• Title/Summary/Keyword: Acne Vulgaris

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Six Cases of Acne Vulgaris Treated by Sasang Constitutional Treatment with Herbal Steam Therapy (사상체질처방과 훈증요법을 병행한 여드름 치험 6례)

  • Kim, Ki-Bae;Kim, Tae-Wook;Choi, Sung-Hee
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.29 no.2
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    • pp.130-141
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    • 2016
  • Objectives : This study was to performed to investigate the effect of herbal steam therapy on acne vulgaris. Methods : 6 patients with acne vulgaris were treated with korean medicine therapy (herbal medicine and acupunture) including herbal steam therapy. We evaluated the effect by Korean Acne Grading System(KAGS) and Pictures. Results : After treatment, the KAGS Grade of all patients treated with korean medicine therapy including herbal steam therapy is 1. Based on this, we could find that korean medicine therapy including herbal steam therapy is effective and available to ameliorate for the symptoms of acne vulgaris. Conclusions : This clinical cases study shows us that korean medicine therapy including herbal steam therapy seem to be effective to improve symptoms of acne vulgaris. Further studies will be needed to identify herbal steam therapy is beneficial to acne vulgaris.

Cryptotanshinone for Treating Acne Vulgaris

  • Kang, Nae-Gyu;Park, Ji-Eun;Song, Young-Sook;Kim, Jung-Ah;Park, Mun-Eok;Lee, Yong-Hwa;Cho, Wan-Goo;Kang, Seh-Hoon
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.28 no.1
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    • pp.99-115
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    • 2002
  • Tests of stability and toxicity, and clinical evaluation of anti-acne activity suggest that cryptotanshinone, a constituent of the roots of Salvia miltiorrhiza Bunge, is an effective active ingredient for acne vulgaris treatments. Acne vulgaris, called acne or pimples, is the most common disease of the pilosebaceous follicle unit of the skin. It affects nearly 80% of people between the ages of 11 and 30. Approximately 30% of teenagers have acne of sufficient severity to require medical treatment. Acne is a follicular disorder of the skin. It occurs in specialized pilosebaceous units on the face and body. Acne develops when these specialized follicles undergo pathologic alterations that result in the formation of non-inflammatory lesions (comedones) and inflammatory lesions (papules, pustules and nodules). An abnormality of keratinizing epithelium of these follicles, thought to be due to the action of sebum synthesized and secreted by the androgen-sensitive sebaceous glands, leads to inflammation induced by the follicular bacterium Propionibacterium acnes. Therapy involves treatments that modify these pathogenic factors and includes drugs with antikeratinizing, antibacterial and antiseborrheic actions. Acne vulgaris is a very frequent disease, seen primarily in adolescents, involving the sebaceous follicles. Acne vulgaris is characterized by a great variety of clinical inflammatory and non-inflammatory lesions: comedones, papules, pustules, nodules, cysts and scars. Acne vulgaris is a multi-factorial disease. Although its pathogenicity is unclear, extensive studies have shown that hyperseborrhea, superinfection by P. acnes and endocrinologic androgenic changes play a role in the development of acne vulgaris.

A Case Report of Acne Vulgaris Patient Treated with Cheongsangbangpung-tang (청상방풍탕(淸上防風湯)으로 호전된 성인 여드름 환자 치험 1례)

  • Kim, Ji-Hyun;Yoo, Dong-Youl
    • Journal of Haehwa Medicine
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    • v.22 no.1
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    • pp.185-191
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    • 2013
  • Purpose: This study aims to explain the effect of Chungsangbangpoong-Tang(as followed CBT) on an adulthoods' acne vulgaris. Methods: This is a case report on a female patient who has been suffering from acne vulgaris since she was 19 years old. To make her acne condition better, we designed to provide a specific combined treatment, mainly drinking CBT 2 or 3 times per a day with taking a herbal, acupuncture therapy and acupuncture once per every week through whole session. Results: After a series of we prescribed CBT treatments, we could find that CBT treatments are effective and available to ameliorate for her symptoms of acne vulgaris within its period. Conclusion: This clinical case study shows us that CBT might have not only a potentiality as a new acne treatment but also an effect as a new available prescription for adulthoods' acne. Hence more specific studies about CBT should be demanded in a treatment fields of adulthoods' acne vulgaris as soon as possible.

