• Title, Summary, Keyword: Anti-fatigue

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Comparison of Ingredient Quantities and Anti-Fatigue Effects of Jakyakgamcho-Tang according to Extraction Solvent (작약감초탕의 추출용매에 따른 성분 분석 및 항피로 효능 비교)

  • Sung, Yoon-Young;Yuk, Heung Joo;Kim, Dong-Seon
    • The Korea Journal of Herbology
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    • v.35 no.2
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    • pp.31-38
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    • 2020
  • Objectives : Jakyakgamcho-tang has been used as analgesic and spasmolytic for muscle pain. It has reported to anti-diabetes, anti-inflammation, and neuro-protective effects. A clinical study of muscle fatigue and pain improvement effect of Jakyakgamcho-tang has been reported with increasing frequency of clinical use. However, the anti-fatigue effect of Jakyakgamcho-tang in animal model has not been studied. In this study, we compared anti-physical fatigue effects of water and 30% ethanol extract of Jakyakgamcho-tang. Methods : The amounts of components contained in water and 30% ethanol extract of Jakyakgamcho-tang were compared by ultra-performance liquid chromatography. Anti-physical fatigue effects were evaluated using weight-loaded forced swimming test. We also investigated the effects of Jakyakgamcho-tang on the change of fatigue parameters by blood biochemical analysis. Results : The relative amount of components of Jakyakgamcho-tang were about 19-53% higher in the 30% ethanol extract than in the water extract. In the swimming test, 30% ethanol extract showed a significantly greater anti-fatigue effects than conventional water extract of Jakyakgamcho-tang. The 30% ethanol extract of Jakyakgamcho-tang improved the exhausted swimming time (54%), and serum lactate dehydrogenase (48%) and lactic acid (60%) levels compared with water extract of Jakyakgamcho-tang. Conclusions : These results showed that differences in the amounts of components by different extraction were associated with differences of anti-fatigue effect of Jakyakgamcho-tang. Thus, the 30% ethanol extraction method could be applied to dose-reducing formulations of traditional herbal medicines.

Antioxidant and Anti-physical fatigue Effects of Polygonati Rhizoma and steamed Polygonati Rhizoma (황정(黃精)과 증숙 황정(蒸熟 黃精)의 항산화, 항피로 효능 비교 연구)

  • Kim, Jeong-Soo;Lee, AhReum;Roh, Seong-Soo;Kwon, OJun;Seo, Young-Bae
    • The Korea Journal of Herbology
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    • v.31 no.3
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    • pp.49-57
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    • 2016
  • Objectives: Polygonati Rhizoma (PR) has containing the bioactive compounds such as poly sccharide A,B,C, oligosaccharide, amino acid, it has reported to anti-diabetes and hypertension, atherosclerosis. In this study, we were evaluates antioxidant and anti-physical fatigue effects of PR and steamed PR.Methods : The sample was divided into 5 groups-PR0 (PR without steaming process), PR1 (PR with once steaming process), PR3 (PR with third steaming process), PR6 (PR with sixth steaming process), PR9 (PR with ninth steaming process). We measured anti-oxidant activity through contents of polyphenol, flavonoid and DPPH, ABTS free radical scavenging capacity. And, anti-physical fatigue effect was evaluated using the swimming test, and the AMPK protein expressions in soleus muscle.Results : As a result, polyphenol, flavonoid, DPPH, ABTS free radical scavenging capacity of PR were increased as steaming times. Anti-physical fatigue effects by swimming test, PR0 have significantly increased, but steamed PR groups were decreased. The AMPK protein expressions of PR0 and PR1 groups were increased comparing with PR3, PR6 and PR9. All groups had effects on decreasing TG, creatine in blood serum, but had no effects on TC in blood serum.Conclusions : In conclusion, PR with 9 steaming process was more excellent than not-processed PR in anti-oxidant effect such as DPPH, ABTS radical scavenging activity and contents of polyphenol, flavonoid, but, not-processed PR increased swimming times than processed PR. These results suggest that processed PR has anti-oxidant effect as steaming times, and not-processed PR may be a novel potential anti-physical fatigue agents than processed PR.

