• Title, Summary, Keyword: Anti-oxidation

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A Study on the Anti-Oxidation Effects of Menthae Herba (I) (부하(溥荷)의 항산화효능(抗酸化效能)에 대한 연구 (I))

  • Jung, Kwang-Hee;Seong, Nak-Sull;Lee, Young-Jong
    • The Korea Journal of Herbology
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    • v.20 no.4
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    • pp.103-112
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    • 2005
  • Objectives : In order to develop effective and safe anti-oxidation, the effects of Menthae Herba (M. spicata L. and M piperita L.) were examined. Methods : M. spicata L. and M. piperita L. of Menthae Herba were used to make water extracts and methanol extracts, and then its anti-oxidative effects were compared in vitro. Results : 1. M. spicata L. was stronger than M. piperita L. in anti-oxidative effects of methanol extracts, and water extracts showed similar anti-oxidation effects. 2. Water extracts of M. spicata L. was stronger than M. piperita L. showed a stronger superoxide anit-oxidation than the same-density ascorbic acid, so that water extracts were proved to be stronger than methanol extracts. 3. Methanol extracts' DPPH anti-oxidation was similar in M. spicata L. and M piperita L.. As for water extracts, M. spicata L. showed higher anti-oxidation and M. piperita L. had no anti-oxidation. 4. As for anti-oxidation of LDL and linoleic acid of methanol extracts, both M. spicata L. and M. piperita L. were stronger than a-tocopherol. As for the water extracts, these two showed similar level of anti-oxidative effect on linoleic acid, which is weaker that mehtanol extracts. 5. M. spicata L. includes more phenol than M. piperita L. Conclusions : Menthae Herba (M. piperita L. M. spicata L.) had anti-oxidation effect, so that it can be medically developed for anti-oxidation.

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Anti-Oxidation Property of Oil-Soluble Zinc-dialkyldithiophosphate (ZnDTP의 산화방지기능에 관한 연구)

  • 김영환
    • Tribology and Lubricants
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    • v.16 no.1
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    • pp.22-26
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    • 2000
  • In this paper, the fuction of Zinc-dialkyldithiophosphate (ZnDTP) as an oxidation ingibitor of mineral oils was investigated and compared with 2,6-Di-tert-Butyl-4-Methylphenol (DBMP). Oxidation tests were conducted using an oxygen absorption apparatus. ZnDTP showedanti-oxidation property, and length of induction period prolonged by increasing ZnDTP concentration. The anti-oxidation property of ZnDTP was simmilar to that with DBMP. The amount of hydroperoxide decomposition ability with ZnDTP was much greater than that with DBMP, But the rate constant of radical scavenging with ZnDTP was less than that with DBMP. The anti-oxidation property of ZnDTP seems to by both synergy effect of hydroperoxide decomposition ability and radical scavenging ability.

The Effects of Houttuyniae Herba extract on the Activity of Anti-bacteria, Anti-inflammation and Anti-oxidation (어성초(魚腥草) 추출물의 항여드름 효과에 관한 연구)

  • Jeon, Oh-do;Seo, Hyeong-Sik
    • Journal of Pharmacopuncture
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    • v.11 no.1
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    • pp.119-125
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    • 2008
  • Objective : This experimental study was performed to investigate the effects of Houttuyniae Herba extract on anti-inflammation and anti-oxidation. Methods : The cytotoxicity of Houttuyniae Herba water extract and ethanol extract about viability of Raw 264.7 cell were tested using a colormetric tetrazolium assay(MTT assay). We investigated the inhibitory effects of Houttuyniae Herba water extract and ethanol extract on Propionibactrium acnes using paper disk diffusion method. To investigate the anti-inflammation effects of Houttuyniae Herba water extract and ethanol extract on LPS-induced macrophage Raw 264.7 cell, we used ELISA kit. We evaluated anti-oxidation effects of Houttuyniae Herba water extract and ethanol extract on HaCaT cell by Enzyme recycling method. Results : 1. In Houttuyniae Herba water extract and ethanol extract, cell toxicity depended on the density and wasn't difference between two extracts. 2. Houttuyniae Herba water extract and ethanol extract has not the significant inhibition effect of Propionibactrium acnes. 3. Concentration of 50, $100{\mu}g/m{\ell}$ Houttuyniae Herba water extract inhibited the production of NO in the Raw 264.7 cell stimulated with LPS. 4. All extracts except for $20{\mu}g/m{\ell}$ Houttuyniae Herba water extract showed anti-oxidation effect by decreasing the DPPH radicals. Conclusion : These results indicate that Houttuyniae Herba extract has anti-inflammation and anti-oxidation effects. If further study is performed, the use of Houttuyniae Herba extract will be valuable and benificial in the therapy of Propionibactrium acnes.

