• Title, Summary, Keyword: Burning mouth syndrome

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Effects of Korean Medicine Therapies on Oral Pain in Patients with Burning Mouth Syndrome: a Before and After Study (구강작열감 증후군 환자의 구강내 통증에 대한 한방치료의 효과: 전.후 비교 연구)

  • Son, Ji-Young;Kim, Ju-Yeon;Kang, Kyung;Baek, Seung-Hwan;Choi, Jane;Jang, Seung-Won;Ryu, Bong-Ha;Kim, Jin-Sung
    • The Journal of Internal Korean Medicine
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    • v.34 no.2
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    • pp.122-133
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    • 2013
  • Objectives : Burning mouth syndrome (BMS) is characterized by chronic pain or a burning sensation in the mouth. There is limited evidence available to provide clear guidelines for treating BMS patients and a variety of different treatments have been used. This study was designed to investigate the Effects of Korean medicine therapies on oral pain in patients with BMS. Methods : We surveyed 30 BMS patients who newly visited the Oral Diseases Clinic in the Kyung Hee University Korean Medicine Hospital from February 2012 to March 2013. When the patients visited the clinic for the first time, they were evaluated on sociodemographic characteristics, BMS questionnaire, severity of pain using visual analogue scale (VAS) and pressure pain threshold (PPT) of the acupuncture point CV17. After 3 weeks of Korean medicine therapies (acupuncture, electroacupuncture, pharmacopuncture and herbal medicine), they were re-evaluated with the VAS and the PPT. Results : After 3 weeks of Korean medicine therapies, 30 patients' oral pain improved and the PPT score on CV17 rose, which means decrease of qi-stagnation score. Conclusions : Korean medicine therapies were effective on oral pain in patients with BMS. To confirm the additional curative effect and evaluate the efficacy of each treatment, well-designed randomized controlled trials will be needed in the future.

Titanium Ions Released from Oral Casting Alloys May Contribute to the Symptom of Burning Mouth Syndrome

  • Park, Yang Mi;Kim, Kyung-Hee;Lee, Sunhee;Jeon, Hye-Mi;Heo, Jun-Young;Ahn, Yong-Woo;Ok, Soo-Min;Jeong, Sung-Hee
    • Journal of Oral Medicine and Pain
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    • v.42 no.4
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    • pp.102-108
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    • 2017
  • Purpose: Many metal ions released from dental casting alloys have been reported to influence the intraoral symptoms of oral lichen planus (OLP) and burning mouth syndrome (BMS). The aim of this study was to investigate the relationship between salivary metal ion levels and the prosthetic duration as well as to evaluate the time-dependent morbid effects of metal ions in OLP and BMS patients. Methods: Three study groups consist of the following subjects respectively: 17 OLP patients, 12 BMS patients, and 12 patients without oral symptoms. The salivary concentrations of 13 metal ions (copper, cobalt, zinc, chromium, nickel, aluminum, silver, iron, titanium [Ti], platinum, tin, palladium, and gold) were measured by Laser Ablation Microprobe Inductively coupled Plasma Mass Spectrometry. Results: The Ti ions had statistically significant differences among the groups with a prosthetic duration of less than 5 years. There were no significant differences between all ion levels among the groups wearing dental cast alloys for over 5 years. In the BMS group, the level of Ti ions in patients with prosthetic restorations less than 5 years old were significantly high (p<0.05). Conclusions: In the BMS group, 3-60 months during which salivary Ti levels were higher were matched with the duration of burning symptoms ($15.6{\pm}17.1months$). Furthermore, Ti ions were statistically high in the oral cavity of BMS patients fitted with dental casting alloys for 5 years. These results suggest that Ti ions released from dental implants and oral prostheses could attribute to burning sensation of BMS.

A Study on The Clinical Characteristics and Treatment in Burning Mouth Syndrome (구강 작엽감 증후군 (BMS)의 임상적 특징 및 치료에 관한 연구)

