• Title, Summary, Keyword: ATP

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A Design of ATP Model Related eCRM Using LTV (LTV를 이용한 eCRM을 연계한 ATP 모델구현에 관한 연구)

  • 박재현;양광모;강경식
    • Journal of the Society of Korea Industrial and Systems Engineering
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    • v.25 no.4
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    • pp.54-60
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    • 2002
  • In the Supply chain, The ATP(Available to Promise) function doesn't only give customers to conformation of delivery. It can be used by the core function with ATP rule that can reconcile supplies and demands on the supply chain. Therefore We can be acquire the conformation about on the due date of supplier by using the ATP function of management about real and concurrent access on the supply chain, also decide the affect about product availability due to forecasting or customer's orders through the ATP. In this paper, It consolidates the necessity on a ATP and analyzes data which is concerned of ATP. tinder the these environments, defines the ATP nile that can improve the customer value and data flow related the eCRM and builds on a algorithm.

Effects of Adenosine on the Ionic Channel Activated by Metabolic Inhibition in Rabbit Ventricular Myocytes

  • Han, Jin;Kim, Eui-Yong;Ho, Won-Kyung;Earm, Yung-E
    • The Korean journal of physiology & pharmacology
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    • v.30 no.1
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    • pp.1-9
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    • 1996
  • The objective of the present study was to characterize the role of adenosine in regulation of ATP-sensitive $K^+\;channel\;(K_{ATP}\;channel)$ activity in isolated rabbit ventricular myocytes using the patch clamp technique. Internal adenosine had little effects on KaTr channel activity. In an outside-out patch with intrapipette GTP and ATP, external adenosine stimulated $K_{ATP}\;channel$ activity. In an inside-out Patch with intrapipette adenosine, ATP reduced $K_{ATP}\;channel$ activity, and GTP stimulated $K_{ATP}\;channel$ activity. Adenosine receptor activation shifted the half-maximal inhibition Of $K_{ATP}\;channel\;from\;70\;to\;241\;{\mu}m$. These results Suggest that activation of adenosine receptors stimulates $K_{ATP}\;channels$ in rabbit ventricular myocytes by reducing the apparent affinity of the channel for ATP. The effect may be important for activating $K_{ATP}\;channels$ during early phase of myocardial ischemia.

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An ATP System with Non-Integer Time Lag for Supply Chain Management (공급 사슬 관리를 위한 비정수 타임 랙을 갖는 ATP 시스템)

  • Kim, Tai-Young
    • 한국경영정보학회:학술대회논문집
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    • pp.478-485
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    • 2008
  • 고객 만족과 납기 충족율을 최대화하기 위하여, 정확하고 실용적인 납기회답 시스템(ATP)은 매우 중요한 역할을 한다. 그러나 복잡한 공급사슬관리 환경 하에서 조달, 제조, 분배 등을 모두 고려한 정확한 ATP 수량 할당은 매우 어려운 업무이고, 때문에 많은 연구들이 이루어져 왔다. 지금까지 기존의 선행 연구에서 시도되었던 ATP 모형들은 공통적으로 정수배의 시간 단위만 고려해 왔고, 이는 실제 산업 현장의 ATP 프로세스를 정확하게 반영하지 못하고 있는 비현실적인 가정이라 할 수 있다. 본 논문에서는 SCM을 위하여 비정수 타임 랙을 사용한 ATP 시스템을 고려한다. 기존 연구들에서 이산형의 무리한 가정으로 표현되어 왔던 시간 단위를 동적 생산 함수(dynamic production function) 개념을 통하여 비음의 실수 범위에서의 자유롭게 나누어 고려할 수 있도록 하였다. 이를 통하여 기존 ATP 연구들의 무리한 가정을 제거하였으며, 보다 더 현실에 가까운 ATP 모델을 제안한다. 본 논문에서는 특히 공급 사슬(Supply Chain) 전체의 재고와 생산, 운송을 모두 고려하며 고객 주문에 대응하는 통합 ATP 시스템을 설계하였고, 기존 연구들이 미처 고려하지 못한 시간 흐름의 연속성에 중점을 두고 선형 계획(LP) 문제의 형태로 비정수 타임랙(non-integer time lag)을 갖는 ATP 시스템을 모델링하였다.

