• Title, Summary, Keyword: 골관절염

Search Result 404, Processing Time 0.036 seconds

Investigating Effects of Negative Emotional States on the Korean Elderly's Osteoarthritis prevalence (국내 노인의 골관절염 유병률에 부정적인 감정이 미치는 영향에 대한 실증연구)

  • Jeon, Hyeon Gyu;Won, Jong Yoon;Lee, Kun Chang
    • Journal of Digital Convergence
    • /
    • v.18 no.3
    • /
    • pp.247-257
    • /
    • 2020
  • Many number of elderly people suffer from osteoarthritis, a degenerative arthritis. Korea is entering an aged society with a rapid increase in the elderly population. This increase in the elderly population has led to an increase in elderly osteoarthritis patients. Therefore, many elderly people are greatly hampered by the quality of life due to osteoarthritis. The purpose of this study is to clarify the risk factors of osteoarthritis and to investigate the relationship between negative emotional states and osteoarthritis. The results proved that demographic risk factors, anthropometric and biochemical factors, and health behaviors influence osteoarthritis. In addition, it was confirmed that negative emotions perceived by the elderly, such as depression and stress, should be regarded as main factors of osteoarthritis.

Health behaviors of the elderly with osteoarthritis across gender groups (남성노인과 여성노인의 골관절염 관련 건강행태 비교)

  • Jeon, Eunyoung
    • Journal of the Korean Data and Information Science Society
    • /
    • v.26 no.6
    • /
    • pp.1453-1463
    • /
    • 2015
  • The purpose of this study was to identify health behaviors of elderly with osteoarthritis across gender groups. Total of 1,654 age 65 over from the fifth Korean National health and Nutrition Examination Survey (KNHANES) were selected. The data analysis was performed using the complex sampling function of SPSS version 20. Logistic regression analysis shows the difference of risk factors of osteoarthritis between men and women elderly people. Prevalence of osteoarthritis in men elderly was associated with drinking, education for osteoarthritis, and treatment of osteoarthritis whereas the factors in woman elderly were depression and muscle strengthen exercise. Most of the subjects had not the opportunity of education of the management of the osteoarthritis. These findings from the study are expected to promote the screening strategy for the aged at risk of osteoarthritis in the Korean community and enhance the effect of the nursing intervention for the elderly with osteoarthritis.

Comparable Influencing Factors for Quality of Health-Life in Osteoarthritis Patients in Urban and Rural Areas (도시와 농촌의 골관절염 환자의 건강관련 삶의 질에 영향을 미치는 융합적 요인 비교)

  • Song, Hye Young;Park, Min Hee
    • Journal of the Korea Convergence Society
    • /
    • v.8 no.6
    • /
    • pp.311-323
    • /
    • 2017
  • The purpose of this study is to compare factors influencing the quality of life of osteoarthritis patients in urban and rural areas. The data were derived from the sixth Korea national health and nutrition examination survey in 2014 and analyzed using the IBM SPSS Statistics version 21.0 software package considering complex samples analysis. The subjects of study were 599 adults with osteoarthritis over 50 years. The results of the study show that the factors affecting the urban patients' quality of life are healthcare coverage types, knee joint pain, knee ankylosis, hip joint pain, low back pain, limited activities, and subjective health status. The rural patients' quality of life are influenced by knee joint pain, limited activities, and alcohol consumptions. Therefore, the government should create differentiating strategies and approaches, including community rehabilitation programs, to improve the quality of life of urban and rural patients with osteoarthritis.