Analysis of Fatigue Safety for Anti-Loose Nuts System with Dual Nuts (이중너트가 적용된 풀림방지너트 시스템의 피로안전성 분석)

  • Choi, Jung-Youl;Kim, Jun-Hyung;Chung, Jee-Seung;Ka, Sang-Hyun
    • Journal of the Korean Society of Safety
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    • v.32 no.4
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    • pp.22-27
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    • 2017
  • In this study, the authors aim to evaluate a structural and fatigue safety of a new type anti-loose nut system with dual nuts composed of main nut and outer nut to enhance the long-term workability and durability so as to improve the performance of conventional anti-loose nut system. Also, a three-dimensional finite-element method analysis was performed to consider the actual geometry and material property of anti-loose nut system with dual nuts and the effect of static and dynamic loads and loading directions. The analytical results showed that the overall static and dynamic stress of the components of the anti-loose nut system with dual nuts were found to be less than that of the fatigue limit of Goodman-smith diagram and allowable stress of each materials, therefore the anti-loose nut system with dual nuts was sufficient to ensure a structural and fatigue safety.

Anti-fatigue effects of Elaeagnus multiflora fruit extracts in mice

  • Jung, Myung-A;Jo, Ara;Shin, Jawon;Kang, Huwon;Kim, Yujin;Oh, Dool-Ri;Choi, Chul-yung
    • Journal of Applied Biological Chemistry
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    • v.63 no.1
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    • pp.69-74
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    • 2020
  • The fruit, leaves, and roots of Elaeagnus multiflora Thunb. have been used in traditional Chinese medicine to treat cough, diarrhea, and itching. However, the anti-fatigue effects of E. multiflora fruit (EMF) extract have not been studied in detail. The aim of this study was to examine the effect of EMF on fatigue and exercise performance in BALB/c mice. EMF was orally administered to mice at four doses (10, 50, 100, and 200 mg/kg/day) for 2 weeks. The anti-fatigue activity was evaluated by determining the exhaustive swimming time. Blood lactate and glucose levels and serum lactate levels after a 10 min swimming time, as well as ammonia, creatine kinase (CK), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), and glycogen contents after exhaustive swimming time were measured. The exhaustive swimming time of the EMF 200 group was significantly increased (p <0.01). The EMF groups showed significantly low levels of CK, BUN, LDH, and lactate compared with the control group (p <0.05). Increased liver glycogen was observed in the EMF 200 group (p <0.05). These results suggest that EMF can be utilized as an efficacious natural resource for its anti-fatigue effects.

Effect of Wongisaengmaek-san Extract on Antioxidative and Anti-Fatigue Activity (원기생맥산(元氣生脈散)의 추출물별 항산화작용과 쥐의 운동피로 회복효과)

  • Kim, Yoo-Seung;Ryu, Bong-Ha;Kim, Jin-Sung
    • The Journal of Internal Korean Medicine
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    • v.30 no.1
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    • pp.94-106
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    • 2009
  • Objectives : This study aimed to evaluate the effect of Wongisaengmaek-san (extracted with water or 50% ethanol) on antioxidative activity and recovery of fatigue induced by weight-loaded forced swimming exercise. Methods : Antioxidant activity of Wongisaengmaek-san was evaluated in terms of total amount of polyphenol, 1.1-diphenyl-2-picrylhvdroxyl (DPPH) radical scavenging activity and xanthine oxidase inhibition. The anti-fatigue effect of Wongisaengmaek-san was investigated using an acute weight-loaded forced swimming test by monitoring swimming test times and blood biochemical parameters creatinine. BUN, lactic acid dehydrogenase (LDH), free fatty acid (FFA) and lactic acid (LA). Results : 1. 50% EE (ethanol extract) had 2.3 times higher amount of total polyphenol compared to water extract. 2. It was identified that 50% ethanol extract showed enhancement of xanthine oxidase inhibition and DPPH scavenging effect in vitro. 3. According to anti-fatigue effect in the scale of 5% weight loaded mouse swimming test, both water and 50% ethanol extract showed significant improvement of swimming time elongation respectively, and 50% ethanol extract induced a more positive result. 4. After swimming for 1% weight-loaded mouse. water extract and 50% ethanol showed significant anti-fatigue effect with manifestation of blood sampling among both of the intervention: 50% ethanol extract showed a greater result. Conclusions : 50% ethanol extract of Wongisaengmaek-san has more effective antioxidant activity and anti-fatigue than water extract.

