• Title, Summary, Keyword: 위험감수성

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Acquired Drug Resistance during Standardized Treatment with First-line Drugs in Patients with Multidrug-Resistant Tuberculosis (다제내성결핵 환자에서 표준 1차 항결핵제 치료 중 발생한 획득 내성)

  • Jeon, Doosoo;Kim, Dohyung;Kang, Hyungseok;Min, Jinhong;Sung, Nackmoon;Hwang, Soohee;Park, Seungkew
    • Tuberculosis and Respiratory Diseases
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    • v.66 no.3
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    • pp.198-204
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    • 2009
  • Background: First-line drugs, if sensitive, are the most potent drugs in the treatment of multidrug-resistant tuberculosis (MDR-TB). This study examined the frequency and risk factors associated with acquired drug resistance to first-line drugs during a standardized treatment using first-line drugs in patients with MDR-TB. Methods: This study included patients who were diagnosed with MDR-TB at the National Masan Tuberculosis Hospital between January 2004 and May 2008, treated with standardized first-line drugs, and for whom the preand post-treatment results of the drug susceptibility test were available. Their medical records were reviewed retrospectively. Results: Of 41 MDR-TB patients, 14 (34.1%) acquired additional resistance to ethambutol (EMB) or pyrazinamide (PZA). Of 11 patients initially resistant to isoniazid (INH) and rifampicin (RFP), 3 (27.3%) acquired additional resistance to both EMB and PZA, and 3 (27.3%) to PZA. Of 18 patients initially resistant to INH, RFP and EMB, 6 (33.3%) acquired additional resistance to PZA. Of 6 patients initially resistant to INH, RFP and PZA, 2 (33.3%) acquired additional resistance to EMB. Ten of the 41 MDR-TB patients (24.4%) changed from resistant to susceptible. No statistically significant risk factors associated with acquired resistance could be found. Conclusion: First-line drugs should be used cautiously in the treatment of MDR-TB in Korea considering the potential acquisition of drug resistance.

보건계열 대학생의 창업가 특성이 창업교육과 창업지원제도에 따라 창업의지에 미치는 영향

  • Lee, Gang-Im;Jeong, Hwa-Yeong;Kim, Myeong-Suk
    • 한국벤처창업학회:학술대회논문집
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    • pp.109-112
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    • 2017
  • 성공적인 창업을 위해서는 창업자 개인의 기본적인 역량뿐만 아니라 체계적인 창업교육과 학습을 통해 창업자가 되기 위한 필요역량을 습득해야 한다(최서윤, 2017). 대학생의 창업을 활성화하기 위해서는 다양한 분야를 전공하고 있는 대학생의 학문적 특성을 고려하고 그들의 전공 및 학문적 특성을 고려하여 창업교육 및 창업지원을 통해 대학생의 창업의지를 높이는 것이 필요하다(이우진 김진수 김용태, 2013). 창업의지는 창업에 대한 행위적 태도를 의미하며, 창업이라는 긴 과정의 첫 단계이고, 개인의 태도와 경험을 창업이라는 행동으로 매개하는 역할을 한다(윤방섭, 2004). 대학이 학생들에게 창업교육 및 창업공간, 멘토링, 컨설팅, 사업화를 위한 창업지원을 하고, 대학생들은 이러한 창업교육 및 창업지원을 긍정적으로 받아들일수록 창업의지가 높아져 취업이 아닌 창업을 선택할 가능성이 높아질 것이다. 조사대상은 전국의 보건계열 대학에 재학 중인 대학생이다. 자료수집 방법은 보건계열 재학 중인 대학생을 대상으로 이메일 설문지가 발송되었고, 자기보고식 작성방법에 따라 설문조사 되었다. 총735개의 설문지가 발송되었고 그 중 불성실하게 응답한 설문을 제외한 총 675개의 설문을 최종 설문으로 사용하였다. 자료수집기간은 2017년 10월 9일부터 2017년 10월 18일까지 10일간 이루어졌다. 본 연구를 수행하기 위해 수집된 자료는 IBM SPSS Statistics 22.0을 활용하여 분석하였다. 본 연구는 보건계열 대학생의 창업가 특성이 창업의지에 영향을 미치는지, 창업교육과 창업지원제도는 기업과 특성과 창업의지의 관계에서 조절효과를 미치는지를 확인하였다. 보건계열대학생의 창업가 특성인 성취욕구, 자기효능감, 위험감수성 중 위험감수성만이 창업의지에 영향을 미치는 것으로 나타났으며, 창업교육, 창업지원제도인 대학창업지원활동, 정부창업지원정책 중 창업가 특성과 창업의지 간의 관계에서 대학창업지원제도만 조절작용을 하는 것으로 나타났다.