Effect of Boswellia serrata Extracts on Degenerative Osteoarthritis in vitro and in vivo Models (보스웰리아 추출물의 골관절염 억제 효과 연구)

  • Nam, Da-Eun;Kim, Ok Kyung;Shim, Tae Jin;Kim, Ji Hoon;Lee, Jeongmin
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.43 no.5
    • /
    • pp.631-640
    • /
    • 2014
  • The inhibitory effects of Boswellia serrata (BW) extracts on degenerative osteoarthritis were investigated in primary-cultured rat cartilage cells and a monosodium-iodoacetate (MIA)-induced osteoarthritis rat model. To identify the protective effects of BW extract against $H_2O_2$ ($800{\mu}M$, 2 hr) in vitro, cell survival was measured by MTT assay. Cell survival after $H_2O_2$ treatment was elevated by BW extract at a concentration of $20{\mu}g/mL$. In addition, BW extract treatment significantly reduced and normalized the productions of pro-inflammatory factors, nuclear transcription factor ${\kappa}B$, cyclooxygenase-2, tumor necrosis factor-${\alpha}$, and interleukin-6 at a concentration of $20{\mu}g/mL$. Treatment of chondrocytes with BW extract significantly reduced 5-lipoxygenase activity and production of prostaglandin E2, especially at a concentration of $10{\sim}20{\mu}g/mL$. For the in vivo animal study, osteoarthritis was induced by intra-articular injection of MIA into knee joints of rats. Consumption of a diet containing BW extract (100 and 200 mg/kg) for 35 days significantly inhibited the development and severity of osteoarthritis in rats. To determine the genetic expression of arthritic factors in articular cartilage, real-time PCR was applied to measure matrix metalloproteinases (MMP-3, MMP-9, and MMP-13), collagen type I, collagen type II, and aggrecan, and BW extract had protective effects at a concentration of 200 mg/kg. In conclusion, BW extract was able to inhibit articular cartilage degeneration by preventing extracellular matrix degradation and chondrocyte injury. One can consider that BW extract may be a potential therapeutic treatment for degenerative osteoarthritis.

Scintigraphic Detection of Adjuvant-induced Arthritis in Rats Using $^{99m}Technetium-methylene$ Diphosphonate ($^{99m}Technetium-methylene$ Diphosphonate의 전신 골격주사술을 이용한 관절염의 핵의학적 진단)

  • 강성수;궁성수;배춘식;최석화
    • Journal of Veterinary Clinics
    • /
    • v.18 no.2
    • /
    • pp.133-138
    • /
    • 2001
  • 본 연구는 랫드에서 Freund's complete adjuvant를 랫드의 후지에 투여하여 인의적으로 유발된 관절염을 진단하기 위한 방법으로 $^{99m}Technetium-MDP (^{99m}Tc_MDP$)을 이용한 골 스캔의 임상적 의의를 찾고자 하였다. 성숙 Sprague-Dawley 암컷 랫드를 대조군과 실험군으로 분리하고, 골의 스캔은 0.05mCi의 $^{99m}Tc_MDP$를 정맥 주사하여 3시간 후에 전신 영상을 얻었다. 골의 스캔과 방사선학적 평가를 비교한 겨과 관절염 유발 7일 후부터 관절염의 병변이 관찰되었지만, 방사선학적 소견에서는 14일 후부터 병변이 관찰되었다. 골의 스캔에서 관절염 유발 7일 후에 유의적으로 골의 이상적 섭취 증각가 관찰되었고(p<0.05), 21일 후에는 전지와 후지의 모든 부위에서 골의 이상적 섭취 증가가 관찰되었지만, 방사선학적 소견에서는 후지에서만 병변 부위가 관찰되었다. 이상의 결과에서 $^{99m}Tc_MDP$을 이용한 골의 스캔은 류마티스 관절염을 임상적으로 진단하는데 방사선학적 진단보다 효과적인 방법임을 알 수가 있었고, 골의 스캔은 류마티스 관절염을 초기에 진단하는데 유효한 진단방법임을 확인하였다.