  • Mi-Jung Yeom;Chong-Youl Kim
    • Journal of Oral Medicine and Pain
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    • v.20 no.1
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    • pp.39-52
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    • 1995
  • Burning mouth syndrome is characterized by a burning sensation in oral cavity without clinical signs. There has b een no established theories about the diagnosis and treatment. The purpose of this article is to examine the clinical feature of BMS patients of Korean and to present a treatment protocol that can be helpful in clinical applications. The subjects chosen for the study were 52 patients who had visited Department of Oral Diagnosis at Yonsei University Dental Hospital and were diagnosed as BMS. We did questionnaires and precise oral exam, laboratory exam, grouping of our patients, individual treatment for the groups and classification of responses to the treatment. The following results were obtained: 1. Chief complaints were throbbing (71.2%), pricking, stinging, tingling (30.8%), burning(25a%). The tongue is the most frequently affected site (82.7%), followed by full mouth, gingiva, palate, buccal mucosa, lips, throat, labial mucosa and floor of mouth. 2. The average age of onset was 48.1 year and the male to female ratio was 1 to 3. The average duration of symptom was 11.69 months for male and 23.07 months for female. 3. 32.7% of patients had appealed continuous pain, which was the most cases. Aggravating factors were peppery food, salty food, hot food, fatigue, tension conversation, sour food, cold food and toothpaste. Reducing factors were cold food, diet, going to sleep and smoking. 4. Associated symptoms were dry mouth, other life problem, altered taste perception, bad taste, throat pain, tingle and difficulty in swallowing. 5. Most of patients had appealed that there was not associated event on onset of symptom, and the order of prevalence is as fallow; dental treatment, stress, denture wearing, an attack of a systemic disease. 92.3% of patient appealed that there was no psychological withering and 7.7% of patients appealed positively. 6. There were eight males and four females that had jobs. 7. There was no family history in 100% of patients in questions about presence of family history. 8. 96.2% of patients appealed that there was no oral habits. 13.5% of patients had dryness of oral mucosa in oral exam. A significant relation to dental prosthesis was not observable, but incidence of diseases due to stress appeared high in BMS which had the clinical characteristics as above. A group having low serum iron was 63.5% and in this group period of potential iron deficiency appeared high in incidence just before move to anemia. A group represented positive response was 38.5% in fungus study for Candida albicans. Since we can expect high treatment response by prescription of iron-contained drug and antifungal drug in these patients, diagnosing patients' condition of BMS can be achieved in more various aspects through study for serum iron and Candida albicans. Furthermore, it is expected that treatment protocol can be made.

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Topical Application of Clonazepam to Burning Mouth Syndrome (구강 작열감 증후군에서 클로나제팜의 국소적 적용)

  • Shim, Young-Joo;Choi, Jong-Hoon;Ahn, Hyung-Joon;Kwon, Jeong-Seung
    • Journal of Oral Medicine and Pain
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    • v.34 no.4
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    • pp.429-433
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    • 2009
  • Burning mouth syndrome (BMS) is defined as burning pain in the tongue or other oral mucous membrane associated with normal sign and laboratory findings at least 4 to 6 months. There are many factors that affect this condition and the pain characters are various among the sufferers, so it is difficult to diagnose exactly and treat properly. The cause of BMS is currently unknown. The etiology is presumed to be that it is related with local, systemic and psychogenic factor. The BMS is related with local factor such as allergic reaction, oral fungal infection(candidiasis), parafunctional oral habits and systemic factors such as diabetes mellitus, hypothyroidism, nutritional deficiencies(vitamin $B_{12}$, folic acid), hyposalivation and psychogenic factor such as depression, anxiety, cancerphobia. So clinicians must be aware of these factors and can give proper treatment options to patients. The management of BMS are pharmacologic management, cognitive behavioral therapy and psychotherapy treatment. Clonazepam, gabapentin, amitriptyline, alpha-lipoic acid and capsaicin are used to manage the BMS. Among these, topical clonazepam is reported that the effect is higher than systemic medication and the complications are rare. This case report is about some cases of the effect of topical clonazepam on BMS.

Review about effects of sleep disturbances on Burning mouth syndrome (수면장애가 구강작열감 증후군에 미치는 영향에 대한 고찰)

  • Lim, Hyun-Dae;Lee, You-Mee
    • Journal of Oral Medicine and Pain
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    • v.38 no.4
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    • pp.313-318
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    • 2013
  • The aim of this study was to the relationship between sleep disturbances and Burning mouth syndrome(BMS). BMS presents as a chronic burning sensation in the oral mucous membrane that is frequently associated with sleep disturbances. BMS is considered neuropathic pain condition with dysfunction of small diameter afferent sensory fiber. A review of the studies reveals, BMS suggested peripheral and cental nervous system changes. Sleep disruption or Rem sleep deprivation cause an inhibition of opioid protein synthesis and a reduced affinity of ${\mu}$ and ${\delta}$ opioid receptors. Let me say that sleep disturbances suggest a risk factor For BMS and support to evaluate as a part of BMS treatment. Further study will be required to ascertain the relationship between distruption of sleep continuity or Rem sleep deprivation and BMS and the evidence of altered neurochemical degeneration of BMS.

Stevens-Johnson syndrome and abuse of anabolic steroids

  • Cocca, Serena;Viviano, Massimo
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.43 no.1
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    • pp.57-60
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    • 2017
  • Stevens-Johnson syndrome (SJS) is characterized by mucocutaneous tenderness and typical hemorrhagic erosions, erythema and epidermal detachment presenting as blisters and areas of denuded skin. SJS is often observed after drug use as well as after bacterial or viral infections. Several drugs are at high risk of inducing SJS, but there are no cases in the English literature regarding anabolic steroid use triggering SJS. In our paper, we describe a case in which use of anabolic androgenic steroids (AAS) was associated with SJS. The patient participated in competitive body-building and regularly took variable doses of AAS. Initial symptoms (headache, weakness, pharyngodynia, and fever) were ignored. After a week he presented to the Emergency Department with a burning sensation on the mouth, lips, and eyes. Painful, erythematous, maculopapular, and vesicular lesions appeared all over the body, including on the genitals. During hospitalization, he also developed a cardiac complication. The patient had not taken any drugs except AAS.

