• Title, Summary, Keyword: 실험실간 정도관리

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Inter-lab validation for the derivatization method by TFE/TFAA of acidic herbicides (산성 제초제류의 TFE/TFAA 유도체화 방법에 대한 실험실간 정도관리)

  • Pyo, Hee-Soo;Park, Song-Ja;Lee, Kang-Jin;Hong, Jong-Ki;Shin, Ho-Sang
    • The Korean Journal of Pesticide Science
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    • v.9 no.2
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    • pp.159-165
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    • 2005
  • A sensitive derivatization method by using the TFE/TFAA as derivative reagent is proposed for the determination of acidic herbicides in water, by using this method, method detection limits are improved by 10 times and sample volumes are decreased by 5 times compared with other methods such as U.S. EPA and SPEED 98. And also, in order to suggest higher creditable standard operating procedure (SOP), intra- and inter-lab validation test carried out by four laboratories include our lab. The results of intra and inter-lab validations in same experimental conditions show good linearity in given range of concentrations as a $0.1{\sim}10.0$ ng/ml, and range of accuracies and precisions show $-20.5{\sim}12.2$ bias%, $0.55{\sim}24.48%$ (for intra-lab validation) and $-6.66{\sim}0.80 bias%$, $1.92{\sim}13.86%$ (for inter-lab validation), respectively.

Inter-laboratory Comparison for Analyses of Heavy Metals and Organic Solvent Metabolites in Biological Samples (생체시료 중 중금속 및 유기용제 대사물 분석의 실험실간 정도관리 프로그램)

  • Yang, Jeong Sun;Lee, Mi Young;Park, In Jeong;Kang, Seong-Kyu
    • Analytical Science and Technology
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    • v.13 no.2
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    • pp.258-267
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    • 2000
  • The result of five year's experience on Inter-laboratory Comparison for Analyses of Heavy Metals and Organic Solvent Metabolites in Biological Samples was described. Since 1995, around a hundred laboratories in the Occupational Health have participated this program twice per year by the Industrial Safety and Health Law. Four metals in blood and five organic solvent metabolites in urine were examined. Reference samples were made by spiking standard materials to human blood or urine pools treated previously to give homogeneity and stability for a specific time periods. Some reference samples for organic solvent metabolites were made from workers' urine who were exposed to the organic solvents. Some items such as Lead in blood and Hippuric acid in urine showed good accordance between participants while the other items such as Mercury and N-methylformamide in urine showed poor proficient rate. The results were published in the internet or newspaper to help the consumer of the laboratory's service to get the information on them and to make competition between them. The inter-laboratory's comparison program have done greate role to improve the ability of analysis and reliability of analytical data produced from each laboratory.

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Preparation of a CRM for QA/QC in dioxin analysis and inter-laboratory study (다이옥신 정도 관리용 CRM 제조와 실험실간 비교평가)

  • Yu, Byeong-Woon;Moon, Young-Hoon;Kim, Min-Kwan;Kyoung, Jong-Dai;Chang, Yoon-Seok
    • Analytical Science and Technology
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    • v.17 no.2
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    • pp.153-162
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    • 2004
  • Dioxin CRM for QA/QC was prepared with fly ash collected from municipal waste incinerator. With that CRM inter-laboratory test was carried out. The collected fly ash was conducted several homogeneity steps including sievings and mixing. Homogeneity test and estimation of uncertainty was performed by one-way ANOVA based on ISO guide 35. Compared concentrations of fly ash of participants to CRM values, PCDDs value was lower than that of CRM in almost participants, and showed higher PCDFs concentration than that of CRM. Although there is a small difference in PCDD/Fs concentrations with congeners of extract, the result was close to mean value.

Status of Health and Safety Management in Occupational Hygiene Laboratories in Korea