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Anti-fatigue activity of a mixture of seahorse (Hippocampus abdominalis) hydrolysate and red ginseng

  • Kang, Nalae;Kim, Seo-Young;Rho, Sum;Ko, Ju-Young;Jeon, You-Jin
    • Fisheries and aquatic sciences
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    • v.20 no.3
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    • pp.3.1-3.8
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    • 2017
  • Seahorse, a syngnathidae fish, is one of the important organisms used in Chinese traditional medicine. Hippocampus abdominalis, a seahorse species successfully cultured in Korea, was validated for use in food by the Ministry of Food and Drug Safety in February 2016; however. the validation was restricted to 50% of the entire composition. Therefore, to use H. abdominalis as a food ingredient, H. abdominalis has to be prepared as a mixture by adding other materials. In this study, the effect of H. abdominalis on muscles was investigated to scientifically verify its potential bioactivity. In addition, the anti-fatigue activity of a mixture comprising H. abdominalis and red ginseng (RG) was evaluated to commercially utilize H. abdominalis in food industry. H. abdominalis was hydrolyzed using Alcalase, a protease, and the effect of H. abdominalis hydrolysate (HH) on the muscles was assessed in C2C12 myoblasts by measuring cell proliferation and glycogen content. In addition, the mixtures comprising HH and RG were prepared at different percentages of RG to HH (20, 30, 40, 50, 60, 70, and 80% RG), and the anti-fatigue activity of these mixtures against oxidative stress was assessed in C2C12 myoblasts. In C2C12 myoblasts, $H_2O_2$-induced oxidative stress caused a decrease in viability and physical fatigue-related biomarkers such as glycogen and ATP contents. However, treatment with RG and HH mixtures increased cell viability and the content of fatigue-related biomarkers. In particular, the 80% RG mixture showed an optimum effect on cell viability and ATP synthesis activity. In this study, all results indicated that HH had anti-fatigue activity at concentrations approved for use in food by the law in Korea. Especially, an 80% RG to HH mixture can be used in food for ameliorating fatigue.

Anti-fatigue Effect of Kyung-Ok-Ko (경옥고의 항피로 효능)

  • Kim, Yong An;Jin, Sun Woo;Kim, Soul Mi;Lee, Gi Ho;Kim, Se Jong;Lee, Wang Lok;Na, MinKyun;Jeong, Hye Gwang
    • Korean Journal of Pharmacognosy
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    • v.47 no.3
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    • pp.258-263
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    • 2016
  • In this study, we tested anti-fatigue effect of Kyung-Ok-Ko (KOK). We examined the exercise performance effects of KOK (600 mg/kg) at 2nd, 3rd and 4th week. The exercise performance of KOK treated group was significantly improved than that of vehicle control (VC) group on grip strength (2nd week), exhausted time of treadmill (3rd week) and exhausted time of weight loaded swimming (4th week). We also investigated the effects of KOK on the change of fatigue parameters in blood, skeletal muscle and liver after swimming exercise. KOK significantly reduced lactate level and enhanced glucose level in blood. Equally KOK significantly increased glycogen in skeletal muscle. However, the glycogen level of KOK in the liver was not significantly increased compared to VC group. These results show that supplementation of KOK may improve the anti-fatigue activity and exercise capacity.

