• Title, Summary, Keyword: Allergic disease

Search Result 431, Processing Time 0.031 seconds

Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population

  • Yoon, Dan-Kyu;Ban, Hyo-Jeong;Kim, Young-Jin;Kim, Eun-Jin;Kim, Hyung-Cheol;Han, Bok-Ghee;Park, Jung-Won;Hong, Soo-Jong;Cho, Sang-Heon;Park, Kie-Jung;Lee, Joo-Shil
    • BMB Reports
    • /
    • v.45 no.5
    • /
    • pp.305-310
    • /
    • 2012
  • Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population.

Comparison of Eating Habits and Living Habits in Fourth Grade Elementary School Children with or without Allergic Diseases (초등학교 4학년 아동의 알레르기 질환 유무에 따른 식습관 및 생활습관 비교)

  • Seo, Hui-Yeon;Han, Jae-Kyung;Kim, Yun-Hee
    • The Journal of Pediatrics of Korean Medicine
    • /
    • v.23 no.3
    • /
    • pp.37-53
    • /
    • 2009
  • Objectives Because allergic disease is currently prevalent and has tendency to become chronic, the purpose of this study is to examine the effects of allergic diseases on eating and living habits of children when they grow. Methods Questionnaire performed by 203 fourth grade elementary school children in Cheonan was analyzed. Results Disease group had low frequency of eating ramen, watching TV or web-surfing than that of normal group, but had higher frequency of eating meat, eating breakfast. Conclusions The allergic disease group had more desirable habits. It was assumed that parent's greater interest and devotion toward their children to cure their allergic disease was the reason for the children's desire habits.

  • PDF

Effect of Allergic Rhinitis and Asthma on Oral Health

  • Kim, Chang-Suk;Lee, Kyeong-Soo
    • Journal of dental hygiene science
    • /
    • v.19 no.4
    • /
    • pp.228-237
    • /
    • 2019
  • Background: This study aimed to investigate allergic rhinitis and the relationship between allergic diseases, such as asthma and allergic rhinitis, and dental caries and periodontal disease using the raw data from third year of the 6th Korean National Health and Nutrition Examination Survey. Methods: A total of 3,729 subjects aged over 30 years who underwent examination for allergic diseases and an oral health checkup were selected. The data were analyzed using SPSS IBM SPSS ver. 25.0 (IBM Corp., USA). Composite sample cross correlation and composite sample logistic regression analyses were performed using the composite sample general linear model. Results: On examining the socioeconomic characteristics of the subjects suffering from allergic disease and the relationship between allergic disease and oral health, allergic rhinitis was more frequently found in younger subjects with a higher level of education. Periodontal disease and dental caries were more frequent among female, older age groups, lower income earners, and subjects with a lower level of education (p<0.05). On examining the relationship between the oral health characteristics of the subject and allergic diseases and oral health, allergic rhinitis was more common in subjects with a good oral health status perception than those who answered "bad" to the oral health status question. The community periodontal index of treatment needs (CPITN) score was higher in subjects who answered "poor" to the oral health status question, lower frequency of brushing, and higher in subjects using secondary oral hygiene products; the decayed, missing and filled teeth (DMFT) index was higher in subjects with a perception of poor oral health status (p<0.05). The DMFT index was high in the asthma group, and the CPITN score was high in the group who answered "no" to allergic rhinitis. Conclusion: There is a relationship between asthma and allergic rhinitis and the DFMT index and CPITN score. Corresponding oral programs for allergic patients need to be developed.

A Convergence Analysis of the Factors Influencing Knowledge and Management of Allergic disease Children of Childcare teacher ; atopic dermatitis, asthma, allergic rhinitis (보육교사의 알레르기 질환에 관한 지식과 관리에 영향을 미치는 융합적 요인 분석 ; 아토피 피부염, 천식, 알레르기 비염을 중심으로)

  • Lee, Sun-Young;Moon, Inn-Oh;Lee, Young-Joo
    • Journal of the Korea Convergence Society
    • /
    • v.8 no.4
    • /
    • pp.37-48
    • /
    • 2017
  • The purpose of the study was to identify factors influencing the knowledge and management of allergic disease. Participants were 220 childcare teachers working in childcare facility, date was collected through self-questionnaire. Data was analyzed using SPSS/WIN 23.0. Age(p=0.13), experience of education(0.49) showed significant difference in athma/ allergic rhinitis. Experience of education(p=0.45), necessity of education(p=.034) in asthma/ allergic rhinitis showed significant difference. There is no significant difference in knowledge and management of atopic dermatitis. Allergic disease management and age accounted for 36.2% influencing on knowledge of asthma/allergic rhinitis. Allergic disease knowlege, education experience and necessity of education accounted for 43.1% influencing management of asthma/ allergic rhinitis. Based on the findings of this study, it can be used to educational programs data for childcare teacher.