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A Study on the Influence of Entrepreneurial Characteristic of Entrepreneurial Intentions : Focused on the Mediating Effects of Entrepreneurial Performance (창업특성이 창업의도에 미치는 영향연구 : 창업성과를 매개효과로)

  • Jo, Young-Jun;Lee, Seung-Hee
    • Journal of Digital Convergence
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    • v.10 no.5
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    • pp.143-154
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    • 2012
  • In this study, Entrepreneurial Intentions of the factors influence the Entrepreneurial Performance and Entrepreneurial Characteristic also was Investigated. Entrepreneurial Characteristic of the each Dimension in the Process of Entrepreneurial Intentions and Entrepreneurial Performance on the Influence of the Mediation Effect was Carried out to Examine. The test results used in this Study Established Entrepreneurial Characteristic of Entrepreneurial Performance and Entrepreneurial Intentions to the Positive Effect was Found. also Verifying the results of the Mediating Effect of Entrepreneurial Performance and Entrepreneurial Performance the Mediation Effect was Verification. These Factors Result in the Entrepreneurial Performance and also in Sales and net profit of Entrepreneurial Intentions Influences. especially, Entrepreneurial Characteristic Specific Need for Achievement, Risk taking and Business Strategy of Entrepreneurial Intentions also the relationship between the Impact is Significant. For this Study K national Institute of Technology, K university, Daegu Y College, J Companies Surveyed Workers and the Findings Were Derived. Specifically, Entrepreneurial in terms of those who have no Experience in Entrepreneurial Characteristic, Entrepreneurial Performance, Entrepreneurial Intentions the Impact on the Relationship Between Entrepreneurial and Provide Suggestions to Determine.

Entrepreneurship and Market Leadership in Culture Industry (문화산업에서 기업가정신의 발현과 마켓리더십)

  • Han, Yoo-Jin
    • The Journal of the Korea Contents Association
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    • v.20 no.1
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    • pp.417-426
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    • 2020
  • The culture industry has been considered very important as firms utilize human creativity as the main source for providing high-value-added services. In this industry, the inspirations and ideas of individual creators have been stressed rather than the roles of entrepreneurs so far. However, in recent years, due to the influence of "Hallyu" or the Korean Wave, entrepreneurial firms have actively participated in producing a variety of products embracing cultural value. In this vein, the entrepreneurship-related elements such as the degree of leaders' innovativeness, risk-taking environment, first mover advantage, employee compensation, and tolerance to failure were selected to investigate their effects on market leadership. As a result, it was observed that risk-taking environment, first mover advantage, employee compensation, and tolerance to failure had a positive effect whereas leaders' innovativeness was not statistically meaningful. These findings show that the creation of an atmosphere where employees' creativity can be fully appreciated is more important than the leader' insight-driven innovativeness. The results of this study indicate that when companies formulate strategies and the government initiate policies in the culture industry, entrepreneurship should be incorporated as a crucial element.