Immuno-stimulating, Anti-stress and Anti-thrombotic Effects of Unossified Velvet Antlers

  • Shin, Kuk-Hyun;YunChoi, Hye-Sook;Lim, Soon-Sung;Won, Do-Hee;Kim, Jae-Kun
    • Natural Product Sciences
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    • v.5 no.1
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    • pp.54-59
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    • 1999
  • Both ethanol and water extracts of unossified velvet antler were found to exhibit a significant immuno-stimulating activity as measured by carbon clearance test in mice, a remarkable anti-fatigue effect in weight-loaded forced swimming performance in mice, a significant anti-stress effect on immobilization in rats. The antler extracts also showed a weak but significant anti-thrombotic activity. These findings are indicative of adaptogenic properties of antlers and their normalizing effects during stressful condition.

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Practical Use and Risk of Modafinil, a Novel Waking Drug

  • Kim, Dong-Soo
    • Environmental Analysis Health and Toxicology
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    • v.27
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    • pp.7.1-7.7
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    • 2012
  • Objectives: Modafinil is a waking drug prescribed to narcolepsy patients, but its usage among healthy individuals is increasing to enhance their alertness or to mitigate fatigue. This study was conducted to investigate practical use and toxic effects on neuro-immune interaction of modafinil. Methods: This study reviewed the significance of psychoactive drugs, and discussed the benefits and risks of the application of modafinil, which seems to be ideal as an anti-psychotic or anti-fatigue agent. Results: Modafinil is known to have less or no adverse effects than those found in traditional psychostimulants such as amphetamine, methylphenidate or cocaine. It can be applied as an anti-psychotic or anti-fatigue agent. However, the waking mechanism of modafinil is yet to be fully revealed. Recent studies reported that modafinil may be subject to abuse and addiction. In addition prolonged sleeplessness induces stress responses and impairs immune function. Conclusions: Modafinil can be used by anyone, who wishes to work late, stay awake, enhance their cognitive reactions, or brighten their moods. Users may already be under a great level of stress, i.e. cancer patients or soldiers in a battle field. A psychoneuroimmunological approach is thus needed to investigate the multi-functional effects of modafinil.

Anti-fatigue effect of fermented porcine placenta through the regulation of fatigue-associated inflammatory cytokines

  • Nam, Sun-Young;Go, Ji-Hyun;Lee, Mikyung;Kim, Jongbae;Jeong, Hyein;Lee, Won Kyung
    • CELLMED
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    • v.6 no.2
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    • pp.13.1-13.7
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    • 2016
  • Fatigue is a common complaint and affects the quality of life in modern people. Physical stress may induce activation of certain immune cells. Fermented porcine placenta (FPP) has been used to alleviate fatigue. Inflammatory cytokines are produced by physical stress and results in symptoms of fatigue. However, the role of FPP on fatigue-associated inflammatory cytokine production has not been elucidated yet. Thus, we estimated the anti-fatigue effect of FPP and its active components, leucine (Leu) and lysine (Lys) in activated RAW264.7 macrophages and forced swimming test (FST) fatigue animal model. Pretreatment with FPP, Leu, or Lys significantly inhibited the lipopolysaccharide (LPS)-induced tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production without inducing cytotoxicity on LPS-stimulated RAW264.7 macrophages. FPP, Leu, or Lys inhibited the production of nitric oxide and downregulated the expression of inducible nitric oxide synthase on LPS-stimulated RAW264.7 macrophages. Furthermore, caspase-1 activities increased by LPS were significantly reduced by FPP, Leu, or Lys. In the FST, inflammatory cytokine levels of the mice administrated with FPP, Lys, and Leu were significantly reduced compared with the control group at 21 days. Collectively, these results show that anti-fatigue effect of FPP and its active components, Leu and Lys might be derived from the down-regulating of inflammatory mediators.