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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Korean Journal of Veterinary Research
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Journal DOI :
The Korean Society of Veterinary Science
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Volume & Issues
Volume 54, Issue 4 - Dec 2014
Volume 54, Issue 3 - Sep 2014
Volume 54, Issue 2 - Jun 2014
Volume 54, Issue 1 - Mar 2014
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Neuroprotective effects of resveratrol on 6-hydroxydopamine-induced damage of SH-SY5Y cell line
Chang, Geon-Cheon ; Kim, Hyoung-Chun ; Wie, Myung-Bok ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 1~6
DOI : 10.14405/kjvr.2014.54.1.1
Parkinson's disease is known to exhibit progressive degeneration of the dopaminergic neurons in the substantia nigra via inhibition of glutathione metabolism. It is well known that 6-Hydroxydopamine (6-OHDA) induces Parkinson's disease-like symptoms, while resveratrol (3,5,4'-trihydroxystilbene) has been shown to have anti-inflammatory and antioxidant effects. In the present study, we investigated the neuroprotective effects of resveratrol, a phytoalexin found in grapes and various plants, on 6-OHDA-induced cell damage to the SH-SY5Y human neuroblastoma cell line. Resveratrol (5 and 10
) inhibited 6-OHDA (60
)-induced cytotoxicity in SH-SY5Y cells and induced a reduction of the number of apoptotic nuclei caused by 6-OHDA treatment. Additionally, the total apoptotic rate of cells treated with both resveratrol (10
) and 6-OHDA (60
) was less than that of 6-OHDA treated cells. Resveratrol also dose-dependently (1, 5 and 10
) scavenged reactive oxygen species (ROS) induced by 6-OHDA in SH-SY5Y cells and prevented depletion of glutathione in response to the 6-OHDA-induced cytotoxicity in the glutathione assay. Overall, these results indicate that resveratrol exerts a neuroprotective effect against 6-OHDA-induced cytotoxicity of SH-SY5Y cells by scavenging ROS and preserving glutathione.
Cutaneous peripheral nerve sheath tumors in 15 dogs
Ko, Seung-Bo ; Song, Kyoung-Ok ; Kang, Sang-Chul ; Kim, Jae-Hoon ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 7~12
DOI : 10.14405/kjvr.2014.54.1.7
Peripheral nerve sheath tumors (PNSTs) are heterogeneous tumor groups of peripheral nerves that originate from either Schwann cells or modified Schwann cells, fibroblasts, or perineural cells. In this study, signalment and clinical data such as tumor location and size were evaluated for 15 cases of PNSTs collected from local animal hospitals. The mean age of dogs with malignant PNST was higher than that of dogs with benign PNST. Additionally, the male to female ratio in dogs with PNST was 1 : 4. In dogs with PNST, the primary sites of involvement were the hindlimb, forelimb, around the mammary glands, the neck, and the abdomen. Histiopathologic examination revealed that eight PNSTs were benign and seven were malignant. The tumor cells were composed of loosely to densely arranged interlacing bundles and wavy spindle cells arranged in short bundles, palisading, and whirling. High mitotic figures, local invasion, multifocal necrosis and atypical multinucleated giant cells were observed in malignant PNST cases. All PNSTs showed immunoreactivity for vimentin and S-100. However, only 93.3% and 73.3% were immunoreactive for NSE and GFAP, respectively. Overall, these results indicated that immunohistochemical markers such as vimentin, S-100 and NSE could help confirm the diagnosis of canine PNSTs.
A study of animal bones excavated from the shell mound of Jeju Jongdali 1819 archaeological site
Kang, Yoonhyoung ; Moon, Jihwan ; Ahn, Meejung ; Bang, Moon-Bae ; Shin, Taekyun ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 13~19
DOI : 10.14405/kjvr.2014.54.1.13
Animal bones excavated with earthenware from the shell mound at the Jeju Jongdali 1819 archeological site, where three consecutive chronological layers covering the Neolithic (B.C. 15C-B.C. 10C), early Tamra, and late Tamra periods have been identified, were morphologically classified. The majority of the bones from all three periods were broken or split. The major fauna of the mammalian bones in all periods were Cervus spp., Sus scrofa, and Bos taurus. In the early and late Tamra periods, bones of small animals including Mustela sibirica coreana, Meles meles, Rodentia, and Aves were also found in small number. The excavated bones were from all parts of the animal bodies, including head, trunk, forelimb, and hindlimb. Collectively, these findings suggest that the major fauna from the Neolithic to late Tamra periods consisted of Cervus spp., Sus scrofa, and Bos taurus and that the fauna was dissected and carried to the shell mound site after hunting. Information from the bone remains in the shell mound are useful data for study of the wildlife and domestic animals living during the prehistoric period of Jeju Island.
