This study aimed to explore the factors having effects on the students' adaptation to college life at C college, and also to establish the measures for helping their successful adaptation to college life. Using the structured questionnaire, students' major satisfaction, learning motivation, time management behavior, core self-evaluation, and ADHD for adults were researched. Using the SPSS 21.0 Program for data analysis, this study conducted the descriptive statistics, t-test, ANOVA for analyzing the factors having effects on the adaptation to college life, and Scheffe for post-test. In the results of study, the major satisfaction, learning motivation, time management behavior, and core self-evaluation were significant on the adaptation to college life. Thus, in order to prevent the drop-out of college students by increasing their adaptation to college life, it is necessary to develop and implement college coping program which are increased the major satisfaction and core self-evaluation.