• Title, Summary, Keyword: Antidiabetic

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Investigation of Antidiabetic Medicinal Plants using an Oriental Medicinal Database (동양의학 데이터베이스를 이용한 당뇨병에 효능을 가진 생약재의 탐색)

  • Kim, Dong-Hyun;Kang, Young-Gu;Kim, Hong;Chae, Hee-Jung
    • KSBB Journal
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    • v.19 no.2
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    • pp.125-131
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    • 2004
  • Various medicinal plants were examined as resources for antidiabetic biomaterials, using an oriental medicinal database. The prescription frequency and dosage of medicinal plants in 131 antidiabetic prescriptions were analyzed. Total prescription score of each medical plant was summed up from prescription table and score table. High-scored medicinal plants have been widely studied in the previous research on the diabetic treatment. Consequently, dangui, hwangryun, maekmoondong, ginseng, chick, saengjihwang, omija, bokryung, Jimo and cheonhwaboon were assumed to have high antidiabetic activities.

Antidiabetic activity of Cultivated Cordyceps pruinosa

  • Kim, Tae-Woong;Sung, Jae-Mo;Yang, Ki-Sook
    • Proceedings of the PSK Conference
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    • pp.209.3-209
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    • 2003
  • Cordyceps species has been used as antiinflammatory, antitoxic, diuretic in folk remedies. Recent research has been reported the effect of anticancer, antidiabetic, antimutagenic, antilipid peroxidation. We examined the antidiabetic activity of cultivated Cordyceps pruinosa on streptozotocin-induced diabetic rats. The blood glucose level was recovered by treatment with Cordyceps pruinosa ethanol extract. The contents of GPT, total cholesterol and xanthine oxidase, glutathione peroxidase, catalase activities of the cytosol were significantly decreased as compared to the diabetic group. (omitted)

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Hypoglycemic, Antidiabetic and Antiulcer Screening of Thespesia Populnea Linn

  • Jayakumari, S.;Rajkumar, M.;Joanofarc, J.;Rao, G. Srinivasa;Kumar, S. Sadish;Umadevi, S.K.
    • Natural Product Sciences
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    • v.9 no.3
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    • pp.167-169
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    • 2003
  • In the present study, Thespesia populnea was extracted with alcohol and water. The extracts were vacuum dried to yield the respective alcoholic and aqueous extracts. The extracts were screened for hypoglycemic, antidiabetic and antiulcer activities at the dose level of 500 mg/kg by standard methods. The extracts exhibited significant response for antidiabetic and antiulcer activities. The present study proved the claims of Thespesia populnea mentioned in the Indian System of Medicine.

Antidiabetic Effect Screening of Some Natural Products (천연물의 항 당뇨 효능검색)

  • Kim, Jong-Ho;Kim, Kyoung-Soon;Park, Jeong-Hill;Lee, Bong-Jin;Huh, Hoon;Jeong, Gi-Hwa;Cheong, Chun-Sik;Kim, Bak-Kwang
    • Biomolecules & Therapeutics
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    • v.4 no.3
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    • pp.291-295
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    • 1996
  • For the screening of antidiabetic effect, this study was carried out to some natural products by measurements of glucose level. MeOH and $CH_2Cl_2$ extracts of natural products were investigated for the effect on glucose level of $N_2$-STZ diabeted Rat. Among the natural products, Dioscorea Rhizoma, Trichosanthes Radix, Nelumbis Semem and Lycii Fructus were shown a remarkable antidiabetic effect.

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Antidiabetic Activity of Lycii Fructus (구기자의 혈당강하작용)

  • Shin, Joon-Su;Kim, Kyoung-Soon;Jeong, Gi-Hwa;Cheong, Chun-Sik;Ko, Kwang-Ho;Park, Jeong-Hill;Huh, Hoon;Kim, Bak-Kwang
    • Korean Journal of Pharmacognosy
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    • v.28 no.3
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    • pp.138-142
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    • 1997
  • To elucidate antidiabetic activity of Lycii Fructus. The extract of the Lycii Fructus was subjected to bioactivity-guided fractionation. The extract of the Lycii Fructus was partitioned suceesively with hexane, dichloromethane, ethylacetate and butanol. The butanol fraction, which is most abundant in the Lycii Fructus was subjected to silica gel column chromatography and resulted in seven fractions namely Fr. I - Fr. VII. Among tested several subfractions, Fr IV. Showed the highest antidiabetic activity in the streptozotocin-induced model rat.

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Antidiabetic and Lipid Metabolism Effect of Paediomyces Japonica in Streptozotocin-Induced Diabetic Rats (눈꽃동충하초(paecilomyces japonica)추출물의 지질대사 및 당대사에 미치는 영향)

  • Kim, Ok-Kyung
    • Journal of the Korean Applied Science and Technology
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    • v.27 no.4
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    • pp.494-500
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    • 2010
  • This study was carried to investigate the antidiabetic and lipid metabolism of water extract paecilomyces japonica(PJ) in Streptozotocin (STZ) induced diabetic rats. Diabetes were induced by intravenous injection of STZ at a dose of 42mg/kg dissolved in citrate buffer. The water extract of paecilomyces japonica were orally administrated once a day for 7 days at a dose of 500mg/kg or 1,000mg/kg. The contents of serum glucose, triglyceride(TG), total cholesterol were significantly decreased in PJ treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase(G-6-PDH), glucokinase(GK) were significantly increased, but activity of glucose-6-phoshatase(G-6-Pase) was significantly decreased in PJ treated group compared to the those of STZ-control group. These results indicated that water extract of paecilomyces japonica would have antidiabetic and lipid metabolism effect in STZ-induced diabetic rats.

