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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Korean Journal of Veterinary Research
Journal Basic Information
Journal DOI :
The Korean Society of Veterinary Science
Editor in Chief :
Volume & Issues
Volume 51, Issue 4 - Dec 2011
Volume 51, Issue 3 - Sep 2011
Volume 51, Issue 2 - Jun 2011
Volume 51, Issue 1 - Mar 2011
Selecting the target year
Pharmacokinetics of amikacin in plasma of healthy goats after intravenous injection once daily for three days
Naseem, Sania ; Sultana, Mudasir ; Raina, Rajinder ; Pankaj, Nrip Kishore ; Verma, Pawan Kumar ; Nasir, Nasir Ahmad ; Ahanger, Azad Ahmad ; Rahman, Shafiqur ; Prawez, Shahid ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 253~257
Amikacin is a semisynthetic derivative of kanamycin and primarily active against aerobic Gram-negative-pathogens with limited activity against Gram-positive bacteria. Meager study was reported on pharmacokinetic data on multi-days administration of amikacin. Hence, pharmacokinetics study was done in five clinically healthy goats (n = 5), after intravenous bolus injection of amikacin sulfate at the dose rate of 10 mg/kg body weight daily for three consecutive days. The amikacin concentrations in plasma and pharmacokinetics-parameters were analyzed by using microbiological assay technique and noncompartmental open-model, respectively. The mean peak plasma concentrations (Mean
SD) of amikacin at time zero (
, on day 1st and 3rd, respectively. The mean elimination half-life (
on day 1st and
on day 3rd. Mean of area under concentration-time curve (
, on day 1st and 3rd respectively. The total body clearance (
) and volume of distribution at steady state (Vdss) on day 1st and 3rd were
, respectively. No-significant difference was noted in both drug-plasma concentration and pharmacokinetics-parameters, respectively. Amikacin concentration in plasma was found higher up-to 4 h and 6 h onward on down-ward trends favour to reduce toxicity. Which also support the pharmacokinetic-pharmacodynamic way of dosing of aminoglycosides and hence, amikacin may be administered 10 mg/kg intravenously daily to treat principally Gram-negative pathogens and limitedly Gram-positive-pathogens.
Protective effect of ethyl acetate extract of Ishige okamurae against carbon tetrachloride-induced acute liver injury in rats
Kang, Sohi ; Yang, Wonjun ; Oh, Hanseul ; Bae, Yeonji ; Ahn, Meejung ; Kang, Min Chul ; Ko, Ryeo Kyeong ; Kim, Gi Ok ; Lee, Jun Hwa ; Hyun, Jin Won ; Moon, Changjong ; Shin, Taekyun ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 259~265
Several compounds and extracts isolated from a brown alga, Ishige (I.) okamurae, exhibit anti-oxidant and anti-inflammatory effects. The present study investigated whether the ethyl acetate (EtOAc) fraction of I. okamurae (EFIO) could ameliorate carbon tetrachloride (
)-induced hepatotoxicity in rats. Sprague-Dawley rats were intraperitoneally (i.p.) administered with EFIO at 10 or 50 mg/kg per day for 2 consecutive days before
injection (3.3 mL/kg, i.p.). Twenty four hours later, the rats were anesthesized with diethyl ether and dissected. Pretreatment with EFIO significantly reduced the increased serum levels of alanine aminotransferase and aspartate aminotransferase in
-treated rats. Pretreatment with EFIO also significantly inhibited the reduced activities of superoxide dismutase and catalase in the
-injured liver. Histopathological evaluations showed that hemorrhage, hepatocyte necrosis, inflammatory cell infiltration, and fatty degeneration induced by
treatment were ameliorated by the administration of EFIO. Additionally, liver immunohistochemical analyses revealed the marked reduction in ED1-positive monocyte-like macrophages in EFIO-pretreated rats given
. These results suggest that EFIO ameliorates
-induced liver injury, possibly through the inhibition of oxidative stress.
Genetic characterization of methicillin-resistant Staphylococcus aureus from humans and animals within the community
Cho, Jae-Keun ; Kim, Jin-Hyun ; Sung, Myung-Suk ; Kim, Ki-Seuk ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 267~275
Methicillin-resistant Staphylococcus (S.) aureus (MRSA) is one of the most important nosocomial pathogens worldwide and the emergence of this strain has become a major clinical problem. In this study, we investigated the prevalence of MRSA and their genetic characteristics in 69 S. aureus isolated from humans and animals. In human isolates, higher antimicrobial resistance rates were observed against penicillin (80.6%), followed by erythromycin (11.9%) and tetracycline (9.0%). All of them were susceptible to clindamycin, enrofloxacin, novobiocin, pirlimycin, trimethoprim/sulfamethoxazole and vancomycin. The resistance patterns in animal isolates were similar to those of human isolates. Two (2.9%) MRSA strains were isolated from human (n = 1) and animal (n = 1), and these isolates were confirmed as carrying the mecA gene. One isolate originating from human was resistant to 7 drugs and the other isolate derived from animal was resistant to 11 drugs. Staphylococcal cassette chromosome mec (SCCmec) variant IIIB was identified in animal isolate but SCCmec type of an isolate from human was not exactly determined. Two MRSA isolates showed unrelated PFGE pattern between them. Our results indicated although the frequency of MRSA isolates from humans and animals was low, a continuous surveillance and monitoring should be called for to prevent the contamination and spread of MRSA in the community. To our knowledge, this is the first time that SCCmec type variant IIIB was detected from animals in Korea.