  • Yang, Hyukseung;Choi, Jaewook;Yoon, Seokjoon;FARR, Terry
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.17 no.1
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    • pp.53-62
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    • 2007
  • 목적: 1990년대 초반부터 시작된 우리나라의 산업 보건에 대한 사회적 관심의 증대와 시장의 요구에 따라 산업위생기관의 양적인 팽창이 이루어지긴 하였으나 실험실 관련 안전보건규정이 미비한 상태에서 추진되어 산업위생 실험실에서 다양한 유해 위험성 인자를 취급함에도 불구하고 사용되는 량이 소규모로 인해 안전보건과 관련된 사항은 대부분 간과하고 있으며, 산업위생 실험실의 안전보건관리 실태는 선진외국에 비해 상당히 낙후되어 있는 실정이다. 따라서 본 연구는 우리나라 산업위생 실험실과 관련한 안전보건관리 실태를 평가함으로써 향후 실험실의 안전보건관리 수준을 향상 시키는데 효과적인 자료로 활용하는데 기여하고자 한다. 방법: 산업위생실험실의 안전보건 실태를 파악하기 위해 설문조사를 수행하였으며, 설문은 실험실의 전반적인 안전보건, 화학물질 저장 및 용기, 가연성 및 인화성 화학물질, 가스 실린더, 의사전달, 응급처치 및 비상사태 장비, 정리정돈, 소방안전, 전기안전, 개인보호구, 흄후드 및 환기, 및 이황화탄소 취급 사례로서 12개 영역으로 구성되었다. 연구대상은 2001년 한국산업안전공단 정도관리프로그램에 참여한 기관으로서 총 대상은 119개 기관이었다. 연구기간은 2002년 7월 01일부터 8월 30일까지 약 60일 이었다. 설문은 반송봉투에 넣어 설문완성 후 연구자에게 보낼 수 있도록 배려하였으며, 1차 설문을 보낸 후 2주 후에 설문 참여를 독려하기 위해 엽서를 발송하였고, 다시 2주 후에 각 산업위생기관에 개별 전화 연락을 취하였다. 그 결과 63% (75개 기관)의 완성된 설문을 얻을 수 있었다. 설문의 총 조사항목은 79문항으로 구성되어 있으며, 산업위생실험실의 안전보건 수준을 정량적으로 평가하기 위해 안전보건 매뉴얼, 교육훈련프로그램 및 한국산업안전공단 실험실 지침서를 보유한 기관과 그렇지 않은 기관간의 차이는 선별된 67문항에 대해 각 문항에 합당하거나 적절할 경우 1점을 부여하는 방식으로 점수화하였다. 이들의 관련성을 파악하기 위하여 Microsoft-Excel 2000 프로그램을 이용하여 two-tailed t-test 분석을 실시하였다. 결과 1. 산업위생실험실 운영과 관련한 67개 항목(항목별로 각 1점 부여)에 대한 안전보건 성과지수화 (100점으로 점수 환산) 결과 안전보건 매뉴얼을 보유한 기관은 $42.98{\pm}13.36$(p<0.001)점, 교육훈련프로그램을 보유한 기관은 $50.75{\pm}14.12$(p<0.01)점, 한국산업안전공단 실험실 지침서를 보유한 기관은 $43.58{\pm}11.92$(p<0.01)점으로 그렇지 않은 기관에 비해 통계적으로 유의하게 높은 점수분포를 보였다. 2. 화학물질 보관 캐비닛이 있는 기관 중 64.8%의 기관은 화학물질을 알파벳 순으로, 27.8%는 분류 기준에 따라, 그리고 7.4%는 무작위로 보관하고 있었다. 3. 단지 8.0% (6개)의 기관만이 실험실내에 눈세정 분수(2 개), 샤워기(3개) 및 눈세정물병(3개, 2개 중복 응답 기관)과 같은 응급처치 장치 및 물품을 갖추고 있었다. 4. 89.0%의 기관이 흄후드내에 화학물질을 보관하고 있었다. 5. 물질안전보건자료, 흄후드 기록지, 비상사태 절차서 및 한국산업안전공단 실험실 지침서와 같은 문서관리는 부적절하게 관리 및 기록되고 있었다. 6. 대부분의 산업위생 실험실은 응급처치 장비, 화학물질 또는 가스용기 보관실과 같은 실험실 안전설비가 부족할 뿐만 아니라 정리정돈, 화학물질 저장 캐비닛, 안전보호구 및 흄후드와 같은 관리가 미비하였다. 결론: 이상의 결과에 근거하여 기관장은 실험실의 안전보건관리를 위하여 문서관리체계를 제공하고, 모든 실험실 종사자가 적절한 개인보호구를 착용할 수 있도록 하며, 비상 장비를 설치하고, 실험실과 관련한 적절한 규정을 제정하며, 교육훈련 프로그램을 제공하여야 한다. 또한 실험실 종사자는 실험 중 적절한 개인보호구의 착용하고, 비상장비 이용에 대한 교육훈련에 참여하며, 적절한 실험실 운영관리에 대한 책임감을 가져야 한다. 위의 권고사항 이행을 위해서 KOSHA는 KQCP 프로그램에 실험실 안전보건관리 항목을 삽입하여 주기적인 평가를 수행할 필요가 있다. 우리나라 실험실의 특성을 고려할 때 본 연구결과는 일반 실험실에도 적용될 수 있을 것으로 생각된다.

