• Title, Summary, Keyword: Burning mouth syndrome

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Effect of Gabapentin for the Treatment of Burning Mouth Syndrome Comorbid with Depression in Postmenopausal Women (폐경 후 여성의 우울증에 수반된 구강 작열감 증후군(Burning Mouth Syndrome)에 대한 Gabapentin의 효과)

  • Kim, Min-Jeong;Kim, Hyun-Seuk;Park, Si-Sung
    • Korean Journal of Psychosomatic Medicine
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    • v.22 no.2
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    • pp.138-142
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    • 2014
  • Burning mouth syndrome is characterized by intra-oral burning sensation without any organic abnormalities. This syndrome is associated with various etiological factors such as neuropathy, malnutrition, menopause and depression. Several medications have been tried for the treatment. Those are analgesics, hormones, anticonvulsants and antidepressants. However, optimal effective pharmacologic treatment remains still unknown. The purpose of this case study is to report the clinical effectiveness of gabapentin in the treatment of burning mouth syndrome in postmenopausal women with comorbid depression. We report two menopausal women. Antidepressants were effective for improving depressive symptoms, but it had no effects on intra-oral burning sensation. Gabapentin reduced intra-oral burning sensation effectively for all two patients. One patient reported 55% reduction(a decrease from 9 to 4 on VAS), the other patient reported 35% reduction(from 8 to 5) of the intra-oral burning sensation during 16 weeks. The minimal effective daily dose of gabapentin was 300mg. This study suggests that gabapentin might be a useful, effective therapeutic option for treating burning mouth syndrome in postmenopausal women with comorbid depression. Further prospective clinical studies are needed to investigate the effectiveness of gabapentin in patients with burning mouth syndrome.

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A Review of Burning Mouth Disorders (구강작열감질환에 관한 고찰 및 의료분쟁 증례보고)

  • Hur, Yun-Kyung;Jung, Jae-Kwang;Choi, Jae-Kap
    • The journal of the Korean dental association
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    • v.48 no.9
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    • pp.688-695
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    • 2010
  • Burning mouth disorders (sometimes referred to as burning mouth syndrome) are characterized by a burning sensation in the tongue or other oral sites, usually in the absence of clinical and laboratory findings. Affected patients often present with multiple oral complaints, including burning, dryness and taste alterations. Burning mouth complaints are reported more often in women, especially after menopause. Typically, patients awaken without pain, but report increasing symptoms through the day and into the evening. Conditions that have been reported in association with burning mouth syndrome include chronic anxiety or depression, various nutritional deficiencies, diabetes and changes in salivary function. However, these conditions have not been consistently linked with the syndrome, and their treatment has had little impact on burning mouth symptoms. Recent studies have pointed to dysfunction of several cranial nerves associated with taste sensation as a possible cause of burning mouth disorders. The most common central mechanism that likely explains burning mouth disorders is a centrally mediated continuous neuropathic pain. Given in low dosages, benzodiazepine, tricyclic antidepressants or anticonvulsants may be effective in patients with burning mouth disorders.

6 Cases of Burning Mouth Syndrome Treated by Korean Medical Treatment (한방 치료로 호전된 구강 작열감 증후군 환자 6명에 대한 증례보고)

  • Kim, Nan-Ee;Kim, Yeon-Soo;Jee, Seon-Young;Hwangbo, Min
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.32 no.3
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    • pp.244-253
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    • 2019
  • Objectives : The purpose of this study is to report the effects of Korean medical treatment on six patients with burning mouth syndrome. Methods : We treated six patients with burning mouth syndrome using following treatments: Oryeong-San, acupuncture and pharmacopuncture. Numeric rating scale(NRS) of burning pain, scores of dry mouth, progression of symptoms were analyzed to evaluate the effects of treatment. Results : NRS of pain and scores of dry mouth decreased after treatment. Conclusions : This clinical study suggests that Korean medical treatment can be effective in treating Burning Mouth Syndrome.

Burning Mouth Syndrome (구강작열감 증후군)

  • Jeong, Sung-Hee
    • The journal of the Korean dental association
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    • v.55 no.9
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    • pp.626-633
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    • 2017
  • Burning mouth syndrome(BMS) is a burning sensation in the oral mucosa and $doesn^{\circ}$Øt have any identifiable oral lesion and organic etiology. Diagnosis of BMS is mainly based on clinical features and serial exclusion of other possible causes. There is no specific examination for BMS and that could embarrasse the dentist. In this study, the characteristics, differential diagnosis and several treatments of BMS are presented so that dentists can better diagnose BMS to maintain a good relationship with the patients.