  • PDF

Convergence on the related depression, suicidal ideation and nutrient intakes in older adults with osteoarthritis using the 6th Korea National Health and Nutrition Examination Survey(KNHANES VI) (50대 이상의 골관절염 환자의 우울감 및 자살사고와 영양섭취에 관한 융합연구 : 국민건강영양조사 6기 자료 이용하여)

  • Hwang, Hyo-Jeong;Choi, Yean Jung
    • Journal of the Korea Convergence Society
    • /
    • v.10 no.8
    • /
    • pp.27-36
    • /
    • 2019
  • We investigated the relationship between depression, suicide risk, and related nutrient intakes in 50-60 year old Korean osteoarthritis patients. In the $6^{th}$ National Health and Nutrition Examination Survey, 4,112 people who have been diagnosed with osteoarthritis by a doctor were analysed. Anxiety and depression level, pain and discomport level, depressive mood and suicidal ideation were significantly higher in osteoarthritis group compared to the non-osteoarthritis group(p<0.05). Dietary intake of energy, protein, n-3 and n-6 fatty acids, calcium, phosphate, thiamin, riboflavin, and niacin were significantly higher in the normal group compared with all the osteoarthritis, depression and suicidal ideation groups(p<0.05). The presented convergence strategy would be applied for emotional health and health care improvement of osteoarthritis patients.

Artemisia argyi H.Lev. & Vaniot Inhibits Matrix metalloproteinases in the Interleukin-1β-stimulated Primary Chondrocytes and Attenuates Osteoarthritis Progression in Mice (황해쑥의 Interleukin-1β 유도 연골세포에서 Matrix metalloproteinase들의 억제효과 및 마우스에서 관절염 진행 감소 효과)

  • Park, Chan Hum;Yang, Chang Yeol;Yang, Siyoung;Yokozawa, Takako;Shin, Yu Su
    • Proceedings of the Plant Resources Society of Korea Conference
    • /
    • /
    • pp.94-94
    • /
    • 2019
  • 황해쑥(Artemisia argyi H.Lev. & Vaniot)은 우수한 항염증 활성을 지닌 것으로 다양하게 보고 되었다. 그러나, 대표적인 염증 질환 중 하나인 골관절염에 미치는 영향은 현재까지 알려져 있지 않다. 따라서, 본 연구에서는 염증 유발 연골 세포 및 골관절염 유발 동물 모델에 미치는 황해쑥 효과에 대해 조사하였다. 첫째, interleukin 1 beta를 투여한 관절 연골 세포에 황해쑥 물 추출물을 투여한 후 metalloporeinase (MMP) -3 및 MMP-13의 발현을 mRNA 및 단백질 수준에서 분석 하였다. 또한, 내측 반월상 연골의 불안정화에 의해 유도 된 골관절염 마우스 모델을 사용하여 황해쑥 물 추출물의 골관절염 억제 효과를 분석 하였다. 세포 실험에서, 본 황해쑥은 MMP-3와 MMP-13의 mRNA 및 단백질 발현을 유의하게 억제하였다. 또한. 황해쑥 물 추출물을 투여한 실험 동물의 관절 조직을 Safranin O 염색을 실시하여 분석한 결과 연골 하 골판 두께의 감소 및 활막 염증 개선 효과가 관찰 되었다. HPLC를 이용한 성분 분석 결과, 황해쑥 물 추출물은 항염증 및 항관절염 활성을 가진 jaceosidin과 eupatilin을 함유하는 것으로 나타났다. 본 연구결과로부터 황해쑥은 골관절염의 치료 또는 예방에 유망한 소재로 개발될 수 있음을 시사한다.

