• Title, Summary, Keyword: BUC

Search Result 18, Processing Time 0.033 seconds

Overexpression and Clinicopathological Contribution of DcR3 in Bladder Urothelial Carcinoma Tissues

  • Jiang, Yi-Qiang;Zhong, Teng-Fei;Dang, Yi-Wu;Zou, Ling-Song;Yang, Liu;Yang, Xia;Chen, Gang
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.21
    • /
    • pp.9137-9142
    • /
    • 2014
  • Background: To explore the expression of DcR3 protein and its clinicopathological significance in bladder urothelial carcinomas (BUC). Materials and Methods: Immunohistochemistry was performed to detect the expression of DcR3, caspase-3, Bcl-2, VEGF, Ki-67, PCNA and P53 in 166 BUC and 56 normal bladder tissues. Western blotting was used to detect the expression of DcR3 in the supernatants of cultured BUC cells. Results: Overexpression of DcR3 was found in BUC tissues and cell lines, with significant elevation as compared to normal bladder tissues (p<0.0001). Higher DcR3 expression was related to the status of invasion, lymph node metastasis and recurrence. Furthermore, DcR3 expression was negatively correlated with caspase-3 and positively associated with Bcl-2, VEGF, Ki-67 labeling index (LI), PCNA LI and P53 (all p<0.0001), respectively. Conclusions: DcR3 may play a crucial role as an oncogene in tumorigenesis, deterioration and progress of BUC via influencing related pathways of apoptosis, proliferation and angiogenesis. The detection of DcR3 protein in the formalinfixed and paraffin-embedded samples could assist to predict in prognosis of BUC patients.

Criticality Uncertainty Analysis of Spent Fuel Transport Cask applying Burnup Credit (연소도이득효과(BUC) 적용 사용후핵연료 운반용기의 임계 불확실도 평가)

  • Lee, Gang-Ug;Park, Jea-Ho;Kim, Do-Hyung;Kim, Tae-Man;Yoon, Jeong-Hyun
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
    • /
    • v.9 no.3
    • /
    • pp.191-198
    • /
    • 2011
  • In general, conventional criticality analyses for spent fuel transport/dry storage systems have been performed based on assumption of fresh fuel concerning the potential uncertainties from number density calculation of Transuranic and Fission Products in spent fuel. However, because of economic loss due to the excessive criticality margin, recently the design of transport/dry storage systems with Burnup Credit(BUC) application has been actively developed. The uncertainties in criticality analyses on transport/storage systems with BUC technique show strong dependance upon initial enrichment and burnup rate, whereas those in the conventional criticality evaluation based on fresh fuel assumption do not show such a dependance. In this study, regulatory-required uncertainties of the criticality analyses for BK 26 Cask, which is conceptually designed spent fuel transport cask with BUC corresponding to the limiting circumstances on nuclear power plants in Korea, are evaluated as a function of initial enrichment and burnup rate. Results of this study will be used as basic data for spent fuel loading curve of BK 26 Cask.

BUC Design and Fabrication for Flyaway Satellite Terminal (운반형 위성단말 고출력 상향 주파수변환기 설계 및 제작)

  • Kim, Joo-Yeon;Shin, Kwan-Ho
    • Journal of IKEEE
    • /
    • v.24 no.1
    • /
    • pp.72-80
    • /
    • 2020
  • This paper describes the design and fabrication of a BUC(Block Up-converter) which is a component of a FST (Flyaway Satellite Terminal), one of the ET(Earth Terminal) of the military satellite. BUC is physically composed of an up-converter module, a high power amplifier module, a receive band suppression filter, a housing, and a cable assembly. It was designed using simulator AWR to satisfy the electrical characteristics of BUC's such as maximum output power, gain, unwanted signal, and intermodulation. The maximum output power and gain characteristics were measured at 43.4dBm and 51.8dB, respectively. The unwanted wave and intermodulation characteristics were -73.5dBc and -31.9dBc, respectively. Of the electrical requirements of Table 1, not only the above four but also all of the items were confirmed to be satisfied.

Design of the Scheduler using the Division Algorithm Based on the Time Petri net (타임 패트리넷 기반의 분할 알고리즘을 이용한 스케쥴러 설계)

  • 송유진;이종근
    • Journal of the Korea Society for Simulation
    • /
    • v.12 no.2
    • /
    • pp.13-24
    • /
    • 2003
  • In this study, we propose a scheduling analysis method of the Flexible management system using the transitive matrix. The Scheduling problem is a combination-optimization problem basically, and a complexity is increased exponentially for a size of the problem. To reduce an increase of a complexity, we define that the basic unit of concurrency (short BUC) is a set of control flows based on behavioral properties in the net. And we propose an algorithm to divide original system into some BUC. To sum up, we divide a petri net model of the Flexible management system Into the basic unit of concurrency through the division algorithm using the transitive matrix. Then we apply it to the division-scheduling algorithm to find an efficient scheduling. Finally, we verify its efficiency with an example.

