• Title/Summary/Keyword: Representative Compound

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Selection on Representative Compound According to the Characteristics of the Change of VOC Concentration Indoor from the Newly Built House in Japan (일본 신축주택의 실내 VOC의 실태와 농도추이 특성에 의한 유형별 대표물질선정)

  • Yoo, Bok-Hee;Tanaka, Tatsuaki;Yoon, Chung-Sook
    • KIEAE Journal
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    • v.1 no.1
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    • pp.35-43
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    • 2001
  • The VOC, which were detected from the newly built house, exist as a certain number of types according to the characteristics of the change of VOC concentration indoors. In this paper, we aim to divide the VOC into types so that those with similar characteristics of the transition of their concentration are in the same group and select the representative compound according to each classified type, and to verify these processes statistically in order to verify and propose new method creating the representing index of the VOC concentration in indoor which is used in evaluation of the degree of air pollution. As a result, the characteristic of the change of VOC concentration in the indoor can be divided into three types. Type1; the group in which the concentration is relatively high right after the completion of the house, and then decreases rapidly. Type2; the group in which the concentration is relatively low right after the completion of the house, and then although it shows the tendency of increasing and decreasing repeatedly, it decreases overall. Type3 is the group, which show only one peak at a certain time during the measuring period. As the method like this was verified to have the statistical significance, the Ethylbenzene was selected as the representative compound of type1, and Styrene was selected as that of type2. Moreover, if considering transition of the VOC from the point of similarity, the research method of making the classification and the selection of the representative compound in this study are said to be significant method.

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Inhibition of CDK4 activity by 7-chloro-4-nitro-benzo[1,2,5]oxadiazole 1-oxide (7-Chloro-4-nitro-benzo[1,2,5]oxadliazole 1-oxide의 CDK4 활성저해)

  • Jeon Yong-Jin;Ko Jong Hee;Yeon Seung Woo;Kim Tae-Yong
    • YAKHAK HOEJI
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    • v.50 no.1
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    • pp.52-57
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    • 2006
  • The activation of cyclin dependent kinase 4 (CDK4) is found in more than half of all human cancers. Therefore CDK4 is an attractive target for the development of a novel anticancer agent. For mass screening of CDK4 inhibitor, we set up in vitro kinase assay for CDK4 activity using a cyclin D1-CDK4 fusion protein, which is constitutively active and exhibits enhanced stability. From the screening of representative compound library of Korea Chemical Bank, we found that 7-chloro-4-nitro-benzo[1,2,5]oxadiazole 1-oxide (FBP-1248) selectively inhibited CDK4 activity in vitro by ATP competitive manner. This compound prevented the phosphorylation of retinoblatsoma tumor suppressor protein, Rb, and inhibited cell growth through cell cycle arrest. In summary, we developed an efficient assay system for CDK4 activity in vitro and identified the CDK4 inhibitory compound, FBP-1248.

Synthesis and Biological Evaluation of Phenoxy-N-phenylacetamide Derivatives as Novel P-glycoprotein Inhibitors

  • Lee, Kyeong;Roh, Sang-Hee;Xia, Yan;Kang, Keon-Wook
    • Bulletin of the Korean Chemical Society
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    • v.32 no.10
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    • pp.3666-3674
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    • 2011
  • Overexpression of P-glycoprotein (Pgp) is associated with multidrug resistance (MDR) of tumor cells to a number of chemotherapeutic drugs. Pgp inhibitors have been shown to effectively reverse Pgp-mediated MDR. We prepared a series of phenoxy-N-phenylacetamide derivatives and tested for their ability to inhibit Pgp as potential MDR reversing agents, using a Pgp over-expressing MCF-7/ADR cell line. Some of the synthesized compounds exhibited moderate to potent reversal activity. Of note, compound 4o showed a 3.0-fold increased inhibition compared with verapamil, a well-known Pgp inhibitor. In addition, co-treatment of the representative compound 4o and a substrate anticancer agent doxorubicin resulted in a remarkable increase in doxorubicin's antitumor effect and inhibition of DNA synthesis in the MCF-7/ADR cell line. Taken together, these findings suggest that compound 4o could be a useful lead for development of a novel Pgp inhibitor for treatment of MDR.