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Clinical Characteristics and Evaluation of Yin-deficiency Syndrome in Patients with Burning Mouth Syndrome (구강작열감증후군 환자의 임상적 특징 및 음허증 평가)

  • Seon, Jong-Ki;Kim, Jin-Sung;Han, Ga-Jin;Oh, Seung-Whan;Son, Ji-Hee;Kang, Kyung;Kim, Ju-Yeon;Ryu, Bong-Ha
    • The Journal of Internal Korean Medicine
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    • v.32 no.4
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    • pp.473-486
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    • 2011
  • Objectives : This study was designed to investigate the clinical characteristics and usefulness of comprehensive diagnosis of Yin-deficiency and heart rate variability in patients with burning mouth syndrome (BMS). Methods : We surveyed 30 burning mouth syndrome patients visiting the Oral Diseases Clinic of Kyung Hee University Oriental Medicine Hospital from April to September of 2011. The subjects were evaluated on self-assessed severity of burning mouth syndrome and xerostomia using visual analogue scale (VAS) score and Yin-deficiency condition (based on the 10-item Yin-deficiency questionnaire). Salivary function was measured by the unstimulated salivary flow rate (USFR), and heart rate variability (HRV) parameters were recorded by SA-2000E (Medicore Co., Ltd., Korea). Results : There were substantial significant positive correlations between burning sensation VAS scores in mouth and Yin-deficiency scores. There was significant negative correlation between xerostomia VAS score and USFR. Compared to the normal range of total power (TP) in HRV parameters, the burning mouth syndrome patients showed significant lower values of TP. Conclusions : The results of this study suggest that comprehensive diagnosis of Yin-deficiecny and HRV parameters are useful in diagnosing of burning mouth syndrome patients. Therefore, we assume that improvement of Yin-deficiency condition can be a potentially effective way to treat burning mouth syndrome.

Antidepressant-induced Burning Mouth Syndrome - A Unique Case

  • Raghavan, Shubhasini Attavar;Puttaswamiah, Rajiv Nidasale;Birur, Praveen N.;Ramaswamy, Bhanushree;Sunny, Sumsum P.
    • The Korean Journal of Pain
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    • v.27 no.3
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    • pp.294-296
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    • 2014
  • Burning Mouth Syndrome (BMS) is defined as a chronic orofacial pain syndrome, without evidence of mucosal lesions and other clinical signs of disease or laboratory abnormalities. Patients with BMS complain of burning pain in the mouth, xerostomia and taste disturbances. It is more common among women and the median age of occurrence is about 60 years. BMS may be primary or secondary to other diseases. The mainstay in the treatment of BMS includes antidepressants, benzodiazepines, and anticonvulsants. A few cases of BMS caused due to medication have been reported. The causative drugs include angiotensin-converting enzyme inhibitors, anticoagulants, antipsychotics, antiretrovirals, and benzodiazepines. This is a case report of a patient on antidepressants who developed symptoms of BMS thereby causing a dilemma in management.

The Relationship between Pain Perception Scale and Keratinization Rate of Oral Mucosa to Nd-YAG Laser Stimulation in Burning Mouth Syndrome Patients (구강작열감 증후군 환자에서 Nd-YAG 레이저 조사에 대한 구강점막 부위의 통증 인지도와 점막세포 각화도와의 관계)

  • Kim, Ji-Yeon;Kim, Byung-Gook;Chung, Sung-Su
    • Journal of Oral Medicine and Pain
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    • v.26 no.2
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    • pp.161-171
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    • 2001
  • In order to determine how oral mucosal change relates to inducing factors of burning mouth syndrome, the difference in pain perception scale and keratinization rate between burning mouth syndrome patients and normal subjects were investigated. Twenty patients (13 female, 7 male, mean age: 59 years), presenting in the Department of Oral Medicine, Chonnam National University Hospital were participated in this study. All subjects had been complaining of constant oral burning pain for more than a year, none took any strong analgesics, and none had oral mucosal lesions. Twenty volunteers (11 females, 9 males, mean age: 25 years) were also participated in this study as a control group. The control subjects had never had any symptoms of oral burning pain. A thermal stimulation using a Nd-YAG laser and cytological smear were carried out to anterodorsal part of tongue, tip of tongue, the left buccal mucosa, the lower lip mucosa and the chief complaint site. Stimulation of the dorsum of left hand was also carried out to contrast the mucosal area of burning mouth syndrome subjects and the control subjects. The laser output power could be adjusted from 0.75W to 4W. The pain perception scale of the burning mouth syndrome subjects were lower than in control subjects in the chief complaint area, the anterodorsal part of tongue and the buccal mucosa(p<0.01). The keratinization rate of burning mouth syndrome subjects, however, was higher keratinization rate than in normal subjects in the same area and lower lip mucosa(p<0.001). From above results, the anterodorsal part of tongue is the most appropriate site to use diagnostic laser stimulation. The higher level of keratinization and the lower level of thermal pain perception of the burning mouth syndrome subjects are explained as a protective mechanism against xerostomia and burning sensations. The application of Nd-YAG laser stimuli and cytological smear to oral mucosal surface could therefore be usefully employed as appropriate and standardized diagnostic tools for chronic orofacial pain subjects.