Anti-diabetic effects of benfotiamine on an animal model of type 2 diabetes mellitus
Chung, Kang Min ; Kang, Wonyoung ; Kim, Dong Geon ; Hong, Hyun Ju ; Lee, Youngjae ; Han, Chang-Hoon ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 21~26
DOI : 10.14405/kjvr.2014.54.1.21
Although benfotiamine has various beneficial anti-diabetic effects, the detailed mechanisms underlying the impact of this compound on the insulin signaling pathway are still unclear. In the present study, we evaluated the effects of benfotiamine on the hepatic insulin signaling pathway in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which are a type 2 diabetes mellitus model. OLETF rats treated with benfotiamine showed decreased body weight gain and reduced adipose tissue weight. In addition, blood glucose levels were lower in OLETF rats treated with benfotiamine. Following treatment with benfotiamine, the levels of Akt phosphorylation (S473/T308) in the OLETF groups increased significantly compared to the OLETF control group so that they were almost identical to the levels observed in the control group. Moreover, benfotiamine restored the phosphorylation levels of both glycogen synthase kinase (GSK)-
(S21, S9) and glycogen synthase (GS; S641) in OLETF rats to nearly the same levels observed in the control group. Overall, these results suggest that benfotiamine can potentially attenuate type 2 diabetes mellitus in OLETF rats by restoring insulin sensitivity through upregulation of Akt phosphorylation and activation of two downstream signaling molecules, GSK-
and GS, thereby reducing blood glucose levels through glycogen synthesis.
Preoperative administration effect of metronidazole, ceftriaxone sodium and their combination on stenotic index of jejunal anastomotic segment of dogs
Rafique, Rehan ; Asi, Muhammad Nadeem ; Saqib, Muhammad ; Hussain, Muhammad Hammad ; Sial, Awais-ur-Rehman ; Mushtaq, Aqsa ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 27~30
DOI : 10.14405/kjvr.2014.54.1.27
The jejunum is the longest part of the small intestine and its lumen is mainly involved in the absorption of the nutrients. The present study was conducted to evaluate the effects of metronidazole, ceftriaxoine sodium and their combination on the stenotic index of the end to end jujunal anastomotic site. To accomplish this, 20 healthy stray dogs were subjected to end to end jejunal ansastmosis. Dogs in Group A (control) underwent jejunal anstomosis with no antibiotic prophylaxis, while those in Group B received surgery and metronidazole alone at 50 mg/kg, those in Group C received ceftriaxone sodium intravenously at 30 mg/kg body weight prior to surgery and dogs in Group D were given metronidazole in combination with ceftriaxone sodium at 50 mg/kg and 30 mg/kg, respectively, 2 h before surgical intervention. No significant difference (p > 0.05) in the stenotic index was observed at 14 days after jejunal anastomosis. These findings indicate that prophylactic administration of metronidazole and ceftriaxone sodium alone or in combination had no significant effect on the stenotic index of the jejunum.
Effect of repeated Paecilomyces japonica treatment on rats
Kim, Yong-Bum ; Hong, Da-Hae ; Cho, Eun-Sang ; Im, Wanjung ; Kim, Il-Hwan ; Son, Hwa-Young ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 31~38
DOI : 10.14405/kjvr.2014.54.1.31
Cordyceps is a fungus used as a traditional medicine in China, Japan, and Korea. Paecilomyces (P.) japonica is a new cordyceps that was recently cultivated on silkworm pupae in Korea. The present study evaluated the toxicological effects of P. japonica in rats. Forty rats were treated with oral doses of P. japonica (0, 20, 100, or 500 mg/kg/day) for 4 weeks. Twenty additional rats were treated with 0 or 500 mg/kg/day of P. japonica for 4 weeks and then maintained for 2 weeks without treatment. Clinical signs, body weight, food and water consumption, and organ weight as well as hematology, serum biochemistry, and histopathology data were examined. Body weight gain of the group treated with 500 mg/kg/day was significantly reduced. Microscopically, karyomegaly, single cell necrosis, and mitosis were observed in the renal tubular epithelium of all treated groups. In conclusion, P. japonica caused a reduction of body weight and renal injury in rats. The no observed adverse effect level (NOAEL) of P. japonica was less than 20 mg/kg/day.
Prevalence of virulence and cytolethal distending toxin (CDT) genes in thermophilic Campylobacter spp. from dogs and humans in Gyeongnam and Busan, Korea
Cho, Hyun-Ho ; Kim, Sang-Hyun ; Min, Wongi ; Ku, Bok-Kyung ; Kim, Yong-Hwan ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 39~48
DOI : 10.14405/kjvr.2014.54.1.39
The prevalence of thermophilic Campylobacter (C.) spp. in stray, breeding, and household dogs was 25.2, 12.0, and 8.8%, respectively. C. jejuni and C. upsaliensis were the predominant Campylobacter spp. from household dogs. cdtA, cdtB, and cdtC were detected by PCR in all isolates. Despite the high cytolethal distending toxin (CDT) gene prevalence, only 26 (31%) C. jejuni strains and one (15.3%) C. coli strain showed evidence of CDT production in HEp-2 cell cytotoxicity assays. Virulence-associated genes detected in the C. jejuni and C. coli isolates were cadF, dnaJ, flaA, racR, ciaB, iamA, pldA, virB11, ceuE, and docC. cadF, dnaJ, flaA, and ceuE were found in all C. jejuni and C. coli isolates. When detecting Guillain-Barr
syndrome-associated genes (galE, cgtB, and wlaN), galE was identified in all isolates. However, cgtB and wlaN were more prevalent in C. jejuni isolates from humans than those from dogs. Adherence and invasion abilities of the C. jejuni and C. coli strains were tested in INT-407 cells. A considerable correlation (adjusted
= 0.678) existed between adherence and invasion activities of the Campylobacter spp. isolates.