Brucellosis in sheep and goat of Bogra and Mymensingh districts of Bangladesh
Rahman, Md. Siddiqur ; Hahsin, Md. Ferdous Ali ; Ahasan, Md. Shamim ; Her, Moon ; Kim, Jeong Yeong ; Kang, Sang Il ; Jung, Suk Chan ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 277~280
Brucellosis is the most important bacterial disease of livestock in Bangladesh. The present study was conducted to determine the seroprevalence of brucellosis in goat and sheep in Mymensingh and Bogra districts of Bangladesh using slow agglutination test and Rose Bengal test as screening test and indirect enzyme linked immunosorbent assay as confirmatory test. Questionnaire based data on age, gender, area, client's complaint, number of animals in herds, disease history, reproductive problems such as abnormal uterine discharge, abortion or previous abortion in sheep and goat and their reproductive diseases were recorded. A total of 200 sera samples were collected from 80 sheep and 120 goats. The prevalence of brucellosis in goat was 2.50% and 1.25% in sheep. Positive reactors were only detected in female of both goat and sheep. In this study, there existed a significant association among abortion and the prevalence of brucellosis (p < 0.01). The prevalence of brucellosis in sheep and goat in Bangladesh is not negligible, and it is therefore worth considering the adoption of preventive measures.
Immuno-enhancing Effects of Lactobacillus salivarius JWS 58 and Lactobacillus plantarum JWS 1354 isolated from duck
Choi, Hyun Jong ; Kim, Ji Ye ; Shin, Myeong Su ; Lee, Sang Myeong ; Lee, Wan Kyu ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 281~288
Lactobacillus salivarius JWS 58 (JWS 58) and Lactobacillus plantarum JWS 1354 (JWS 1354) are isolated from duck intestine and have ability to produce bacteriocin. The objective of this study was to evaluate the immunomodulatory effects of JWS 58 and JWS 1354. The nitric oxide (NO) and cytokines (IL-
) were measured in C57BL/6 mouse peritoneal macrophages to determine immune enhancing effects of JWS 58 and JWS 1354. A Listeria (L.) monocytogenes challenge mice model was used to evaluate immune enhancement ability of JWS 58 and JWS 1354 in vivo. The results showed that JWS 58 and JWS 1354 increased the production of NO or cytokines by peritoneal macrophages and that oral administration of viable probiotic strains in mice elicited the immuno-modulatory effect upon L. monocytogenes challenge. JWS 1354 showed stronger immune enhancing effects than JWS 58. Collectively, this study demonstrated that Lactobacillus strain JWS 58 and JWS 1354 possess immune enhancing effect. Furthermore, two stains are expected to use feed supplement to prevent diseases by pathogenic bacteria through releasing bacteriocin and enhancing host immune responses in animal.
The anti-parasitic efficacy of ivermectin and pyrantel pamoate compound against canine Toxocara canis and Trichuris vulpis
Youn, Heejeong ; Ra, Jeong Chan ; Kim, Byung Ki ; Bae, Bokyoung ; Lim, Yong Suk ; Kim, Kyong Hee ; Lee, Kyong-Eun ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 289~295
Toxocara (T.) canis and Trichuris (T.) vulpis are very important canine parasitic nematodes. T. canis parasitize in small intestine and T. vulpis parasitize in large intestine. In order to control of these nematodes, ivermectin and pyrantel pamoate compound was applied to the dogs infected with these parasites naturally and artificially. This drug was composed of
of ivermectin and 57.0 mg of pyrantel pamoate for small animal,
of ivermectin and 114.0 mg of pyrantel pamoate for middle animal, and
of ivermectin and 227.0 mg of pyrantel pamoate for large animal. Ivermectin in this drug is activity to nematodes and ectoparisites. Pyrantel pamoate in this drug is also activity to nematodes. In this experiment, this drug had a good efficacy against T. canis and T. vulpis in the infected dogs.