The Latest Trends of Treatment for Acne Vulgaris in PubMed (PubMed를 통해 살펴 본 최신 여드름 치료 연구 경향 최근 3년 간 북미, 유럽 논문을 중심으로)

  • Lee, Woo-Gun;Kim, Bong-Hyun;Jeon, Sun-Woo;Kim, Kyu-Seok;Nam, Hae-Jeong;Kim, Yoon-Bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.24 no.2
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    • pp.41-56
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    • 2011
  • Objective : The purpose of this study is to study trends in Western(North America and Europe) medical treatments for the acne vulgaris. This study analyzed research on acne vulgaris in PubMed. Methods : We searched PubMed related the latest medical treatments for acne vulgaris. We analyzed 21 research papers and examined published journals, years, countries, and their methods, results, interventions, participants, periods and instruments of assessment. Results : The method of studies was mostly double-blind, randomized controlled trial. There were research papers concerning treatment with light-lazer, topical agents, and oral contraceptives. There were more positive results compared to negative results for efficacy of treatment. The median for number of participants was 364.0 persons. The median for periods was 67.8 days. Assessment for outcomes were lesion counts, adverse effects, VAS, etc. Conclusions : It is necessary to study latest trends of Western medical treatments for acne vulgaris and understand strengths and weaknesses of those. It will be helpful to more in-depth develop clinical treatments of Oriental Medicine for acne vulgaris.

Acne Vulgaris Improved in Female Patients Diagnosed as 'Stagnation Pattern' Treated with Yukul-tang Gamibang and External Treatments: 2-Case Report (육울탕가미방(六鬱湯加味方)과 외치법(外治法)을 병용한 울증(鬱症)으로 변증된 여성 여드름 환자 치험 2례)

  • Choi, Seok-Young;Hwang, Deok-Sang;Lee, Jin-Moo;Jang, Jun-Bock;Lee, Kyung-Sub;Lee, Chang-Hoon
    • The Journal of Korean Obstetrics and Gynecology
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    • v.28 no.2
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    • pp.133-142
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    • 2015
  • Objectives : Acne vulgaris is a common skin disorder prevalent among adolescence into adulthood, and its consequences can be detrimental especially for women. The purpose of this study was to investigate the effect of Yukul-tang Gamibang (YG) on female acne vulgaris. Methods : We treated 2 cases of female acne patients diagnosed as ‘Stagnation Pattern’ with herbal medication and external treatments. Herbal medication was orally administered 2 times a day and external treatments were applied once a week on average during the whole treatment period. Results : Photographs were taken at the start of each session, and the pictures of before and after the treatment period were compared. The severity of acne vulgaris was evaluated according to the Korean Acne Grading System (KAGS). We observed clinical improvement and decrease in KAGS grades after treatment. Conclusions : After taking YG, acne vulgaris was significantly improved in both patients. The results suggest that YG may be effective in treating acne vulgaris in female patients diagnosed as ‘Stagnation Pattern’.

Topical Photodynamic Therapy with Triptophan and Riboflavin for the Treatment of Acne vulgaris (트립토판과 리보플라빈을 이용한 광역동 치료의 여드름 치료 효과)

  • Yun, Young-Hee;Kim, Tae-Yeol;Choi, In-Hwa
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.25 no.4
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    • pp.89-98
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    • 2012
  • Objective : Photodynamic therapy (PDT) using topical aminolevulinic acid (ALA) has increasingly been used for the treatment of acne vulgaris and several studies have shown its clinical efficacy. However, ALA-PDT needs a relatively long incubation period and is frequently associated with adverse effects. Triptophan and Riboflavin has been introduced as a new photosensitizer for the treatment of acne recently. Method : 11 patients with acne vulgaris were received PDT with tryptophan and riboflavin four to six times over two to three months. The photos of each patient were taken before and after treatment. Result and conclusion : PDT with tryptophan and riboflavin may be an effective and safe treatment for the Acne vulgaris patients.

Therapeutic Evaluation of a Topical Unani Formulation, Tila-i Muhāsā in Buthūr Labaniyya (Acne Vulgaris): A Randomized, Controlled Clinical Study

  • Azahar, Mohd;Uddin, Qamar;Kazmi, Munawwar Husain;Khatoon, Faiza;Husain, Nazim
    • CELLMED
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    • v.10 no.2
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    • pp.15.1-15.9
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    • 2020
  • Introduction: Buthūr Labaniyya (Acne vulgaris) is a multifactorial disorder of the pilosebaceous units characterized by non-inflammatory and inflammatory clinical lesions. Several Unani medications have been used for centuries to treat acne. Objectives: Evaluation of safety and efficacy of Tila-i Muhāsā in patients with acne vulgaris Materials and Methods: This clinical study was conducted in patients with acne vulgaris. Patients applied Tila-i Muhāsā or 5% Benzoyl Peroxide (BPO) once daily for 6 weeks. Assessment of efficacy was carried out by Global Acne Grading System (GAGS) and Patient Global Assessment (PGA) scores. In addition, overall severity of acne was evaluated on a 5-point Cook's acne grading scale using photographic standards. Assessment of safety was performed through adverse drug reactions, local dermal tolerability, vital signs, and routine laboratory investigations. Results: A total of 60 patients (30 in each group) completed 6 weeks of treatment. The mean percentage reduction in GAGS score at 6 weeks from baseline in Unani group (66.97%) and BPO group (59.09%) was statistically significant (P<0.0001). After 6 weeks of therapy, the mean percentage reduction in PGA score compared to baseline in Unani group (57.44%) and BPO group (50.23%) was statistically significant (P<0.0001). No serious adverse events were reported in both groups; however, mild adverse events occurred more frequently in BPO group (30%) compared to Unani group (10%). Conclusion: Tila-i Muhāsā was found to be effective and safe in the treatment of acne vulgaris. However, further clinical studies with larger sample size and longer duration of therapy need to be conducted.