Korean Translation and Validation of the Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) (Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ)의 한국어판 개발과 신뢰도, 타당도에 대한 연구)

  • Park, Seul Ki;Kim, Sehyun;Lee, Sun Haeng;Chang, Gyu Tae
    • The Journal of Pediatrics of Korean Medicine
    • /
    • v.27 no.3
    • /
    • pp.41-52
    • /
    • 2013
  • Objectives In pediatrics of Korean Medicine, it is crucial to evaluate the overall symptoms of children, especially in the children who have serious troubles in their life. In the era when diagnosis in Korean Medicine is quite suitable to evaluate multiple allergic diseases, and when growing numbers are in needs, development of an objective measurement scale for diagnosis of allergic disease in Korean Medicine became essential. Therefore, in the study, pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) was translated into Korean version with validations on some aspects. Methods In this study, we translated and validated the PADQLQ and established psychometric evidence on its utility in Korean children with similar problems. 71 children, age of 6 ~ 18 with allergic disease has participated. Results The internal consistency reliability of the PADQLQ by Cronbach's ${\alpha}$ was 0.94. In three domains (Practical, Physical, Emotional), the Cronbach's ${\alpha}$ was 0.77, 0.90 and 0.69. The Spearman's rank correlation coefficient between PADQLQ total score and VAS was 0.75 (p<0.001). And, Structural validity was evaluated by the ANOVA test. QoL differences of the four groups in the three domains (practical, physical, emotional) were significant. The item discriminative indices were ranged from 0.1651 to 0.8188. Conclusions Korean version PADQLQ is highly reliable and valid for children with allergic diseases. This is significant to assess the relative seriousness of the allergic diseases and to evaluate the efficacy of different treatments in Korean Medicine.

Research on pediatric allergic rhinitis in Korea (한국 소아 알레르기비염의 연구)

  • Lee, Kyung Suk;Rha, Yeong Ho
    • Allergy, Asthma & Respiratory Disease
    • /
    • v.6 no.sup1
    • /
    • pp.58-65
    • /
    • 2018
  • Allergic rhinitis is the most common chronic rhinitis in children and is the most common allergic disease in childhood and adolescence in Korea and most countries around the world. In this review article, we have summarized some of the research articles on allergic rhinitis that have been published in the Korean Academy of Pediatric Allergy and Respiratory Disease (KAPARD) Journals so far in order to celebrate and look back on the 30th anniversary of the KAPARD. Over the past 30 years, the members of the KAPARD have published many research papers on the epidemiology, causes, risk factors, and comorbid conditions of allergic rhinitis based on 'one airway diseases' and treatment and we hope that these studies will be helpful not only in confirming the research capacity of KAPARD but also in setting up research subjects and research topics related to allergic rhinitis in the future.

Clinical manifestations patterns of allergic disease in Korean children under the age of 6 : multi-center study (다 기관 설문 조사를 통한 알레르기 질환의 연령별 임상 양상)

  • Kim, Dong Il;Yang, Hyeon Jong;Park, Young Mean;Rha, Yeong Ho;Choung, Ji Tai;Pyun, Bok Yang
    • Clinical and Experimental Pediatrics
    • /
    • v.51 no.6
    • /
    • pp.640-645
    • /
    • 2008
  • Purpose : It is widely known that allergic diseases progress through an allergic march. However, there have not been any recent reports in Korea on how the diseases progress. Methods : Parents who visited one of the Pediatric Allergy Clinics of four university hospitals in Seoul with a child under the age of 6 years during the period from May 1-30, 2006 were asked to complete a questionnaire. Results : A total of 229 parents answered the questionnaire about their children, of which 122 were male and 107 were female. The most common allergic disease before 2 years of age was atopic dermatitis (79%). Meanwhile, in 2- to 4-year age group, allergic rhinitis (38%) and asthma (37%) were predominant. The most common allergic disease in the 4- to 6-year age group was asthma (72%), followed by allergic rhinitis (64%). Seventy-three percent of the children had a family history of allergic disease, most often in the fathers (39%). Among patients with allergic rhinitis, 50% had experienced asthma in their earlier days and 30% had experienced atopic dermatitis. In addition, 57% of the children with asthma had suffered from atopic dermatitis. Parents believed that asthma was the most serious allergic disease. Conclusion : In the present study, allergic disease showed a tendency to march from atopic dermatitis to asthma and then to allergic rhinitis. Early diagnosis and treatment of atopic dermatitis is, therefore, considered important for prevention of the allergic march.