Antioxidant and Antidiabetic Activities of Ulmus davidiana Extracts

  • Guo, Jia;Wang, Myeong-Hyeon
    • Food Science and Biotechnology
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    • v.16 no.1
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    • pp.55-61
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    • 2007
  • The antioxidant activities of water, ethanol, methanol, and chloroform extracts of Ulmus davidiana were evaluated using various antioxidant assays: DPPH (1,1-diphenyl-2-pricrylhydrazyl) free radical scavenging; hydroxyl radical scavenging; lipid peroxidation scavenging; and reducing power assays. All extracts, except the chloroform extract, demonstrated strong antioxidant activity in all assays. The chloroform extract had the highest hydroxyl radical scavenging activity, and its activity was equivalent to $\alpha$-tocopherol at a concentration of 0.5 mg/mL. Additionally, the antidiabetic activity of their extracts was also evaluated using a rat intestinal $\alpha$-glucosidase inhibition assay. Among all extracts investigated, the methanol extract had the highest $\alpha$-glucosidase inhibitory activity, although its activity was less than acarbose at $0.5\;{\mu}g/mL$. This result suggested that U. davidiana extracts may have antidiabetic activity. Total phenolic compounds and flavonoids were also measured. Phenolic compounds such as tannic acid, p-coumatric acid, and kaempferol were detected by high-performance liquid chromatography (HPLC). These results suggest that U. davidiana extracts may be useful as a potential source of antioxidant and antidiabetic materials.

Antioxidant and antidiabetic activities of extracts from Cirsium japonicum roots

  • Yin, Jie;Heo, Seong-Il;Wang, Myeong-Hyeon
    • Nutrition Research and Practice
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    • v.2 no.4
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    • pp.247-251
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    • 2008
  • This study investigated the antioxidant activity of methanol (MeOH) and water extracts from roots of Cirsium japonicum in vitro, MeOH extract showed a stronger tree radical scavenging activity than water extract. However, both of extracts showed a concentration dependent hydroxyl radical scavenging activity, reducing power and metal chelating ability, MeOH extract had greater phenolic and flavonoid contents than water extract. The antidiabetic activity of these two extracts was evaluated by the a-glucosidase inhibition assay, The water extract showed a considerable a-glucosidase inhibitory activity. To our knowledge, this may be the first time to report the antioxidant and antidiabetic activities in Cirsium japonicum roots.

Antidiabetic Effect of Ha-Su-O(polygoni radix) (하수오 추출물의 혈당강하작용)

  • Kim, Ok-Kyung
    • Journal of the Korean Applied Science and Technology
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    • v.25 no.3
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    • pp.347-354
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    • 2008
  • This study was done to investigate the antidiabetic effect of polygoni radix in Streptozotocin(STZ)-induced diabetic rats. Diabetes was induced by intravenous injection of STZ at a dose of 45mg/kg dissolved in citrate buffer. The ethanol extract of polygoni radix was orally administrated once a day for 7 days. The content of serum glucose, triglyceride(TG), total cholesterol were significantly decreased in polygoni radix treated STZ-sample group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-6-phosphate dehydrogenase(Glucose-6-PDH), glucokinase were significantly increased, but activity of glucose-6-phoshatase was decreased in polygoni radix treated STZ-sample group compared to the those of STZ-control group. These results indicated that ethanol extract of polygoni radix would have antidiabetic effect in STZ-induced diabetic rats.

Antidiabetic Effect of Auricularia auricula Mycelia in Streptozotocin-induced Diabetic Rats

  • Kim, Sung-Kyu;Hong, Un-Pyo;Kim, Jong-Soo;Kim, Cherl-Hyun;Lee, Ki-Woong;Choi, Sun-Eun;Park, Kwan-Hee;Lee, Min-Won
    • Natural Product Sciences
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    • v.13 no.4
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    • pp.390-393
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    • 2007
  • Auricularia auricula (Heterobasidiae) called 'tree ear' or 'ear mushroom' was investigated to know its antidiabetic effect. Administration of dried powder of Auricularia auricula mycelia (AAM) (0.5 g/kg bw and 1.0 g/kg bw) caused a statistically significant reduction of plasma glucose (35% and 39%, respectively), total cholesterol (18% and 22%, respectively), triglyceride (12% and 13%, respectively), GOT (53% and 56%, respectively) GPT (26% and 37%, respectively), levels and the rate of liver weight against final total body weight (6% and 7%, respectively) compared with diabetic control group. These results support the antidiabetic effect of AAM.