A Case Report of Soeumbyeong Acne Vulgaris Patient Treated with Osuyu-tang (Wuzhuyu-tang, 吳茱萸湯) (오수유탕(吳茱萸湯)으로 호전된 소음병(少陰病) 여드름 1례)

  • Shin, Jung-min;Hyun, Jun-yeong
    • 대한상한금궤의학회지
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    • v.5 no.1
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    • pp.93-100
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    • 2013
  • Objective : This study aims to explain the effect of Osuyu-tang on an acne vulgaris which a Soeumbyeong patient has. Methods : This is a case report on a female patient who has been suffering from acne vulgaris which is not controlled by normal dermatological treatments. According to Diagnostic system based on Shanghanlun provisions, Osuyu-tang was provided for fifty days. Results : After a series of Osuyu-tang treatments, the patient's symptoms and result of KAGS improved. Conclusions : This case study showed an effectiveness of using Osuyu-tang according to Diagnostic system based on Shanghanlun provisions on acne.

Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome

  • Yang, Gabsik;Lee, Seon Joo;Kang, Han Chang;Cho, Yong-Yeon;Lee, Hye Suk;Zouboulis, Christos C.;Han, Sin-Hee;Ma, Kyung-Ho;Jang, Jae-Ki;Lee, Joo Young
    • Biomolecules & Therapeutics
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    • v.28 no.5
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    • pp.437-442
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    • 2020
  • Activation of the NLRP3 inflammasome is critical for host defense as well as the progression of inflammatory diseases through the production of the proinflammatory cytokine IL-1β, which is cleaved by active caspase-1. It has been reported that overactivation of the NLRP3 inflammasome contributes to the development and pathology of acne vulgaris. Therefore, inhibiting activation of the NLRP3 inflammasome may provide a new therapeutic strategy for acne vulgaris. In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris. Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1β in primary mouse macrophages and human sebocytes. In a P. acnes-induced acne mouse model, injection of P. acnes into the ears of mice induced acne symptoms such as redness, swelling, and neutrophil infiltration. Topical application of auranofin (0.5 or 1%) to mouse ears significantly reduced the inflammatory symptoms of acne vulgaris induced by P. acnes injection. Topical application of auranofin led to the downregulation of the NLRP3 inflammasome activated by P. acnes in mouse ear skin. These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms. The results further suggest that topical application of auranofin could be a new therapeutic strategy for treating acne vulgaris by targeting the NLRP3 inflammasome.

A Study on the Major Symptoms by Each Pattern of Acne Vulgaris (여드름의 변증 유형별 주요 증후에 관한 연구)

  • Jeong, Woo-Yeol;Hong, Eu-Gene;Shin, Jun-Hyuk;Kim, Yoon-Bum;Nam, Hae-Jung;Kim, Kyu-Seok;Lee, Jun-Hee
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.27 no.4
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    • pp.76-86
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    • 2014
  • Objective : This study was performed to find out the differential points of the pattern identification for Acne vulgaris and suggest them to the clinic setting Methods : We searched the papers that suggest patterns identification for Acne vulgaris through China National Knowledge Infrastructure(CNKI), Oriental Medicine Advanced Searching Integrated System(OASIS), Korean Traditional Knowledge Portal(KTKP), Korean Studies Information Service System(KISS). We looked through all the papers, excluded unintended papers, and finally chose some papers that are suitable for inclusion. Then, We extracted all the patterns of Acne vulgaris and chose frequently suggested patterns. Finally we extracted symptoms from selected patterns and arranged them in order of frequency. Results and Conclusions : 1. We found 215 papers and chose 17 papers (Korean : 6, Chinese : 11). 2. We extracted total 67 demonstrations and chose Patterns of Wind-Heat, Damp-Heat, Phlegm and Static blood, Disharmony of the Thoroughfare and Controlling vessels. 3. In Acne vulgaris, the pattern of Wind-Heat tends to have a red papule, sometimes pustule, pain with itching, burning sensation, tidal reddening of the cheeks, white head or black head. The pattern of Damp-Heat tends to have a pustule, node, redness and swelling, pain and greasy skin. The pattern of Phlegm and Static blood has a tendency to be a nodule or cystoma that is hard, dark, painful, long lasting and hard to recover and easy to recur with a scar, pimple, pigmentation. The pattern of Disharmony of the Thoroughfare and Controlling vessels tends to be exacerbated before menstruation, have a small papule that is not easily treated under the chin or around the mouth.