Epidemiology of allergic diseases in Korean children (한국 소아 알레르기 역학연구의 과거와 미래)

  • Lee, Eun;Lee, So-Yeon;Yang, Hyeon-Jong;Hong, Soo-Jong
    • Allergy, Asthma & Respiratory Disease
    • /
    • v.6 no.sup1
    • /
    • pp.9-20
    • /
    • 2018
  • In order to overcome a certain disease, it is necessary to confirm the prevalence, natural course and risk factors of the disease. The Korean Academy of Pediatric Allergy and Respiratory Disease has become the mainstream and has been paying a great deal of attention to the epidemiologic research of allergic diseases in Korean children since 1995. In this review, we would like to summarize the International Study of Asthma and Allergies in Childhood epidemiology study in Korea, the cohort study for allergic diseases, and the national medical big data. New epidemiological studies are needed to clarify the relationships between allergic diseases and factors such as air pollution, climate changes, microbiome, and diet, which are likely to be new risk factors for allergic diseases. Based on these epidemiological studies, we hope to find ways to overcome pediatric allergic diseases in Korea and also to share epidemiologic techniques and manpower.

Allergic disease-related articles in Korean newspapers (1920-1972 year) (우리나라 신문 기사를 통해 살펴본 알레르기질환 (1920-1972년))

  • Kim, Kyu Earn
    • Allergy, Asthma & Respiratory Disease
    • /
    • v.6 no.sup1
    • /
    • pp.85-89
    • /
    • 2018
  • Purpose: This study aimed to investigate which Korean newspaper articles were reported on allergic diseases before the establishment of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI). Methods: This study was performed in 3 newspapers, Chosun Ilbo, DongA Ilbo, and JoongAng Ilbo, which were founded and used the databases established before the establishment of KAAACI in 1972. The databases were searched using 42 keywords associated with allergic diseases (allergy, asthma, rhinitis, etc.). Results: Among the 42 keywords, there were only 7 that were able to search: allergy, urticaria, asthma, dermatitis, rhinitis, pollen and eczema. The total number of articles related to allergic diseases were 62, as follows: allergy (n= 21), urticaria (n= 15), asthma (n= 8), dermatitis (n= 8), rhinitis (n= 5), pollen (n= 3), and eczema (n= 2). There were 31 articles in Chosun Ilbo, 9 in DongA Ilbo, and 22 in JoongAng Ilbo. The first allergic disease published in the newspapers was asthma on the article entitled "Treat the cause of asthma" (on page 8 of November 10, 1960 DongA Ilbo). The first article that used the term allergy appeared in a column entitled, "Childhood illness and allergy" (on page 4 of May 30, 1960 DongA Ilbo). Conclusion: Since 1920, articles related to allergic diseases published in the Korean newspapers increased every year. These articles may have appeared due to the increase in the prevalence of allergic disease and the pioneering efforts of senior allergy researchers.

A Comparative Study of the Prevalence of Allergic Disease between Rural and Urban Elementary School Students (도시와 농촌에 거주하는 초등학생의 알레르기질환 유병률 비교 분석)

  • Song, Mi-Ryeong;Kang, Myung-Hwa;Park, Joon-Soo;Jo, Hae-Kyung
    • Child Health Nursing Research
    • /
    • v.18 no.1
    • /
    • pp.29-35
    • /
    • 2012
  • Purpose: The purpose of this study was to analyze the prevalence of allergic disease among elementary school students in rural and urban areas. Methods: In this study, 1,513 elementary students (1,163 in urban areas, 350 in rural areas) were surveyed. Data were analyzed using frequency, percentage of allergic symptoms and $X^2$ test was used to identify differences in the prevalence of allergic symptoms between urban and rural area students. The SAS program was used in the data analysis. Results: There were significant differences in the prevalence of allergic disease according to whether there was a family member with a prior history of allergy symptoms. 48.7% of surveyed students (49.4% in urban, 46.3% in rural) had allergic symptoms. Allergic rhinitis was the most frequent allergic symptom in both urban and rural students. Conclusion: These results suggest that there is a need to prevent and manage allergies among elementary students. The family history should be considered an important factor when a program for allergy prevention and management is developed. Interventions are needed in both areas, especially for students with allergic rhinitis.