The Need for QA/QC in the Measurements of Airborne Pollutants - Conduction of and Directions towards an Interlaboratory Comparison Test in 1998 by the Measurement and Analysis Division of KOSAE (대기오염측정에 대한 정도관리의 필요성 - 1998년도 한국대기환경학회 측정분석분과회의 실험실간 비교분석사업 시행과 전개방향)

  • 김기현;이강웅;김조천;서영화;이종해;허귀석
    • Journal of Korean Society for Atmospheric Environment
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    • v.15 no.1
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    • pp.63-69
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    • 1999
  • To offer a general guideline for the quantitative analysis of airborne pollutants, we designed and conducted a comprehensive QA/QC test using two different strategic approaches, namely (1) field-based comparative measurement and (2) laboratory-based comparative analysis. The former task was performed to make meaningful comparison of combined errors occurring from both sampling and analytical techniques in the measurements of such components as: (1) criteria pollutants, (2) volatile organic compounds (VOCs), and (3) particulate matters with the associated metals and ions. The latter task was also conducted to compare various types of bias arising mainly from the laboratory analytical procedures of (1) gaseous standards of VOCs and (2) of aqueous standards of metals and ions. The concentration data derived from each of these two different types of major tasks were evaluated per chemical species categorized as above. While the very details of these studies are to be reported on an individual basis according to the above classification of the project, this paper is presented to provide an overview of the whole project - its aim and direction.

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Proficiency test for analyzing illegal compounds in food (식품 중 부정유해물질의 분석 능력평가)

  • Chang, Moonik;Yoon, Taehyung;Hong, Mooki;Choi, Dongmi
    • Analytical Science and Technology
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    • v.20 no.1
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    • pp.78-83
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    • 2007
  • To perform proficiency test for determining anti-impotence drug-like compounds in food, interlaboratory test has been done. Targets were 6 such as sildenafil, tadalafil, vardenafil, homosildenafil, hydroxy-homosildenafil and pseudo-vardenafilI. Total 13 institutes were participated and all is in charging of food analysis. To do double blind test, the reference materials were made as 13 different ginseng drink samples and each sample had random 3 targets. By the official method for anti-impotence drug-like compounds in food code, sample was just diluted in water, extracted in organic solvents, determined by HPLC/UV and then confirmed by LC/MS. The analytical duration was 60 days after receiving sample. Ten out of 13 institutes were satisfied by evaluation of Z-score and RSZ according to the regulation for managing analytical quality assurance.

Interlaboratory Comparison of Blood Lead Determination in Some Occupational Health Laboratories in Korea (일부 산업보건기관들의 혈중연 분석치 비교)

