Philippe ; Drochon, Agnes ;
Advances in biomechanics and applications , volume 1, issue 4, 2014, Pages 279~292
DOI : 10.12989/aba.2014.1.4.279
This paper presents some simulations of fluxes and pressures in the coronary network, in the case of very severe coronary disease (several stenoses on the left branches and total occlusion of the right coronary artery). In that case, coronary artery bypass graft surgery is the commonly performed procedure. However, the success of the intervention depends on many factors. Modeling of the coronary circulation is thus important since it can help to understand the influence of all these factors on the coronary haemodynamics. We previously developed an analog electrical model that includes the eventual presence of collateral flows, and can describe the different revascularization strategies (two grafts, three grafts, ...). The aim of the present work is to introduce in our simulations the time-dependence of the coronary microvascular resistances, in order to better represent the effect of the systolic ventricular contraction (which induces an elevation of the resistances because the vessels are squeezed).