• Title, Summary, Keyword: 미소바늘

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Prestrain-induced Reduction in Skin Tissue Puncture Force of Microneedle (초기변형률에 의한 미소바늘의 피부조직 관통력 감소)

  • Kim, Jonghun;Park, Sungmin;Nam, Gyungmok;Yoon, Sang-Hee
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.40 no.10
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    • pp.851-856
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    • 2016
  • Despite all the recent advances in biodegradable material-based microneedles, the bending and failure (especially buckling) of a biodegradable microneedle during skin tissue insertion remains a major technical hurdle for its large-scale commercialization. A reduction in skin tissue puncture force during microneedle insertion remains an essential issue in successfully developing a biodegradable microneedle. Here, we consider uniaxial and equibiaxial prestrains applied to a skin tissue as mechanophysical stimuli that can reduce the skin tissue puncture force, and investigate the effect of prestrain on the changes in skin tissue puncture force. For a porcine skin tissue similar to that of humans, the skin tissue puncture force of a flat-end microneedle is measured with a z-axis stage equipped with a load cell, which provides a force-time curve during microneedle insertion. The findings of this study lead to a quantitative characterization of the relationship between prestrain and the skin tissue puncture force.

Epitaxial Growth of Nickel Silicide $(NiSi_2)$ in Vacuum Deposited Nickel and Gold Films on (III) Silicon Single Crystals (규소(III) 단 결정에 진공 증착한 닉켈과 금 박막에서 $NiSi_2$의 적층성장)

  • 윤기현;이희수
    • Journal of the Korean Ceramic Society
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    • v.13 no.3
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    • pp.55-62
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    • 1976
  • 순수한 닉켈과 금 박막을 (III)규소 단 결정위에 진공 증착시켰다. Ni/Au/Si나 Au/Ni/Si시료를 진공중에서 약 55$0^{\circ}C$로 가열하였을 때 육방정 혹은 변형된 육방정의 미소 결정들이 규소 기질위에 형성되었다. 이들 미소 결정들의 형성과정 및 조성은 X-선 회절법, scanning electron microscopy 및 scanning Auger microprobe 법을 사용하여 결정하였다. 이들 미소 결정은 NiSi2임이 확인되었다. Ni/Au/Si 시료에서는 Au-Si 공융점(37$0^{\circ}C$) 이상으로 온도가 증가됨에 따라 닉켈과 규소가 Au-Si 공융체 속으로 이동한 후 반응하여 NiSi2를 형성하였다. Au/Ni/Si 시료에 있어서의 Au-Si 공융체 형성은 닉켈 박막에 있는 바늘구멍형의 표면 결함과 관련 지을 수 있겠다. 금이 닉켈 박막의 grain boundary를 통하여 Ni/Si 계면으로 확산되어 그 계면을 습윤시킨 다음 Au-Si 공융체를 형성하였다. 이런 Au-Si 공용체는 닉켈과 규소 원자에 대한 높은 확산 매질로서 작용하여 NiSi2 형성을 촉진시켰다. 표면에 평행한 (III)규소면 위의 NiSi2 미소 결정은 유사한 육방정으로 나타났으며, 경사진 미소결정은 부등변 사변형과 유사하였다. Auger 스펙트럼 및 Ni, Au 및 Si에 대한 내층조성(indepth Composition Profiles)은 NiSi2 미소 결정이 Au-Si 공융체의 matrix에 미소 부분으로 나타났음을 보여주었다.

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Hybrid UV Lithography for 3D High-Aspect-Ratio Microstructures (하이브리드 자외선 노광법을 이용한 3차원 고종횡비 미소구조물 제작)

  • Park, Sungmin;Nam, Gyungmok;Kim, Jonghun;Yoon, Sang-Hee
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.40 no.8
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    • pp.731-736
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    • 2016
  • Three-dimensional (3D) high-aspect-ratio (HAR) microstructures for biomedical applications (e.g., microneedle, microadhesive, etc.) are microfabricated using the hybrid ultraviolet (UV) lithography in which inclined, rotational, and reverse-side UV exposure processes are combined together. The inclined and rotational UV exposure processes are intended to fabricate tapered axisymmetric HAR microstructures; the reverse-side UV exposure process is designed to sharpen the end tip of the microstructures by suppressing the UV reflection on a bottom substrate which is inevitable in conventional UV lithography. Hybrid UV lithography involves fabricating 3D HAR microstructures with an epoxy-based negative photoresist, SU-8, using our customized UV exposure system. The effects of hybrid UV lithography parameters on the geometry of the 3D HAR microstructures (aspect ratio, radius of curvature of the end tip, etc.) are measured. The dependence of the end-tip shape on SU-8 soft-baking condition is also discussed.

A Synecological Description of Ohmi Moor with Sphagnum Islet in Jeju, Korea (물이끼섬을 포함하는 제주도 오미 습원의 군락생태)

  • Kim, Jong-Won;Lee, Gyeong-Yeon;Kim, Yun-Ha;Eom, Byeong-Cheol
    • Korean Journal of Ecology and Environment
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    • v.51 no.2
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    • pp.174-183
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    • 2018
  • In the Sumeunmulbaengdui Wetland Protected Area of Jeju Island, there exists a unique pond, a so-called 'Ohmi', which is likely to be an oasis supporting the wildlife and escaped-livestock. We exquisitely described the diversity and distribution of plant community of the Ohmi. Despite its small area, six syntaxa were identified: Sphagnum community of peat bog type, Nymphoides coreana community of the floating-leaf limnetic vegetation, Scirpus triangulatus community and Schoenoplectus hotarui community of the littoral zone vegetation, and Deinostema violacea-Eleocharis congesta community and Eriocaulon atrum-miquelianum community of the ephemeral vegetation. A zonal distribution of plant communities along the water depth was recognized. The Sphagnum islets regarded as a typical component of peat bog, in Korea were first described at the center of the Ohmi. We conclude that the Ohmi is a primeval keystone habitat of the Sumeunmulbaengdui intermediate moor with a less oligotrophic ombrotrophic environment.