• Title, Summary, Keyword: Balding

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Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient

  • Kim, Yun-Ji;Yoon, Byulee;Han, Kyudong;Park, Byung Cheol
    • Annals of dermatology
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    • v.29 no.5
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    • pp.597-601
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    • 2017
  • Background: Trichorhinophalangeal syndrome (TRPS) patients tend to have alopecia that appears to be androgenetic, and this genetic model might give clues to the pathogenesis of hair loss or hair morphogenesis. Objective: This study was conducted to identify additional genetic evidence of TRPS and hair morphogenesis from a TRPS patient. Methods: From one TRPS type I patient, we extracted RNA and profiled whole transcriptome in non-balding and balding scalp areas using high-throughput RNA sequencing. Results: We found a total of 26,320 genes, which comprised 14,892 known genes with new isoforms and 4,883 novel genes from the non-balding and balding areas. Among these, a total of 1,242 genes showed different expression in the two scalp areas (p<0.05 and log2 fold-change >0). Several genes related to the skin and hair, alopecia, and the TRPS1 gene were validated by qRT-PCR. Twelve of 15 genes (KRT6C, KRTAP3-1, MKI67, GPRC5D, TYRP1, DSC1, PMEL, WIF1, SOX21, TINAG, PTGDS, and TRPS1) were down-regulated (10 genes: p<0.01; SOX21 and PTGDS: p>0.05), and the three other genes (HBA2, GAL, and DES) were up-regulated (p<0.01) in the balding scalp. Many genes related to keratin and hair development were down-regulated in the balding scalp of the TRPS type I patient. In particular, the TRPS1 gene might be related to androgen metabolism and hair morphogenesis. Conclusion: Our result could suggest a novel perspective and evidence to support further study of TRPS and hair morphogenesis.

Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells

  • Kwack, Mi-Hee;Ahn, Ji-Sup;Kim, Moon-Kyu;Kim, Jung-Chul;Sung, Young-Kwan
    • BMB Reports
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    • v.43 no.10
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    • pp.688-692
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    • 2010
  • In a previous study, we recently claimed that dihydrotestosterone (DHT)-inducible dickkopf-1 (DKK-1) expression is one of the key factors involved in androgen-potentiated balding. We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs). Here, we investigated whether or not L-threonate could attenuate DHT-induced DKK-1 expression. We observed via RT-PCR analysis and enzyme-linked immunosorbent assay that DHT-induced DKK-1 expression was attenuated in the presence of L-threonate. We also found that DHT-induced activation of DKK-1 promoter activity was significantly repressed by L-threonate. Moreover, a co-culture system featuring outer root sheath (ORS) keratinocytes and DPCs showed that DHT inhibited the growth of ORS cells, which was then significantly reversed by L-threonate. Collectively, these results indicate that L-threonate inhibited DKK-1 expression in DPCs and therefore is a good treatment for the prevention of androgen-driven balding.

The Clinical Study Using Oriental Medicine Extract on Male Pattern Hair Loss

  • Lee Yoon-Gyeong;Kim Jeong-Ki;Cho Hyun Gug
    • Biomedical Science Letters
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    • v.10 no.3
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    • pp.317-324
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    • 2004
  • In order to examine the clinical effects on male pattern hair loss, the oriental medicine extract composed of Polygoni multiflori Radix, Angelica gigantis Radix and Lycii Fructus was tested to balding people. 40 males and 10 females were participated in this experiment, and they had spread the extract on their scalp themselves one time a day for 18 months. After 18 months, all participants submitted the reports that had questionnaires to determine the effect of topical oriental medicine extract on hair growth and/or hair loss preventing in balding people. In the results, ir was found that hair density on the entire scalp was gradually increased during the spreading period of the extract in most of balding people. The hair loss was observed about 1 week or 2 months after extract treatment and hair growth was observed about 6 months after extract treatment. In the reports, 74% of participants answered that the extract was effective on hair growth and hair loss preventing, and improvement of scalp condition. From these results, it is suggested that the extract composed of Polygoni multiflori Radix, Angelica gigantis Radix and Lycii Fructus may be an effective medical care to hair growth and hair loss preventing in human.