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A Case Study of Burning Mouth Syndrome with Oro-facial Dyskinesia Treated with Korean Medicine using Se-sim Pharmacopuncture (심화상염(心火上炎)으로 진단된 설통(舌痛)과 구강안면부 진전(振顫)의 세심약침을 이용한 한의치료 1례)

  • Kim, Min-serh;Lee, Jun-su;Park, Sang-eun;Hong, Sang-hoon
    • The Journal of Internal Korean Medicine
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    • v.38 no.5
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    • pp.564-575
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    • 2017
  • Objectives: This clinical report describes one patient with the clinical characteristics of burning mouth syndrome accompanied by oro-facial dyskinesia. Methods: The patient with burning mouth syndrome and jaw tremor was treated using the following Korean medicine treatments: the herbal medicines Yukgunja-tang-gami (六君子湯加味) and Sibak-tang-gami (柴朴湯加味) and acupuncture for 16 days, together with 10 Se-sim (Uncaria Ramulus et Uncus) pharmacopuncture procedures. Patient symptoms were evaluated daily using a Visual Analog Scale questionnaire and twice using the STAI (State-Trait Anxiety Inventory) questionnaire. Results: After the treatments, the oro-facial dyskinesia and burning sensation on the tongue were improved by 62.5%. The mental state of anxiety, regarded as the reason for these complaints, was also improved, based on the State-Trait Anxiety Inventory results (67/61 versus 57/52). We found that the improvement was better when combining Se-sim (Uncaria Ramulus et Uncus) pharmacopuncture with the conventional herbal medicine and acupuncture used in Korean medicine. Conclusion: Korean medicine treatments may be valuable for patients with burning mouth syndrome and oro-facial dyskinesia.

Clinical Effects of Salivary Peroxidase System Containing Gel on the Patients with Burning Mouth Syndrome (Salivary peroxidase system 함유 gel의 구강내 작열감 증후군 환자에 대한 치료효과)

  • Sung-Woo Lee;Jin-Woo Chung
    • Journal of Oral Medicine and Pain
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    • v.21 no.1
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    • pp.133-140
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    • 1996
  • Saliva have many important functions in the maintenance of oral health. Saliva contains protective components, antibacterial enzymes, and other rubricating glycoprotein elements. When the salivary flow decreases of the salivary composition changes, a normally healthy mouth can become susceptible to caries, periodontal disease, and mucositis, and other diseases. Salivary peroxidase system acts as an antimicrobial factor in the oral cavity, having a role in the prevention of dental plaque accumulation, dental caries and gingivitis. Recently, this enzyme system has been introduced by many researchers in the form of toothpaste, mouthwash or moisturizing gel for use in patients with various disease states . The author prescribed the peroxidase system containing gel (Oralbalance) to the 18 Burning Mouth Syndrome (BMS) patients for 1 week and investigated the changes of the subjective symptoms, $HOSCN/OSCN^-$ levels of unstimulated whole saliva, and the salivary flow rates. The obtained results were as follows : 1. The patients reported decrease in all symptoms of BMS after the use of peroxidase system containing gel, particulary, a significantly higher decreases of dry mouth and burning symptoms. 2. Decreased $HOSCN/OSCN^-$ levels of unstimulated whole saliva were detected in the patients with BMS after the use of perosidase system containing gel for 1 week. 3. There was no difference between the flow rates of unstimulated whole saliva before and after uses of peroxidase system containing gel for 1 week.

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The Relationship between Burning Mouth Syndrome and Helicobacter pylori in the Oral Cavity (구강작열감증후군과 구강 내 Helicobacter pylori의 상호관련성)

  • Kim, Jun-Ho;Ryu, Ji-Won;Yoon, Chang-Lyuk;Ahn, Jong-Mo
    • Journal of Oral Medicine and Pain
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    • v.36 no.2
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    • pp.91-97
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    • 2011
  • Helicobacter pylori (H. pylori) is bacterial infection, with more than half of the world population infected and relates to many oral disease such oral lichen planus, recurrent aphthous ulceration, periodontal disease and halitosis and so on. Burning mouth syndrome(BMS) is defined as a burning sensation of the oral mucosa, lips, and/or tongue, in the absence of specific oral lesions. The etiology of BMS is suggested local, systemic and psychological factors and researchs related BMS and to infection of H. pyloir in the oral cavity are few. The purpose of this study was to evaluate relationship between burning mouth syndrome and H. pylori in the oral cavity. We recruited 21 subjects with burning mouth syndrome and 21 subjects as control group. Samples in the oral cavity were taken area of buccal mucosa, dorsum of the tongue and saliva. We analysed samples by nested polymerase chain reaction(PCR). The results were as follows: 1. Among 21 patients with burning mouth sydrome and 21 subjects of control group, 6(29%) and 3(14%) were positive respectively(P>0.05). 2. In detection rate of H. pylori in area taken sample, 3(14%), 2(10%) and 4(19%) were positive in buccal mucosa, dorsum of the tongue and saliva of patient and 2(10%) and 1(5%) were positive in dorsum of the tongue and saliva of control group(P>0.05). Conclusively, we can guess that H. pylori in the oral cavity is not related with burning mouth syndrome.