Comparison of pathogens and antimicrobial susceptibility of Staphylococcus aureus isolated from conventional and robotic milking herds
Lee, Sung-Hwan ; Kim, Doo ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 49~52
DOI : 10.14405/kjvr.2014.54.1.49
This study was conducted to compare the patterns of mastitic pathogens and the antimicrobial susceptibility of Staphylococcus (S.) aureus from conventional milking (CM) and robotic milking (RM) dairy herds. To accomplish this, the minimum inhibitory concentrations of 14 antimicrobial agents were tested against S. aureus by the microdilution method. Regardless of the milking system, S. aureus, coagulase negative staphylococcus, and Streptococcus uberis were isolated. Additionally, significant differences in the antimicrobial susceptibility of S. aureus isolates between RM and CM farms were only observed in response to tetracycline.
Serum cardiac troponin I concentrations in clinically normal and Dirofilaria immitis infected Korean Jindo dogs
Hwang, Soo-Hyen ; Park, Hyung-Jin ; Seo, Kyoung-Won ; Lee, Sang-Eun ; Song, Kun-Ho ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 53~54
DOI : 10.14405/kjvr.2014.54.1.53
This study was conducted to determine the serum cardiac troponin I (cTnI) concentrations in clinically normal (uninfected) Korean Jindo dogs and those infected with Dirofilaria (D.) immitis. Forty Korean Jindo dogs (22 females, 18 males) were obtained from two kennels in the Boryeong area of Chungnam Province and the Daejeon area, Korea. Significantly higher cTnI concentrations were observed in D. immitis-infected dogs than clinically normal dogs. cTnI testing in addition to thoracic radiography, echocardiography, and electrocardiography shows promise as an additional method for diagnosis of heartworm infection.
Effective DNA extraction method to improve detection of Mycobacterium avium subsp. paratuberculosis in bovine feces
Park, Hong-Tae ; Shin, Min-Kyoung ; Sung, Kyung Yong ; Park, Hyun-Eui ; Cho, Yong-Il ; Yoo, Han Sang ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 55~57
DOI : 10.14405/kjvr.2014.54.1.55
Paratuberculosis caused by Mycobacterium avium subsp. paratuberculosis (MAP) has extended latent periods of infection. Due to this property, difficulties in the detection of fecal shedder have been raised. A newly designed method for DNA extraction from fecal specimens, mGITC/SC was evaluated in terms of diagnostic efficiency. The detection limit of IS900 real-time PCR was about 50 MAP (1.5 cfu) in 250 mg of feces (6 cfu per g). Also, this DNA extraction method was faster and cheaper than that using commercial kit or other methods. Consequently, the mGITC/SC is an economical DNA extraction method that could be a useful tool for detecting MAP from fecal specimens.
Focal form of acquired myasthenia gravis with megaesophagus in a Yorkshire terrier dog
Hahn, Tae-Yeon ; Kang, Min-Hee ; Eom, Ki-Dong ; Park, Hee-Myung ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 59~62
DOI : 10.14405/kjvr.2014.54.1.59
A 12-year-old, castrated male Yorkshire terrier dog presented with frequent regurgitations that had begun 45 days earlier and become more progressive. Radiographs revealed an air-trap region behind the cranial esophageal sphincter muscle in the esophagus and esophagographies with barium contrast showed mild esophageal dilation with decreased motility. Esophageal motility increased within 5 min of neostigmine methylsulfate administration and acetylcholine receptor antibodies titer increased to beyond the normal range. Based on these findings, acquired myasthenia gravis with focal form was diagnosed, making this the first such case diagnosed by an acetylcholine receptor antibody test in Korea.
Myxoid liposarcoma in a dog
Jeon, Sung-Joo ; Cho, Eun-Sang ; Noh, Hye-Jin ; Son, Hwa-Young ;
Korean Journal of Veterinary Research, volume 54, issue 1, 2014, Pages 63~66
DOI : 10.14405/kjvr.2014.54.1.63
The pathological features of a mass in the back skin region of an 8-year-old castrated male dog are described herein. The cut section of the tumor was white to tan with a soft multilobulated mass containing hemorrhagic and necrotic foci and a mucinous-like composition. Microscopically, the tumor was composed of a mixture of lipocytes, lipoblasts, spindle cells and stellate cells and had a myxoid background. Oil red O staining revealed that the cytoplasm of neoplastic cells contained large numbers of lipid droplets. Immunohistochemically, tumor cells were positive for vimentin and S-100 protein. The skin mass was diagnosed as myxoid liposarcoma.