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Analysis of Hairpiece-related Patent Trends (가발 관련기술에 대한 특허동향 연구)

  • Park, Jang-Soon;Kim, Young-Joo;Lim, Sun-Nye
    • Journal of Digital Convergence
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    • v.16 no.12
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    • pp.611-617
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    • 2018
  • This study divided hairpiece-related technologies into three categories: Materials, Structure, Hair Extensions. Then, it investigated the current patent application trends in the above technologies and attempted to determine what aspects should be focused on in terms of the growth potential of hairpiece-related technologies and future technologies. A hairpiece is used to cover a specific balding area resulting from innate factors such as heredity or acquired traits including disease or accident. It is also used to make short hair look longer. Recently, as the rates of hair loss caused by stress increase, there has been a rising demand for hairpieces that can quickly and conveniently cover a balding region as well as satisfy people's aesthetic needs through diverse hairstyling. Even though patents have been applied evenly across hairpiece technology fields, patent activity has declined since 2010 was confirmed. Therefore, this study targets the facilitation and expansion of the hairpiece technology market by suggesting desirable R&D directions for future hairpiece-related technologies after analyzing current hairpiece patent trends.

Hair Growth Promoting Effect of Radish Crude Saponin Extract on Athymic Nude Mice

  • Kim, Hyun-Kyoung
    • International journal of advanced smart convergence
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    • v.8 no.1
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    • pp.184-195
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    • 2019
  • This study investigates the hair restoration efficacy of selected radish saponin extracts on nude mice. Nude mice genetically predisposed to pattern balding were used in this study. Our study revealed the underlying mechanism of stimulating hair growth in athymic nude mice by repair the nu/nu follicular keratin differentiation defect. Thus, the topical application of radish saponin may represent a novel strategy for the management and therapy of certain forms of alopecia. The term of hair density of PEE treated nude mice were significantly increase as compared with of control nude mice. Histological observation of skin sample showed no hair follicle or only distorted hair follicles were observed in the control samples, in contrast, by the PEE treatment groups showed a fully formed and increased the number of hair follicles up to three times higher than that of control group in terms of the number of hair follicles in nude mouse skin.PEE treated mice the number of BrdU-labeled keratinocytes per anagen follicle increased significantly, especially in the follicular bulbs and outer root sheath compared with the control mice. Moreover, PEE-treated nude mice also exhibited a significant increase in the number of BrdU-labeled epidermal keratinocyte proliferation.

Countermeasures to Irregulor Abrasion of Section Insulators for Electric Railroad Catenary (전차선 절연구분장치 절연재의 이상마모 대책)

  • 최규형
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.16 no.6
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    • pp.87-94
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    • 2002
  • As a section insulator dividing the electric railroad catenaries with different phases, the AC/DC section insulator which divides AC and DC railroad catenary have the complex structure, and suffer irregular abrasion on the surface or insulator rods when it is installed at the underground railroad. This paper intended as an investigation of the irregular abrasion of section insulators, provides the field measurements of abrasion level along insulator length and the abrasion patterns. The height variation of insulator parts and the balding length of insulators against pantograph's contact force are analysed experimentally, and the irregular abrasion mechanism is clarified with the help of theoretical analysis on the interaction between pantographs and section insulators. On the basis of experimental and theoretical analysis, the countermeasures to reduce the irregular abrasion are provided too.

The Functional Effects for the Prevention and Treatment on Hair Loss from Astringent Persimmon Fruit Extracts (떫은감 추출물의 발모 및 탈모의 기능성 효과)

  • Im, Hyung SiK
    • The Journal of the Convergence on Culture Technology
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    • v.4 no.3
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    • pp.253-259
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    • 2018
  • Astrigent persimmon fruit resources have been used traditionally to treat different systemic diseases and acclaimed for various biological activities including hair growth. This study investigates the hair restoration efficacy of astrigent persimmon fruit extracts on genetically predisposed to balding pattern Black mice model. Water extract of astrigent persimmon fruit(10 mg/mouse/day) with standardized vehicle formulation, only vehicle and positive control minoxidil (2%) were applied daily until completion of two full hair growth generations. The changing pattern of hair growth were observed through two hair growth generations of C57BL/6 Black mice. The hair existing area and hair length was increased significantly (P > 0.001) in astrigent persimmon fruit treated mice than vehicle-treated control mice. Furthermore, histological assessment revealed that the number of hair follicles did not remarkably increase after astrigent persimmon fruit treatment in compare to control mice. Thus, our data revealed that the topical application of astrigent persimmon fruit may promote hair growth in nude mice by extend the hair existing area and increase hair length which is an indicator of prolong anagen phase.