Comparison of 2,4,6-tribromophenol removal using in-situ liquid ferrate(VI) and stable ferrate(VI) (원위치 제조 액상 Ferrate(VI)와 안정화 Ferrate(VI)를 이용한 2,4,6-tribromophenol의 제거 비교연구)

  • Laksono, Fajar Budi;Jung, Sun-Young;Kim, Il-Kyu
    • Journal of Korean Society of Water and Wastewater
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    • v.32 no.2
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    • pp.123-130
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    • 2018
  • This paper provided the information related to the removal of 2,4,6-tribromophenol using in-situ and stable liquid ferrates(VI). This research's goal was to observe the differences of oxidation power between in-situ liquid ferrate(VI) and stable liquid ferrate(VI). The in-situ liquid ferrate(VI) ($FeO_4{^{2-}}$) has been successfully produced with the concentration 42,000 ppm (Fe) after 11 minutes of reaction time. The stable liquid ferrate(VI) was also successfully produced following the modification method by Sharma with the produced concentrations 7,000 ppm. The stable liquid ferrate(VI) was stable for 44 days and slightly decreased afterwards. This research has been carried out using 2,4,6-tribromophenol as the representative compound. Both of ferrates(VI) have the highest oxidation capability at the neutral condition. Furthermore, the stable liquid ferrate(VI) has higher oxidation power than the in-situ liquid ferrate(VI).

Monthly Variation of the Kalopanaxsaponin Content in the Leaves of Kalopanax pictus (개두릅에서 칼로파낙스사포닌의 월별 함량 변화의 추이)

  • Nam, Jung-Hwan;Jung, Hyun-Ju;Choi, Jong-Won;Park, Kwang-Kyun;Kim, Won-Bae;Lee, Myung-Sun;Park, Hee-Juhn
    • Korean Journal of Pharmacognosy
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    • v.37 no.3
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    • pp.184-189
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    • 2006
  • To find the monthly variation of kalopanaxsaponin contents in the leaves of Kalopanax pictus with thorns (KPT) and with no thorns (KPN), the leaves monthly collected from May to September were extracted with MeOH and then the kalopanaksaponin fractions were prepared. KPT collected on May showed the lowest saponin content of the KPTs whereas KPT on August exhibited the highest saponin content. From September, the saponin content in the loaves decreased. The highest saponin content was shown to be 7.3% in KPN collected on August. Evaluation of six kalopanaxsaponins A, I, J, B, H and K (KPA, KPI, KPJ, KPB, KPH, and KPK) were performed using TLC densitometer. In this measurement, considerably higher KPB and KPH, both hederagenin bisdesmosides, were found whereas very low contents In monodesrnosides KPI and KPJ were observed. In conclusion, it was shown that the leaves of KPN of August could be a biomaterial source for the kalopanaxsaponin fraction. It was also suggested that measurement of the weight of kalopanaxsaponin fraction and the content of KPB as the representative compound for kalopanaxsaponins will be used for the quantitative evaluation of the kalopanaxsaponins of K. pictus.

Quantitative Analysis of Pentachlorophenol in Paper Products (종이재 중의 Pentachlorophenol 정량 분석)

  • Hahn, Airan;Park, Jihye;Choi, Hyeongki;Hong, Sungyeap;Han, Hyechul;Jo, Byoungmuk;Oh, Jungsoo
    • Applied Chemistry for Engineering
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    • v.16 no.3
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    • pp.323-327
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    • 2005
  • Pentachlorophenol (PCP) is a representative compound of chlorophenol derivatives which are especially toxic and potentially carcinogenic compounds in the priority pollutant list of the EPA (Environmental Protection Agency, USA). The aim of this study was to investigate an analysis method of PCP in infinitesimal quantity retained in paper. PCP in paper was pretreated by solid phase extraction (SPE) in a phenyl cartridge. The extracted sample was acetylated or silylated and analyzed with GC/MS-SIM. The detection sensitivity of silylated PCP was improved significantly when compared with those of PCP itself and acetylated PCP. As a test specimen, an office paper and a wallpaper were used.