청년농업 예비 창업자의 창업의도에 영향을 미치는 요인에 관한 연구

  • Lee, Il-Han;Lee, Eun-Cheon
    • 한국벤처창업학회:학술대회논문집
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    • pp.97-102
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    • 2019
  • 예비 청년 창업농을 대상으로 개인적 특성을 파악하고 개인적특성, 사회적인식, 네트워크, 창농정책, 자기효능감, 주관적규범을 조사하여 창업의도에 영향을 주는 요인들을 파악하고자 하였다. 개인적 특성의 하위 변수로 성취욕구, 위험감수성, 혁신성을 설정하여 자기효능감, 주관적규범, 창업의도와의 관련성을 연구 하였다. 본 연구의 자료 수집을 위한 설문조사는 2018년 10월 2일부터 2018년 10월 27일까지 농업관련 창업교육 프로그램을 수강하였거나 농업분야에 관심이 있는 청년 농업 예비 창업자들에게 본 연구의 목적과 취지를 설명하고 연구의 동의를 얻어 설문지 300부를 배부하였다. 배부된 설문지 중 263부가 회수되었으며, 설문지 중 미응답이 한 문항이라도 있거나 불성실하게 응답한 설문지 15부를 제외한 248부를 최종분석 자료로 활용하였다. 본 연구의 결과는 다음과 같다. 청년 농업 예비창업자의 창업의도에 영향을 주는 요인으로 개인적 특성 중 위험감수성과 혁신성이 파악되었다. 또한 상관관계에서도 혁신성과 위험감수성은 상관관계가 높은 것으로 분석되었다. 그리고 환경적 요인인 사회적 인식, 네트워크와 창농정책은 모두 창업 의지에 영향을 주는 것으로 검증되었다.

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Analysis of Pyrethroid Resistance Allele in Malaria Vector Anopheles sinensis from Malaria High-risk Area (말라리아 위험지역에서 채집된 말라리아 매개모기 Anopheles sinensis의 피레스로이드계 저항성 대립형질 분석)

  • Choi, Kwang Shik;Lee, Seung-Yeol;Hwang, Do-Un;Kim, Heung-Chul;Chang, Kyu-Sik;Jung, Hee-Young
    • The Korean Journal of Pesticide Science
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    • v.20 no.4
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    • pp.286-292
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    • 2016
  • Malaria is mainly transmitted by Anopheles sinensis which is dominant species in malaria high-risk area, northern part of Gyeonggi province in Korea. Pyrethroid insecticide is used for malaria vector, An. sinensis in Korea and the previous investigation consistently reported insecticide resistance from the vector. This study investigated insecticide susceptible and resistant alleles from An. sinensis and the status of malaria vector control in malaria high-risk area. For the study, An. sinensis collected from Paju, Gimpo and Ganghwa were sequenced for kdr detection. In Paju, there was no homozygous susceptibility and all of tested samples had homozygous or heterozygous resistance. There were 6.7% for susceptible homozygosity and 93.3% for resistant homozygosity or heterozygosity in Gimpo. Furthermore, the percentages of homozygous susceptibility and homozygous or heterozygous resistance in Ganghwa were 5.7% and 94.3% respectively. The results showed that the frequency of the insecticide resistance from An. sinensis in malaria high-risk area were increased much more than the previous investigation. Hence, this study suggests that malaria vector control programs should have to be prepared for the management of pyrethroid insecticide resistance.

창업기업의 동적역량 효과에 관한 탐색 연구

  • Ahn, Tae-Uk;Kang, Tae-Won
    • 한국벤처창업학회:학술대회논문집
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    • pp.131-134
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    • 2019
  • 정부의 창업 인프라 구축 및 창업 정책이 증가되고 있다. 그러나 실제적으로 창업기업의 성과를 높이기 위하여 기업가 정신과 동적역량이 중요하다. 동적역량은 창업기업의 기회탐색, 자원획득, 자원재구성 능력이며 기업이 성장함에 있어 매우 필요한 역량이다. 본 연구는 창업기업의 기업가정신, 동적역량, 경영성과의 효과와 관계를 검증하는데 중요한 목적이 있다. 본 연구를 위해 창업기업을 대상으로 설문조사를 진행하여 최종 361개 표본으로 자료 분석에 사용하였다. 본 연구의 결과는 다음과 같다. 기업가정신의 혁신성, 위험감수성, 진취성은 동적역량에 긍정적인 영향을 미치는 것으로 나타났다. 둘째, 기업가정신의 혁신성과 위험감수성은 경영성과에 유의미한 긍정적인 영향을 미쳤으나, 진취성은 유의미하지 않은 결과가 도출되었다. 셋째, 동적역량은 경영성과에 유의미한 긍정적인 영향을 미치는 것으로 나타났다.