Effects of Malvae Semen and Abutili Semen on Anti-oxidation Activities (동규자(冬葵子)와 경마자의 항산화(抗酸化) 효능(效能) 연구(硏究))

  • Choi, Jung-Woon;Seong, Nak-Sull;Lee, Young-Jong
    • The Korea Journal of Herbology
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    • v.21 no.4
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    • pp.159-170
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    • 2006
  • Objectives : Anti-oxidation activities of Malvae Semen and Abutili Semen were compared and evaluated. Methods : We tested the anti-oxidant effect through in vitro experiment and in vivo experiment that induced oxidative stress using ethanol. Results : 1. In the anti-oxidative activities of Malvae Semen and Abutili Semen they had high effects in case of the scavenging activitie of DPPH and superoxide anion radical, and inhibitory effect of linoleic acid oxidation. 2. Malvae Semen had large quantities of phenolic compound than Abutili Semen, but the anti-oxidative activity of Malvae Semen was weaker than that of Abutili Semen. 3. The anti-oxidative effect of Abutili Semen was more strong than that of Malvae Semen in the rat stressed by ethanol. Conclusion : Anti-oxidation activities of Abutili Semen were stronger than those of Malvae Semen. Therefore, the complementary usage of Malvae Semen and Abutili Semen can be considered.

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Anti-Oxidation Property of Organo-Molybdenum Dialkyldithiophosphate (유용성 몰리부덴 화합물의 산화방지기능에 관한 연구)

  • 김영환;전광식
    • Tribology and Lubricants
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    • v.18 no.6
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    • pp.396-401
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    • 2002
  • ln this paper, the fuction of molybdenum dialkyl dithiophosphate (MoDTP) as an oxidation inhibitor of mineral oils was investigated and compared with 2,6-Di-tert-Butyl-4-Methylphenol (DBMP). Oxidation tests were conducted using an oxygen absorption apparatus. MoDTP showed anti-oxidation property, and length of induction time prolonged by increasing MoDTP concentration. However the induction time of DBMP was longer than those of MoDTP. The anti-oxidation property of MoDTP was found to be inferior to that of DBMP The capability of hydroperoxide decomposition ability with MoDTP was much greater than that with DBMP. However the rate constant of radical scavenging with MoDTP was much better than that with DBMP. It was found that the performance of MoDTP is exellent with respect to hydroperoxide decomposition but it is susceptible to chemical decomposition. From the fact that formation of phenol was observed when MoDTP was added to hexane solution of cumene hydroperoxide (CHPO), it is indicated that the decomposition of hydroperoxide with MoDTP occurs by means of ionic mechanism.

Application and evaluation of boron nitride-assisted liquid silicon infiltration for preparing Cf/SiC composites

  • Kim, Jin-Hoon;Jeong, Eui-Gyung;Kim, Se-Young;Lee, Young-Seak
    • Carbon letters
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    • v.12 no.2
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    • pp.116-119
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    • 2011
  • C/SiC composites were prepared by boron nitride (BN)-assisted liquid silicon infiltration (LSI), and their anti-oxidation and mechanical properties were investigated. The microstructures, bulk densities, and porosities of the C/SiC composites demonstrated that the infiltration of liquid silicon into the composites improved them, because the layered-structure BN worked as a lubricant. Increasing the amount of BN improved the anti-oxidation of the prepared C/SiC composites. This synergistic effect was induced by the assistance of BN in the LSI. More thermally stable SiC was formed in the composite, and fewer pores were formed in the composite, which reduced inward oxygen diffusion. The mechanical strength of the composite increased up to the addition of 3% BN and decreased thereafter due to increased brittleness from the presence of more SiC in the composite. Based on the anti-oxidation and mechanical properties of the prepared composites, we concluded that improved anti-oxidation of C/SiC composites can be achieved through BN-assisted LSI, although there may be some degradation of the mechanical properties. The desired anti-oxidation and mechanical properties of the composite can be achieved by optimizing the BN-assisted LSI conditions.

The Effects of Sulfur extract on Anti-Inflammation and Anti-Propionibacterium acnes (유황(硫黃)이 여드름 유발균과 염증에 미치는 영향)

  • Lee, Seon-Yong;Seo, Hyeong-Sik
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.20 no.2
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    • pp.68-76
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    • 2007
  • Objectives : This experimental study was performed to investigate the effects of Sulfur extract on anti-inflammation and anti-Propionibacterium acnes. Methods : The cytotoxicity of Sulfur extract about viability of Raw 264.7 cell were tested using a colorimetric tetrazolium assay(MTT assay). To investigate the anti-inflammation effects of Sulfur extract on LPS-induced macrophage Raw 264.7 cell, we used ELISA kit and Western blots. We evaluated anti-oxidation effects of Sulfur extract on HaCaT cell by Enzyme recycling method. And we investigated the inhibitory effects of Sulfur extract on Propionibactrium acnes using paper disk diffusion method. Results: 1. Sulfur extract has a little cytotoxicity in Raw 264.7 cell. 2. Concentration of $100\;{\mu}g/m{\ell}$ Sulfur extract inhibited the production of NO in the Raw 264.7 cell stimulated with LPS. 3. Sulfur extract showed a oxidation inhibition effect by decreasing the DPPH radicals. 4. Sulfur extract has not the significant inhibition effect of Propionibactrium acnes. Conclusions: These results indicate that Sulfur extract has anti-inflammation and anti-oxidation effects. If further study is performed, the use of Sulfur extract will be valuable and benificial in the therapy of Propionibactrium acnes.