  • Ahn, Kyu Dong;Lee, Byung Kook
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.5 no.1
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    • pp.8-15
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    • 1995
  • The reliable measurement of metal in biological media in human body is one of critical indicators for the proper evaluation of its toxic effect on human health. Recently in Korea the necessity of quality assurance of measurement in occupational health and occupational hygiene fields brought out regulatory quality control program. Lead is often used as a standard metal for the program in both fields of occupational health and hygiene. During last 20 years lead poisoning was prevalent in Korea and still is one of main heavy metal poisoning and the capability of the measurement of blood lead is one of prerequisites for institute of specialized occupational health in Korea. Furthermore blood lead is most important indicator to evaluate lead burden of human exposure to lead and the reliable and accurate analysis is most needed whenever possible. To evaluate the extent of the interlaboratory differences of blood lead measurement in several well-known institute specialized in occupational health in Korea, authors prepared 68 blood samples from two storage battery industries and all samples were divided into samples with 2 ml. One set of 68 samples were analyzed by authors's laboratory(Soonchunhyang University Institute of Industrial Medicine: SIIM) and 40 samples of other set were analyzed by C University Institute of Industrial Medicine(CIIM) and the rest 28 samples of other set were analyzed by Japanese institute(K Occupational Health Center:KOHC). Authors also prepared test bovine samples which were obtained from Japanese Federation of Occupational Health Organization (JFOHO) for quality control. Authors selected 2 other well-known occupational health laboratories and one laboratory specialized for instrumental analysis. A total of 6 laboratories joined the interlaboratory comparison of blood lead measurement and the results obtained were as follows: 1. There was no significant difference in average blood lead between SIIM and CIIM in different group of blood lead concentration, and the relative standard deviation of two laboratories was less than 3.0%. On the other hand, there was also no significant difference of average blood lead between SIIM and KOHC with relative standard deviation of 6.84% as maximum. 2. Taking less than 15% difference of mean or less than 6 ug/dl difference in below 40 ug/dl in whole blood as a criteria of agreement of measurement between two laboratories, agreement rates were 87.5%(35/40) and 78.6%(22/28) between SIIM and CIIM, SIIM and KOHC respectively. 3. The correlation of blood lead between SIIM and CIIM was 0.975 (p=0.0001) and the regression equation was SIIM = 2.19 + 0.9243 ClIM, whereas the correlation between SUM and KOHC was O.965(p=0.0001) with the equation of SIIM = 1.91 + 0.9794 KOHC. 4. Taking the reference value as a dependent variable and each of 6 laboratories's measurement value as a independent variable, the determination coefficient($R^2$) of simple regression equations of blood lead measurement for bovine test samples were very high($R^2>0.99$), and the regression coefficient(${\beta}$) was between 0.972 and 1.15 which indicated fairly good agreement of measurement results.

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Intercomparison and Determination of Trace Elements in Urban Dust by Neutron Activation Analysis (중성자방사화분석법을 이용한 대기분진중의 미량원소 비교분석)

  • Chung, Yong-Sam;Moon, Jong-Hwa;Kim, Sun-Ha;Park, Kwang-Won;Kang, Sang-Hun
    • Analytical Science and Technology
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    • v.13 no.2
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    • pp.179-188
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    • 2000
  • Trace elements in air samples artificially loaded on filters with urban dust and the bulk material of urban dust as an environmental sample were determined non-destructively using instrumental neutron activation analysis. Standard reference material (Urban Dust, SRM 1648) of the National Institute of Standard and Technology was used for the analytical quality control. The relative error for 37 elements was less than 15% and the standard deviation was less than 10%. 29 elements in the urban dust and 21 elements in the loaded filter sample were determined respectively. To evaluate the proficiency and reliability of the measurement, data intercomparison was performed and 39 analytical laboratories participated in the analysis using different analytical methods; neutron activation analysis, particle induced X-ray emission analysis, X-ray fluorescence analysis and atomic absorption spectrometry. Z-scores were calculated using the standard deviation of the laboratorie's mean as target standard deviation, and a good result was obtained that the values fall between -1 and +1 except some elements.

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The collaborative study for verification of analytical results and assurance confidences for pesticide residue (분석결과 검증 및 신뢰성 확보를 위한 실험실간 협력 실험)

  • Park, Hye-Jin;Ko, Kwang-Yong;Han, Kook-Tak;Kim, Il-Jung;Lee, Yong-Jae;Kim, Sung-Hun;Lee, Kyu-Seung
    • Korean Journal of Agricultural Science
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    • v.32 no.2
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    • pp.215-221
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    • 2005
  • The residual study of pesticide has been used in various areas, such as food safety, environmental protection, establishment of tolerance, and explaining the pathway and reaction mode of pesticides, and its importance was expected to increase further more. The aspect of food safety, the pesticide residue survey have been practiced at many organizations, but there were no verification of analytical results at present. In this experiment, we focused on instrumental stability, including response of each instrument and the recovery ratio of each organization's method. As samples for this experiment, we prepared cucumber and sesame, and chose 4 pesticides (bifenthrin, chlorpyrifos, diazinon, and ethoprophos), which were mostly detected from pesticide residue survey and widely used for each crop. The standard deviation of peak areas in the chromatogram of each pesticide were under 1.212 %, so it showed that most instruments were stable. The relationship of recovery ratio of each organization were over 0.996 for every pesticide and each organization. Finally, the analytical results for pesticide residue from each participated organization were not statically significant and we could put confidence in the result from each organization.