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Alterations in Membrane Transport Function and Cell Viability Induced by ATP Depletion in Primary Cultured Rabbit Renal Proximal Tubular Cells

  • Lee, Sung-Ju;Kwon, Chae-Hwa;Kim, Yong-Keun
    • The Korean Journal of Physiology and Pharmacology
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    • v.13 no.1
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    • pp.15-22
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    • 2009
  • This study was undertaken to elucidate the underlying mechanisms of ATP depletion-induced membrane transport dysfunction and cell death in renal proximal tubular cells. ATP depletion was induced by incubating cells with 2.5 mM potassium cyanide(KCN)/0.1 mM iodoacetic acid(IAA), and membrane transport function and cell viability were evaluated by measuring $Na^+$-dependent phosphate uptake and trypan blue exclusion, respectively. ATP depletion resulted in a decrease in $Na^+$-dependent phosphate uptake and cell viability in a time-dependent manner. ATP depletion inhibited $Na^+$-dependent phosphate uptake in cells, when treated with 2 mM ouabain, a $Na^+$ pump-specific inhibitor, suggesting that ATP depletion impairs membrane transport functional integrity. Alterations in $Na^+$-dependent phosphate uptake and cell viability induced by ATP depletion were prevented by the hydrogen peroxide scavenger such as catalase and the hydroxyl radical scavengers(dimethylthiourea and thiourea), and amino acids(glycine and alanine). ATP depletion caused arachidonic acid release and increased mRNA levels of cytosolic phospholipase $A_2(cPLA_2)$. The ATP depletion-dependent arachidonic acid release was inhibited by $cPLA_2$ specific inhibitor $AACOCF_3$. ATP depletion-induced alterations in $Na^+$-dependent phosphate uptake and cell viability were prevented by $AACOCF_3$. Inhibition of $Na^+$-dependent phosphate uptake by ATP depletion was prevented by antipain and leupetin, serine/cysteine protease inhibitors, whereas ATP depletion-induced cell death was not altered by these agents. These results indicate that ATP depletion-induced alterations in membrane transport function and cell viability are due to reactive oxygen species generation and $cPLA_2$ activation in renal proximal tubular cells. In addition, the present data suggest that serine/cysteine proteases play an important role in membrane transport dysfunction, but not cell death, induced by ATP depletion.

The Influence of Frequency on Wayside Transmitter of ATP System upon Reinforcing Bars in Concrete Slab Track (콘크리트 슬래브궤도에서 철근이 ATP시스템 지상자의 주파수에 미치는 영향)

  • Kim, Min-Seok;Yoon, In-Mo;Ko, Jun-Seog;Lee, Jong-Woo
    • Journal of the Korean Society for Railway
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    • v.11 no.6
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    • pp.536-542
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    • 2008
  • In concrete slab track, the signal current using wayside transmitter of ATP (Automatic Train Protection) system is influenced by reinforcing bars. The magnetic coupling between reinforcing bars and wayside transmitter of ATP system as a filter makes an input current distorted. So, it makes an alternating current signal with a desirable size not transmit to on-board system of a train. Way to decrease the distortion of an input current signal frequency is to avoid maximum induction current frequency. And the induction phenomenon between reinforcing bars insulated and wayside transmitter of ATP system does not occur. In this paper, we represent the model about wayside transmitter of ATP system and reinforcing bars on the concrete slab tracks, and calculated the parameters demanded for the model. Also, we demonstrated it through the Maxwell program. Furthermore, we calculated impedance on wayside transmitter used in KVB system and ERTMS/ETCS system which are a kind of ATP system, frequency response of induction current, using Matlab, and demonstrated the validity of it, using PSpice program.