  • PDF

Prevalence and Related Factors of Knee Osteoarthritis in Rural Women (농촌여성의 무릎 골관절염 유병률 및 관련요인)

  • Seo, Joong-Hwan;Kang, Pock-Soo;Lee, Kyeong-Soo;Yun, Sung-Ho;Hwang, Tae-Yoon;Park, Jong-Seo
    • Journal of agricultural medicine and community health
    • /
    • v.30 no.2
    • /
    • pp.167-182
    • /
    • 2005
  • Objectives: This study was performed to investigate the prevalence of knee osteoarthritis according to the criteria of diagnosing knee osteoarthritis in rural women and the factors related with this disease. Methods: The data obtained from 200 women older than 40 years of age residing in 5 Ri's in Goryeong-gun. Gyeongsanbuk-do by random cluster sampling from September to October 2002. Knee osteoarthritis was determined positive according to the Kellgren and Lawrence classification and knee pain. Results: Among these subjects, 71.0% showed more than grade 2 in radiologic finding and the rate of knee pain according to the survey was 67.0%. The rate of subjects meeting the criteria of knee osteoarthritis was 54.0%. According to univariate analysis, the prevalence of knee osteoarthritis increased with age and those farming people and people working in household industry was significantly high at 58.9% compared with others. The prevalence of knee osteoarthritis showed a significant relationship with the family history and past history of knee injury and knee surgery(p<0.01), and diabetes mellitus(p<0.05). The score of ADL was significantly different in the subjects with knee osteoarthritis compared with normal group(p<0.05). When the presence of knee osteoarthritis and the period of the life style of seating down on the floor were compared, a significant difference was present between the osteoarthritis group and normal group. As for metabolic factors, the blood sugar level, bone density, and body mass index(BMI) were significantly different in the osteoarthritis group compared with normal group. When multiple logistic regression analysis was performed with the presence of knee osteoarthritis as the dependent variable, the prevalence of knee osteoarthritis was significantly affected by older age, subjects farming or working in household industry, the history of knee injury, the history of surgery, higher blood sugar level, and higher BMI. Conclusions: These subjects need an intervention through self-care programs such as exercise for preventing osteoarthritis, weight control programs, other exercise programs strengthening knee joints, and guidelines when working in vinyl houses.

  • PDF

A Study on Usefulness of Planar Bone Scan and Bone SPECT in Diagnosis of Temporomandibular Joint Arthritides (측두하악관절의 관절염 진단에 있어서 골스캔과 단광자방출 전산화 단층촬영의 유용성에 관한 연구)

  • Kim, Chang-Yong;Ahn, Yong-Woo;Park, June-Sang;Ko, Myung-Yun
    • Journal of Oral Medicine and Pain
    • /
    • v.30 no.1
    • /
    • pp.107-119
    • /
    • 2005
  • Temporomandibular joint arthritides is divided into osteoarthritis, osteoarthrosis and polyarthritis. Because the signs, symptoms and radiographical features of osteoarthritis and osteoarthrosis are similar without arthralgia, diffenential diagnosis is difficult. Also non-radiographically change in early Osteoarthritis leads to misdiagnose. Planar bone scan and SPECT are useful to detect bone change early. This study was carried out in order to make diagnostic criteria of planar bone scan and SPECT. Three hundred and four temporomandibular joints were examined with clinical examination, computerized tomograph, planar bone scan, and SPECT. The obtained results were as follows. 1. If temporomandibular joint simple uptake ratio of patient in twenties is over 1.397%, it's condition may be osteoarthritis. And simple uptake ratio over in thirties-fourties may mean osteoarthritis. 2. It may mean osteoarthritis of temporomandibular joint that the number of coronal and transverse SPECT frame with hot spot is over four. 3. Destructive stage may goes on, if simple uptake ratio is over 1.370% in tweenties and over 1.104% in thirties-fourties. 4. If the number of coronal SPECT frame with hot spot is over four, temporomandibular joint may be on destructive stage in tweenties, thirties-fourties. And if the number of transverse SPECT frame with hot spot is over three, it may be on destructive stage in all ages. 5. When patient complains subjective arthralgia and palpation arthralgia, bone change may be more active than each arthralgia. 6. Osteoarthritis may progress gradually worse in 4.5 anamnesis. And then it may be stable gradually and turn to osteoarthrosis.