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Anti-oxidative effects of fractionated Pulsatilla koreana $N_{AKAI}$ extracts (백두옹 분획층의 항산화 효과)

  • Cho, Hyun-Jin;Yun, Hyun-Jeong;Yi, Hyo-Seung;Park, Sun-Dong
    • The Korea Journal of Herbology
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    • v.25 no.2
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    • pp.99-106
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    • 2010
  • Objectives : This study was designed to investigate the effects of anti-oxidation of fractionated Pulsatilla koreana $N_{AKAI}$ (PK) extracts. And we examined to determine that a certain fractionated extract has the best anti-oxidative effects between the fractionated PK extracts. Methods : Anti-oxidative effects of fractionated PK extracts was measured by scavenging activities of DPPH, superoxide, nitric oxide (NO) and peroxynitrite radicals. And also scavenging activities of anti-oxidation in lipopolysaccharide (LPS)-treated RAW 264.7 cell was measured. After these examination, we determined a fraction that has best anti-oxidative effects. Results : Fractionated PK extracts inhibited radicals effectively. Also in RAW 264.7 cell, intracellular oxidation has inhibited by PK extracts. In these tests, ethyl acetate (EA) fraction has the best anti-oxidative effects among PK extracts. Conclusions : This results demonstrate that PK extracts exhibit anti-oxidative effects. And EA fraction has the best inhibition effects among the six fractions of PK.

The Experimental Study on Anti-inflammation and Anti-oxidation of Indigo Naturalis and Rehmanniae Radix (청대(靑黛)와 생지황(生地黃)의 항염 및 항산화 효과에 대한 실험적 연구)

  • Seo, Hyeong-Sik
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.21 no.3
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    • pp.104-110
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    • 2008
  • Objectives : This experiment study was performed to investigate the anti-inflammation and anti-oxidant effects of Indigo Naturalis(IN) and Rehmanniae Radix(RR) which were herbs for clearing heat. Methods : Anti-inflammation and anti-oxidation effects of IN and RR that were measured by the inhibitory ability of Nitric oxide(NO) production and the scavenging for 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical. Results : 1. IN and RR groups were not showed cell toxicity. 2. In the inhibitory ability of NO production, IN groups were better than RR groups, but there were no statistical significances among the groups. 3. In the scavenging for DPPH radical, IN groups were better than RR groups, but there were no statistical significances among the groups. Conclusions : These results showed that the IN group was better than the RR group in treating skin eruptions, especially those such as erythema, purple spot, papule, pustules which appear in acute inflammation.

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The Comparative Study of Anti-inflammation and Anti-oxidation in Accodance with Extraction Solvents of Jeondo-san (전도산(顚倒散)의 추출용매에 따른 항염 및 항산화 비교 연구)

  • Seo, Hyung-Sik
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.23 no.2
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    • pp.69-80
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    • 2010
  • Objective : The purpose of this study was to compare anti-Inflammation and anti-oxidation of Jeondo-San(JDS) extracted with two kinds of solvents, ethanol and water. Methods : Two kinds of JDS extractions were prepared 20, 50, $100\;{\mu}g/mg$. The Cytotoxicity was measured by MTT assay in Raw 264.7 cell. The anti-inflammation effects were measured by inhibitory efficacy on $PGE_2$, NO, TNF-$\alpha$, COX-2 and iNOS in Raw 264.7 cell. The anti-oxidation effects were measured by ROS inhibitory efficacy, intracellular GSH synthesis and DPPH Radical scavenging in HaCaT cell. Results : 1. All of JDS extraction groups had no cytotoxicity in Raw 264.7 cell. 2. All of JDS extraction groups showed significantly inhibitory effect on production of $PGE_2$. Inhibitory efficacy increased in accodance with concentration. 3. All of JDS extraction groups showed significantly inhibitory effect on production of NO. Inhibitory efficacy increased in accodance with concentration. 4. All of JDS extraction groups did not show significantly inhibitory effect on production of TNF-$\alpha$. 5. $100\;{\mu}g/ml$ JDS extracted with ethanol and $50\;{\mu}g/ml$, $100\;{\mu}g/ml$ JDS extracted with water showed inhibitory effect on iNOS expression. 6. All of JDS extraction groups showed significantly inhibitory effect on production of ROS. Inhibitory efficacy increased in accodance with concentration. Ethanol extractions were better than water extractions. 7. $100\;{\mu}g/ml$ JDS extracted with ethanol only produced GSH of $32{\pm}5.2%$. 8. All of JDS extraction groups showed significantly scavenging effect of DPPH radicals. Inhibitory efficacy increased in accodance with concentration. Ethanol extractions were better than water extractions. Conclusion : Two kinds of JDS extractions have not cytotoxicity and inhibit production of NO. JDS extracted with water was effective in anti-inflammation, JDS extracted with ethanol was effective in anti-oxidation.