Rate of return to race after arthroscopic surgeries in Thoroughbred racehorses (2005~2010)
Yang, Jaehyuk ; Lim, Yoon-Kyu ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 297~301
The racehorses that under arthroscopic surgery due to be injured his limbs were studied during exercise or training at Busan Race Park from 2005 to 2010. Rate of arthroscopic surgical treatments was 1.4% (63/4,642). Affected bones were radius, radial carpal bone, third carpal bone, proximal phalanx, third metacarpal bone, femur, tibia, proximal sesamoid bone and intermediate carpal bone. The lesions were fracture, chip fracture, slap fracture, osteochonrosis, and osteochondrotitis dissencans. Number of patients under arthroscopic surgery were 63. Success horses of returned to racetrack or tried to return to racetrack were 58, and 5 horses were in training or resting at the time of publication. Success horses of returned to their previous use in the patients were 49 horses (84.4%) and no returned to the racetrack were 9 horses (15.6%) in 58 horses.
Awareness effects by aquapuncture with dexamethasone in tiletamine/zolazepam anesthetized dogs
Park, Hyung-Jin ; Song, Kun-Ho ; Kim, Duck-Hwan ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 303~307
Awareness effect of aquapuncture with dexamethasone on GV-26 was studied in tiletamine/zolazapam anesthetized six healthy crossbred dogs using a randomized cross-over experimental study design. After anesthesia by tiletamine/zolazapam, 0.1 mg dexamethasone was injected on GV-26 at 20 min in the experimental group. For the control group, 0.1 mg dexamethasone was injected on the quadriceps femoralis. A significant difference was evident in the sedation score between groups at 60 and 90 min (p < 0.05). A significant difference was also evident in the analgesia score at 50 and 60 min (p < 0.05). At 90 min, all dogs in the experimental group responded strongly to pain (p < 0.01). Head up time, sternal recumbent time, standing time, and walking time was shorter in the experimental group, but the difference from the control group was statistically significant only for head up time and walking time (p < 0.05). GV-26 acupuncture with dexamethasone is useful for awareness effects after anesthesia.
Effect of variable degrees of jejunal resection upon different clinico-biochemical parameters in dogs
Dilawer, Muhammad Sohail ; Khan, Muhammad Arif ; Abidin, Zain ul ; Azeem, Shahan ; Majeed, Khalid Abdul ; Shahbaz, Adeel ; Khan, Aamir Riaz ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 309~313
Dogs are considered to be the best companions of human beings due to their loyalty, obedience and pleasant disposition. Jejunum is the largest part of small intestine mainly involved in absorption of nutrients. Jejunal resection up to 80% allows normal weight gain while resection up to 90% increased morbidity and mortality. In the present study, 20 dogs were divided into 4 groups based on the degree of jejunal resection i.e. A (70% resection), B (80% resection) and C (100% resection) while group D served as control. Dogs in the 70% and 80% jejunal resection group showed normal growth and function while 100% jejunal resection resulted in weight loss and alteration of hematological and biochemical parameters.
Pattern alopecia in a miniature pinscher dog
Kang, Jongil ; Lee, Wanghui ; Park, Jeongho ; Oh, Taeho ; Cho, Seongwhan ; Park, Seongjun ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 315~318
A dog (5.6 kg, 4-year-old, castrated male, Miniature pinscher) with diffuse symmetric alopecia on the chest and excessive scales was referred to Veterinary Medical Teaching Hospital of Chungnam National University, Korea. On physical examination, diffuse alopecia on ventral aspect of the neck and caudomedial thighs, and severe scales were presented. Dermatologic tests of lesions revealed bacterial infections. Histopathologically, atrophy of hair bulb was observed in the severely alopecic lesion of caudomedial thighs. ACTH stimulation test was performed to differentiate the endocrine disorder related to generalized alopecia. The pre-ACTH serum testosterone and progesterone concentrations were above normal ranges and the post-ACTH serum testosterone concentration was high. The pre- and post-ACTH serum estradiol and cortisol concentrations were within normal ranges. Canine pattern alopecia was diagnosed based on history, physical examination, hormonal assay and dermatohistopathologic examination. After 3 months of melatonin administration, multifocal alopecia on the trunk was improved and general hair regrowth was identified.
Central diabetic insipidus associated with suspected pituitary gland tumor in a dog
Lee, Kyo-Im ; Park, Hee-Myung ;
Korean Journal of Veterinary Research, volume 51, issue 4, 2011, Pages 319~323
A 12-year-old spayed female Yorkshire terrier dog was presented with two-weeks history of lethargy, mental dullness and polydipsia. Neurologic examination revealed proprioceptive defect of all limbs and loss of swallowing gag reflex. The dog revealed persistent dehydration, hypernatremia, hyperosmolarity and hyposthenuria. On magnetic resornance imaging (MRI), the mass were heterogeneous signality on T1 weighted images, hyperintense signality on T2 weighted image with contrast enhancement on hypothalamohypophyseal lesion. Based on these findings, the dog was suspected as having pituitary gland tumor. Through water deprivation test and response to desmopressin acetate (1-deamino-8-D-arginine, DDAVP), this case was diagnosed by central diabetes insipidus (CDI). This paper reports the clinical sign, MRI, response to the exogenous antidiuretic hormone of CDI due to suspected pituitary tumor in a dog and DDAVP administration was evaluated effective therapy to correct hypernatremia induced by CDI.