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A Study for Real-Time Information Service (실시간 교통정보 제공에 관한 연구)

  • 김수희
    • Proceedings of the KOR-KST Conference
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    • pp.151-160
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    • 1998
  • 실시간 교통정보 처리과정은 현장설비로부터 수집되는 각종 교통상황자료를 분석/처리하여 소통상황, 주행속도, 통행시간 등의 교통상황을 단기 예측하는 과정으로서 이는 주행안내시스템의 핵심요소기술이다. 주행안내 시스템 개발의 필요성은 선진국을 중심으로 제기되어 왔으며, 주행안내시스템은 각국 정부의 강력한 지원정책을 바탕으로 연구개발 단계를 거쳐 시범운영의 단계에 있다. 국내에서도 교통정체의 해소와 안전주행의 연구개발 단계를 거쳐 시범운영의 단계에 있다. 국내에서도 교통정체의 해소와 안전주행의 여건마련을 위하여 교통정보를·처리·제공하는 기술의 개발이 활발하게 진행되고 있다. 그러나 국내 기술수준을 보면 전자통신기술을 바탕으로 교통정보의 수집과 제공에 관한 연구는 어느 정도 진행되고 있으나 운전자가 필요로 하는 교통정보의 분석과 처리에 관한 연구는 매우 저조한 실정이다. 본 연구의 목적은 다양한 시스템에서 수집되는 자료를 종합적으로 처리, 저장,관리하고 이의 분석결과를 제공하는 교통정보센터의 프로토타입(Prototype)을 설정하는 것이다. 이러한 목표를 수행하기 위해서 요구되는 교통정보실험실의 기능은 수집된 교통자료의 신뢰성 분석, 교통정보의 종합적인 처리·저장·관리, 그리고 교통정보의 제공은 구분할 수 있다. 따라서, 현재 교통정보실험실에서 운영중인 정보의 형태를 제시하며, 이들 정보의 신뢰성을 실측자료와 비교한 실험적 결과를 예시한다. 또한, 개별 정보이용자에게 실시간 교통정보를 제공하기 위한 통신기술의 검토가 이루어진다. 차내 이용자에게 정보를 실시간으로 제공하기 위해서는 궁극적으로 무선통신기술의 응용이 필요하며, 정보이용자에게 다양한 정보를 제공하기 위해서 인터넷 통신과 연계시키는 것이 합리적으로 판단된다. 결론 부분에서는 교통정보실험실의 기능을 강화시키기 위한 향후의 연구과제를 제시한다.Si결정의 크기를 비교하였을 때 45$\mu\textrm{m}$ 이하의 분말을 섞어 압출하였을 때 가장 작은 초정 Si입자 크기를 얻음 을 볼 수 있었다. 주의 Fairfax County에 소재한 주간 고속도로 66번(I-66)과 인접 교통망의 교통자료를 사용하여 각종 돌발교통 혼잡 상황을 전제로 한 Traffic Simulation과 정보제공시나\리오를 INTEGRATION Model을 이용해 실행하였다. 그 결과 적응형 알고리즘이 개개인의 최단시간 경로를 제공하는 사용자 평형 경로안내전략에 비해 교통혼잡도와 정체시간의 체류정도에 따라 3%에서 10%까지 전체통행시간을 절약할 수 있다는 결론을 얻었다.출발참, 구성대외개방선면축심, 실현국제항선적함접화국내항반적전항, 형성다축심복사식항선망; 가강기장건설, 개피포동제이국제기장건설, 괄응포동개발경제발전적수요. 부화개시일은 각 5월 26일과 5월 22일이었다. 11. 6월 중순에 애벌레를 대상으로 처리한 Phenthoate EC가 96.38%의 방제가로 약효가 가장 우수하였고 3월중순 및 4월중순 월동후 암컷을 대상으로 처리한 Machine oil, Phenthoate EC 및 Trichlorfon WP는 비교적 약효가 낮았다.>$^{\circ}$E/$\leq$30$^{\circ}$NW 단열군이 연구지역 내에서 지하수 유동성이 가장 높은 단열군으로 추정된다. 이러한 사실은 3개 시추공을 대상으로 실시한 시추공 내 물리검층과 정압주입시험에서도 확인된다.. It was resulted from increase of weight of single cocoon. "Manta"2.5ppm produced 22.2kg of cocoon. It is equal to 9% increase in index, as com

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