Effects of ATP on Regulatory Volume Decrease in Mouse Cholangiocytes (ATP가 마우스 담관세포의 세포크기 조절에 미치는 영향)

  • Park, Jae Seung
    • Korean Journal of Clinical Laboratory Science
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    • v.48 no.2
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    • pp.153-157
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    • 2016
  • Although the adenosine triphosphate (ATP) efflux pathway is thought to play a major regulatory role in RVD in some cells, including cholangiocarcinoma cells, the role of ATP in regulatory volume decrease (RVD) of normal cholangiocytes is not well defined. Thus, this study was conducted to investigate the role of extra cellular ATP and ATP pathways of BDCCs isolated from normal mice. Changes in cell volume of BDCCs were indirectly assessed by measurement of the cross-sectional area (CSA) by quantitative videomicroscopy. The relative CSA of BDCCs from normal mice increased with hypotonic maneuver to $1.20{\pm}0.02$ (n=20) within 10 min, but decreased to $1.06{\pm}0.03$ at 40 min. Administration of ATP, ATP hydrolase apyrase or the P2 receptor blocker suramin during RVD had no significant effects compared with untreated controls. In addition, treatment with the PKC inhibitors, Bisindolamide I and Ro 31-8220, during RVD had no significant effects when compared with untreated controls. These results indicate that unlike the results from cholangiocarcinoma cells, ATP plays no significant role in the RVD of normal mouse cholangiocytes.

Effects of $Cl^-$ Channel Blockers on the Cardiac ATP-sensitive $K^+$ Channel

  • Kwak, Yong-Geun
    • The Korean Journal of Physiology and Pharmacology
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    • v.3 no.3
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    • pp.305-313
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    • 1999
  • To explore whether $Cl^-$ channel blockers interact with the ATP-sensitive $K^+\;(K_{ATP})$ channel, I have examined the effect of two common $Cl^-$ channel blockers on the $K_{ATP}$ channel activity in isolated rat ventricular myocytes using patch clamp techniques. In inside-out patches, 4,4'-diisothio-cyanatostilbene- 2,2'-disulfonic acid (DIDS) and niflumic acid applied to bath solution inhibited the $K_{ATP}$ channel activity in a concentration-dependent manner with $IC_{50}$ of 0.24 and 927 ${\mu}M,$ respectively. The inhibitory action of DIDS was irreversible whereas that of niflumic acid was reversible. Furthermore, DIDS-induced block was not recovered despite exposure to ATP (1 mM). In cell-attached and inside-out patches, DIDS blocked the pinacidil- or 2,4-dinitrophenol (DNP)-induced $K_{ATP}$ channel openings. In contrast, niflumic acid did not block the pinacidil-induced $K_{ATP}$ channel openings in inside-out patches, but inhibited it in cell-attached patches. DIDS and niflumic acid produced additional block in the presence of ATP and did not affect current-voltage relationship and channel kinetics. All these results indicate that DIDS among $Cl^-$ channel blockers specifically blocks the cardiac $K_{ATP}$ channel.

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Glucose Deprivation and Immunostimulation Induced Death in Rat Primary Astrocytes is Mediated by Their Synergistic Effect on the Decrease in Cellular ATP Level