A Study on Life Changes of Burning Mouth Syndrome Patients Through SRRS (SRRS를 이용한 BMS 환자의 생활변화에 관한연구)

  • Ko, Myung-Yun;Ok, Su-Min;Kwon, Kyung-Min;Tae, Il-Ho;Ahn, Yong-Woo
    • Journal of Oral Medicine and Pain
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    • v.34 no.2
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    • pp.189-195
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    • 2009
  • The life changes of burning mouth syndrome patients were evaluated through the Social Readjustment Rating Scale (SRRS) questionnaire. 67 subjects were included for the study and they were categorized into 2 groups (BMS 33 persons, control 34 persons) and investigated in the Dept. of Oral Medicine, Pusan National University Hospital from January to December, 2008. The obtained results were as follows : 1. BMS Group have experienced more changes in their lives than the control group within one year. This difference is showed between 7 to 12 months before hospital visit. 2. There is no significant difference between high score group(life vairation above 150) and the control group. 3. When the survey is divided by six categories, no significant difference shows within six categories. However, the BMS group shows high score within the social life category.

Treatment and diagnosis of oral pain without identifiable oral mucosa lesion (정상 구강 점막 소견의 구강 통증 환자의 진단 및 치료)

  • Kim, Tae-Su;Kim, Sang-Yoon;Nam, Soon-Yuhl;Roh, Jong-Lyel;Choi, Seung-Ho
    • Korean Journal of Bronchoesophagology
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    • v.14 no.1
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    • pp.29-33
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    • 2008
  • Objectives : Oral pain without identifiable oral mucosa lesion is probably multifactorial origin, which include burning mouth syndrome (BMS), oral candidiasis and so on. The aim of this study was to analyze the characteristics of oral pain without identifiable oral mucosa lesion and to evaluate treatment outcome of those patients. Materials and Methods : We reviewed 50 patients without identifiable oral mucosa lesion who were complaint of oral pain. The patients were analyzed according tothe sites, associated symptoms, laboratory tests and fungus culture. The questionnaire included questions on their current diseases, smoking and alcoholic history, psychological factors, and symptoms. Results : The average age of patients was 60 years old. The most frequently involved site was tongue (92%), followed by palate, lower lip, oropharynx, and gingiva. 60% of the patients has psychological disorder as self reported. Culture for Candida was positive in 36% of patients and serum zinc deficiency was present in 60% of patients. Serum iron, vitamin B12, hemoglobin, folic acid deficiency were present in 6-2% of patients. Seventeen patients (65%) with BMS and twelve patients (66%) with oral candidiasis were improved after treatment. Conclusion : We recommend oral candida culture to oral pain patients without oral mucosa lesion. Zinc supplementation of zinc depletion patients may be helpful whereas other laboratory tests have no diagnostic values.

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A Study on the Taste of Burning Mouth Syndrome Patients (구강작열감증후군 환자의 미각에 관한 연구)

  • Ko, Myung-Yun;Jang, Yong-Seog;Heo, Jun-Young;Ahn, Yong-Woo
    • Journal of Oral Medicine and Pain
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    • v.31 no.4
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    • pp.275-281
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    • 2006
  • The purpose of this study was to investigate whether there were any changes in taste function with buring mouth syndrome(BMS). 133 subjects (31 males and 99 females) were included for the study and they were categorized into 2 groups BMS 33 persons, control 100 persons) and investigated in the Dept. of Oral Medicine, Pusan National University Hospital from April,2005 to February,2006. The electrical taste thresholds were measured using an electrogustometer of 4 different sites in oral cavity (tongue tip, tongue lateral, circumvallate papillar and soft palate). The results were as follows : 1. The electrical taste threshold in BMS group was very significantly low. 2. The electrical taste thresholds in male and female of BMS group were significantly lower each other than those of control group 3. The electrical taste threshold of BMS group according to single/multiple lesions and chronicity were not different. 4. After treatment, electrical taste threshold and NAS decreased more significantly.

Three Case Reports of Glossodynia Patients Treated with Cheonggansoyo-san (청간소요산으로 호전된 설통 환자 3례)

  • Kim, Yeon-jin;Yang, Seung-bo;Kim, Jeong-hwa;Lee, Sang-hwa;Cho, Seung-yeon;Park, Seong-uk;Park, Jung-mi;Ko, Chang-nam
    • The Journal of Internal Korean Medicine
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    • v.38 no.4
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    • pp.491-500
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    • 2017
  • Objectives: This clinical study reports the effects of Cheonggansoyo-san (CSS) on three patients with glossodynia. Methods: Three patients with glossodynia were treated with CSS (i.e., an herbal medicine) and acupuncture. Numeric rating scales (NRSs) for glossodynia and dry mouth and hwa-byung questionnaire scores were evaluated, and the results from heart rate variability (HRV) evaluations were analyzed. Results: After treatment with CSS, three patients' glossodynia symptoms, such as burning sensations, tingling, and numbness of the tongue, were improved. NRS ratings for glossodynia and dry mouth and the hwa-byung questionnaire scores also improved, and HRV parameters were closer to the normal range. Conclusion: Cheonggansoyo-san could be used to treat glossodynia.