  • PDF

Slices Method of Petri Nets Using the Transitive Matrix for Scheduling Analysis in FMS (유연생산 시스템 스케쥴링 분석을 위한 추이적 행렬을 이용한 패트리 넷의 분할)

  • Song, You-Jin;Kim, Jong-Wuk;Lee, Jong-Kun
    • Journal of Institute of Control, Robotics and Systems
    • /
    • v.8 no.4
    • /
    • pp.292-298
    • /
    • 2002
  • We focus on the slicing off some sub-nets using the transitive matrix. Control flows in the Petri nets is done based on the token flows. One control f]ow explains the independent tokens status and if the token-in divides into several tokens after firing a transition then the control flow divides to several flows, as well. Accordingly, we define that the basic unit of concur-rency (short BUC) is a set of the executed control flows based on the behavioral properties in the net. The BUC is S-invariant which has one control flow. We show the usefulness of transitive matrix to slice off some subnets from the original net based on BUC-through on an example.

Quantitative Evaluation of Criticality According to the Major Influence of Applied with Burnup Credit on Dual-purpose Metal Cask (국내 금속겸용용기의 연소도 이득효과 적용 시 주요영향인자에 따른 정량적 핵임계 평가)

  • Dho, Ho-seog;Kim, Tae-man;Cho, Chun-Hyung
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
    • /
    • v.13 no.2
    • /
    • pp.141-154
    • /
    • 2015
  • In general, conventional criticality analysis for spent fuel transport/storage systems have been performed based on the assumption of fresh fuel concerning the potential uncertainties from number density calculations of actinide nuclides and fission products in spent fuel. However, these evaluation methods cause financial losses due to an excessive criticality margin. In order to overcome this disadvantage, many studies have recently been conducted to design and commercialize a transportation and storage cask applied to the Burnup Credit (BUC). This study conducted an assessment to ensure criticality safety for reactor operating parameters, axial burn-up profiles and misload accident conditions, which are the factors that are likely to affect criticality safety when the BUC is applied to the dual-purpose cask under development at the KOrea RADioactive waste agency (KORAD). As a result, it was found that criticality resulting from specific power, changed substantially and relied on conditions of low enrichment and high burn-up. Considering the end effect in the case of high burn-up produced a positive-definite result. In particular, the increment of maximum effective multiplication factors due to misloading was 0.18467, confirming that misload is a factor that must be taken into account when applying the BUC. The results of this study may therefore be utilized as references in developing technologies to apply the BUC to domestic models and operational procedures or preventing any misload accidents during the process of spent fuel loading.

A Study on the Radiation Source Effect to the Radiation Shielding Analysis for a Spent-Fuel Cask Design with Burnup-Credit (연소도이득효과를 적용한 사용후핵연료 수송용기의 방사선원별 차폐영향 분석)

  • Kim, Kyung-O;Kim, Soon-Young;Ko, Jae-Hoon;Lee, Gang-Ug;Kim, Tae-Man;Yoon, Jeong-Hyun
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
    • /
    • v.9 no.2
    • /
    • pp.73-80
    • /
    • 2011
  • The radiation shielding analysis for a Burnup-credit (BUC) cask designed under the management of Korea Radioactive Waste Management Corporation (KRMC) was performed to examine the contribution of each radiation source affecting dose rate distribution around the cask. Various radiation sources, which contain neutron and gamma-ray sources placed in active fuel region and the activation source, and imaginary nuclear fuel were all considered in the MCNP calculation model to realistically simulate the actual situations. It was found that the maximum external and surface dose rates of the spent fuel cask were satisfied with the domestic standards both in normal and accident conditions. In normal condition, the radiation dose rate distribution around the cask was mainly influenced by activation source ($^{60}Co$ radioisotope); in another case, the neutron emitted in active fuel region contributed about 90% to external dose rate at 1m distance from side surface of the cask. Besides, the contribution level of activation source was dramatically increased to the dose rates in top and bottom regions of the cask. From this study, it was recognized that the detailed investigation on the radiation sources should be performed conservatively and accurately in the process of radiation shielding analysis for a BUC cask.

A Study of Cyclic Scheduling Analysis in FMS Based on the Transitive Matrix (추이적 행렬을 이용한 유연생산시스템의 순환 스케쥴링 분석)

  • 이종근
    • Journal of the Korea Society for Simulation
    • /
    • v.11 no.4
    • /
    • pp.57-68
    • /
    • 2002
  • The analysis of the cyclic scheduling problem in FMS using the transitive matrix has been proposed. Since the transitive matrix may explain all the relations between the places and transitions, we propose an algorithm to get good solution after slicing off some subnets from the original net based on machines operations. For analyzing the schedule problem, we considered two time functions such as produce time and waiting time using the P-invariant. In addition, we are shown the effectiveness of proposed algorithm after comparing with unfolding algorithms.

  • PDF

Transmitter Design for Earth Station Terminal Operating with Military Geostationary Satellites on Ka-band (Ka 대역 군위성통신 지상단말 송신기 설계)

  • Kim, Chun-Won;Park, Byung-Jun;Yoon, Won-Sang;Lee, Seong-Jae
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
    • /
    • v.25 no.4
    • /
    • pp.393-400
    • /
    • 2014
  • In this paper, we have designed the transmitter for earth station terminal operating with military geostationary satellite on Ka-band that is complied with MIL-STD-188-164A. The designed antenna of this terminal is dual-offset gregorian reflector which is consist of corrugated horn and iris polarizer, othermode transducer. This antenna meets radiation pattern and transmit EIRP spectral density requirements in this standard. The designed RF systems of this terminal are consist of Block Up Converter(BUC) converting frequency band from IF to Ka band and SSPA having low-power consumption and compact light-weight using the pHEMT MMIC compound devices. This RF systems applied with VSWR, spurious/harmonic suppression, output flatness and phase noise requirement in this standard.