  • Choi, Ji-Woong;Yoo, Byoung-Kwon;Yoon, Seo-Young;Jeon, Mi-Jin;Ko, Kwang-Ho
    • Biomolecules & Therapeutics
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    • v.12 no.1
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    • pp.25-33
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    • 2004
  • In this study we investigated whether ATP loss was involved in the potentiated death of immunostimulated rat primary astrocytes in glucose-deprived condition. Rat primary astrocytes immunostimulated with LPS plus IFN-${\gamma}$ for 48 h underwent death upon glucose deprivation, which dependent on the production of peroxynitrite. Intracellular ATP level synergistically decreased by glucose deprivation in immunostimulated astrocytes but not in control cells, and the loss of ATP occurred well ahead of the LDH release. The synergistic cell death and ATP loss by immunostimulation and glucose deprivation were inhibited by iNOS inhibitor (L-NAME and L-NNA) or peroxynitrite decomposition catalyst (also a superoxide anion scavenger), Mn(III)tetrakis(N-methyl-4'-pyridyl)porphyrin (MnTMPyP). Exogenous addition of peroxynitrite generator, SIN-l timedependently induced ATP loss and cell death in the glucose-deprived astrocytes. Depletion of intracellular glutathione (GSH) and dis겨ption of mitochondrial transmembrane potential (MTP) were also observed under same conditions. Supply cellular ATP by the addition of exogenous adenosine or ATP during glucose deprivation inhibited ATP depletion, GSH depletion, MTP disruption and cell death in SIN-l treated or immunostimulated astrocytes. This study showed that perturbation in the regulation of intracellular ATP level in immunostimulated astrocytes might make them more vulnerable to energy challenging stimuli.

The Influence of Frequency on Wayside Transmitter of ATP System upon Reinforcing Bars in Concrete Slab Track (콘크리트 슬래브궤도에서 ATP시스템 지상자의 주파수가 철근에 미치는 영향)

  • Kim, Min-Seok;Lee, Jong-Woo;Ko, Jun-Seog
    • Proceedings of the KSR Conference
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    • pp.691-706
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    • 2008
  • ATP(Automatic Train Protection) system in railway signaling system is the important one grasping the position and velocity of a train. The wayside transmitter of ATP system is installed between rails. In concrete slab track, the signal current using wayside transmitter of ATP system is influenced by reinforcing bars. The magnetic coupling between reinforcing bars and wayside transmitter of ATP system as a filter makes an input current distorted. So, it makes an alternating current signal with a desirable size not transmit to on-board system of a train. Way to decrease the distortion of an input current signal frequency is to avoid maximum induction current frequency. And the induction phenomenon between reinforcing bars insulated and wayside transmitter of ATP system does not occur. In this paper, we represent the model about wayside transmitter of ATP system and reinforcing bars on the concrete slab tracks, and calculated the parameters demanded for the model. Also, we demonstrated it through the Maxwell program. Furthermore, we calculated impedance on wayside transmitter used in KVB system and ERTMS/ETCS system which are a kind of ATP system, frequency response of induction current, using the Matlab, and demonstrated the validity of it, using the PSpice program.

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ATP Model in SCM Environment for Improving the Value of Customer Service (고객가치 향상을 위한 SCM환경에서의 ATP모델 연구)

  • 김원식;남호기;박상민
    • Proceedings of the Safety Management and Science Conference
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    • pp.73-80
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    • 2000
  • 공급망상에서 ATP는 단순히 고객에게 납기를 확약해 주는 고객 서비스 기능이 아니다. 이것은 공급 망상에서 ATP Rule을 기반으로 하여 수요와 공급 일치에 도달하기 위한 핵심 기능이다 따라서 SCM Solution을 이용하여 공급 체인 전반에 걸쳐 제품 가용성에 대한 즉시 및 동시 엑세스를 관리하여 기업의 납기 일의 정확도에 대한 최고의 확신을 가져올 수 있으며, SCM Solution을 통해 주문이나 예측 수주로 인하여 새로운 수요가 제품 가용성에 미칠 영향을 결정할 수 있다. 본 논문에서는 공급체인 전체의 통합관리 솔루션을 통하여 SCM에 대한 필요성을 정리하고 ATP관련 데이터를 분석을 수행한다. 이 것을 바탕으로 고객관계 관리( Customer Relationship Management)와 연계하여 세부데이터의 흐름 및 고객 가치를 향상 할 수 있는 ATP Rule을 정의한 후, 본 논문에서는 공급망상에 ATP Rule을 적용하여 ATP관련 데이터를 유연성 있게 취합할 수 있는 방안과 분류체계를 제시한 다단계 ATP모형을 제시 한다.

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