• 제목, 요약, 키워드: 치환 Thiadiazole 유도체

검색결과 2건 처리시간 0.022초

몇 가지 치환 Thiadiazole에 대한 전기화학적 연구 (Electrochemical Studies on Some Substituted Thiadiazoles)

  • El Maghraby, A. A.;Abou-Elenien, G. M.;Abdel-Reheem, N. A.;Abdel-Tawab, H. R.
    • 대한화학회지
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    • v.50 no.4
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    • pp.307-314
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    • 2006
  • 2-Ketohydrazono-3-phenyl-5-substituted-2,3-dihydro-1,3,4-thiadiazole과 그 유도체들(1a-h)의 산화환원 특성을 백금 전극의 지지전해질로서 0.1 M tetra n-butylammonium perchlorate (TBAP)을 함유한 1,2-dichloroethane (DCE), dichloromethane (DCM), acetonitrile (AN), tetrahydrofuran (THF), and dimethylsulfoxide (DMSO)와 같은 비수용매 속에서 조사하였다. 조사한 화합물들의 산화 및 환원 생성물들을 조절전위 전해법으로 분리 확인하였으며, 산화환원 메커니즘을 제안하고 이를 증명하였다. 조사한 모든 화합물은 잘 알려진 EC 메커니즘에 이은 두 번의 비가역 일전자 과정에 의해 산화되는 반면, 환원의 경우에는 치환기의 성질에 따라, 잘 알려진 EEC 메커니즘에 이은 한번의 이전자 또는 두 번의 연속적인 일전자 과정에 의해 이루어짐을 알았다.

방광암(HCV29T) 및 직장암(SW707) 세포에 대한 N-치환(R)-2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole 유도체의 항증식 활성에 관한 CoMFA 분석 (CoMFA on the Antiproliferative Activity of N-Substituted(R) 2-Amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole Analogues against Bladder and Rectal Cancer Cells)

  • 명평근;강나나;이재황;성낙도
    • 약학회지
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    • v.54 no.5
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    • pp.328-333
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    • 2010
  • Comparative molecular field analyses (CoMFA) on the antiproliferative activity of N-substituted (R) 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole analogues (ADTs: 1-17) against bladder cancer (HCV29T) and rectal cancer (SW707) cells were studied quantitatively. The statistical predictability and fitness of CoMFA A1 model for bladder cancer cells were better than those of CoMFA F1 model for rectal cancer cells and the antiproliferative activity of ADTs depends on steric field (HCV29T: 93.1% & SW707: 83.8%). Also, from the contour maps of optimized CoMFA models, the activity for bladder cancer cells had predicted to increase when sterically favored groups were substituted on meta- and para-position, and sterically disfavored groups were substituted on one ortho-position of phenyl ring. The activity for rectal cancer cells had predicted to increase when sterically favored groups were substituted on para-position, and sterically disfavored groups were substituted on two ortho-position of phenyl ring as R-group.