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A Study on Relationship between CEO′s Entrepreneurship in Venture Business and Organizational Effectiveness. - Focused on Innovativeness, Risk-taking and Proactiveness- (벤처기업 CEO의 기업가정신과 조직유효성의 관계에 관한 연구 -혁신성, 위험감수성, 진취성을 중심으로-)

  • Park David S.;Kim Yeon Jeong
    • Journal of Korea Technology Innovation Society
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    • v.7 no.3
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    • pp.479-505
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    • 2004
  • The purpose of this study is to investigate between CEO's Entrepreneurship in Venture Business and Organizational Effectiveness. CEO's Entrepreneurship variable consist of Innovativeness, Risk-taking and Proactiveness. Organizational effectiveness concept composed of system approach and the contingency theory and it's variable consisted of job satisfaction and organizational commitment. Statistical methods are adapted Frequency, Factor Analysis and CFA(Confirmatory Factor Analysis) of LISREL.8 program. Refined Survey data are 412/Major findings are as follows; Only Proactiveness variable of CEO's entrepreneurship have significant relation to Organizational Effectiveness(job satisfaction and organizational involvement). Innovativeness and Risk taking variables are partially supported to influence to Organizational Effectiveness.

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Study on the Influence of Personal Traits to the Entrepreneurial Intention - Focusing on the Mediating Effect of Globalization Capability - (개인특성이 창업의지에 미치는 영향에 관한 연구 -글로벌역량의 매개변수를 중심으로-)

  • Lee, Ru-Ri;Lee, So-Young
    • Journal of Digital Convergence
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    • v.14 no.5
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    • pp.217-225
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    • 2016
  • This study examines whether personal traits and globalization capability would affect the entrepreneurial intention. Survey using questionnaires was conducted toward 257 male and female adults aged 21 above across the nation. The analysis of the data shows that the desire for self-fulfillment, risk-taking propensity and sense of self-efficiency as personal traits have positive influence on entrepreneurial intention. And the globalization capability as mediating variable has meaningful influence on entrepreneurial intention, that is, globalization capability under the control of respective personal trait makes positive influence on entrepreneurial intention. Current study would support the potential entrepreneur and the educator to create effective entrepreneurial education program.

Incidence of Escherichia coli and Its Susceptibility to Antimicrobials in Childhood Urinary Tract Infection (소아 요로감염에서 Escherichia coli의 빈도와 항생제 감수성에 대한 연구)

  • Chi Hye-Mi;Kwahk Jae-Hyok;Lee Jun-Ho;Park Hye-Won
    • Childhood Kidney Diseases
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    • v.10 no.1
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    • pp.18-26
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    • 2006
  • Purpose : Empirical antimicrobial treatment is indicated before bacteriological results are available for young children with febrile UTI to minimize renal scarring. To ensure appropriate therapy, knowledge of the prevalence of causative organisms and their susceptibility patterns to antimicrobials is mandatory. We performed a retrospective analysis investigating the local prevalence and resistance patterns of uropathogens, primarily E. coli, isolated from community-acquired UTIs. Methods : A total of 103 positive urine cultures from children with febrile UTI collected at Bundang CHA General Hospital from February 2004 to February 2005 were analyzed. Inclusion criteria were fever higher than $37.5^{\circ}C$, significant bacteriuria with single strain growth of at least 10s colony forming units/mL urine, and leukocyturia >5/HPF. Results : E. coli(89.3%) was the leading uropathogen followed by Enterococcus spp.(3.9%) Klebsiella spp.(2.9%), Citrobctcter spp.(1.9%) and Enterobacter spp.(1.9%). E. coli strains revealed a low proportion of antimicrobial susceptibility to ampicillin(AMP; 27.2%) ampicillinsulbactam(AMS; 34.8%) and trimethoprim-sulfamethoxazole(SXT; 65.2%). Susceptibility patterns to cephalosporins were as follows; cefazolin(1st generation; 91.3%), cefoxitin(2nd; 100%), ceftriaxone(3rd; 97.8%) and cefepime(4th; 97.8%). Three E. coli isolates produced ex tended - spectrum beta-lactamase(ESBL). Conclusion : Empirical treatment with AMP, AMS and SXT, which are commonly used in pediatric clinics, is not recommended for childhood UTI due to high incidence of resistance. The high level of susceptibility to cephalosporins makes these drugs reasonable alternatives. However the emergence of ESBL-producers, even though they are quite few, may have an impact on cephalosporin treatment in the future. (J Korean Soc Pediatr Nephrol 2006;10:18-26)

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